Protein-tyrosine-phosphatase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCY1_LEIMA

TriTrypDb:

LmjF.20.0590 , LMJLV39_200011800 , LMJSD75_200011600

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCY1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.706
CLV_C14_Caspase3-7	392	396	PF00656	0.734
CLV_C14_Caspase3-7	585	589	PF00656	0.700
CLV_NRD_NRD_1	32	34	PF00675	0.582
CLV_NRD_NRD_1	38	40	PF00675	0.550
CLV_NRD_NRD_1	525	527	PF00675	0.569
CLV_PCSK_KEX2_1	32	34	PF00082	0.582
CLV_PCSK_KEX2_1	38	40	PF00082	0.550
CLV_PCSK_KEX2_1	524	526	PF00082	0.575
CLV_PCSK_SKI1_1	333	337	PF00082	0.557
CLV_PCSK_SKI1_1	382	386	PF00082	0.539
CLV_PCSK_SKI1_1	496	500	PF00082	0.471
DEG_Nend_Nbox_1	1	3	PF02207	0.411
DEG_SPOP_SBC_1	355	359	PF00917	0.676
DEG_SPOP_SBC_1	513	517	PF00917	0.696
DOC_ANK_TNKS_1	37	44	PF00023	0.722
DOC_CDC14_PxL_1	127	135	PF14671	0.681
DOC_CDC14_PxL_1	488	496	PF14671	0.641
DOC_CYCLIN_RxL_1	167	177	PF00134	0.708
DOC_MAPK_gen_1	418	426	PF00069	0.703
DOC_MAPK_MEF2A_6	418	426	PF00069	0.703
DOC_PP4_FxxP_1	489	492	PF00568	0.637
DOC_PP4_FxxP_1	84	87	PF00568	0.672
DOC_USP7_MATH_1	106	110	PF00917	0.662
DOC_USP7_MATH_1	194	198	PF00917	0.801
DOC_USP7_MATH_1	209	213	PF00917	0.655
DOC_USP7_MATH_1	355	359	PF00917	0.814
DOC_USP7_MATH_1	362	366	PF00917	0.821
DOC_USP7_MATH_1	475	479	PF00917	0.619
DOC_USP7_MATH_1	513	517	PF00917	0.704
DOC_USP7_MATH_1	529	533	PF00917	0.770
DOC_USP7_MATH_1	598	602	PF00917	0.813
DOC_USP7_MATH_1	608	612	PF00917	0.701
DOC_USP7_MATH_1	80	84	PF00917	0.766
DOC_USP7_MATH_1	94	98	PF00917	0.834
DOC_WW_Pin1_4	245	250	PF00397	0.776
DOC_WW_Pin1_4	258	263	PF00397	0.797
DOC_WW_Pin1_4	356	361	PF00397	0.701
DOC_WW_Pin1_4	450	455	PF00397	0.669
LIG_14-3-3_CanoR_1	382	391	PF00244	0.758
LIG_14-3-3_CanoR_1	439	445	PF00244	0.630
LIG_14-3-3_CanoR_1	599	609	PF00244	0.767
LIG_14-3-3_CanoR_1	77	83	PF00244	0.735
LIG_Actin_WH2_2	11	29	PF00022	0.436
LIG_Actin_WH2_2	427	443	PF00022	0.701
LIG_Actin_WH2_2	488	503	PF00022	0.649
LIG_BIR_III_4	572	576	PF00653	0.742
LIG_BRCT_BRCA1_1	402	406	PF00533	0.634
LIG_BRCT_BRCA1_1	610	614	PF00533	0.736
LIG_BRCT_BRCA1_1	80	84	PF00533	0.663
LIG_FHA_1	386	392	PF00498	0.724
LIG_FHA_1	42	48	PF00498	0.700
LIG_FHA_1	461	467	PF00498	0.623
LIG_FHA_2	110	116	PF00498	0.768
