Chaperone protein DNAJ-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DNAJ-like protein

Species:

Leishmania major

UniProt:

Q4QCY5_LEIMA

TriTrypDb:

LmjF.20.0550 , LMJLV39_200011400 , LMJSD75_200011200

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QCY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCY5

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	21
GO:0006458	'de novo' protein folding	3	3
GO:0009987	cellular process	1	21
GO:0042026	protein refolding	3	3
GO:0051084	'de novo' post-translational protein folding	4	3
GO:0051085	chaperone cofactor-dependent protein refolding	4	3
GO:0061077	chaperone-mediated protein folding	3	3
GO:0006950	response to stress	2	9
GO:0009266	response to temperature stimulus	3	9
GO:0009408	response to heat	3	9
GO:0009628	response to abiotic stimulus	2	9
GO:0050896	response to stimulus	1	9

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	21
GO:0005515	protein binding	2	21
GO:0031072	heat shock protein binding	3	21
GO:0043167	ion binding	2	20
GO:0043169	cation binding	3	19
GO:0046872	metal ion binding	4	19
GO:0051082	unfolded protein binding	3	21
GO:0000166	nucleotide binding	3	9
GO:0005524	ATP binding	5	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0030544	Hsp70 protein binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.584
CLV_NRD_NRD_1	284	286	PF00675	0.241
CLV_NRD_NRD_1	307	309	PF00675	0.325
CLV_NRD_NRD_1	44	46	PF00675	0.557
CLV_NRD_NRD_1	77	79	PF00675	0.416
CLV_NRD_NRD_1	89	91	PF00675	0.357
CLV_PCSK_KEX2_1	105	107	PF00082	0.372
CLV_PCSK_KEX2_1	14	16	PF00082	0.713
CLV_PCSK_KEX2_1	307	309	PF00082	0.325
CLV_PCSK_KEX2_1	44	46	PF00082	0.557
CLV_PCSK_KEX2_1	77	79	PF00082	0.451
CLV_PCSK_KEX2_1	89	91	PF00082	0.486
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.529
CLV_PCSK_SKI1_1	209	213	PF00082	0.564
CLV_PCSK_SKI1_1	269	273	PF00082	0.310
CLV_PCSK_SKI1_1	476	480	PF00082	0.415
CLV_PCSK_SKI1_1	84	88	PF00082	0.470
DEG_Nend_Nbox_1	1	3	PF02207	0.510
DOC_CKS1_1	281	286	PF01111	0.428
DOC_CYCLIN_yClb1_LxF_4	62	67	PF00134	0.337
DOC_CYCLIN_yCln2_LP_2	397	403	PF00134	0.354
DOC_MAPK_DCC_7	428	437	PF00069	0.235
DOC_MAPK_gen_1	474	481	PF00069	0.364
DOC_MAPK_MEF2A_6	428	437	PF00069	0.235
DOC_PP1_RVXF_1	3	10	PF00149	0.510
DOC_PP1_RVXF_1	62	68	PF00149	0.512
DOC_PP2B_LxvP_1	397	400	PF13499	0.319
DOC_USP7_MATH_1	183	187	PF00917	0.628
DOC_USP7_MATH_1	387	391	PF00917	0.284
DOC_USP7_MATH_1	484	488	PF00917	0.504
DOC_USP7_MATH_1	507	511	PF00917	0.733
DOC_USP7_MATH_1	533	537	PF00917	0.621
DOC_USP7_MATH_1	57	61	PF00917	0.618
DOC_USP7_UBL2_3	535	539	PF12436	0.432
DOC_WW_Pin1_4	280	285	PF00397	0.445
