Tubulin delta chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Tubulin delta chain

Gene product:

zeta tubulin, putative

Species:

Leishmania major

UniProt:

Q4QCZ3_LEIMA

TriTrypDb:

LmjF.20.0470 , LMJLV39_200010500 , LMJSD75_200010300

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	8
GO:0005737	cytoplasm	2	2
GO:0005814	centriole	5	8
GO:0005874	microtubule	6	8
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0099080	supramolecular complex	2	8
GO:0099081	supramolecular polymer	3	8
GO:0099512	supramolecular fiber	4	8
GO:0099513	polymeric cytoskeletal fiber	5	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8

Expansion

Sequence features

Q4QCZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCZ3

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0000278	mitotic cell cycle	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	8
GO:0007049	cell cycle	2	2
GO:0009987	cellular process	1	8
GO:0016043	cellular component organization	3	8
GO:0030030	cell projection organization	4	8
GO:0071840	cellular component organization or biogenesis	2	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0005198	structural molecule activity	1	8
GO:0005200	structural constituent of cytoskeleton	2	8
GO:0005488	binding	1	8
GO:0005525	GTP binding	5	8
GO:0017076	purine nucleotide binding	4	8
GO:0019001	guanyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032561	guanyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	413	417	PF00656	0.602
CLV_C14_Caspase3-7	539	543	PF00656	0.416
CLV_NRD_NRD_1	146	148	PF00675	0.245
CLV_NRD_NRD_1	219	221	PF00675	0.260
CLV_NRD_NRD_1	397	399	PF00675	0.683
CLV_NRD_NRD_1	432	434	PF00675	0.636
CLV_NRD_NRD_1	458	460	PF00675	0.664
CLV_NRD_NRD_1	530	532	PF00675	0.469
CLV_NRD_NRD_1	555	557	PF00675	0.447
CLV_NRD_NRD_1	589	591	PF00675	0.384
CLV_PCSK_KEX2_1	107	109	PF00082	0.517
CLV_PCSK_KEX2_1	146	148	PF00082	0.260
CLV_PCSK_KEX2_1	219	221	PF00082	0.261
CLV_PCSK_KEX2_1	397	399	PF00082	0.683
CLV_PCSK_KEX2_1	432	434	PF00082	0.636
CLV_PCSK_KEX2_1	457	459	PF00082	0.712
CLV_PCSK_KEX2_1	530	532	PF00082	0.520
CLV_PCSK_KEX2_1	555	557	PF00082	0.459
CLV_PCSK_KEX2_1	589	591	PF00082	0.392
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.564
CLV_PCSK_SKI1_1	286	290	PF00082	0.517
CLV_PCSK_SKI1_1	334	338	PF00082	0.451
CLV_PCSK_SKI1_1	355	359	PF00082	0.394
CLV_PCSK_SKI1_1	555	559	PF00082	0.369
CLV_PCSK_SKI1_1	56	60	PF00082	0.260
CLV_PCSK_SKI1_1	65	69	PF00082	0.260
DEG_APCC_DBOX_1	499	507	PF00400	0.489
DEG_APCC_DBOX_1	508	516	PF00400	0.376
DEG_APCC_DBOX_1	554	562	PF00400	0.409
DOC_MAPK_gen_1	219	229	PF00069	0.461
DOC_MAPK_gen_1	51	60	PF00069	0.465
DOC_MAPK_gen_1	555	561	PF00069	0.418
DOC_MAPK_HePTP_8	175	187	PF00069	0.502
DOC_MAPK_HePTP_8	288	300	PF00069	0.329
DOC_MAPK_MEF2A_6	178	187	PF00069	0.502
DOC_MAPK_MEF2A_6	220	229	PF00069	0.460
DOC_MAPK_MEF2A_6	291	300	PF00069	0.314
DOC_PP1_RVXF_1	182	188	PF00149	0.502
DOC_PP1_RVXF_1	284	291	PF00149	0.453
DOC_PP2B_LxvP_1	300	303	PF13499	0.316