LIG_FHA_2	212	218	PF00498	0.708
LIG_GBD_Chelix_1	2	10	PF00786	0.391
LIG_LIR_Apic_2	487	492	PF02991	0.639
LIG_LIR_Apic_2	81	87	PF02991	0.677
LIG_LIR_Gen_1	155	161	PF02991	0.639
LIG_LIR_Gen_1	591	602	PF02991	0.720
LIG_LIR_Nem_3	155	159	PF02991	0.596
LIG_LIR_Nem_3	487	491	PF02991	0.639
LIG_LIR_Nem_3	591	597	PF02991	0.774
LIG_MLH1_MIPbox_1	610	614	PF16413	0.736
LIG_NRBOX	14	20	PF00104	0.392
LIG_NRBOX	5	11	PF00104	0.471
LIG_PCNA_PIPBox_1	482	491	PF02747	0.627
LIG_PCNA_yPIPBox_3	482	496	PF02747	0.628
LIG_Pex14_1	46	50	PF04695	0.757
LIG_Pex14_2	472	476	PF04695	0.639
LIG_Pex14_2	498	502	PF04695	0.646
LIG_REV1ctd_RIR_1	495	505	PF16727	0.638
LIG_SH2_GRB2like	270	273	PF00017	0.767
LIG_SH2_NCK_1	446	450	PF00017	0.682
LIG_SH2_PTP2	425	428	PF00017	0.679
LIG_SH2_SRC	446	449	PF00017	0.682
LIG_SH2_STAP1	270	274	PF00017	0.671
LIG_SH2_STAT5	175	178	PF00017	0.773
LIG_SH2_STAT5	270	273	PF00017	0.767
LIG_SH2_STAT5	421	424	PF00017	0.572
LIG_SH2_STAT5	425	428	PF00017	0.564
LIG_SH2_STAT5	459	462	PF00017	0.606
LIG_SH2_STAT5	613	616	PF00017	0.764
LIG_SH3_3	199	205	PF00018	0.775
LIG_SH3_3	251	257	PF00018	0.762
LIG_SH3_3	358	364	PF00018	0.745
LIG_SH3_3	448	454	PF00018	0.703
LIG_SH3_3	577	583	PF00018	0.749
LIG_SH3_3	79	85	PF00018	0.800
LIG_SH3_3	88	94	PF00018	0.757
LIG_SUMO_SIM_anti_2	390	395	PF11976	0.681
LIG_SUMO_SIM_par_1	261	267	PF11976	0.747
LIG_SxIP_EBH_1	29	39	PF03271	0.733
LIG_UBA3_1	15	23	PF00899	0.411
LIG_WRC_WIRS_1	153	158	PF05994	0.706
LIG_WRC_WIRS_1	265	270	PF05994	0.806
MOD_CK1_1	109	115	PF00069	0.775
MOD_CK1_1	120	126	PF00069	0.685
MOD_CK1_1	184	190	PF00069	0.783
MOD_CK1_1	212	218	PF00069	0.733
MOD_CK1_1	261	267	PF00069	0.757
MOD_CK1_1	280	286	PF00069	0.767
MOD_CK1_1	478	484	PF00069	0.628
MOD_CK1_1	571	577	PF00069	0.770
MOD_CK1_1	97	103	PF00069	0.696
MOD_CK2_1	119	125	PF00069	0.786
MOD_CK2_1	598	604	PF00069	0.741
MOD_GlcNHglycan	122	125	PF01048	0.497
MOD_GlcNHglycan	144	147	PF01048	0.515
MOD_GlcNHglycan	183	186	PF01048	0.561
MOD_GlcNHglycan	198	201	PF01048	0.540
MOD_GlcNHglycan	217	220	PF01048	0.409
MOD_GlcNHglycan	282	285	PF01048	0.587
MOD_GlcNHglycan	300	303	PF01048	0.518
MOD_GlcNHglycan	314	317	PF01048	0.522
MOD_GlcNHglycan	319	323	PF01048	0.521
MOD_GlcNHglycan	341	344	PF01048	0.609
MOD_GlcNHglycan	348	351	PF01048	0.558
MOD_GlcNHglycan	401	405	PF01048	0.439
MOD_GlcNHglycan	460	463	PF01048	0.529
MOD_GlcNHglycan	509	512	PF01048	0.422
MOD_GlcNHglycan	531	534	PF01048	0.627
MOD_GlcNHglycan	543	546	PF01048	0.513
MOD_GlcNHglycan	572	576	PF01048	0.473
MOD_GlcNHglycan	610	613	PF01048	0.590
MOD_GSK3_1	105	112	PF00069	0.738
MOD_GSK3_1	192	199	PF00069	0.811
MOD_GSK3_1	211	218	PF00069	0.692
MOD_GSK3_1	264	271	PF00069	0.731
MOD_GSK3_1	303	310	PF00069	0.743
MOD_GSK3_1	371	378	PF00069	0.749
MOD_GSK3_1	385	392	PF00069	0.792
MOD_GSK3_1	400	407	PF00069	0.614
MOD_GSK3_1	548	555	PF00069	0.772
MOD_GSK3_1	94	101	PF00069	0.746
MOD_N-GLC_1	295	300	PF02516	0.586
MOD_N-GLC_1	333	338	PF02516	0.545
MOD_N-GLC_1	404	409	PF02516	0.416
MOD_NEK2_1	1	6	PF00069	0.375
MOD_NEK2_1	174	179	PF00069	0.757
MOD_NEK2_1	268	273	PF00069	0.822
MOD_NEK2_1	277	282	PF00069	0.728
MOD_NEK2_1	307	312	PF00069	0.769
MOD_NEK2_1	339	344	PF00069	0.826
MOD_NEK2_1	345	350	PF00069	0.756
MOD_NEK2_1	406	411	PF00069	0.614
MOD_NEK2_1	460	465	PF00069	0.630
MOD_NEK2_1	476	481	PF00069	0.649
MOD_NEK2_1	502	507	PF00069	0.723
MOD_PIKK_1	478	484	PF00454	0.628
MOD_PK_1	389	395	PF00069	0.689
MOD_PKA_2	31	37	PF00069	0.752
MOD_PKA_2	440	446	PF00069	0.627
MOD_PKA_2	507	513	PF00069	0.705
MOD_PKA_2	598	604	PF00069	0.804
MOD_PKB_1	331	339	PF00069	0.746
MOD_Plk_1	295	301	PF00069	0.785
MOD_Plk_1	404	410	PF00069	0.615
MOD_Plk_2-3	447	453	PF00069	0.695
MOD_Plk_4	1	7	PF00069	0.411
MOD_Plk_4	303	309	PF00069	0.760
MOD_Plk_4	389	395	PF00069	0.689
MOD_Plk_4	41	47	PF00069	0.701
MOD_Plk_4	460	466	PF00069	0.624
MOD_ProDKin_1	245	251	PF00069	0.775
MOD_ProDKin_1	258	264	PF00069	0.794
MOD_ProDKin_1	356	362	PF00069	0.700
MOD_ProDKin_1	450	456	PF00069	0.666
MOD_SUMO_rev_2	145	153	PF00179	0.725
TRG_ENDOCYTIC_2	421	424	PF00928	0.614
TRG_ENDOCYTIC_2	425	428	PF00928	0.606
TRG_ER_diArg_1	37	39	PF00400	0.777
TRG_ER_diArg_1	418	421	PF00400	0.666
TRG_ER_diArg_1	438	441	PF00400	0.474
TRG_ER_diArg_1	524	526	PF00400	0.775

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1B3	Leptomonas seymouri	47%	99%
A0A3S7WVW3	Leishmania donovani	88%	100%
A4HYQ2	Leishmania infantum	88%	100%
E9AIB6	Leishmania braziliensis	73%	100%
E9AUK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%