Putative RNA polymerase subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-directed RNA polymerase 2, RPB12 subunit, putative

Species:

Leishmania major

UniProt:

Q4QCZ1_LEIMA

TriTrypDb:

LmjF.20.0490 , LMJLV39_200010700 , LMJSD75_200010500

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	1
GO:0030880	RNA polymerase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

Q4QCZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCZ1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006351	DNA-templated transcription	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0032774	RNA biosynthetic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0097659	nucleic acid-templated transcription	6	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003824	catalytic activity	1	4
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	4
GO:0005488	binding	1	2
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4
GO:0016779	nucleotidyltransferase activity	4	4
GO:0034062	5'-3' RNA polymerase activity	5	4
GO:0097159	organic cyclic compound binding	2	2
GO:0097747	RNA polymerase activity	4	4
GO:0140098	catalytic activity, acting on RNA	3	4
GO:0140640	catalytic activity, acting on a nucleic acid	2	4
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	58	60	PF00675	0.664
CLV_PCSK_KEX2_1	58	60	PF00082	0.664
DEG_Nend_Nbox_1	1	3	PF02207	0.576
DOC_MAPK_gen_1	102	111	PF00069	0.535
DOC_MAPK_gen_1	58	66	PF00069	0.672
DOC_USP7_MATH_1	130	134	PF00917	0.487
DOC_USP7_MATH_1	21	25	PF00917	0.738
DOC_USP7_UBL2_3	67	71	PF12436	0.672
LIG_14-3-3_CanoR_1	58	62	PF00244	0.542
LIG_BRCT_BRCA1_1	138	142	PF00533	0.506
LIG_BRCT_BRCA1_2	138	144	PF00533	0.510
LIG_FHA_1	106	112	PF00498	0.551
LIG_FHA_1	114	120	PF00498	0.524
LIG_FHA_1	51	57	PF00498	0.653
LIG_FHA_2	148	154	PF00498	0.574
LIG_FHA_2	94	100	PF00498	0.646
LIG_LIR_Gen_1	150	155	PF02991	0.593
LIG_LIR_Nem_3	139	145	PF02991	0.501
LIG_LIR_Nem_3	150	155	PF02991	0.421
LIG_PCNA_yPIPBox_3	87	101	PF02747	0.519
LIG_PDZ_Class_3	150	155	PF00595	0.593
LIG_SH2_STAT5	110	113	PF00017	0.456
LIG_SH2_STAT5	120	123	PF00017	0.385
LIG_SH3_3	10	16	PF00018	0.530
LIG_TRAF2_1	82	85	PF00917	0.671
LIG_TRAF2_1	92	95	PF00917	0.487
LIG_TYR_ITSM	148	155	PF00017	0.584
MOD_CK1_1	133	139	PF00069	0.518
MOD_GlcNHglycan	61	64	PF01048	0.753
MOD_GSK3_1	1	8	PF00069	0.669
MOD_GSK3_1	133	140	PF00069	0.511
MOD_GSK3_1	144	151	PF00069	0.369
MOD_N-GLC_1	113	118	PF02516	0.479
MOD_NEK2_1	1	6	PF00069	0.563
MOD_NEK2_2	137	142	PF00069	0.507
MOD_PIKK_1	80	86	PF00454	0.672
MOD_PIKK_1	90	96	PF00454	0.489
MOD_PKA_2	57	63	PF00069	0.628
MOD_Plk_2-3	148	154	PF00069	0.574
MOD_Plk_4	105	111	PF00069	0.563
MOD_Plk_4	137	143	PF00069	0.508
MOD_SUMO_for_1	66	69	PF00179	0.674
MOD_SUMO_for_1	70	73	PF00179	0.632
TRG_ENDOCYTIC_2	152	155	PF00928	0.628
TRG_ER_diArg_1	39	42	PF00400	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBK2	Leishmania donovani	88%	76%
A4HYR2	Leishmania infantum	93%	100%