CTP_transf_like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCZ0_LEIMA

TriTrypDb:

LmjF.20.0500 , LMJLV39_200010900 , LMJSD75_200010700

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCZ0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	4
GO:0009058	biosynthetic process	2	4
GO:0009117	nucleotide metabolic process	5	2
GO:0009165	nucleotide biosynthetic process	6	2
GO:0009435	NAD biosynthetic process	8	2
GO:0009987	cellular process	1	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019359	nicotinamide nucleotide biosynthetic process	7	2
GO:0019362	pyridine nucleotide metabolic process	5	2
GO:0019363	pyridine nucleotide biosynthetic process	6	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway	9	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046496	nicotinamide nucleotide metabolic process	6	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072524	pyridine-containing compound metabolic process	4	2
GO:0072525	pyridine-containing compound biosynthetic process	5	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901293	nucleoside phosphate biosynthetic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	6	2
GO:0003824	catalytic activity	1	4
GO:0016462	pyrophosphatase activity	5	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016779	nucleotidyltransferase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0070566	adenylyltransferase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.520
CLV_NRD_NRD_1	30	32	PF00675	0.530
CLV_NRD_NRD_1	421	423	PF00675	0.305
CLV_NRD_NRD_1	428	430	PF00675	0.288
CLV_NRD_NRD_1	501	503	PF00675	0.317
CLV_NRD_NRD_1	546	548	PF00675	0.530
CLV_PCSK_FUR_1	127	131	PF00082	0.612
CLV_PCSK_KEX2_1	129	131	PF00082	0.522
CLV_PCSK_KEX2_1	30	32	PF00082	0.571
CLV_PCSK_KEX2_1	421	423	PF00082	0.313
CLV_PCSK_KEX2_1	428	430	PF00082	0.277
CLV_PCSK_SKI1_1	221	225	PF00082	0.633
CLV_PCSK_SKI1_1	281	285	PF00082	0.537
CLV_PCSK_SKI1_1	30	34	PF00082	0.556
CLV_PCSK_SKI1_1	40	44	PF00082	0.448
DEG_APCC_DBOX_1	280	288	PF00400	0.626
DOC_CYCLIN_RxL_1	34	44	PF00134	0.509
DOC_MAPK_DCC_7	243	253	PF00069	0.670
DOC_MAPK_gen_1	127	137	PF00069	0.524
DOC_MAPK_gen_1	428	435	PF00069	0.542
DOC_MAPK_MEF2A_6	130	139	PF00069	0.528
DOC_MAPK_MEF2A_6	56	65	PF00069	0.423
DOC_PP1_RVXF_1	81	88	PF00149	0.621
DOC_PP2B_LxvP_1	516	519	PF13499	0.517
DOC_USP7_MATH_1	147	151	PF00917	0.661
DOC_USP7_MATH_1	231	235	PF00917	0.642
DOC_USP7_MATH_1	264	268	PF00917	0.717
DOC_USP7_MATH_1	290	294	PF00917	0.707
DOC_USP7_MATH_1	348	352	PF00917	0.730
DOC_USP7_MATH_1	36	40	PF00917	0.509
DOC_USP7_UBL2_3	407	411	PF12436	0.527
DOC_WW_Pin1_4	10	15	PF00397	0.420
DOC_WW_Pin1_4	154	159	PF00397	0.725
DOC_WW_Pin1_4	244	249	PF00397	0.771
DOC_WW_Pin1_4	317	322	PF00397	0.587
LIG_14-3-3_CanoR_1	16	20	PF00244	0.454
LIG_14-3-3_CanoR_1	243	248	PF00244	0.737
LIG_14-3-3_CanoR_1	259	264	PF00244	0.533
LIG_14-3-3_CanoR_1	432	442	PF00244	0.556
LIG_14-3-3_CanoR_1	502	507	PF00244	0.556
LIG_14-3-3_CanoR_1	51	58	PF00244	0.626
LIG_14-3-3_CterR_2	547	552	PF00244	0.520
LIG_Actin_WH2_2	412	430	PF00022	0.551
LIG_APCC_ABBAyCdc20_2	83	89	PF00400	0.403
LIG_BIR_II_1	1	5	PF00653	0.499
LIG_CaM_IQ_9	371	387	PF13499	0.551
LIG_Clathr_ClatBox_1	454	458	PF01394	0.556
LIG_CtBP_PxDLS_1	248	252	PF00389	0.665
LIG_eIF4E_1	368	374	PF01652	0.607
LIG_FHA_1	10	16	PF00498	0.316
LIG_FHA_1	108	114	PF00498	0.565
LIG_FHA_1	118	124	PF00498	0.402
LIG_FHA_1	369	375	PF00498	0.607
LIG_FHA_1	376	382	PF00498	0.524
LIG_FHA_1	399	405	PF00498	0.512
