Glycerol-3-phosphate dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerol-3-phosphate dehydrogenase-like protein

Species:

Leishmania major

UniProt:

Q4QCZ7_LEIMA

TriTrypDb:

LmjF.20.0430 , LMJLV39_200010100 , LMJSD75_200009900

Length:

791

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0009331	glycerol-3-phosphate dehydrogenase complex	4	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	10
GO:1990204	oxidoreductase complex	3	10

Expansion

Sequence features

Q4QCZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCZ7

Function

Biological processes
Term	Name	Level	Count
GO:0006072	glycerol-3-phosphate metabolic process	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0019637	organophosphate metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0052646	alditol phosphate metabolic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901135	carbohydrate derivative metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004368	glycerol-3-phosphate dehydrogenase (quinone) activity	5	10
GO:0016491	oxidoreductase activity	2	10
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	10
GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	4	10
GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	6	6
GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	7	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.502
CLV_C14_Caspase3-7	397	401	PF00656	0.452
CLV_C14_Caspase3-7	410	414	PF00656	0.382
CLV_C14_Caspase3-7	477	481	PF00656	0.708
CLV_C14_Caspase3-7	669	673	PF00656	0.323
CLV_C14_Caspase3-7	708	712	PF00656	0.455
CLV_C14_Caspase3-7	88	92	PF00656	0.273
CLV_NRD_NRD_1	168	170	PF00675	0.530
CLV_NRD_NRD_1	27	29	PF00675	0.590
CLV_NRD_NRD_1	385	387	PF00675	0.248
CLV_NRD_NRD_1	6	8	PF00675	0.363
CLV_NRD_NRD_1	647	649	PF00675	0.673
CLV_NRD_NRD_1	664	666	PF00675	0.449
CLV_NRD_NRD_1	686	688	PF00675	0.633
CLV_NRD_NRD_1	739	741	PF00675	0.462
CLV_NRD_NRD_1	772	774	PF00675	0.503
CLV_NRD_NRD_1	781	783	PF00675	0.549
CLV_PCSK_KEX2_1	168	170	PF00082	0.530
CLV_PCSK_KEX2_1	27	29	PF00082	0.590
CLV_PCSK_KEX2_1	385	387	PF00082	0.248
CLV_PCSK_KEX2_1	6	8	PF00082	0.335
CLV_PCSK_KEX2_1	647	649	PF00082	0.673
CLV_PCSK_KEX2_1	664	666	PF00082	0.449
CLV_PCSK_KEX2_1	739	741	PF00082	0.485
CLV_PCSK_KEX2_1	772	774	PF00082	0.503
CLV_PCSK_KEX2_1	781	783	PF00082	0.545
CLV_PCSK_PC7_1	381	387	PF00082	0.215
CLV_PCSK_SKI1_1	359	363	PF00082	0.330
CLV_PCSK_SKI1_1	98	102	PF00082	0.465
DEG_APCC_DBOX_1	717	725	PF00400	0.267
DEG_SCF_TRCP1_1	711	716	PF00400	0.347
DEG_SPOP_SBC_1	414	418	PF00917	0.515
DEG_SPOP_SBC_1	474	478	PF00917	0.610
DOC_CDC14_PxL_1	532	540	PF14671	0.404
