WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCY8_LEIMA

TriTrypDb:

LmjF.20.0520 , LMJLV39_200011100 , LMJSD75_200010900

Length:

960

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	669	673	PF00656	0.450
CLV_NRD_NRD_1	19	21	PF00675	0.660
CLV_NRD_NRD_1	397	399	PF00675	0.549
CLV_NRD_NRD_1	438	440	PF00675	0.586
CLV_NRD_NRD_1	582	584	PF00675	0.810
CLV_NRD_NRD_1	70	72	PF00675	0.702
CLV_NRD_NRD_1	800	802	PF00675	0.741
CLV_PCSK_KEX2_1	19	21	PF00082	0.720
CLV_PCSK_KEX2_1	396	398	PF00082	0.552
CLV_PCSK_KEX2_1	438	440	PF00082	0.594
CLV_PCSK_KEX2_1	582	584	PF00082	0.810
CLV_PCSK_KEX2_1	645	647	PF00082	0.685
CLV_PCSK_KEX2_1	670	672	PF00082	0.450
CLV_PCSK_KEX2_1	799	801	PF00082	0.754
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.685
CLV_PCSK_PC1ET2_1	670	672	PF00082	0.450
CLV_PCSK_SKI1_1	397	401	PF00082	0.589
CLV_PCSK_SKI1_1	565	569	PF00082	0.602
CLV_PCSK_SKI1_1	606	610	PF00082	0.573
CLV_PCSK_SKI1_1	765	769	PF00082	0.661
CLV_PCSK_SKI1_1	901	905	PF00082	0.401
CLV_Separin_Metazoa	93	97	PF03568	0.605
DEG_APCC_DBOX_1	421	429	PF00400	0.631
DEG_APCC_KENBOX_2	302	306	PF00400	0.732
DEG_SCF_FBW7_1	308	315	PF00400	0.803
DEG_SPOP_SBC_1	571	575	PF00917	0.761
DEG_SPOP_SBC_1	628	632	PF00917	0.777
DEG_SPOP_SBC_1	749	753	PF00917	0.790
DEG_SPOP_SBC_1	822	826	PF00917	0.772
DOC_CKS1_1	309	314	PF01111	0.723
DOC_CKS1_1	515	520	PF01111	0.749
DOC_CKS1_1	636	641	PF01111	0.718
DOC_CYCLIN_RxL_1	896	905	PF00134	0.401
DOC_CYCLIN_yCln2_LP_2	693	699	PF00134	0.689
DOC_MAPK_gen_1	133	140	PF00069	0.818
DOC_MAPK_gen_1	396	402	PF00069	0.558
DOC_MAPK_gen_1	702	710	PF00069	0.630
DOC_MAPK_gen_1	71	79	PF00069	0.689
DOC_MAPK_gen_1	776	785	PF00069	0.740
DOC_MAPK_MEF2A_6	133	140	PF00069	0.818
DOC_PP1_RVXF_1	837	843	PF00149	0.543
DOC_PP2B_LxvP_1	516	519	PF13499	0.810
DOC_PP2B_LxvP_1	677	680	PF13499	0.411
DOC_PP2B_LxvP_1	719	722	PF13499	0.733
DOC_PP2B_LxvP_1	794	797	PF13499	0.684
DOC_USP7_MATH_1	155	159	PF00917	0.717
DOC_USP7_MATH_1	179	183	PF00917	0.747
DOC_USP7_MATH_1	214	218	PF00917	0.728
DOC_USP7_MATH_1	329	333	PF00917	0.728
DOC_USP7_MATH_1	392	396	PF00917	0.586
DOC_USP7_MATH_1	44	48	PF00917	0.698
DOC_USP7_MATH_1	468	472	PF00917	0.658
DOC_USP7_MATH_1	505	509	PF00917	0.749
DOC_USP7_MATH_1	604	608	PF00917	0.743
DOC_USP7_MATH_1	628	632	PF00917	0.758
DOC_USP7_MATH_1	715	719	PF00917	0.742
DOC_USP7_MATH_1	736	740	PF00917	0.840