LIG_FHA_1	485	491	PF00498	0.607
LIG_FHA_2	39	45	PF00498	0.486
LIG_FHA_2	394	400	PF00498	0.468
LIG_FHA_2	469	475	PF00498	0.542
LIG_Integrin_RGD_1	238	240	PF01839	0.564
LIG_LIR_Gen_1	222	232	PF02991	0.604
LIG_LIR_LC3C_4	185	188	PF02991	0.465
LIG_LIR_Nem_3	222	227	PF02991	0.567
LIG_LIR_Nem_3	362	366	PF02991	0.517
LIG_LRP6_Inhibitor_1	350	356	PF00058	0.408
LIG_SH2_NCK_1	402	406	PF00017	0.440
LIG_SH2_SRC	402	405	PF00017	0.498
LIG_SH2_STAP1	322	326	PF00017	0.481
LIG_SH2_STAP1	342	346	PF00017	0.680
LIG_SH2_STAP1	402	406	PF00017	0.517
LIG_SH2_STAT5	496	499	PF00017	0.516
LIG_SH3_3	141	147	PF00018	0.570
LIG_SH3_3	460	466	PF00018	0.556
LIG_SH3_3	524	530	PF00018	0.563
LIG_SH3_3	96	102	PF00018	0.637
LIG_Sin3_3	224	231	PF02671	0.647
LIG_SUMO_SIM_anti_2	181	188	PF11976	0.536
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.585
LIG_SUMO_SIM_anti_2	250	256	PF11976	0.662
MOD_CDC14_SPxK_1	13	16	PF00782	0.433
MOD_CDK_SPxK_1	10	16	PF00069	0.424
MOD_CK1_1	128	134	PF00069	0.668
MOD_CK1_1	151	157	PF00069	0.766
MOD_CK1_1	208	214	PF00069	0.709
MOD_CK1_1	247	253	PF00069	0.709
MOD_CK1_1	262	268	PF00069	0.647
MOD_CK1_1	297	303	PF00069	0.583
MOD_CK1_1	317	323	PF00069	0.490
MOD_CK1_1	393	399	PF00069	0.440
MOD_CK2_1	128	134	PF00069	0.668
MOD_CK2_1	173	179	PF00069	0.667
MOD_CK2_1	227	233	PF00069	0.719
MOD_CK2_1	264	270	PF00069	0.739
MOD_CK2_1	38	44	PF00069	0.506
MOD_CK2_1	393	399	PF00069	0.577
MOD_CK2_1	467	473	PF00069	0.607
MOD_CK2_1	536	542	PF00069	0.517
MOD_Cter_Amidation	500	503	PF01082	0.317
MOD_GlcNHglycan	120	123	PF01048	0.459
MOD_GlcNHglycan	153	156	PF01048	0.718
MOD_GlcNHglycan	229	232	PF01048	0.713
MOD_GlcNHglycan	233	236	PF01048	0.760
MOD_GlcNHglycan	266	269	PF01048	0.729
MOD_GlcNHglycan	275	279	PF01048	0.545
MOD_GlcNHglycan	292	295	PF01048	0.622
MOD_GlcNHglycan	316	319	PF01048	0.668
MOD_GlcNHglycan	322	325	PF01048	0.585
MOD_GlcNHglycan	343	347	PF01048	0.699
MOD_GlcNHglycan	66	69	PF01048	0.546
MOD_GSK3_1	118	125	PF00069	0.514
MOD_GSK3_1	147	154	PF00069	0.698
MOD_GSK3_1	227	234	PF00069	0.643
MOD_GSK3_1	243	250	PF00069	0.744
MOD_GSK3_1	290	297	PF00069	0.692
MOD_GSK3_1	389	396	PF00069	0.570
MOD_NEK2_1	314	319	PF00069	0.641
MOD_NEK2_1	79	84	PF00069	0.511
MOD_PIKK_1	51	57	PF00454	0.556
MOD_PK_1	259	265	PF00069	0.660
MOD_PKA_1	30	36	PF00069	0.591
MOD_PKA_1	502	508	PF00069	0.607
MOD_PKA_2	128	134	PF00069	0.558
MOD_PKA_2	15	21	PF00069	0.454
MOD_PKA_2	208	214	PF00069	0.661
MOD_PKA_2	242	248	PF00069	0.727
MOD_PKA_2	30	36	PF00069	0.519
MOD_PKA_2	50	56	PF00069	0.301
MOD_Plk_1	389	395	PF00069	0.582
MOD_Plk_1	398	404	PF00069	0.526
MOD_Plk_1	511	517	PF00069	0.522
MOD_Plk_4	109	115	PF00069	0.412
MOD_Plk_4	249	255	PF00069	0.701
MOD_ProDKin_1	10	16	PF00069	0.420
MOD_ProDKin_1	154	160	PF00069	0.715
MOD_ProDKin_1	244	250	PF00069	0.769
MOD_ProDKin_1	317	323	PF00069	0.587
TRG_DiLeu_BaEn_1	182	187	PF01217	0.523
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.502
TRG_ENDOCYTIC_2	166	169	PF00928	0.592
TRG_ENDOCYTIC_2	496	499	PF00928	0.517
TRG_ER_diArg_1	127	130	PF00400	0.537
TRG_ER_diArg_1	29	31	PF00400	0.576
TRG_ER_diArg_1	381	384	PF00400	0.551
TRG_ER_diArg_1	421	423	PF00400	0.509
TRG_ER_diArg_1	427	429	PF00400	0.478
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7H4	Leptomonas seymouri	54%	100%
A0A0S4ILY4	Bodo saltans	34%	100%
A0A3S7WVU1	Leishmania donovani	92%	100%
A4HYR1	Leishmania infantum	92%	100%
E9AIA7	Leishmania braziliensis	78%	99%
E9AUJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%