DOC_CDC14_PxL_1	656	664	PF14671	0.273
DOC_CDC14_PxL_1	752	760	PF14671	0.330
DOC_CKS1_1	700	705	PF01111	0.384
DOC_CYCLIN_RxL_1	691	702	PF00134	0.374
DOC_CYCLIN_yCln2_LP_2	700	706	PF00134	0.350
DOC_MAPK_DCC_7	647	655	PF00069	0.343
DOC_MAPK_gen_1	3	12	PF00069	0.603
DOC_MAPK_gen_1	647	655	PF00069	0.343
DOC_MAPK_gen_1	692	700	PF00069	0.373
DOC_MAPK_gen_1	781	789	PF00069	0.326
DOC_MAPK_MEF2A_6	297	305	PF00069	0.507
DOC_MAPK_MEF2A_6	3	12	PF00069	0.612
DOC_MAPK_MEF2A_6	307	316	PF00069	0.448
DOC_MAPK_MEF2A_6	647	655	PF00069	0.343
DOC_MAPK_MEF2A_6	782	791	PF00069	0.340
DOC_MAPK_RevD_3	650	665	PF00069	0.364
DOC_PP1_RVXF_1	508	514	PF00149	0.400
DOC_PP1_RVXF_1	762	769	PF00149	0.198
DOC_PP2B_LxvP_1	258	261	PF13499	0.467
DOC_PP2B_LxvP_1	461	464	PF13499	0.465
DOC_PP4_FxxP_1	250	253	PF00568	0.344
DOC_PP4_FxxP_1	506	509	PF00568	0.400
DOC_USP7_MATH_1	204	208	PF00917	0.239
DOC_USP7_MATH_1	228	232	PF00917	0.253
DOC_USP7_MATH_1	241	245	PF00917	0.416
DOC_USP7_MATH_1	375	379	PF00917	0.579
DOC_USP7_MATH_1	41	45	PF00917	0.369
DOC_USP7_MATH_1	472	476	PF00917	0.525
DOC_USP7_MATH_1	549	553	PF00917	0.449
DOC_USP7_MATH_1	57	61	PF00917	0.386
DOC_WW_Pin1_4	117	122	PF00397	0.260
DOC_WW_Pin1_4	276	281	PF00397	0.532
DOC_WW_Pin1_4	371	376	PF00397	0.577
DOC_WW_Pin1_4	391	396	PF00397	0.395
DOC_WW_Pin1_4	408	413	PF00397	0.503
DOC_WW_Pin1_4	505	510	PF00397	0.380
DOC_WW_Pin1_4	51	56	PF00397	0.448
DOC_WW_Pin1_4	699	704	PF00397	0.398
DOC_WW_Pin1_4	744	749	PF00397	0.256
LIG_14-3-3_CanoR_1	140	146	PF00244	0.294
LIG_14-3-3_CanoR_1	168	174	PF00244	0.233
LIG_14-3-3_CanoR_1	297	302	PF00244	0.467
LIG_14-3-3_CanoR_1	30	38	PF00244	0.372
LIG_14-3-3_CanoR_1	386	395	PF00244	0.504
LIG_14-3-3_CanoR_1	404	412	PF00244	0.453
LIG_14-3-3_CanoR_1	510	514	PF00244	0.400
LIG_14-3-3_CanoR_1	560	565	PF00244	0.471
LIG_14-3-3_CanoR_1	578	587	PF00244	0.218
LIG_14-3-3_CanoR_1	67	74	PF00244	0.358
LIG_14-3-3_CanoR_1	739	745	PF00244	0.287
LIG_14-3-3_CanoR_1	782	788	PF00244	0.329
LIG_Actin_WH2_2	124	142	PF00022	0.257
LIG_Actin_WH2_2	83	100	PF00022	0.247
LIG_AP2alpha_2	72	74	PF02296	0.325
LIG_BIR_II_1	1	5	PF00653	0.659
LIG_BIR_III_4	637	641	PF00653	0.453
LIG_Clathr_ClatBox_1	213	217	PF01394	0.284
LIG_CtBP_PxDLS_1	628	632	PF00389	0.411
LIG_deltaCOP1_diTrp_1	135	138	PF00928	0.285
LIG_deltaCOP1_diTrp_1	376	382	PF00928	0.398
LIG_deltaCOP1_diTrp_1	767	774	PF00928	0.263
LIG_eIF4E_1	656	662	PF01652	0.393
LIG_EVH1_1	535	539	PF00568	0.305
LIG_FHA_1	142	148	PF00498	0.267
LIG_FHA_1	195	201	PF00498	0.262
LIG_FHA_1	220	226	PF00498	0.322
LIG_FHA_1	230	236	PF00498	0.274
LIG_FHA_1	298	304	PF00498	0.595
LIG_FHA_1	415	421	PF00498	0.462