DOC_USP7_MATH_1	808	812	PF00917	0.764
DOC_USP7_MATH_1	822	826	PF00917	0.778
DOC_WW_Pin1_4	144	149	PF00397	0.692
DOC_WW_Pin1_4	242	247	PF00397	0.726
DOC_WW_Pin1_4	308	313	PF00397	0.809
DOC_WW_Pin1_4	316	321	PF00397	0.745
DOC_WW_Pin1_4	37	42	PF00397	0.706
DOC_WW_Pin1_4	514	519	PF00397	0.786
DOC_WW_Pin1_4	537	542	PF00397	0.682
DOC_WW_Pin1_4	635	640	PF00397	0.722
DOC_WW_Pin1_4	803	808	PF00397	0.780
DOC_WW_Pin1_4	815	820	PF00397	0.661
LIG_14-3-3_CanoR_1	211	219	PF00244	0.728
LIG_14-3-3_CanoR_1	52	56	PF00244	0.634
LIG_14-3-3_CanoR_1	565	571	PF00244	0.725
LIG_14-3-3_CanoR_1	603	609	PF00244	0.741
LIG_14-3-3_CanoR_1	627	636	PF00244	0.832
LIG_14-3-3_CanoR_1	71	75	PF00244	0.576
LIG_APCC_ABBAyCdc20_2	121	127	PF00400	0.795
LIG_BIR_III_4	131	135	PF00653	0.707
LIG_BRCT_BRCA1_1	604	608	PF00533	0.805
LIG_BRCT_BRCA1_1	932	936	PF00533	0.389
LIG_deltaCOP1_diTrp_1	940	946	PF00928	0.455
LIG_FHA_1	11	17	PF00498	0.614
LIG_FHA_1	139	145	PF00498	0.774
LIG_FHA_1	264	270	PF00498	0.774
LIG_FHA_1	353	359	PF00498	0.566
LIG_FHA_1	635	641	PF00498	0.761
LIG_FHA_1	725	731	PF00498	0.610
LIG_FHA_1	749	755	PF00498	0.735
LIG_FHA_1	84	90	PF00498	0.702
LIG_FHA_1	948	954	PF00498	0.504
LIG_FHA_2	157	163	PF00498	0.643
LIG_FHA_2	226	232	PF00498	0.725
LIG_FHA_2	331	337	PF00498	0.726
LIG_FHA_2	363	369	PF00498	0.559
LIG_FHA_2	429	435	PF00498	0.605
LIG_FHA_2	515	521	PF00498	0.710
LIG_FHA_2	663	669	PF00498	0.512
LIG_FHA_2	808	814	PF00498	0.695
LIG_FHA_2	943	949	PF00498	0.485
LIG_LIR_Apic_2	24	28	PF02991	0.605
LIG_LIR_Apic_2	73	78	PF02991	0.573
LIG_LIR_Nem_3	13	18	PF02991	0.612
LIG_PDZ_Class_1	955	960	PF00595	0.593
LIG_Pex14_1	942	946	PF04695	0.455
LIG_Pex14_2	662	666	PF04695	0.411
LIG_PTB_Apo_2	271	278	PF02174	0.615
LIG_PTB_Phospho_1	271	277	PF10480	0.615
LIG_RPA_C_Fungi	412	424	PF08784	0.657
LIG_SH2_CRK	589	593	PF00017	0.692
LIG_SH2_CRK	956	960	PF00017	0.537
LIG_SH2_CRK	99	103	PF00017	0.616
LIG_SH2_PTP2	15	18	PF00017	0.651
LIG_SH2_STAP1	277	281	PF00017	0.747
LIG_SH2_STAP1	479	483	PF00017	0.558
LIG_SH2_STAP1	910	914	PF00017	0.352
LIG_SH2_STAP1	956	960	PF00017	0.537
LIG_SH2_STAP1	99	103	PF00017	0.740
LIG_SH2_STAT3	781	784	PF00017	0.620
LIG_SH2_STAT5	15	18	PF00017	0.613
LIG_SH2_STAT5	26	29	PF00017	0.602
LIG_SH2_STAT5	279	282	PF00017	0.752
LIG_SH2_STAT5	458	461	PF00017	0.548
LIG_SH2_STAT5	781	784	PF00017	0.599