DOC_WW_Pin1_4	383	388	PF00397	0.376
LIG_14-3-3_CanoR_1	106	114	PF00244	0.587
LIG_14-3-3_CanoR_1	14	22	PF00244	0.745
LIG_14-3-3_CanoR_1	248	252	PF00244	0.244
LIG_14-3-3_CanoR_1	446	454	PF00244	0.616
LIG_14-3-3_CanoR_1	501	506	PF00244	0.508
LIG_14-3-3_CanoR_1	77	87	PF00244	0.438
LIG_BIR_III_4	233	237	PF00653	0.440
LIG_CSL_BTD_1	33	36	PF09270	0.502
LIG_FHA_1	242	248	PF00498	0.364
LIG_FHA_1	300	306	PF00498	0.442
LIG_FHA_1	372	378	PF00498	0.298
LIG_FHA_1	418	424	PF00498	0.278
LIG_FHA_1	78	84	PF00498	0.379
LIG_FHA_1	93	99	PF00498	0.316
LIG_FHA_2	157	163	PF00498	0.737
LIG_FHA_2	490	496	PF00498	0.470
LIG_HCF-1_HBM_1	379	382	PF13415	0.235
LIG_LIR_Gen_1	456	466	PF02991	0.394
LIG_LIR_Gen_1	59	68	PF02991	0.406
LIG_LIR_Nem_3	456	462	PF02991	0.380
LIG_LIR_Nem_3	59	65	PF02991	0.411
LIG_OCRL_FandH_1	352	364	PF00620	0.386
LIG_PTB_Apo_2	347	354	PF02174	0.403
LIG_SH2_CRK	459	463	PF00017	0.327
LIG_SH2_CRK	62	66	PF00017	0.442
LIG_SH2_SRC	160	163	PF00017	0.700
LIG_SH2_STAP1	126	130	PF00017	0.434
LIG_SH2_STAT5	114	117	PF00017	0.460
LIG_SH2_STAT5	160	163	PF00017	0.700
LIG_SH2_STAT5	311	314	PF00017	0.439
LIG_SH2_STAT5	382	385	PF00017	0.372
LIG_SH3_2	319	324	PF14604	0.525
LIG_SH3_3	30	36	PF00018	0.512
LIG_SH3_3	315	321	PF00018	0.491
LIG_SH3_3	334	340	PF00018	0.319
LIG_SH3_3	407	413	PF00018	0.274
LIG_SH3_3	418	424	PF00018	0.249
LIG_SH3_3	460	466	PF00018	0.376
LIG_SH3_3	496	502	PF00018	0.429
LIG_SH3_3	95	101	PF00018	0.379
LIG_SUMO_SIM_anti_2	402	407	PF11976	0.366
LIG_SUMO_SIM_par_1	373	379	PF11976	0.294
LIG_TYR_ITIM	457	462	PF00017	0.323
MOD_CDC14_SPxK_1	386	389	PF00782	0.235
MOD_CDK_SPK_2	280	285	PF00069	0.268
MOD_CDK_SPxK_1	280	286	PF00069	0.268
MOD_CDK_SPxK_1	383	389	PF00069	0.235
MOD_CK1_1	16	22	PF00069	0.690
MOD_CK1_1	169	175	PF00069	0.585
MOD_CK1_1	190	196	PF00069	0.627
MOD_CK1_1	224	230	PF00069	0.590
MOD_CK1_1	487	493	PF00069	0.589
MOD_CK1_1	518	524	PF00069	0.497
MOD_CK2_1	489	495	PF00069	0.553
MOD_CK2_1	76	82	PF00069	0.413
MOD_CMANNOS	34	37	PF00535	0.646
MOD_GlcNHglycan	16	19	PF01048	0.646
MOD_GlcNHglycan	171	174	PF01048	0.619
MOD_GlcNHglycan	185	188	PF01048	0.604
MOD_GlcNHglycan	189	192	PF01048	0.622
MOD_GlcNHglycan	216	219	PF01048	0.606
MOD_GlcNHglycan	224	227	PF01048	0.572
MOD_GlcNHglycan	275	278	PF01048	0.310
MOD_GlcNHglycan	294	297	PF01048	0.297
MOD_GlcNHglycan	299	302	PF01048	0.292
MOD_GlcNHglycan	428	431	PF01048	0.358
MOD_GlcNHglycan	447	450	PF01048	0.555
MOD_GlcNHglycan	471	474	PF01048	0.463
MOD_GlcNHglycan	489	492	PF01048	0.535
MOD_GlcNHglycan	517	520	PF01048	0.730
MOD_GSK3_1	121	128	PF00069	0.535
MOD_GSK3_1	14	21	PF00069	0.642
MOD_GSK3_1	183	190	PF00069	0.632
