Gamma-glutamylcyclotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AIG2-like family, putative

Species:

Leishmania major

UniProt:

Q4QCZ6_LEIMA

TriTrypDb:

LmjF.20.0440 , LMJLV39_200010200 , LMJSD75_200010000

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCZ6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0003839	gamma-glutamylcyclotransferase activity	5	7
GO:0016829	lyase activity	2	7
GO:0016840	carbon-nitrogen lyase activity	3	7
GO:0016842	amidine-lyase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.478
CLV_C14_Caspase3-7	418	422	PF00656	0.328
CLV_NRD_NRD_1	332	334	PF00675	0.371
CLV_NRD_NRD_1	367	369	PF00675	0.338
CLV_NRD_NRD_1	483	485	PF00675	0.573
CLV_PCSK_KEX2_1	332	334	PF00082	0.371
CLV_PCSK_KEX2_1	481	483	PF00082	0.567
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.567
CLV_PCSK_SKI1_1	333	337	PF00082	0.361
CLV_PCSK_SKI1_1	42	46	PF00082	0.528
CLV_PCSK_SKI1_1	50	54	PF00082	0.390
CLV_PCSK_SKI1_1	97	101	PF00082	0.565
DEG_APCC_DBOX_1	49	57	PF00400	0.371
DOC_MAPK_gen_1	246	256	PF00069	0.496
DOC_MAPK_gen_1	332	343	PF00069	0.367
DOC_MAPK_MEF2A_6	249	256	PF00069	0.585
DOC_MAPK_NFAT4_5	249	257	PF00069	0.536
DOC_PP2B_LxvP_1	163	166	PF13499	0.430
DOC_USP7_MATH_1	269	273	PF00917	0.645
DOC_USP7_MATH_1	28	32	PF00917	0.444
DOC_USP7_MATH_1	312	316	PF00917	0.424
DOC_USP7_UBL2_3	481	485	PF12436	0.573
DOC_WW_Pin1_4	201	206	PF00397	0.599
DOC_WW_Pin1_4	211	216	PF00397	0.583
DOC_WW_Pin1_4	473	478	PF00397	0.493
DOC_WW_Pin1_4	81	86	PF00397	0.704
LIG_BIR_II_1	1	5	PF00653	0.539
LIG_BRCT_BRCA1_1	5	9	PF00533	0.460
LIG_BRCT_BRCA1_1	92	96	PF00533	0.493
LIG_CtBP_PxDLS_1	70	74	PF00389	0.474
LIG_FHA_1	134	140	PF00498	0.336
LIG_FHA_1	154	160	PF00498	0.260
LIG_FHA_1	227	233	PF00498	0.596
LIG_FHA_1	306	312	PF00498	0.382
LIG_FHA_1	344	350	PF00498	0.351
LIG_FHA_1	469	475	PF00498	0.413
LIG_FHA_2	14	20	PF00498	0.384
LIG_FHA_2	435	441	PF00498	0.309
LIG_FHA_2	90	96	PF00498	0.567
LIG_GBD_Chelix_1	107	115	PF00786	0.312
LIG_LIR_Gen_1	237	248	PF02991	0.651
LIG_LIR_Gen_1	250	258	PF02991	0.450
LIG_LIR_Gen_1	318	326	PF02991	0.389
LIG_LIR_Gen_1	428	434	PF02991	0.315
LIG_LIR_Nem_3	126	132	PF02991	0.400
LIG_LIR_Nem_3	237	243	PF02991	0.614
LIG_LIR_Nem_3	245	251	PF02991	0.509
LIG_LIR_Nem_3	308	313	PF02991	0.358
LIG_LIR_Nem_3	318	322	PF02991	0.374
LIG_LIR_Nem_3	428	433	PF02991	0.315
LIG_LIR_Nem_3	6	12	PF02991	0.461
LIG_MYND_1	43	47	PF01753	0.452
LIG_PCNA_yPIPBox_3	187	201	PF02747	0.556
LIG_Pex14_1	309	313	PF04695	0.354
LIG_Pex14_2	96	100	PF04695	0.464
LIG_SH2_CRK	132	136	PF00017	0.377
LIG_SH2_CRK	240	244	PF00017	0.528
LIG_SH2_CRK	293	297	PF00017	0.460
LIG_SH2_CRK	49	53	PF00017	0.408
LIG_SH2_GRB2like	359	362	PF00017	0.446
LIG_SH2_PTP2	340	343	PF00017	0.351
LIG_SH2_SRC	17	20	PF00017	0.378
LIG_SH2_SRC	392	395	PF00017	0.315
LIG_SH2_STAP1	109	113	PF00017	0.408
LIG_SH2_STAP1	240	244	PF00017	0.476
LIG_SH2_STAP1	284	288	PF00017	0.592
LIG_SH2_STAP1	409	413	PF00017	0.360
LIG_SH2_STAT3	432	435	PF00017	0.305