DOC_PP2B_LxvP_1	339	342	PF13499	0.428
DOC_PP2B_LxvP_1	465	468	PF13499	0.677
DOC_PP4_FxxP_1	187	190	PF00568	0.460
DOC_USP7_MATH_1	272	276	PF00917	0.627
DOC_USP7_MATH_1	30	34	PF00917	0.417
DOC_USP7_MATH_1	342	346	PF00917	0.492
DOC_USP7_MATH_1	450	454	PF00917	0.674
DOC_USP7_MATH_1	573	577	PF00917	0.361
DOC_WW_Pin1_4	43	48	PF00397	0.518
DOC_WW_Pin1_4	466	471	PF00397	0.691
DOC_WW_Pin1_4	516	521	PF00397	0.404
LIG_14-3-3_CanoR_1	184	190	PF00244	0.535
LIG_14-3-3_CanoR_1	286	291	PF00244	0.517
LIG_14-3-3_CanoR_1	344	350	PF00244	0.469
LIG_14-3-3_CanoR_1	402	408	PF00244	0.781
LIG_14-3-3_CanoR_1	458	468	PF00244	0.720
LIG_Actin_WH2_2	550	565	PF00022	0.349
LIG_BIR_II_1	1	5	PF00653	0.296
LIG_BRCT_BRCA1_1	154	158	PF00533	0.502
LIG_BRCT_BRCA1_1	45	49	PF00533	0.475
LIG_FHA_1	178	184	PF00498	0.491
LIG_FHA_1	237	243	PF00498	0.483
LIG_FHA_1	283	289	PF00498	0.478
LIG_FHA_1	372	378	PF00498	0.423
LIG_FHA_1	403	409	PF00498	0.596
LIG_FHA_1	424	430	PF00498	0.635
LIG_FHA_2	287	293	PF00498	0.364
LIG_FHA_2	599	605	PF00498	0.439
LIG_GBD_Chelix_1	175	183	PF00786	0.302
LIG_LIR_Gen_1	155	164	PF02991	0.463
LIG_LIR_Gen_1	17	25	PF02991	0.502
LIG_LIR_Gen_1	345	353	PF02991	0.456
LIG_LIR_Gen_1	535	546	PF02991	0.403
LIG_LIR_Gen_1	576	583	PF02991	0.365
LIG_LIR_Nem_3	155	161	PF02991	0.463
LIG_LIR_Nem_3	17	23	PF02991	0.460
LIG_LIR_Nem_3	416	422	PF02991	0.544
LIG_LIR_Nem_3	535	541	PF02991	0.515
LIG_LIR_Nem_3	576	581	PF02991	0.367
LIG_LYPXL_SIV_4	591	599	PF13949	0.402
LIG_MAD2	334	342	PF02301	0.422
LIG_MLH1_MIPbox_1	45	49	PF16413	0.460
LIG_NRBOX	296	302	PF00104	0.374
LIG_PCNA_yPIPBox_3	291	301	PF02747	0.383
LIG_PDZ_Class_3	600	605	PF00595	0.381
LIG_Pex14_1	94	98	PF04695	0.474
LIG_REV1ctd_RIR_1	356	366	PF16727	0.425
LIG_REV1ctd_RIR_1	46	55	PF16727	0.456
LIG_SH2_NCK_1	578	582	PF00017	0.423
LIG_SH2_SRC	578	581	PF00017	0.416
LIG_SH2_STAP1	200	204	PF00017	0.502
LIG_SH2_STAT3	307	310	PF00017	0.370
LIG_SH2_STAT5	186	189	PF00017	0.460
LIG_SH2_STAT5	371	374	PF00017	0.514
LIG_SH2_STAT5	511	514	PF00017	0.421
LIG_SH2_STAT5	523	526	PF00017	0.306
LIG_SH3_3	266	272	PF00018	0.525
LIG_SH3_3	370	376	PF00018	0.454
LIG_SH3_3	39	45	PF00018	0.492
LIG_SH3_3	465	471	PF00018	0.697
LIG_SH3_3	554	560	PF00018	0.363
LIG_SUMO_SIM_anti_2	159	166	PF11976	0.460
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.461
LIG_SUMO_SIM_anti_2	542	548	PF11976	0.321
LIG_SUMO_SIM_par_1	159	166	PF11976	0.460
LIG_TRAF2_1	601	604	PF00917	0.437
LIG_TRAF2_2	192	197	PF00917	0.502
LIG_TYR_ITIM	524	529	PF00017	0.428
LIG_TYR_ITIM	96	101	PF00017	0.460
LIG_UBA3_1	318	327	PF00899	0.399
LIG_UBA3_1	357	362	PF00899	0.420
LIG_WW_1	323	326	PF00397	0.464
MOD_CK1_1	106	112	PF00069	0.666
MOD_CK1_1	177	183	PF00069	0.472
MOD_CK1_1	273	279	PF00069	0.627
MOD_CK1_1	282	288	PF00069	0.457
MOD_CK1_1	29	35	PF00069	0.499
MOD_CK1_1	345	351	PF00069	0.468
MOD_CK1_1	400	406	PF00069	0.827
MOD_CK1_1	453	459	PF00069	0.630
MOD_CK1_1	466	472	PF00069	0.762
MOD_CK1_1	475	481	PF00069	0.665
MOD_CK1_1	494	500	PF00069	0.470
MOD_CK2_1	146	152	PF00069	0.506