LIG_FHA_1	597	603	PF00498	0.324
LIG_FHA_1	693	699	PF00498	0.346
LIG_FHA_1	744	750	PF00498	0.289
LIG_FHA_2	306	312	PF00498	0.596
LIG_FHA_2	706	712	PF00498	0.432
LIG_FHA_2	726	732	PF00498	0.397
LIG_FHA_2	86	92	PF00498	0.273
LIG_LIR_Apic_2	248	253	PF02991	0.344
LIG_LIR_Gen_1	135	146	PF02991	0.326
LIG_LIR_Gen_1	376	387	PF02991	0.398
LIG_LIR_Gen_1	512	520	PF02991	0.341
LIG_LIR_Gen_1	59	70	PF02991	0.364
LIG_LIR_Gen_1	72	79	PF02991	0.250
LIG_LIR_Gen_1	84	93	PF02991	0.253
LIG_LIR_Nem_3	135	139	PF02991	0.291
LIG_LIR_Nem_3	149	155	PF02991	0.215
LIG_LIR_Nem_3	318	322	PF02991	0.507
LIG_LIR_Nem_3	376	382	PF02991	0.489
LIG_LIR_Nem_3	512	516	PF02991	0.348
LIG_LIR_Nem_3	59	65	PF02991	0.368
LIG_LIR_Nem_3	72	77	PF02991	0.307
LIG_LIR_Nem_3	84	90	PF02991	0.279
LIG_MYND_1	211	215	PF01753	0.284
LIG_MYND_1	270	274	PF01753	0.467
LIG_PDZ_Class_2	786	791	PF00595	0.386
LIG_Rb_LxCxE_1	669	686	PF01857	0.262
LIG_Rb_pABgroove_1	434	442	PF01858	0.506
LIG_SH2_CRK	319	323	PF00017	0.475
LIG_SH2_CRK	458	462	PF00017	0.533
LIG_SH2_CRK	656	660	PF00017	0.252
LIG_SH2_CRK	745	749	PF00017	0.290
LIG_SH2_NCK_1	319	323	PF00017	0.449
LIG_SH2_NCK_1	87	91	PF00017	0.260
LIG_SH2_SRC	319	322	PF00017	0.530
LIG_SH2_SRC	460	463	PF00017	0.502
LIG_SH2_STAP1	421	425	PF00017	0.426
LIG_SH2_STAP1	458	462	PF00017	0.521
LIG_SH2_STAP1	607	611	PF00017	0.368
LIG_SH2_STAP1	729	733	PF00017	0.265
LIG_SH2_STAT3	556	559	PF00017	0.363
LIG_SH2_STAT5	126	129	PF00017	0.260
LIG_SH2_STAT5	237	240	PF00017	0.391
LIG_SH2_STAT5	421	424	PF00017	0.452
LIG_SH2_STAT5	460	463	PF00017	0.480
LIG_SH2_STAT5	745	748	PF00017	0.392
LIG_SH2_STAT5	87	90	PF00017	0.261
LIG_SH3_2	372	377	PF14604	0.450
LIG_SH3_3	157	163	PF00018	0.344
LIG_SH3_3	325	331	PF00018	0.536
LIG_SH3_3	369	375	PF00018	0.550
LIG_SH3_3	406	412	PF00018	0.450
LIG_SH3_3	533	539	PF00018	0.398
LIG_SH3_3	587	593	PF00018	0.405
LIG_SH3_3	611	617	PF00018	0.329
LIG_SH3_3	622	628	PF00018	0.404
LIG_SUMO_SIM_anti_2	515	520	PF11976	0.347
LIG_SUMO_SIM_anti_2	627	633	PF11976	0.460
LIG_SUMO_SIM_anti_2	75	80	PF11976	0.265
LIG_SUMO_SIM_par_1	143	151	PF11976	0.267
LIG_SUMO_SIM_par_1	299	304	PF11976	0.502
LIG_SUMO_SIM_par_1	354	360	PF11976	0.515
LIG_SUMO_SIM_par_1	627	633	PF11976	0.443
LIG_TRAF2_1	308	311	PF00917	0.502
LIG_TRAF2_1	324	327	PF00917	0.377
LIG_TYR_ITIM	317	322	PF00017	0.308
LIG_WW_2	536	539	PF00397	0.379
MOD_CDC14_SPxK_1	374	377	PF00782	0.288
MOD_CDK_SPK_2	505	510	PF00069	0.400
MOD_CDK_SPxK_1	371	377	PF00069	0.288
MOD_CDK_SPxxK_3	51	58	PF00069	0.569
MOD_CK1_1	111	117	PF00069	0.355
MOD_CK1_1	2	8	PF00069	0.562
MOD_CK1_1	276	282	PF00069	0.483
MOD_CK1_1	329	335	PF00069	0.282
MOD_CK1_1	339	345	PF00069	0.325