MOD_GSK3_1	193	200	PF00069	0.620
MOD_GSK3_1	214	221	PF00069	0.557
MOD_GSK3_1	247	254	PF00069	0.248
MOD_GSK3_1	269	276	PF00069	0.372
MOD_GSK3_1	344	351	PF00069	0.337
MOD_GSK3_1	371	378	PF00069	0.411
MOD_GSK3_1	383	390	PF00069	0.421
MOD_GSK3_1	441	448	PF00069	0.323
MOD_GSK3_1	507	514	PF00069	0.724
MOD_N-GLC_1	209	214	PF02516	0.574
MOD_N-GLC_1	238	243	PF02516	0.516
MOD_NEK2_1	251	256	PF00069	0.274
MOD_NEK2_1	348	353	PF00069	0.345
MOD_NEK2_1	371	376	PF00069	0.256
MOD_NEK2_1	515	520	PF00069	0.477
MOD_NEK2_1	527	532	PF00069	0.427
MOD_NEK2_1	534	539	PF00069	0.393
MOD_NEK2_2	18	23	PF00069	0.501
MOD_NEK2_2	417	422	PF00069	0.235
MOD_NEK2_2	57	62	PF00069	0.552
MOD_PIKK_1	507	513	PF00454	0.720
MOD_PKA_1	105	111	PF00069	0.386
MOD_PKA_1	14	20	PF00069	0.536
MOD_PKA_1	77	83	PF00069	0.387
MOD_PKA_2	105	111	PF00069	0.366
MOD_PKA_2	13	19	PF00069	0.722
MOD_PKA_2	166	172	PF00069	0.662
MOD_PKA_2	247	253	PF00069	0.237
MOD_PKA_2	273	279	PF00069	0.328
MOD_PKA_2	28	34	PF00069	0.678
MOD_PKA_2	292	298	PF00069	0.318
MOD_PKA_2	445	451	PF00069	0.666
MOD_PKA_2	76	82	PF00069	0.438
MOD_Plk_1	241	247	PF00069	0.309
MOD_Plk_1	251	257	PF00069	0.270
MOD_Plk_4	348	354	PF00069	0.413
MOD_Plk_4	36	42	PF00069	0.579
MOD_Plk_4	371	377	PF00069	0.291
MOD_Plk_4	453	459	PF00069	0.324
MOD_Plk_4	57	63	PF00069	0.454
MOD_ProDKin_1	280	286	PF00069	0.291
MOD_ProDKin_1	383	389	PF00069	0.376
MOD_SUMO_rev_2	100	107	PF00179	0.446
MOD_SUMO_rev_2	108	113	PF00179	0.411
TRG_ENDOCYTIC_2	114	117	PF00928	0.449
TRG_ENDOCYTIC_2	459	462	PF00928	0.420
TRG_ENDOCYTIC_2	62	65	PF00928	0.444
TRG_ER_diArg_1	353	356	PF00400	0.299
TRG_ER_diArg_1	76	78	PF00400	0.442
TRG_ER_diArg_1	88	90	PF00400	0.435
TRG_NES_CRM1_1	242	252	PF08389	0.386
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZS2	Leptomonas seymouri	61%	100%
A0A0S4J3B2	Bodo saltans	33%	100%
A0A1X0NLD4	Trypanosomatidae	27%	100%
A0A1X0NWP1	Trypanosomatidae	45%	100%
A0A3Q8IET3	Leishmania donovani	95%	100%
A0A3R7KX88	Trypanosoma rangeli	40%	100%
A0A3S7WNT6	Leishmania donovani	26%	100%
A0A422N924	Trypanosoma rangeli	26%	100%
A4H3Y7	Leishmania braziliensis	26%	100%
A4H886	Leishmania braziliensis	25%	100%
A4HS91	Leishmania infantum	26%	100%
A4HYQ6	Leishmania infantum	95%	100%
C9ZI72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
C9ZY84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AIB2	Leishmania braziliensis	84%	100%
E9AK75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AUJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O97016	Leishmania major	26%	100%
Q8DKR7	Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)	25%	100%
V5AY81	Trypanosoma cruzi	26%	100%