Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QCY3_LEIMA

TriTrypDb:

LmjF.20.0570 , LMJLV39_200011600 , LMJSD75_200011400

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QCY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCY3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	346	350	PF00656	0.613
CLV_NRD_NRD_1	100	102	PF00675	0.515
CLV_PCSK_FUR_1	98	102	PF00082	0.508
CLV_PCSK_KEX2_1	540	542	PF00082	0.486
CLV_PCSK_KEX2_1	98	100	PF00082	0.504
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.478
CLV_PCSK_SKI1_1	249	253	PF00082	0.461
CLV_PCSK_SKI1_1	261	265	PF00082	0.388
CLV_PCSK_SKI1_1	316	320	PF00082	0.446
CLV_PCSK_SKI1_1	367	371	PF00082	0.287
DEG_APCC_DBOX_1	366	374	PF00400	0.287
DEG_ODPH_VHL_1	356	368	PF01847	0.287
DEG_SPOP_SBC_1	179	183	PF00917	0.670
DEG_SPOP_SBC_1	343	347	PF00917	0.614
DOC_CDC14_PxL_1	241	249	PF14671	0.671
DOC_CKS1_1	478	483	PF01111	0.644
DOC_PP2B_LxvP_1	318	321	PF13499	0.696
DOC_PP4_FxxP_1	505	508	PF00568	0.712
DOC_USP7_MATH_1	159	163	PF00917	0.820
DOC_USP7_MATH_1	165	169	PF00917	0.756
DOC_USP7_MATH_1	171	175	PF00917	0.702
DOC_USP7_MATH_1	193	197	PF00917	0.756
DOC_USP7_MATH_1	227	231	PF00917	0.796
DOC_USP7_MATH_1	350	354	PF00917	0.652
DOC_USP7_MATH_1	376	380	PF00917	0.287
DOC_USP7_MATH_1	402	406	PF00917	0.446
DOC_USP7_MATH_1	448	452	PF00917	0.580
DOC_USP7_MATH_1	534	538	PF00917	0.677
DOC_USP7_MATH_1	91	95	PF00917	0.641
DOC_WW_Pin1_4	109	114	PF00397	0.660
DOC_WW_Pin1_4	161	166	PF00397	0.739
DOC_WW_Pin1_4	167	172	PF00397	0.674
DOC_WW_Pin1_4	186	191	PF00397	0.630
DOC_WW_Pin1_4	477	482	PF00397	0.638
DOC_WW_Pin1_4	511	516	PF00397	0.666
LIG_14-3-3_CanoR_1	234	241	PF00244	0.659
LIG_14-3-3_CanoR_1	249	254	PF00244	0.617
LIG_14-3-3_CanoR_1	316	321	PF00244	0.660
LIG_14-3-3_CanoR_1	441	446	PF00244	0.619
LIG_14-3-3_CanoR_1	479	487	PF00244	0.699
LIG_Actin_WH2_2	366	384	PF00022	0.318
LIG_BRCT_BRCA1_1	425	429	PF00533	0.357
LIG_Clathr_ClatBox_1	391	395	PF01394	0.399
LIG_CSL_BTD_1	88	91	PF09270	0.641
LIG_deltaCOP1_diTrp_1	274	279	PF00928	0.654
LIG_EH1_1	363	371	PF00400	0.287
LIG_eIF4E_1	364	370	PF01652	0.318
LIG_eIF4E_1	375	381	PF01652	0.309
LIG_FHA_1	114	120	PF00498	0.656
LIG_FHA_1	173	179	PF00498	0.782
LIG_FHA_1	21	27	PF00498	0.716
LIG_FHA_1	250	256	PF00498	0.676
LIG_FHA_1	381	387	PF00498	0.375
LIG_FHA_1	410	416	PF00498	0.431
LIG_FHA_1	425	431	PF00498	0.239
LIG_FHA_1	444	450	PF00498	0.567
LIG_FHA_2	116	122	PF00498	0.715
LIG_FHA_2	344	350	PF00498	0.615
LIG_FHA_2	458	464	PF00498	0.645
LIG_FXI_DFP_1	264	268	PF00024	0.419
LIG_LIR_Apic_2	219	224	PF02991	0.677
LIG_LIR_Apic_2	502	508	PF02991	0.712
LIG_LIR_Gen_1	273	283	PF02991	0.642
LIG_LIR_Gen_1	426	437	PF02991	0.357
LIG_LIR_Nem_3	273	279	PF02991	0.673
LIG_LIR_Nem_3	426	432	PF02991	0.427
LIG_LIR_Nem_3	66	71	PF02991	0.645
LIG_LIR_Nem_3	86	92	PF02991	0.577
LIG_NRBOX	376	382	PF00104	0.357
LIG_PTB_Apo_2	240	247	PF02174	0.619
LIG_PTB_Phospho_1	240	246	PF10480	0.619
LIG_SH2_NCK_1	76	80	PF00017	0.671
LIG_SH2_SRC	74	77	PF00017	0.681
LIG_SH2_STAP1	445	449	PF00017	0.623
LIG_SH2_STAP1	76	80	PF00017	0.671
LIG_SH2_STAT3	288	291	PF00017	0.655
LIG_SH2_STAT5	246	249	PF00017	0.673
LIG_SH2_STAT5	33	36	PF00017	0.712
LIG_SH2_STAT5	364	367	PF00017	0.357
LIG_SH2_STAT5	445	448	PF00017	0.625
LIG_SH2_STAT5	459	462	PF00017	0.553
LIG_SH2_STAT5	74	77	PF00017	0.681