MOD_CK1_1	390	396	PF00069	0.424
MOD_CK1_1	407	413	PF00069	0.484
MOD_CK1_1	475	481	PF00069	0.693
MOD_CK1_1	512	518	PF00069	0.313
MOD_CK1_1	531	537	PF00069	0.387
MOD_CK1_1	565	571	PF00069	0.453
MOD_CK1_1	581	587	PF00069	0.296
MOD_CK1_1	60	66	PF00069	0.429
MOD_CK1_1	630	636	PF00069	0.552
MOD_CK1_1	705	711	PF00069	0.677
MOD_CK2_1	179	185	PF00069	0.360
MOD_CK2_1	204	210	PF00069	0.215
MOD_CK2_1	260	266	PF00069	0.433
MOD_CK2_1	305	311	PF00069	0.410
MOD_CK2_1	725	731	PF00069	0.434
MOD_CK2_1	744	750	PF00069	0.165
MOD_CK2_1	772	778	PF00069	0.430
MOD_CMANNOS	170	173	PF00535	0.360
MOD_GlcNHglycan	110	113	PF01048	0.315
MOD_GlcNHglycan	181	184	PF01048	0.359
MOD_GlcNHglycan	202	205	PF01048	0.372
MOD_GlcNHglycan	206	209	PF01048	0.331
MOD_GlcNHglycan	275	278	PF01048	0.418
MOD_GlcNHglycan	327	331	PF01048	0.434
MOD_GlcNHglycan	34	37	PF01048	0.438
MOD_GlcNHglycan	39	42	PF01048	0.425
MOD_GlcNHglycan	390	393	PF01048	0.376
MOD_GlcNHglycan	406	409	PF01048	0.369
MOD_GlcNHglycan	43	46	PF01048	0.486
MOD_GlcNHglycan	569	572	PF01048	0.418
MOD_GlcNHglycan	62	65	PF01048	0.308
MOD_GlcNHglycan	68	71	PF01048	0.418
MOD_GlcNHglycan	711	714	PF01048	0.651
MOD_GlcNHglycan	715	718	PF01048	0.202
MOD_GSK3_1	111	118	PF00069	0.355
MOD_GSK3_1	190	197	PF00069	0.291
MOD_GSK3_1	200	207	PF00069	0.332
MOD_GSK3_1	216	223	PF00069	0.263
MOD_GSK3_1	241	248	PF00069	0.358
MOD_GSK3_1	297	304	PF00069	0.439
MOD_GSK3_1	336	343	PF00069	0.370
MOD_GSK3_1	367	374	PF00069	0.413
MOD_GSK3_1	37	44	PF00069	0.456
MOD_GSK3_1	387	394	PF00069	0.249
MOD_GSK3_1	395	402	PF00069	0.330
MOD_GSK3_1	404	411	PF00069	0.253
MOD_GSK3_1	415	422	PF00069	0.222
MOD_GSK3_1	472	479	PF00069	0.635
MOD_GSK3_1	505	512	PF00069	0.308
MOD_GSK3_1	56	63	PF00069	0.436
MOD_GSK3_1	562	569	PF00069	0.477
MOD_GSK3_1	570	577	PF00069	0.384
MOD_GSK3_1	698	705	PF00069	0.431
MOD_GSK3_1	709	716	PF00069	0.509
MOD_GSK3_1	783	790	PF00069	0.462
MOD_GSK3_1	81	88	PF00069	0.284
MOD_N-GLC_1	426	431	PF02516	0.391
MOD_N-GLC_1	442	447	PF02516	0.228
MOD_NEK2_1	141	146	PF00069	0.360
MOD_NEK2_1	216	221	PF00069	0.290
MOD_NEK2_1	31	36	PF00069	0.459
MOD_NEK2_1	312	317	PF00069	0.416
MOD_NEK2_1	336	341	PF00069	0.500
MOD_NEK2_1	354	359	PF00069	0.344
MOD_NEK2_1	387	392	PF00069	0.422
MOD_NEK2_1	495	500	PF00069	0.549
MOD_NEK2_1	504	509	PF00069	0.270
MOD_NEK2_1	566	571	PF00069	0.430
MOD_NEK2_1	609	614	PF00069	0.460
MOD_NEK2_1	65	70	PF00069	0.391
MOD_NEK2_1	683	688	PF00069	0.428
MOD_NEK2_1	698	703	PF00069	0.400
MOD_NEK2_1	783	788	PF00069	0.394
MOD_NEK2_2	432	437	PF00069	0.457
MOD_NEK2_2	464	469	PF00069	0.203
MOD_PIKK_1	337	343	PF00454	0.467
MOD_PIKK_1	581	587	PF00454	0.438