MOD_CK2_1	286	292	PF00069	0.378
MOD_CK2_1	435	441	PF00069	0.569
MOD_CK2_1	573	579	PF00069	0.438
MOD_CK2_1	598	604	PF00069	0.432
MOD_GlcNHglycan	152	157	PF01048	0.293
MOD_GlcNHglycan	172	175	PF01048	0.254
MOD_GlcNHglycan	271	275	PF01048	0.674
MOD_GlcNHglycan	278	281	PF01048	0.563
MOD_GlcNHglycan	28	31	PF01048	0.388
MOD_GlcNHglycan	32	35	PF01048	0.251
MOD_GlcNHglycan	437	440	PF01048	0.722
MOD_GlcNHglycan	465	468	PF01048	0.650
MOD_GlcNHglycan	474	477	PF01048	0.704
MOD_GlcNHglycan	494	497	PF01048	0.624
MOD_GlcNHglycan	563	566	PF01048	0.337
MOD_GlcNHglycan	575	578	PF01048	0.351
MOD_GlcNHglycan	87	90	PF01048	0.288
MOD_GSK3_1	142	149	PF00069	0.484
MOD_GSK3_1	170	177	PF00069	0.480
MOD_GSK3_1	210	217	PF00069	0.477
MOD_GSK3_1	25	32	PF00069	0.499
MOD_GSK3_1	272	279	PF00069	0.586
MOD_GSK3_1	282	289	PF00069	0.454
MOD_GSK3_1	322	329	PF00069	0.539
MOD_GSK3_1	397	404	PF00069	0.695
MOD_GSK3_1	446	453	PF00069	0.635
MOD_GSK3_1	459	466	PF00069	0.753
MOD_GSK3_1	490	497	PF00069	0.696
MOD_LATS_1	395	401	PF00433	0.631
MOD_N-GLC_1	225	230	PF02516	0.291
MOD_NEK2_1	210	215	PF00069	0.417
MOD_NEK2_1	25	30	PF00069	0.529
MOD_NEK2_1	357	362	PF00069	0.336
MOD_NEK2_1	381	386	PF00069	0.445
MOD_NEK2_1	561	566	PF00069	0.328
MOD_NEK2_1	567	572	PF00069	0.355
MOD_PIKK_1	18	24	PF00454	0.502
MOD_PIKK_1	214	220	PF00454	0.491
MOD_PIKK_1	236	242	PF00454	0.460
MOD_PKA_1	146	152	PF00069	0.452
MOD_PKA_1	397	403	PF00069	0.667
MOD_PKA_2	142	148	PF00069	0.530
MOD_PKA_2	397	403	PF00069	0.710
MOD_PKA_2	460	466	PF00069	0.657
MOD_PKB_1	457	465	PF00069	0.635
MOD_Plk_1	210	216	PF00069	0.432
MOD_Plk_1	225	231	PF00069	0.454
MOD_Plk_4	157	163	PF00069	0.522
MOD_Plk_4	279	285	PF00069	0.536
MOD_Plk_4	334	340	PF00069	0.359
MOD_Plk_4	460	466	PF00069	0.642
MOD_ProDKin_1	43	49	PF00069	0.518
MOD_ProDKin_1	466	472	PF00069	0.692
MOD_ProDKin_1	516	522	PF00069	0.399
MOD_SUMO_for_1	101	104	PF00179	0.510
MOD_SUMO_for_1	583	586	PF00179	0.419
MOD_SUMO_rev_2	197	205	PF00179	0.491
MOD_SUMO_rev_2	46	55	PF00179	0.555
MOD_SUMO_rev_2	61	67	PF00179	0.396
TRG_DiLeu_BaLyEn_6	557	562	PF01217	0.335
TRG_ENDOCYTIC_2	207	210	PF00928	0.533
TRG_ENDOCYTIC_2	346	349	PF00928	0.458
TRG_ENDOCYTIC_2	419	422	PF00928	0.544
TRG_ENDOCYTIC_2	526	529	PF00928	0.431
TRG_ENDOCYTIC_2	578	581	PF00928	0.465
TRG_ENDOCYTIC_2	592	595	PF00928	0.235
TRG_ENDOCYTIC_2	98	101	PF00928	0.460
TRG_ER_diArg_1	182	185	PF00400	0.502
TRG_ER_diArg_1	219	222	PF00400	0.502
TRG_ER_diArg_1	396	398	PF00400	0.673
TRG_ER_diArg_1	432	434	PF00400	0.655
TRG_ER_diArg_1	457	459	PF00400	0.718
TRG_ER_diArg_1	529	531	PF00400	0.525
TRG_ER_diArg_1	555	557	PF00400	0.446
TRG_ER_diArg_1	588	590	PF00400	0.378
TRG_ER_KDEL_1	602	605	PF00810	0.444
TRG_NES_CRM1_1	501	513	PF08389	0.469
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1C0	Leptomonas seymouri	59%	89%
A0A1X0NWW5	Trypanosomatidae	45%	100%
A0A3S5H784	Leishmania donovani	93%	100%
A4HYR4	Leishmania infantum	93%	100%
E9AIA4	Leishmania braziliensis	85%	100%
E9AUJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%