Kinetoplast_ribosomal_PPR-repeat_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast ribosomal PPR-repeat containing protein 3, putative

Species:

Leishmania major

UniProt:

Q4QCZ2_LEIMA

TriTrypDb:

LmjF.20.0480 , LMJLV39_200010600 , LMJSD75_200010400

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	2
GO:0005762	mitochondrial large ribosomal subunit	3	2
GO:0015934	large ribosomal subunit	4	2
GO:0032991	protein-containing complex	1	2
GO:0044391	ribosomal subunit	3	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QCZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCZ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	210	212	PF00675	0.462
CLV_NRD_NRD_1	25	27	PF00675	0.689
CLV_NRD_NRD_1	267	269	PF00675	0.518
CLV_NRD_NRD_1	312	314	PF00675	0.508
CLV_NRD_NRD_1	488	490	PF00675	0.448
CLV_NRD_NRD_1	500	502	PF00675	0.379
CLV_NRD_NRD_1	7	9	PF00675	0.613
CLV_NRD_NRD_1	73	75	PF00675	0.585
CLV_PCSK_KEX2_1	24	26	PF00082	0.638
CLV_PCSK_KEX2_1	267	269	PF00082	0.538
CLV_PCSK_KEX2_1	312	314	PF00082	0.407
CLV_PCSK_KEX2_1	319	321	PF00082	0.414
CLV_PCSK_KEX2_1	488	490	PF00082	0.445
CLV_PCSK_KEX2_1	499	501	PF00082	0.406
CLV_PCSK_KEX2_1	7	9	PF00082	0.615
CLV_PCSK_KEX2_1	73	75	PF00082	0.585
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.440
CLV_PCSK_PC7_1	3	9	PF00082	0.591
CLV_PCSK_SKI1_1	106	110	PF00082	0.607
CLV_PCSK_SKI1_1	11	15	PF00082	0.613
CLV_PCSK_SKI1_1	274	278	PF00082	0.585
CLV_PCSK_SKI1_1	353	357	PF00082	0.361
CLV_PCSK_SKI1_1	360	364	PF00082	0.404
CLV_PCSK_SKI1_1	488	492	PF00082	0.430
CLV_PCSK_SKI1_1	514	518	PF00082	0.389
CLV_PCSK_SKI1_1	548	552	PF00082	0.570
DEG_Nend_UBRbox_3	1	3	PF02207	0.670
DEG_SPOP_SBC_1	342	346	PF00917	0.499
DOC_CKS1_1	299	304	PF01111	0.597
DOC_CKS1_1	434	439	PF01111	0.501
DOC_CKS1_1	63	68	PF01111	0.600
DOC_CYCLIN_RxL_1	185	197	PF00134	0.522
DOC_CYCLIN_RxL_1	349	359	PF00134	0.383
DOC_CYCLIN_RxL_1	511	519	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	397	403	PF00134	0.512
DOC_MAPK_DCC_7	320	330	PF00069	0.500
DOC_MAPK_HePTP_8	533	545	PF00069	0.463
DOC_MAPK_MEF2A_6	536	545	PF00069	0.461
DOC_PP2B_LxvP_1	286	289	PF13499	0.747
DOC_PP2B_LxvP_1	397	400	PF13499	0.529
DOC_PP4_FxxP_1	322	325	PF00568	0.469
DOC_SPAK_OSR1_1	98	102	PF12202	0.466
DOC_USP7_MATH_1	130	134	PF00917	0.416
DOC_USP7_MATH_1	287	291	PF00917	0.723
DOC_WW_Pin1_4	111	116	PF00397	0.462
DOC_WW_Pin1_4	219	224	PF00397	0.441
DOC_WW_Pin1_4	298	303	PF00397	0.635
DOC_WW_Pin1_4	321	326	PF00397	0.376
DOC_WW_Pin1_4	433	438	PF00397	0.500
DOC_WW_Pin1_4	62	67	PF00397	0.653
LIG_14-3-3_CanoR_1	11	16	PF00244	0.630
LIG_14-3-3_CanoR_1	129	135	PF00244	0.432
LIG_14-3-3_CanoR_1	312	322	PF00244	0.405
LIG_14-3-3_CanoR_1	367	376	PF00244	0.336
LIG_14-3-3_CanoR_1	389	397	PF00244	0.479
LIG_14-3-3_CanoR_1	463	468	PF00244	0.460
LIG_14-3-3_CanoR_1	488	497	PF00244	0.415
LIG_14-3-3_CanoR_1	520	525	PF00244	0.443
