Transmembrane protein 231

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transmembrane protein 231, putative

Species:

Leishmania major

UniProt:

Q4QCZ4_LEIMA

TriTrypDb:

LmjF.20.0460 , LMJLV39_200010400 , LMJSD75_200010200

Length:

375

Annotations

LeishMANIAdb annotations

Homologous to mammalian TMEM231 protein. Probably flagellar and required for its maintenance, based on homology.. Localization: Flagellar membrane (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0031253	cell projection membrane	4	11
GO:0035869	ciliary transition zone	2	2
GO:0060170	ciliary membrane	5	11
GO:0098588	bounding membrane of organelle	4	11
GO:0098590	plasma membrane region	3	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QCZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCZ4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0032879	regulation of localization	3	2
GO:0032880	regulation of protein localization	5	2
GO:0044782	cilium organization	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0060271	cilium assembly	6	2
GO:0060341	regulation of cellular localization	4	2
GO:0065007	biological regulation	1	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.267
CLV_C14_Caspase3-7	151	155	PF00656	0.371
CLV_NRD_NRD_1	187	189	PF00675	0.652
CLV_NRD_NRD_1	289	291	PF00675	0.693
CLV_NRD_NRD_1	372	374	PF00675	0.481
CLV_PCSK_FUR_1	185	189	PF00082	0.547
CLV_PCSK_KEX2_1	187	189	PF00082	0.613
CLV_PCSK_KEX2_1	289	291	PF00082	0.693
CLV_PCSK_KEX2_1	372	374	PF00082	0.481
CLV_PCSK_SKI1_1	353	357	PF00082	0.236
DEG_APCC_DBOX_1	352	360	PF00400	0.529
DEG_Nend_Nbox_1	1	3	PF02207	0.619
DEG_SPOP_SBC_1	201	205	PF00917	0.437
DOC_CDC14_PxL_1	178	186	PF14671	0.363
DOC_MAPK_MEF2A_6	351	359	PF00069	0.521
DOC_MAPK_RevD_3	174	188	PF00069	0.308
DOC_PP2B_LxvP_1	257	260	PF13499	0.317
DOC_PP2B_LxvP_1	314	317	PF13499	0.296
DOC_USP7_MATH_1	201	205	PF00917	0.491
DOC_USP7_MATH_1	233	237	PF00917	0.402
DOC_WW_Pin1_4	186	191	PF00397	0.425
DOC_WW_Pin1_4	208	213	PF00397	0.299
DOC_WW_Pin1_4	229	234	PF00397	0.345
DOC_WW_Pin1_4	241	246	PF00397	0.281
LIG_14-3-3_CanoR_1	18	24	PF00244	0.492
LIG_14-3-3_CanoR_1	269	274	PF00244	0.267
LIG_14-3-3_CanoR_1	365	375	PF00244	0.653
LIG_14-3-3_CanoR_1	69	74	PF00244	0.251
LIG_Actin_WH2_2	317	334	PF00022	0.267
LIG_Actin_WH2_2	337	355	PF00022	0.139
LIG_APCC_ABBA_1	275	280	PF00400	0.314
LIG_APCC_ABBA_1	4	9	PF00400	0.492
LIG_BRCT_BRCA1_1	21	25	PF00533	0.362
LIG_DCNL_PONY_1	1	4	PF03556	0.629
LIG_deltaCOP1_diTrp_1	77	86	PF00928	0.236
LIG_EH1_1	24	32	PF00400	0.404
LIG_eIF4E_1	168	174	PF01652	0.307
LIG_eIF4E_1	224	230	PF01652	0.317
LIG_eIF4E_1	343	349	PF01652	0.338
LIG_FHA_1	224	230	PF00498	0.281
LIG_FHA_1	307	313	PF00498	0.225
LIG_FHA_1	356	362	PF00498	0.476
LIG_FHA_2	101	107	PF00498	0.314
LIG_FHA_2	215	221	PF00498	0.257
LIG_FHA_2	79	85	PF00498	0.286
LIG_GBD_Chelix_1	20	28	PF00786	0.321
LIG_GBD_Chelix_1	294	302	PF00786	0.639
LIG_GBD_Chelix_1	344	352	PF00786	0.307
LIG_LIR_Gen_1	115	124	PF02991	0.292
LIG_LIR_Gen_1	309	319	PF02991	0.346
LIG_LIR_Gen_1	326	331	PF02991	0.329
LIG_LIR_Nem_3	115	119	PF02991	0.312
LIG_LIR_Nem_3	164	168	PF02991	0.283
LIG_LIR_Nem_3	22	28	PF02991	0.319
LIG_LIR_Nem_3	232	237	PF02991	0.336
LIG_LIR_Nem_3	307	311	PF02991	0.352
LIG_LIR_Nem_3	326	330	PF02991	0.139
LIG_LYPXL_SIV_4	277	285	PF13949	0.359
LIG_Pex14_1	335	339	PF04695	0.259
LIG_Pex14_2	119	123	PF04695	0.295
LIG_Pex14_2	161	165	PF04695	0.238
LIG_Pex14_2	38	42	PF04695	0.414
LIG_Pex14_2	43	47	PF04695	0.345
LIG_PTB_Apo_2	228	235	PF02174	0.355
LIG_PTB_Phospho_1	228	234	PF10480	0.354
LIG_SH2_GRB2like	116	119	PF00017	0.270