LIG_SH2_STAT5	790	793	PF00017	0.490
LIG_SH2_STAT5	848	851	PF00017	0.493
LIG_SH2_STAT5	872	875	PF00017	0.411
LIG_SH2_STAT5	917	920	PF00017	0.436
LIG_SH2_STAT5	956	959	PF00017	0.517
LIG_SH3_2	2	7	PF14604	0.720
LIG_SH3_3	175	181	PF00018	0.712
LIG_SH3_3	240	246	PF00018	0.706
LIG_SH3_3	270	276	PF00018	0.797
LIG_SH3_3	306	312	PF00018	0.722
LIG_SH3_3	358	364	PF00018	0.772
LIG_SH3_3	38	44	PF00018	0.727
LIG_SH3_3	494	500	PF00018	0.741
LIG_SH3_3	512	518	PF00018	0.502
LIG_SH3_3	558	564	PF00018	0.727
LIG_SH3_3	633	639	PF00018	0.679
LIG_SH3_3	774	780	PF00018	0.662
LIG_SUMO_SIM_anti_2	265	273	PF11976	0.634
LIG_SUMO_SIM_anti_2	884	890	PF11976	0.286
LIG_SUMO_SIM_par_1	675	682	PF11976	0.512
LIG_TRAF2_1	365	368	PF00917	0.640
LIG_TRAF2_1	771	774	PF00917	0.687
LIG_WW_1	518	521	PF00397	0.686
LIG_WW_3	624	628	PF00397	0.829
MOD_CDK_SPK_2	37	42	PF00069	0.728
MOD_CDK_SPxxK_3	537	544	PF00069	0.611
MOD_CK1_1	143	149	PF00069	0.782
MOD_CK1_1	678	684	PF00069	0.711
MOD_CK1_1	739	745	PF00069	0.803
MOD_CK1_1	824	830	PF00069	0.774
MOD_CK2_1	156	162	PF00069	0.639
MOD_CK2_1	242	248	PF00069	0.759
MOD_CK2_1	291	297	PF00069	0.740
MOD_CK2_1	330	336	PF00069	0.739
MOD_CK2_1	362	368	PF00069	0.569
MOD_CK2_1	428	434	PF00069	0.622
MOD_CK2_1	505	511	PF00069	0.779
MOD_CK2_1	662	668	PF00069	0.512
MOD_CK2_1	807	813	PF00069	0.696
MOD_DYRK1A_RPxSP_1	635	639	PF00069	0.593
MOD_GlcNHglycan	151	154	PF01048	0.775
MOD_GlcNHglycan	159	162	PF01048	0.690
MOD_GlcNHglycan	212	215	PF01048	0.786
MOD_GlcNHglycan	216	219	PF01048	0.700
MOD_GlcNHglycan	294	297	PF01048	0.799
MOD_GlcNHglycan	443	447	PF01048	0.545
MOD_GlcNHglycan	470	473	PF01048	0.660
MOD_GlcNHglycan	507	510	PF01048	0.816
MOD_GlcNHglycan	555	558	PF01048	0.801
MOD_GlcNHglycan	631	634	PF01048	0.718
MOD_GlcNHglycan	711	714	PF01048	0.779
MOD_GlcNHglycan	810	813	PF01048	0.760
MOD_GlcNHglycan	826	829	PF01048	0.717
MOD_GlcNHglycan	928	931	PF01048	0.312
MOD_GSK3_1	138	145	PF00069	0.728
MOD_GSK3_1	210	217	PF00069	0.802
MOD_GSK3_1	259	266	PF00069	0.855
MOD_GSK3_1	277	284	PF00069	0.692
MOD_GSK3_1	308	315	PF00069	0.755
MOD_GSK3_1	316	323	PF00069	0.794
MOD_GSK3_1	503	510	PF00069	0.733
MOD_GSK3_1	553	560	PF00069	0.796
MOD_GSK3_1	566	573	PF00069	0.646
MOD_GSK3_1	598	605	PF00069	0.807
MOD_GSK3_1	675	682	PF00069	0.411
MOD_GSK3_1	724	731	PF00069	0.821
MOD_GSK3_1	737	744	PF00069	0.838
