TFIIH_basal_transcription_factor_subunit_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TFIIH basal transcription factor subunit, putative

Species:

Leishmania major

UniProt:

Q4QD00_LEIMA

TriTrypDb:

LmjF.20.0400 , LMJLV39_200009700 , LMJSD75_200009500

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QD00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.686
CLV_C14_Caspase3-7	505	509	PF00656	0.407
CLV_NRD_NRD_1	142	144	PF00675	0.580
CLV_NRD_NRD_1	244	246	PF00675	0.494
CLV_NRD_NRD_1	327	329	PF00675	0.565
CLV_NRD_NRD_1	520	522	PF00675	0.532
CLV_NRD_NRD_1	537	539	PF00675	0.629
CLV_NRD_NRD_1	566	568	PF00675	0.577
CLV_PCSK_FUR_1	325	329	PF00082	0.495
CLV_PCSK_FUR_1	518	522	PF00082	0.599
CLV_PCSK_FUR_1	535	539	PF00082	0.604
CLV_PCSK_KEX2_1	142	144	PF00082	0.580
CLV_PCSK_KEX2_1	244	246	PF00082	0.494
CLV_PCSK_KEX2_1	327	329	PF00082	0.506
CLV_PCSK_KEX2_1	520	522	PF00082	0.599
CLV_PCSK_KEX2_1	534	536	PF00082	0.615
CLV_PCSK_KEX2_1	537	539	PF00082	0.616
CLV_PCSK_KEX2_1	566	568	PF00082	0.577
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.586
CLV_PCSK_PC7_1	240	246	PF00082	0.515
CLV_PCSK_SKI1_1	240	244	PF00082	0.501
CLV_PCSK_SKI1_1	264	268	PF00082	0.422
CLV_PCSK_SKI1_1	371	375	PF00082	0.475
CLV_PCSK_SKI1_1	413	417	PF00082	0.662
CLV_PCSK_SKI1_1	482	486	PF00082	0.497
CLV_PCSK_SKI1_1	494	498	PF00082	0.465
CLV_PCSK_SKI1_1	550	554	PF00082	0.618
CLV_PCSK_SKI1_1	94	98	PF00082	0.579
DEG_Kelch_Keap1_1	440	445	PF01344	0.550
DEG_SPOP_SBC_1	333	337	PF00917	0.460
DEG_SPOP_SBC_1	438	442	PF00917	0.682
DEG_SPOP_SBC_1	82	86	PF00917	0.563
DOC_MAPK_gen_1	142	149	PF00069	0.419
DOC_MAPK_gen_1	325	333	PF00069	0.504
DOC_PP2B_LxvP_1	278	281	PF13499	0.482
DOC_PP4_FxxP_1	408	411	PF00568	0.616
DOC_PP4_FxxP_1	559	562	PF00568	0.620
DOC_SPAK_OSR1_1	258	262	PF12202	0.503
DOC_USP7_MATH_1	170	174	PF00917	0.713
DOC_USP7_MATH_1	179	183	PF00917	0.739
DOC_USP7_MATH_1	201	205	PF00917	0.525
DOC_USP7_MATH_1	332	336	PF00917	0.575
DOC_USP7_MATH_1	411	415	PF00917	0.618
DOC_USP7_MATH_1	423	427	PF00917	0.657
DOC_USP7_MATH_1	430	434	PF00917	0.564
DOC_USP7_MATH_1	438	442	PF00917	0.632
DOC_USP7_MATH_1	77	81	PF00917	0.598
DOC_USP7_MATH_1	82	86	PF00917	0.612
DOC_USP7_UBL2_3	159	163	PF12436	0.552
DOC_WW_Pin1_4	113	118	PF00397	0.445
DOC_WW_Pin1_4	421	426	PF00397	0.654
DOC_WW_Pin1_4	472	477	PF00397	0.549
DOC_WW_Pin1_4	6	11	PF00397	0.466
DOC_WW_Pin1_4	78	83	PF00397	0.647
LIG_14-3-3_CanoR_1	498	506	PF00244	0.620
LIG_Actin_WH2_2	355	373	PF00022	0.373
LIG_APCC_ABBA_1	127	132	PF00400	0.412
LIG_BIR_II_1	1	5	PF00653	0.427
LIG_BRCT_BRCA1_1	559	563	PF00533	0.535
LIG_Clathr_ClatBox_1	266	270	PF01394	0.391
LIG_FHA_1	129	135	PF00498	0.399
LIG_FHA_1	200	206	PF00498	0.662