LIG_BRCT_BRCA1_1	16	20	PF00533	0.661
LIG_FHA_1	159	165	PF00498	0.627
LIG_FHA_1	17	23	PF00498	0.568
LIG_FHA_1	271	277	PF00498	0.680
LIG_FHA_1	293	299	PF00498	0.707
LIG_FHA_1	334	340	PF00498	0.392
LIG_FHA_1	389	395	PF00498	0.459
LIG_FHA_1	405	411	PF00498	0.202
LIG_FHA_1	434	440	PF00498	0.444
LIG_FHA_1	443	449	PF00498	0.368
LIG_FHA_1	471	477	PF00498	0.344
LIG_FHA_1	489	495	PF00498	0.373
LIG_FHA_1	506	512	PF00498	0.406
LIG_FHA_2	147	153	PF00498	0.669
LIG_FHA_2	299	305	PF00498	0.621
LIG_FHA_2	78	84	PF00498	0.591
LIG_LIR_Gen_1	17	28	PF02991	0.576
LIG_LIR_Gen_1	359	365	PF02991	0.389
LIG_LIR_Gen_1	457	467	PF02991	0.440
LIG_LIR_Gen_1	472	480	PF02991	0.262
LIG_LIR_Nem_3	17	23	PF02991	0.590
LIG_LIR_Nem_3	359	364	PF02991	0.398
LIG_LIR_Nem_3	368	373	PF02991	0.356
LIG_LIR_Nem_3	472	477	PF02991	0.387
LIG_LIR_Nem_3	484	490	PF02991	0.360
LIG_NRBOX	215	221	PF00104	0.486
LIG_NRBOX	405	411	PF00104	0.426
LIG_NRBOX	442	448	PF00104	0.398
LIG_NRBOX	508	514	PF00104	0.345
LIG_PCNA_yPIPBox_3	503	517	PF02747	0.367
LIG_PTB_Apo_2	236	243	PF02174	0.452
LIG_PTB_Phospho_1	236	242	PF10480	0.445
LIG_SH2_CRK	474	478	PF00017	0.378
LIG_SH2_NCK_1	260	264	PF00017	0.452
LIG_SH2_SRC	172	175	PF00017	0.423
LIG_SH2_SRC	75	78	PF00017	0.707
LIG_SH2_STAP1	242	246	PF00017	0.480
LIG_SH2_STAP1	370	374	PF00017	0.318
LIG_SH2_STAP1	390	394	PF00017	0.199
LIG_SH2_STAP1	474	478	PF00017	0.347
LIG_SH2_STAP1	524	528	PF00017	0.307
LIG_SH2_STAT3	315	318	PF00017	0.437
LIG_SH2_STAT3	524	527	PF00017	0.314
LIG_SH2_STAT5	134	137	PF00017	0.492
LIG_SH2_STAT5	172	175	PF00017	0.434
LIG_SH2_STAT5	315	318	PF00017	0.360
LIG_SH2_STAT5	370	373	PF00017	0.371
LIG_SH2_STAT5	390	393	PF00017	0.194
LIG_SH2_STAT5	418	421	PF00017	0.426
LIG_SH2_STAT5	474	477	PF00017	0.410
LIG_SH2_STAT5	75	78	PF00017	0.707
LIG_SH3_1	296	302	PF00018	0.445
LIG_SH3_1	535	541	PF00018	0.530
LIG_SH3_3	193	199	PF00018	0.518
LIG_SH3_3	296	302	PF00018	0.603
LIG_SH3_3	359	365	PF00018	0.378
LIG_SH3_3	398	404	PF00018	0.511
LIG_SH3_3	431	437	PF00018	0.535
LIG_SH3_3	535	541	PF00018	0.530
LIG_SH3_3	63	69	PF00018	0.655
LIG_SUMO_SIM_anti_2	254	261	PF11976	0.457
LIG_SUMO_SIM_anti_2	335	341	PF11976	0.486
LIG_SUMO_SIM_anti_2	420	427	PF11976	0.306
LIG_SUMO_SIM_anti_2	475	480	PF11976	0.355
LIG_SUMO_SIM_par_1	326	331	PF11976	0.361
LIG_SUMO_SIM_par_1	335	341	PF11976	0.377
LIG_SUMO_SIM_par_1	444	450	PF11976	0.357
LIG_TRAF2_1	124	127	PF00917	0.537
LIG_TRFH_1	361	365	PF08558	0.487
LIG_TYR_ITSM	369	376	PF00017	0.461
LIG_UBA3_1	405	411	PF00899	0.426
LIG_UBA3_1	476	483	PF00899	0.474
MOD_CDK_SPK_2	65	70	PF00069	0.689
MOD_CK1_1	252	258	PF00069	0.474
MOD_CK1_1	261	267	PF00069	0.468
MOD_CK1_1	338	344	PF00069	0.450
MOD_CK1_1	36	42	PF00069	0.724
MOD_CK1_1	424	430	PF00069	0.472
MOD_CK1_1	442	448	PF00069	0.305
MOD_CK2_1	172	178	PF00069	0.428
MOD_GlcNHglycan	28	31	PF01048	0.696
MOD_GlcNHglycan	290	293	PF01048	0.723
