LeishMANIAdb
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Checkpoint protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Checkpoint protein
Gene product:
Cell cycle checkpoint protein RAD1-like, putative
Species:
Leishmania major
UniProt:
Q4QD01_LEIMA
TriTrypDb:
LmjF.20.0390 , LMJLV39_200009600 , LMJSD75_200009400
Length:
362

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0030896 checkpoint clamp complex 3 2
GO:0032991 protein-containing complex 1 2
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0140513 nuclear protein-containing complex 2 2

Expansion

Sequence features

Q4QD01
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD01

Function

Biological processes
Term Name Level Count
GO:0000075 cell cycle checkpoint signaling 4 12
GO:0000077 DNA damage checkpoint signaling 5 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006259 DNA metabolic process 4 12
GO:0006281 DNA repair 5 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0006950 response to stress 2 12
GO:0006974 DNA damage response 4 12
GO:0007165 signal transduction 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0010564 regulation of cell cycle process 5 12
GO:0010948 negative regulation of cell cycle process 6 12
GO:0031570 DNA integrity checkpoint signaling 5 12
GO:0033554 cellular response to stress 3 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0035556 intracellular signal transduction 3 12
GO:0042770 signal transduction in response to DNA damage 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0045786 negative regulation of cell cycle 5 12
GO:0046483 heterocycle metabolic process 3 12
GO:0048519 negative regulation of biological process 3 12
GO:0048523 negative regulation of cellular process 4 12
GO:0050789 regulation of biological process 2 12
GO:0050794 regulation of cellular process 3 12
GO:0050896 response to stimulus 1 12
GO:0051716 cellular response to stimulus 2 12
GO:0051726 regulation of cell cycle 4 12
GO:0065007 biological regulation 1 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901987 regulation of cell cycle phase transition 6 12
GO:1901988 negative regulation of cell cycle phase transition 7 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0004518 nuclease activity 4 1
GO:0004527 exonuclease activity 5 1
GO:0004529 DNA exonuclease activity 5 1
GO:0004536 DNA nuclease activity 4 1
GO:0008853 obsolete exodeoxyribonuclease III activity 7 1
GO:0016787 hydrolase activity 2 1
GO:0016788 hydrolase activity, acting on ester bonds 3 1
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 1
GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 6 1
GO:0140097 catalytic activity, acting on DNA 3 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 279 283 PF00656 0.727
CLV_C14_Caspase3-7 75 79 PF00656 0.410
CLV_MEL_PAP_1 157 163 PF00089 0.493
CLV_PCSK_SKI1_1 56 60 PF00082 0.437
CLV_PCSK_SKI1_1 68 72 PF00082 0.350
CLV_PCSK_SKI1_1 93 97 PF00082 0.502
DEG_APCC_DBOX_1 152 160 PF00400 0.594
DOC_CYCLIN_RxL_1 53 61 PF00134 0.486
DOC_MAPK_gen_1 150 159 PF00069 0.467
DOC_MAPK_HePTP_8 192 204 PF00069 0.554
DOC_MAPK_MEF2A_6 153 161 PF00069 0.482
DOC_MAPK_MEF2A_6 195 204 PF00069 0.560
DOC_MAPK_MEF2A_6 340 348 PF00069 0.506
DOC_MAPK_MEF2A_6 6 14 PF00069 0.414
DOC_PP2B_LxvP_1 71 74 PF13499 0.470
DOC_USP7_MATH_1 186 190 PF00917 0.523
DOC_USP7_MATH_1 302 306 PF00917 0.733
DOC_USP7_MATH_1 354 358 PF00917 0.574
DOC_USP7_MATH_1 88 92 PF00917 0.612
DOC_WW_Pin1_4 107 112 PF00397 0.545
DOC_WW_Pin1_4 6 11 PF00397 0.506
LIG_14-3-3_CanoR_1 141 147 PF00244 0.558
LIG_14-3-3_CanoR_1 15 21 PF00244 0.473
LIG_14-3-3_CanoR_1 160 166 PF00244 0.337
LIG_14-3-3_CanoR_1 237 245 PF00244 0.488
LIG_14-3-3_CanoR_1 322 326 PF00244 0.496