LIG_FHA_1	308	314	PF00498	0.690
LIG_FHA_1	367	373	PF00498	0.438
LIG_FHA_1	461	467	PF00498	0.706
LIG_FHA_1	495	501	PF00498	0.552
LIG_FHA_2	104	110	PF00498	0.312
LIG_FHA_2	117	123	PF00498	0.462
LIG_FHA_2	86	92	PF00498	0.661
LIG_GBD_Chelix_1	375	383	PF00786	0.291
LIG_LIR_Apic_2	251	256	PF02991	0.489
LIG_LIR_Apic_2	406	411	PF02991	0.576
LIG_LIR_Apic_2	424	430	PF02991	0.400
LIG_LIR_Apic_2	558	562	PF02991	0.620
LIG_LIR_Gen_1	14	23	PF02991	0.341
LIG_LIR_Gen_1	2	11	PF02991	0.486
LIG_LIR_Gen_1	225	235	PF02991	0.539
LIG_LIR_Gen_1	460	469	PF02991	0.677
LIG_LIR_Gen_1	52	61	PF02991	0.420
LIG_LIR_Nem_3	14	20	PF02991	0.348
LIG_LIR_Nem_3	161	165	PF02991	0.575
LIG_LIR_Nem_3	2	7	PF02991	0.471
LIG_LIR_Nem_3	225	231	PF02991	0.521
LIG_LIR_Nem_3	460	465	PF02991	0.682
LIG_LIR_Nem_3	52	57	PF02991	0.359
LIG_Pex14_1	427	431	PF04695	0.601
LIG_Pex14_2	49	53	PF04695	0.352
LIG_Pex14_2	555	559	PF04695	0.631
LIG_Rb_pABgroove_1	263	271	PF01858	0.468
LIG_SH2_CRK	253	257	PF00017	0.464
LIG_SH2_NCK_1	157	161	PF00017	0.455
LIG_SH2_NCK_1	253	257	PF00017	0.360
LIG_SH2_NCK_1	31	35	PF00017	0.452
LIG_SH2_PTP2	228	231	PF00017	0.539
LIG_SH2_PTP2	95	98	PF00017	0.433
LIG_SH2_STAP1	431	435	PF00017	0.599
LIG_SH2_STAT3	486	489	PF00017	0.610
LIG_SH2_STAT5	152	155	PF00017	0.379
LIG_SH2_STAT5	228	231	PF00017	0.490
LIG_SH2_STAT5	260	263	PF00017	0.502
LIG_SH2_STAT5	31	34	PF00017	0.374
LIG_SH2_STAT5	95	98	PF00017	0.489
LIG_SH3_3	226	232	PF00018	0.387
LIG_SH3_3	24	30	PF00018	0.477
LIG_SH3_3	389	395	PF00018	0.459
LIG_SH3_3	463	469	PF00018	0.677
LIG_SUMO_SIM_anti_2	263	270	PF11976	0.395
LIG_SUMO_SIM_par_1	263	270	PF11976	0.353
LIG_SUMO_SIM_par_1	350	356	PF11976	0.362
LIG_SUMO_SIM_par_1	396	402	PF11976	0.496
LIG_SUMO_SIM_par_1	477	483	PF11976	0.551
LIG_TRAF2_1	248	251	PF00917	0.587
LIG_TRAF2_1	88	91	PF00917	0.661
LIG_UBA3_1	268	277	PF00899	0.386
LIG_WRC_WIRS_1	405	410	PF05994	0.577
MOD_CDK_SPxxK_3	421	428	PF00069	0.510
MOD_CK1_1	116	122	PF00069	0.512
MOD_CK1_1	172	178	PF00069	0.692
MOD_CK1_1	190	196	PF00069	0.540
MOD_CK1_1	254	260	PF00069	0.456
MOD_CK1_1	302	308	PF00069	0.713
MOD_CK1_1	337	343	PF00069	0.655
MOD_CK1_1	390	396	PF00069	0.478
MOD_CK1_1	437	443	PF00069	0.673
MOD_CK1_1	502	508	PF00069	0.639
MOD_CK1_1	81	87	PF00069	0.664
MOD_CK2_1	103	109	PF00069	0.331
MOD_CK2_1	201	207	PF00069	0.712
MOD_CK2_1	308	314	PF00069	0.692
MOD_CK2_1	411	417	PF00069	0.534
MOD_CK2_1	439	445	PF00069	0.574
MOD_CK2_1	85	91	PF00069	0.572
MOD_Cter_Amidation	532	535	PF01082	0.728
MOD_GlcNHglycan	136	139	PF01048	0.410
MOD_GlcNHglycan	172	175	PF01048	0.659
MOD_GlcNHglycan	181	184	PF01048	0.713
MOD_GlcNHglycan	189	192	PF01048	0.704
MOD_GlcNHglycan	336	339	PF01048	0.627