LIG_SH2_GRB2like	168	171	PF00017	0.303
LIG_SH2_NCK_1	55	59	PF00017	0.270
LIG_SH2_PTP2	311	314	PF00017	0.329
LIG_SH2_SRC	168	171	PF00017	0.364
LIG_SH2_SRC	278	281	PF00017	0.355
LIG_SH2_SRC	323	326	PF00017	0.263
LIG_SH2_SRC	327	330	PF00017	0.274
LIG_SH2_STAP1	116	120	PF00017	0.270
LIG_SH2_STAP1	327	331	PF00017	0.329
LIG_SH2_STAT3	343	346	PF00017	0.293
LIG_SH2_STAT5	100	103	PF00017	0.288
LIG_SH2_STAT5	168	171	PF00017	0.303
LIG_SH2_STAT5	224	227	PF00017	0.383
LIG_SH2_STAT5	234	237	PF00017	0.305
LIG_SH2_STAT5	241	244	PF00017	0.223
LIG_SH2_STAT5	26	29	PF00017	0.301
LIG_SH2_STAT5	278	281	PF00017	0.377
LIG_SH2_STAT5	311	314	PF00017	0.281
LIG_SH2_STAT5	323	326	PF00017	0.187
LIG_SH2_STAT5	338	341	PF00017	0.298
LIG_SH2_STAT5	343	346	PF00017	0.346
LIG_SH2_STAT5	53	56	PF00017	0.333
LIG_SH2_STAT5	78	81	PF00017	0.249
LIG_SH3_3	271	277	PF00018	0.329
LIG_SH3_3	31	37	PF00018	0.209
LIG_SUMO_SIM_anti_2	291	296	PF11976	0.447
LIG_SUMO_SIM_par_1	353	358	PF11976	0.550
LIG_TRAF2_1	245	248	PF00917	0.327
LIG_TYR_ITIM	336	341	PF00017	0.259
LIG_WRC_WIRS_1	305	310	PF05994	0.270
MOD_CDK_SPxxK_3	186	193	PF00069	0.370
MOD_CK1_1	139	145	PF00069	0.566
MOD_CK1_1	204	210	PF00069	0.481
MOD_CK2_1	130	136	PF00069	0.300
MOD_CK2_1	323	329	PF00069	0.251
MOD_CK2_1	99	105	PF00069	0.257
MOD_CMANNOS	347	350	PF00535	0.297
MOD_GlcNHglycan	138	141	PF01048	0.628
MOD_GlcNHglycan	208	211	PF01048	0.632
MOD_GlcNHglycan	262	265	PF01048	0.564
MOD_GSK3_1	135	142	PF00069	0.511
MOD_GSK3_1	196	203	PF00069	0.447
MOD_GSK3_1	204	211	PF00069	0.525
MOD_GSK3_1	225	232	PF00069	0.309
MOD_GSK3_1	233	240	PF00069	0.302
MOD_N-GLC_1	176	181	PF02516	0.515
MOD_N-GLC_1	196	201	PF02516	0.512
MOD_N-GLC_1	269	274	PF02516	0.463
MOD_NEK2_1	119	124	PF00069	0.269
MOD_NEK2_1	129	134	PF00069	0.294
MOD_NEK2_1	157	162	PF00069	0.296
MOD_NEK2_1	222	227	PF00069	0.316
MOD_NEK2_1	361	366	PF00069	0.509
MOD_NEK2_1	90	95	PF00069	0.288
MOD_PIKK_1	148	154	PF00454	0.404
MOD_PK_1	269	275	PF00069	0.312
MOD_PK_1	290	296	PF00069	0.488
MOD_PKA_2	260	266	PF00069	0.422
MOD_PKA_2	366	372	PF00069	0.643
MOD_PKA_2	68	74	PF00069	0.236
MOD_PKB_1	365	373	PF00069	0.507
MOD_Plk_1	129	135	PF00069	0.306
MOD_Plk_1	157	163	PF00069	0.368
MOD_Plk_1	269	275	PF00069	0.263
MOD_Plk_1	290	296	PF00069	0.396
MOD_Plk_1	58	64	PF00069	0.272
MOD_Plk_2-3	130	136	PF00069	0.270
MOD_Plk_4	130	136	PF00069	0.296
MOD_Plk_4	157	163	PF00069	0.294
MOD_Plk_4	19	25	PF00069	0.460
MOD_Plk_4	2	8	PF00069	0.529
MOD_Plk_4	225	231	PF00069	0.349
MOD_Plk_4	233	239	PF00069	0.335
MOD_Plk_4	269	275	PF00069	0.299
MOD_Plk_4	290	296	PF00069	0.389
MOD_Plk_4	69	75	PF00069	0.344
MOD_ProDKin_1	186	192	PF00069	0.436
MOD_ProDKin_1	208	214	PF00069	0.289
MOD_ProDKin_1	229	235	PF00069	0.346
MOD_ProDKin_1	241	247	PF00069	0.286
MOD_SUMO_rev_2	105	114	PF00179	0.329
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.297
TRG_ENDOCYTIC_2	116	119	PF00928	0.374
TRG_ENDOCYTIC_2	311	314	PF00928	0.341
TRG_ENDOCYTIC_2	327	330	PF00928	0.234
TRG_ENDOCYTIC_2	338	341	PF00928	0.217
TRG_ER_diArg_1	186	188	PF00400	0.427
TRG_ER_diArg_1	288	290	PF00400	0.457
TRG_ER_diArg_1	365	368	PF00400	0.622
TRG_ER_diArg_1	371	373	PF00400	0.662
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFJ2	Leptomonas seymouri	63%	97%
A0A0S4J387	Bodo saltans	30%	100%
A0A1X0NXU0	Trypanosomatidae	42%	100%
A0A3S7WW02	Leishmania donovani	95%	100%
A0A422NCH0	Trypanosoma rangeli	45%	100%
A4HYR5	Leishmania infantum	95%	100%
C9ZI65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AUJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DS46	Trypanosoma cruzi	44%	100%