MOD_GlcNHglycan	39	42	PF01048	0.650
MOD_GlcNHglycan	415	418	PF01048	0.401
MOD_GSK3_1	152	159	PF00069	0.580
MOD_GSK3_1	168	175	PF00069	0.484
MOD_GSK3_1	26	33	PF00069	0.610
MOD_GSK3_1	270	277	PF00069	0.537
MOD_GSK3_1	288	295	PF00069	0.669
MOD_GSK3_1	338	345	PF00069	0.404
MOD_GSK3_1	368	375	PF00069	0.489
MOD_GSK3_1	442	449	PF00069	0.425
MOD_GSK3_1	61	68	PF00069	0.629
MOD_GSK3_1	77	84	PF00069	0.590
MOD_N-GLC_1	413	418	PF02516	0.426
MOD_N-GLC_1	439	444	PF02516	0.350
MOD_NEK2_1	168	173	PF00069	0.522
MOD_NEK2_1	258	263	PF00069	0.416
MOD_NEK2_1	31	36	PF00069	0.616
MOD_NEK2_1	333	338	PF00069	0.363
MOD_NEK2_1	413	418	PF00069	0.426
MOD_NEK2_1	462	467	PF00069	0.476
MOD_NEK2_1	528	533	PF00069	0.353
MOD_NEK2_1	81	86	PF00069	0.705
MOD_NEK2_2	454	459	PF00069	0.381
MOD_PIKK_1	481	487	PF00454	0.478
MOD_PIKK_1	75	81	PF00454	0.684
MOD_PIKK_1	83	89	PF00454	0.636
MOD_PK_1	463	469	PF00069	0.483
MOD_PKA_1	488	494	PF00069	0.504
MOD_PKA_2	128	134	PF00069	0.427
MOD_PKA_2	366	372	PF00069	0.336
MOD_PKA_2	388	394	PF00069	0.464
MOD_PKA_2	462	468	PF00069	0.545
MOD_PKA_2	488	494	PF00069	0.439
MOD_PKA_2	69	75	PF00069	0.625
MOD_PKB_1	24	32	PF00069	0.732
MOD_Plk_1	439	445	PF00069	0.347
MOD_Plk_1	505	511	PF00069	0.562
MOD_Plk_2-3	77	83	PF00069	0.574
MOD_Plk_4	130	136	PF00069	0.450
MOD_Plk_4	168	174	PF00069	0.567
MOD_Plk_4	252	258	PF00069	0.523
MOD_Plk_4	261	267	PF00069	0.460
MOD_Plk_4	335	341	PF00069	0.440
MOD_Plk_4	421	427	PF00069	0.356
MOD_Plk_4	442	448	PF00069	0.430
MOD_Plk_4	472	478	PF00069	0.378
MOD_Plk_4	528	534	PF00069	0.394
MOD_ProDKin_1	111	117	PF00069	0.456
MOD_ProDKin_1	219	225	PF00069	0.445
MOD_ProDKin_1	298	304	PF00069	0.632
MOD_ProDKin_1	321	327	PF00069	0.375
MOD_ProDKin_1	433	439	PF00069	0.493
MOD_ProDKin_1	62	68	PF00069	0.654
TRG_DiLeu_BaEn_1	254	259	PF01217	0.481
TRG_DiLeu_BaEn_1	421	426	PF01217	0.307
TRG_DiLeu_BaEn_1	472	477	PF01217	0.380
TRG_DiLeu_BaEn_2	231	237	PF01217	0.450
TRG_DiLeu_BaLyEn_6	350	355	PF01217	0.353
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.501
TRG_DiLeu_BaLyEn_6	546	551	PF01217	0.555
TRG_ENDOCYTIC_2	373	376	PF00928	0.419
TRG_ENDOCYTIC_2	459	462	PF00928	0.437
TRG_ENDOCYTIC_2	474	477	PF00928	0.238
TRG_ENDOCYTIC_2	529	532	PF00928	0.364
TRG_ER_diArg_1	183	186	PF00400	0.466
TRG_ER_diArg_1	23	26	PF00400	0.729
TRG_ER_diArg_1	266	268	PF00400	0.499
TRG_ER_diArg_1	311	313	PF00400	0.513
TRG_ER_diArg_1	487	489	PF00400	0.454
TRG_ER_diArg_1	499	501	PF00400	0.401
TRG_ER_diArg_1	73	75	PF00400	0.753
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Z9	Leptomonas seymouri	70%	100%
A0A0S4J3K2	Bodo saltans	38%	77%
A0A1X0NWF6	Trypanosomatidae	50%	100%
A0A3Q8IBN5	Leishmania donovani	96%	100%
A0A3R7K7U1	Trypanosoma rangeli	48%	100%
A4HYR3	Leishmania infantum	97%	100%
C9ZI67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AUJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BQU6	Trypanosoma cruzi	55%	100%