LIG_SH3_3	131	137	PF00018	0.694
LIG_SH3_3	352	358	PF00018	0.512
LIG_SH3_3	475	481	PF00018	0.741
LIG_SUMO_SIM_par_1	112	118	PF11976	0.702
LIG_SUMO_SIM_par_1	23	32	PF11976	0.716
LIG_SUMO_SIM_par_1	80	86	PF11976	0.615
LIG_TRAF2_1	136	139	PF00917	0.727
LIG_TRAF2_1	460	463	PF00917	0.579
LIG_UBA3_1	406	414	PF00899	0.413
LIG_ULM_U2AF65_1	98	103	PF00076	0.710
MOD_CK1_1	160	166	PF00069	0.789
MOD_CK1_1	169	175	PF00069	0.724
MOD_CK1_1	183	189	PF00069	0.646
MOD_CK1_1	309	315	PF00069	0.633
MOD_CK1_1	337	343	PF00069	0.679
MOD_CK1_1	451	457	PF00069	0.585
MOD_CK1_1	495	501	PF00069	0.705
MOD_CK2_1	457	463	PF00069	0.644
MOD_CMANNOS	299	302	PF00535	0.465
MOD_GlcNHglycan	159	162	PF01048	0.605
MOD_GlcNHglycan	185	188	PF01048	0.518
MOD_GlcNHglycan	229	232	PF01048	0.596
MOD_GlcNHglycan	302	305	PF01048	0.457
MOD_GlcNHglycan	308	311	PF01048	0.481
MOD_GlcNHglycan	339	342	PF01048	0.453
MOD_GlcNHglycan	352	355	PF01048	0.291
MOD_GlcNHglycan	47	50	PF01048	0.502
MOD_GlcNHglycan	482	485	PF01048	0.540
MOD_GlcNHglycan	494	497	PF01048	0.543
MOD_GlcNHglycan	499	502	PF01048	0.555
MOD_GlcNHglycan	516	519	PF01048	0.428
MOD_GlcNHglycan	534	537	PF01048	0.425
MOD_GlcNHglycan	57	60	PF01048	0.481
MOD_GlcNHglycan	93	96	PF01048	0.497
MOD_GSK3_1	109	116	PF00069	0.674
MOD_GSK3_1	117	124	PF00069	0.710
MOD_GSK3_1	157	164	PF00069	0.743
MOD_GSK3_1	165	172	PF00069	0.713
MOD_GSK3_1	173	180	PF00069	0.678
MOD_GSK3_1	193	200	PF00069	0.630
MOD_GSK3_1	266	273	PF00069	0.624
MOD_GSK3_1	312	319	PF00069	0.669
MOD_GSK3_1	376	383	PF00069	0.329
MOD_GSK3_1	402	409	PF00069	0.444
MOD_GSK3_1	419	426	PF00069	0.216
MOD_GSK3_1	510	517	PF00069	0.757
MOD_GSK3_1	523	530	PF00069	0.689
MOD_N-GLC_1	197	202	PF02516	0.472
MOD_N-GLC_1	234	239	PF02516	0.502
MOD_NEK2_1	122	127	PF00069	0.718
MOD_NEK2_1	178	183	PF00069	0.672
MOD_NEK2_1	306	311	PF00069	0.616
MOD_NEK2_1	334	339	PF00069	0.636
MOD_NEK2_1	380	385	PF00069	0.442
MOD_NEK2_1	394	399	PF00069	0.361
MOD_NEK2_1	423	428	PF00069	0.357
MOD_NEK2_1	47	52	PF00069	0.714
MOD_NEK2_1	492	497	PF00069	0.686
MOD_NEK2_1	509	514	PF00069	0.610
MOD_NEK2_1	527	532	PF00069	0.662
MOD_NEK2_1	61	66	PF00069	0.668
MOD_NEK2_2	212	217	PF00069	0.691
MOD_NEK2_2	283	288	PF00069	0.636
MOD_PIKK_1	180	186	PF00454	0.685
MOD_PIKK_1	202	208	PF00454	0.777
MOD_PIKK_1	40	46	PF00454	0.694
MOD_PIKK_1	443	449	PF00454	0.575
MOD_PKA_2	193	199	PF00069	0.691
MOD_PKA_2	233	239	PF00069	0.651
MOD_PKA_2	40	46	PF00069	0.686
MOD_PKA_2	457	463	PF00069	0.607
MOD_PKB_1	441	449	PF00069	0.625
MOD_Plk_1	197	203	PF00069	0.681
MOD_Plk_1	523	529	PF00069	0.661
MOD_Plk_2-3	27	33	PF00069	0.668
MOD_Plk_4	173	179	PF00069	0.691
MOD_Plk_4	283	289	PF00069	0.639
MOD_Plk_4	295	301	PF00069	0.659
MOD_Plk_4	327	333	PF00069	0.643
MOD_Plk_4	376	382	PF00069	0.294
MOD_Plk_4	402	408	PF00069	0.423
MOD_Plk_4	419	425	PF00069	0.216
MOD_Plk_4	500	506	PF00069	0.664
MOD_ProDKin_1	109	115	PF00069	0.656
MOD_ProDKin_1	161	167	PF00069	0.735
MOD_ProDKin_1	186	192	PF00069	0.690
MOD_ProDKin_1	477	483	PF00069	0.640
MOD_ProDKin_1	511	517	PF00069	0.667
MOD_SUMO_for_1	216	219	PF00179	0.668
TRG_DiLeu_BaEn_1	259	264	PF01217	0.721
TRG_ER_diArg_1	10	13	PF00400	0.683
TRG_ER_diArg_1	473	476	PF00400	0.750
TRG_ER_diArg_1	98	101	PF00400	0.704
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AIB4	Leishmania braziliensis	56%	95%