MOD_PKA_1	772	778	PF00069	0.437
MOD_PKA_2	2	8	PF00069	0.446
MOD_PKA_2	31	37	PF00069	0.445
MOD_PKA_2	387	393	PF00069	0.350
MOD_PKA_2	509	515	PF00069	0.443
MOD_PKA_2	57	63	PF00069	0.538
MOD_PKA_2	66	72	PF00069	0.459
MOD_PKA_2	738	744	PF00069	0.308
MOD_PKA_2	772	778	PF00069	0.437
MOD_PKB_1	30	38	PF00069	0.386
MOD_PKB_1	386	394	PF00069	0.261
MOD_PKB_1	560	568	PF00069	0.474
MOD_PKB_1	718	726	PF00069	0.288
MOD_Plk_1	147	153	PF00069	0.400
MOD_Plk_1	375	381	PF00069	0.445
MOD_Plk_1	574	580	PF00069	0.478
MOD_Plk_4	141	147	PF00069	0.317
MOD_Plk_4	162	168	PF00069	0.380
MOD_Plk_4	209	215	PF00069	0.384
MOD_Plk_4	221	227	PF00069	0.231
MOD_Plk_4	245	251	PF00069	0.295
MOD_Plk_4	312	318	PF00069	0.360
MOD_Plk_4	456	462	PF00069	0.308
MOD_Plk_4	512	518	PF00069	0.345
MOD_Plk_4	562	568	PF00069	0.494
MOD_Plk_4	627	633	PF00069	0.586
MOD_Plk_4	720	726	PF00069	0.366
MOD_ProDKin_1	117	123	PF00069	0.302
MOD_ProDKin_1	276	282	PF00069	0.402
MOD_ProDKin_1	371	377	PF00069	0.466
MOD_ProDKin_1	391	397	PF00069	0.210
MOD_ProDKin_1	408	414	PF00069	0.362
MOD_ProDKin_1	505	511	PF00069	0.380
MOD_ProDKin_1	51	57	PF00069	0.560
MOD_ProDKin_1	699	705	PF00069	0.499
MOD_ProDKin_1	744	750	PF00069	0.296
TRG_DiLeu_BaEn_1	627	632	PF01217	0.590
TRG_DiLeu_BaEn_2	677	683	PF01217	0.319
TRG_DiLeu_BaLyEn_6	575	580	PF01217	0.481
TRG_DiLeu_BaLyEn_6	648	653	PF01217	0.515
TRG_DiLeu_BaLyEn_6	657	662	PF01217	0.412
TRG_DiLeu_BaLyEn_6	761	766	PF01217	0.461
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.360
TRG_ENDOCYTIC_2	319	322	PF00928	0.313
TRG_ENDOCYTIC_2	458	461	PF00928	0.295
TRG_ENDOCYTIC_2	656	659	PF00928	0.429
TRG_ENDOCYTIC_2	87	90	PF00928	0.284
TRG_ER_diArg_1	131	134	PF00400	0.284
TRG_ER_diArg_1	167	169	PF00400	0.359
TRG_ER_diArg_1	26	28	PF00400	0.468
TRG_ER_diArg_1	29	32	PF00400	0.453
TRG_ER_diArg_1	385	388	PF00400	0.319
TRG_ER_diArg_1	6	8	PF00400	0.407
TRG_ER_diArg_1	664	666	PF00400	0.421
TRG_ER_diArg_1	718	721	PF00400	0.398
TRG_ER_diArg_1	772	774	PF00400	0.439
TRG_ER_diArg_1	781	783	PF00400	0.446
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.274
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.288
TRG_Pf-PMV_PEXEL_1	664	668	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	764	769	PF00026	0.259

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L0	Leptomonas seymouri	47%	94%
A0A1X0NY01	Trypanosomatidae	31%	100%
A0A3Q8IDJ7	Leishmania donovani	89%	100%
A4HYM4	Leishmania infantum	90%	100%
C9ZI64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AIA2	Leishmania braziliensis	75%	100%
E9AUI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BVH7	Trypanosoma cruzi	32%	100%