LIG_SH2_STAT5	11	14	PF00017	0.345
LIG_SH2_STAT5	138	141	PF00017	0.362
LIG_SH2_STAT5	17	20	PF00017	0.378
LIG_SH2_STAT5	251	254	PF00017	0.558
LIG_SH2_STAT5	310	313	PF00017	0.348
LIG_SH2_STAT5	340	343	PF00017	0.351
LIG_SH2_STAT5	386	389	PF00017	0.315
LIG_SH2_STAT5	432	435	PF00017	0.315
LIG_SH2_STAT5	462	465	PF00017	0.416
LIG_SH3_1	467	473	PF00018	0.401
LIG_SH3_2	470	475	PF14604	0.473
LIG_SH3_3	144	150	PF00018	0.510
LIG_SH3_3	197	203	PF00018	0.619
LIG_SH3_3	212	218	PF00018	0.596
LIG_SH3_3	374	380	PF00018	0.475
LIG_SH3_3	467	473	PF00018	0.489
LIG_TYR_ITIM	338	343	PF00017	0.451
LIG_WW_1	459	462	PF00397	0.294
MOD_CDC14_SPxK_1	84	87	PF00782	0.655
MOD_CDK_SPK_2	473	478	PF00069	0.544
MOD_CDK_SPxK_1	81	87	PF00069	0.650
MOD_CK1_1	173	179	PF00069	0.465
MOD_CK1_1	263	269	PF00069	0.663
MOD_CK1_1	272	278	PF00069	0.565
MOD_CK1_1	283	289	PF00069	0.458
MOD_CK1_1	3	9	PF00069	0.488
MOD_CK1_1	315	321	PF00069	0.384
MOD_CK1_1	33	39	PF00069	0.412
MOD_CK1_1	420	426	PF00069	0.345
MOD_CK2_1	261	267	PF00069	0.591
MOD_CK2_1	89	95	PF00069	0.569
MOD_GlcNHglycan	110	114	PF01048	0.422
MOD_GlcNHglycan	272	275	PF01048	0.690
MOD_GlcNHglycan	30	33	PF01048	0.497
MOD_GlcNHglycan	39	42	PF01048	0.503
MOD_GlcNHglycan	56	59	PF01048	0.346
MOD_GSK3_1	149	156	PF00069	0.404
MOD_GSK3_1	201	208	PF00069	0.741
MOD_GSK3_1	263	270	PF00069	0.670
MOD_GSK3_1	33	40	PF00069	0.389
MOD_GSK3_1	345	352	PF00069	0.422
MOD_GSK3_1	77	84	PF00069	0.617
MOD_N-GLC_1	226	231	PF02516	0.478
MOD_N-GLC_1	297	302	PF02516	0.680
MOD_N-GLC_1	315	320	PF02516	0.296
MOD_NEK2_1	154	159	PF00069	0.450
MOD_NEK2_1	23	28	PF00069	0.421
MOD_NEK2_2	133	138	PF00069	0.507
MOD_NEK2_2	228	233	PF00069	0.636
MOD_PIKK_1	149	155	PF00454	0.507
MOD_PIKK_1	226	232	PF00454	0.571
MOD_PIKK_1	234	240	PF00454	0.577
MOD_PIKK_1	392	398	PF00454	0.395
MOD_PKA_2	414	420	PF00069	0.345
MOD_Plk_1	173	179	PF00069	0.458
MOD_Plk_1	315	321	PF00069	0.420
MOD_Plk_4	13	19	PF00069	0.344
MOD_Plk_4	154	160	PF00069	0.447
MOD_Plk_4	173	179	PF00069	0.411
MOD_Plk_4	305	311	PF00069	0.394
MOD_Plk_4	33	39	PF00069	0.296
MOD_Plk_4	69	75	PF00069	0.456
MOD_ProDKin_1	201	207	PF00069	0.597
MOD_ProDKin_1	211	217	PF00069	0.582
MOD_ProDKin_1	473	479	PF00069	0.493
MOD_ProDKin_1	81	87	PF00069	0.707
MOD_SUMO_rev_2	300	308	PF00179	0.487
MOD_SUMO_rev_2	90	99	PF00179	0.637
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.389
TRG_ENDOCYTIC_2	132	135	PF00928	0.372
TRG_ENDOCYTIC_2	240	243	PF00928	0.582
TRG_ENDOCYTIC_2	251	254	PF00928	0.469
TRG_ENDOCYTIC_2	293	296	PF00928	0.458
TRG_ENDOCYTIC_2	340	343	PF00928	0.351
TRG_ENDOCYTIC_2	359	362	PF00928	0.365
TRG_ENDOCYTIC_2	49	52	PF00928	0.408
TRG_ER_diArg_1	332	334	PF00400	0.402
TRG_ER_diArg_1	447	450	PF00400	0.245
TRG_NES_CRM1_1	153	169	PF08389	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P468	Leptomonas seymouri	55%	96%
A0A3Q8IAR7	Leishmania donovani	90%	100%
A4HYM3	Leishmania infantum	90%	100%
E9AIA3	Leishmania braziliensis	74%	99%
E9AUI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%