MOD_GlcNHglycan	342	345	PF01048	0.579
MOD_GlcNHglycan	389	392	PF01048	0.480
MOD_GlcNHglycan	436	439	PF01048	0.571
MOD_GlcNHglycan	442	445	PF01048	0.684
MOD_GlcNHglycan	501	504	PF01048	0.611
MOD_GSK3_1	168	175	PF00069	0.662
MOD_GSK3_1	185	192	PF00069	0.700
MOD_GSK3_1	201	208	PF00069	0.693
MOD_GSK3_1	295	302	PF00069	0.582
MOD_GSK3_1	333	340	PF00069	0.615
MOD_GSK3_1	430	437	PF00069	0.659
MOD_GSK3_1	440	447	PF00069	0.612
MOD_GSK3_1	468	475	PF00069	0.568
MOD_GSK3_1	77	84	PF00069	0.711
MOD_N-GLC_1	438	443	PF02516	0.475
MOD_NEK2_1	205	210	PF00069	0.666
MOD_NEK2_1	545	550	PF00069	0.533
MOD_NEK2_1	557	562	PF00069	0.533
MOD_NEK2_1	69	74	PF00069	0.474
MOD_NEK2_2	201	206	PF00069	0.504
MOD_PIKK_1	299	305	PF00454	0.684
MOD_PIKK_1	468	474	PF00454	0.606
MOD_PKA_2	194	200	PF00069	0.704
MOD_PKA_2	205	211	PF00069	0.688
MOD_PKA_2	293	299	PF00069	0.514
MOD_PKA_2	333	339	PF00069	0.606
MOD_PKA_2	387	393	PF00069	0.552
MOD_PKA_2	512	518	PF00069	0.516
MOD_Plk_1	224	230	PF00069	0.459
MOD_Plk_1	286	292	PF00069	0.517
MOD_Plk_1	482	488	PF00069	0.486
MOD_Plk_1	489	495	PF00069	0.481
MOD_Plk_1	557	563	PF00069	0.510
MOD_Plk_2-3	103	109	PF00069	0.435
MOD_Plk_4	116	122	PF00069	0.600
MOD_Plk_4	205	211	PF00069	0.700
MOD_Plk_4	35	41	PF00069	0.585
MOD_Plk_4	411	417	PF00069	0.610
MOD_Plk_4	430	436	PF00069	0.396
MOD_ProDKin_1	113	119	PF00069	0.443
MOD_ProDKin_1	421	427	PF00069	0.655
MOD_ProDKin_1	472	478	PF00069	0.543
MOD_ProDKin_1	6	12	PF00069	0.459
MOD_ProDKin_1	78	84	PF00069	0.646
MOD_SUMO_for_1	358	361	PF00179	0.486
MOD_SUMO_rev_2	155	165	PF00179	0.537
TRG_DiLeu_BaEn_1	263	268	PF01217	0.457
TRG_DiLeu_BaEn_1	52	57	PF01217	0.551
TRG_DiLeu_BaEn_2	17	23	PF01217	0.398
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.472
TRG_ENDOCYTIC_2	162	165	PF00928	0.608
TRG_ENDOCYTIC_2	17	20	PF00928	0.377
TRG_ENDOCYTIC_2	228	231	PF00928	0.539
TRG_ENDOCYTIC_2	431	434	PF00928	0.598
TRG_ENDOCYTIC_2	95	98	PF00928	0.433
TRG_ER_diArg_1	110	113	PF00400	0.391
TRG_ER_diArg_1	141	143	PF00400	0.541
TRG_ER_diArg_1	324	327	PF00400	0.522
TRG_ER_diArg_1	518	521	PF00400	0.601
TRG_ER_diArg_1	535	538	PF00400	0.607
TRG_ER_diArg_1	92	95	PF00400	0.435
TRG_NLS_Bipartite_1	520	538	PF00514	0.550
TRG_NLS_MonoCore_2	533	538	PF00514	0.661
TRG_NLS_MonoExtC_3	533	538	PF00514	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC36	Leptomonas seymouri	53%	91%
A0A1X0NWG5	Trypanosomatidae	31%	100%
A0A3R7MIM2	Trypanosoma rangeli	32%	100%
A0A3S7WVS1	Leishmania donovani	92%	100%
A4HYM7	Leishmania infantum	91%	100%
C9ZI60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AI99	Leishmania braziliensis	79%	96%
E9AUI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	96%
V5BAC8	Trypanosoma cruzi	30%	100%