MOD_GSK3_1	748	755	PF00069	0.772
MOD_GSK3_1	803	810	PF00069	0.697
MOD_GSK3_1	820	827	PF00069	0.794
MOD_GSK3_1	828	835	PF00069	0.664
MOD_GSK3_1	926	933	PF00069	0.312
MOD_NEK2_1	442	447	PF00069	0.661
MOD_NEK2_1	629	634	PF00069	0.733
MOD_NEK2_1	662	667	PF00069	0.512
MOD_NEK2_2	942	947	PF00069	0.473
MOD_PIKK_1	312	318	PF00454	0.746
MOD_PIKK_1	320	326	PF00454	0.838
MOD_PIKK_1	648	654	PF00454	0.664
MOD_PK_1	493	499	PF00069	0.573
MOD_PKA_1	553	559	PF00069	0.781
MOD_PKA_2	210	216	PF00069	0.717
MOD_PKA_2	225	231	PF00069	0.791
MOD_PKA_2	429	435	PF00069	0.627
MOD_PKA_2	51	57	PF00069	0.641
MOD_PKA_2	602	608	PF00069	0.808
MOD_PKA_2	634	640	PF00069	0.634
MOD_PKA_2	70	76	PF00069	0.575
MOD_PKA_2	701	707	PF00069	0.752
MOD_Plk_1	126	132	PF00069	0.670
MOD_Plk_1	844	850	PF00069	0.535
MOD_Plk_1	947	953	PF00069	0.477
MOD_Plk_2-3	162	168	PF00069	0.628
MOD_Plk_4	11	17	PF00069	0.614
MOD_Plk_4	267	273	PF00069	0.752
MOD_Plk_4	59	65	PF00069	0.578
MOD_Plk_4	70	76	PF00069	0.575
MOD_Plk_4	844	850	PF00069	0.496
MOD_Plk_4	868	874	PF00069	0.413
MOD_Plk_4	98	104	PF00069	0.574
MOD_ProDKin_1	144	150	PF00069	0.695
MOD_ProDKin_1	242	248	PF00069	0.729
MOD_ProDKin_1	308	314	PF00069	0.808
MOD_ProDKin_1	316	322	PF00069	0.744
MOD_ProDKin_1	37	43	PF00069	0.710
MOD_ProDKin_1	514	520	PF00069	0.786
MOD_ProDKin_1	537	543	PF00069	0.683
MOD_ProDKin_1	635	641	PF00069	0.724
MOD_ProDKin_1	803	809	PF00069	0.779
MOD_ProDKin_1	815	821	PF00069	0.663
MOD_SUMO_for_1	552	555	PF00179	0.787
MOD_SUMO_rev_2	35	41	PF00179	0.580
MOD_SUMO_rev_2	496	506	PF00179	0.588
MOD_SUMO_rev_2	761	767	PF00179	0.676
TRG_DiLeu_BaEn_4	408	414	PF01217	0.658
TRG_ENDOCYTIC_2	15	18	PF00928	0.613
TRG_ENDOCYTIC_2	862	865	PF00928	0.476
TRG_ENDOCYTIC_2	956	959	PF00928	0.517
TRG_ENDOCYTIC_2	99	102	PF00928	0.741
TRG_ER_diArg_1	18	20	PF00400	0.699
TRG_ER_diArg_1	236	239	PF00400	0.677
TRG_ER_diArg_1	396	398	PF00400	0.551
TRG_ER_diArg_1	410	413	PF00400	0.558
TRG_ER_diArg_1	422	425	PF00400	0.566
TRG_ER_diArg_1	799	801	PF00400	0.580
TRG_ER_diArg_1	839	842	PF00400	0.537
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	398	403	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V3	Leptomonas seymouri	42%	95%
A0A3Q8IBI8	Leishmania donovani	90%	100%
A4HYQ9	Leishmania infantum	89%	100%
E9AIA9	Leishmania braziliensis	67%	100%
E9AUJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%