LIG_14-3-3_CanoR_1 331 336 PF00244 0.436
LIG_Actin_WH2_2 145 162 PF00022 0.556
LIG_APCC_ABBA_1 37 42 PF00400 0.423
LIG_BIR_II_1 1 5 PF00653 0.388
LIG_deltaCOP1_diTrp_1 25 32 PF00928 0.385
LIG_FHA_1 110 116 PF00498 0.544
LIG_FHA_1 147 153 PF00498 0.441
LIG_FHA_1 17 23 PF00498 0.456
LIG_FHA_1 238 244 PF00498 0.437
LIG_FHA_1 322 328 PF00498 0.457
LIG_FHA_1 347 353 PF00498 0.409
LIG_FHA_1 49 55 PF00498 0.462
LIG_FHA_1 90 96 PF00498 0.484
LIG_FHA_2 108 114 PF00498 0.498
LIG_FHA_2 129 135 PF00498 0.715
LIG_FHA_2 174 180 PF00498 0.486
LIG_FHA_2 336 342 PF00498 0.516
LIG_FHA_2 73 79 PF00498 0.426
LIG_LIR_Gen_1 2 12 PF02991 0.410
LIG_LIR_Gen_1 25 32 PF02991 0.400
LIG_LIR_Gen_1 289 297 PF02991 0.668
LIG_LIR_Gen_1 61 70 PF02991 0.516
LIG_LIR_Nem_3 2 7 PF02991 0.399
LIG_LIR_Nem_3 25 30 PF02991 0.403
LIG_LIR_Nem_3 315 320 PF02991 0.495
LIG_LIR_Nem_3 61 65 PF02991 0.475
LIG_NRBOX 142 148 PF00104 0.550
LIG_PDZ_Class_3 357 362 PF00595 0.618
LIG_PTB_Apo_2 284 291 PF02174 0.684
LIG_PTB_Phospho_1 284 290 PF10480 0.687
LIG_SH2_CRK 4 8 PF00017 0.412
LIG_SH2_NCK_1 62 66 PF00017 0.527
LIG_SH2_STAP1 239 243 PF00017 0.533
LIG_SH2_STAT5 239 242 PF00017 0.540
LIG_SH2_STAT5 290 293 PF00017 0.673
LIG_SH2_STAT5 4 7 PF00017 0.389
LIG_SH3_3 348 354 PF00018 0.434
LIG_SUMO_SIM_anti_2 349 354 PF11976 0.473
LIG_SUMO_SIM_par_1 105 110 PF11976 0.398
LIG_SUMO_SIM_par_1 18 23 PF11976 0.429
LIG_SUMO_SIM_par_1 221 229 PF11976 0.573
MOD_CDK_SPxxK_3 107 114 PF00069 0.600
MOD_CK1_1 233 239 PF00069 0.524
MOD_CK1_1 258 264 PF00069 0.768
MOD_CK1_1 86 92 PF00069 0.557
MOD_GlcNHglycan 124 127 PF01048 0.736
MOD_GlcNHglycan 166 169 PF01048 0.420
MOD_GlcNHglycan 231 235 PF01048 0.532
MOD_GlcNHglycan 258 261 PF01048 0.691
MOD_GlcNHglycan 297 300 PF01048 0.660
MOD_GlcNHglycan 304 307 PF01048 0.609
MOD_GSK3_1 142 149 PF00069 0.472
MOD_GSK3_1 16 23 PF00069 0.432
MOD_GSK3_1 164 171 PF00069 0.318
MOD_GSK3_1 182 189 PF00069 0.479
MOD_GSK3_1 226 233 PF00069 0.512
MOD_GSK3_1 255 262 PF00069 0.761
MOD_GSK3_1 26 33 PF00069 0.332
MOD_GSK3_1 331 338 PF00069 0.433
MOD_GSK3_1 46 53 PF00069 0.420
MOD_N-GLC_1 46 51 PF02516 0.537
MOD_NEK2_1 142 147 PF00069 0.466
MOD_NEK2_1 273 278 PF00069 0.762
MOD_NEK2_1 295 300 PF00069 0.620
MOD_NEK2_1 32 37 PF00069 0.455
MOD_NEK2_1 48 53 PF00069 0.455
MOD_NEK2_2 312 317 PF00069 0.643
MOD_PIKK_1 128 134 PF00454 0.762
MOD_PIKK_1 335 341 PF00454 0.540
MOD_PK_1 331 337 PF00069 0.433
MOD_PKA_2 159 165 PF00069 0.552
MOD_PKA_2 273 279 PF00069 0.786
MOD_PKA_2 283 289 PF00069 0.594
MOD_PKA_2 321 327 PF00069 0.464
MOD_Plk_1 190 196 PF00069 0.481
MOD_Plk_4 142 148 PF00069 0.507
MOD_Plk_4 26 32 PF00069 0.428
MOD_Plk_4 312 318 PF00069 0.613
MOD_Plk_4 331 337 PF00069 0.423
MOD_Plk_4 346 352 PF00069 0.360
MOD_Plk_4 72 78 PF00069 0.476
MOD_ProDKin_1 107 113 PF00069 0.559
MOD_ProDKin_1 6 12 PF00069 0.504
MOD_SUMO_rev_2 101 106 PF00179 0.573
MOD_SUMO_rev_2 191 200 PF00179 0.578
MOD_SUMO_rev_2 341 347 PF00179 0.600
TRG_DiLeu_BaEn_2 342 348 PF01217 0.511
TRG_ENDOCYTIC_2 211 214 PF00928 0.533
TRG_ENDOCYTIC_2 290 293 PF00928 0.673
TRG_ENDOCYTIC_2 4 7 PF00928 0.389
TRG_ENDOCYTIC_2 62 65 PF00928 0.518
TRG_Pf-PMV_PEXEL_1 104 108 PF00026 0.400
TRG_Pf-PMV_PEXEL_1 178 183 PF00026 0.553

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HUB9 Leptomonas seymouri 68% 100%
A0A0S4J1V0 Bodo saltans 33% 100%
A0A1X0NWX4 Trypanosomatidae 45% 100%
A0A3S7WVU5 Leishmania donovani 98% 100%
A0A422NCM6 Trypanosoma rangeli 42% 100%
A4HYN1 Leishmania infantum 97% 100%
C9ZI59 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9AI98 Leishmania braziliensis 87% 100%
E9AUI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 99%
V5BVI1 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS