Mitochondrial editosome-like complex associated TUTase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCY0_LEIMA

TriTrypDb:

LmjF.20.0600 , LMJLV39_200011900 , LMJSD75_200011700

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	10
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QCY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCY0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0031123	RNA 3'-end processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071076	RNA 3' uridylation	8	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016779	nucleotidyltransferase activity	4	10
GO:0050265	RNA uridylyltransferase activity	4	10
GO:0070569	uridylyltransferase activity	5	10
GO:0140098	catalytic activity, acting on RNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.376
CLV_C14_Caspase3-7	83	87	PF00656	0.420
CLV_NRD_NRD_1	270	272	PF00675	0.332
CLV_NRD_NRD_1	289	291	PF00675	0.409
CLV_NRD_NRD_1	350	352	PF00675	0.366
CLV_NRD_NRD_1	5	7	PF00675	0.406
CLV_PCSK_KEX2_1	270	272	PF00082	0.312
CLV_PCSK_KEX2_1	291	293	PF00082	0.411
CLV_PCSK_KEX2_1	350	352	PF00082	0.366
CLV_PCSK_KEX2_1	365	367	PF00082	0.352
CLV_PCSK_KEX2_1	5	7	PF00082	0.381
CLV_PCSK_KEX2_1	91	93	PF00082	0.373
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.354
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.382
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.328
CLV_PCSK_SKI1_1	177	181	PF00082	0.421
CLV_PCSK_SKI1_1	217	221	PF00082	0.378
CLV_PCSK_SKI1_1	380	384	PF00082	0.509
DEG_Nend_UBRbox_3	1	3	PF02207	0.434
DEG_SPOP_SBC_1	307	311	PF00917	0.562
DOC_ANK_TNKS_1	349	356	PF00023	0.394
DOC_MAPK_gen_1	356	364	PF00069	0.501
DOC_MAPK_HePTP_8	39	51	PF00069	0.350
DOC_MAPK_MEF2A_6	356	364	PF00069	0.377
DOC_MAPK_MEF2A_6	42	51	PF00069	0.499
DOC_PP2B_LxvP_1	211	214	PF13499	0.376
DOC_PP4_FxxP_1	223	226	PF00568	0.339
DOC_USP7_MATH_1	175	179	PF00917	0.322
DOC_USP7_MATH_1	308	312	PF00917	0.669
DOC_USP7_MATH_1	316	320	PF00917	0.479
DOC_USP7_MATH_1	375	379	PF00917	0.366
DOC_USP7_MATH_1	395	399	PF00917	0.648
DOC_USP7_UBL2_3	164	168	PF12436	0.268
DOC_WW_Pin1_4	73	78	PF00397	0.394
LIG_14-3-3_CanoR_1	17	24	PF00244	0.312
LIG_14-3-3_CanoR_1	270	276	PF00244	0.319
LIG_14-3-3_CanoR_1	306	316	PF00244	0.533
LIG_Actin_WH2_2	236	251	PF00022	0.405
LIG_AP2alpha_1	379	383	PF02296	0.461
LIG_BRCT_BRCA1_1	311	315	PF00533	0.668
LIG_BRCT_BRCA1_1	68	72	PF00533	0.394
LIG_FHA_1	185	191	PF00498	0.249
LIG_FHA_1	220	226	PF00498	0.445
LIG_FHA_1	261	267	PF00498	0.270
LIG_FHA_1	333	339	PF00498	0.421
LIG_FHA_1	384	390	PF00498	0.519
LIG_FHA_2	20	26	PF00498	0.502
LIG_FHA_2	205	211	PF00498	0.382
LIG_FHA_2	60	66	PF00498	0.372
LIG_LIR_Apic_2	221	226	PF02991	0.333
LIG_LIR_Gen_1	178	188	PF02991	0.300
LIG_LIR_Gen_1	252	259	PF02991	0.357
LIG_LIR_Gen_1	274	284	PF02991	0.322
LIG_LIR_Nem_3	154	159	PF02991	0.257
LIG_LIR_Nem_3	178	183	PF02991	0.317
LIG_LIR_Nem_3	205	211	PF02991	0.298
LIG_LIR_Nem_3	241	247	PF02991	0.272
LIG_LIR_Nem_3	252	257	PF02991	0.257
LIG_LIR_Nem_3	274	279	PF02991	0.322
LIG_LIR_Nem_3	294	298	PF02991	0.201
LIG_LIR_Nem_3	340	345	PF02991	0.298
LIG_LIR_Nem_3	363	367	PF02991	0.293
LIG_LIR_Nem_3	378	382	PF02991	0.343
LIG_LIR_Nem_3	69	75	PF02991	0.306
LIG_Pex14_2	379	383	PF04695	0.345
LIG_SH2_CRK	276	280	PF00017	0.426
LIG_SH2_GRB2like	345	348	PF00017	0.271
LIG_SH2_PTP2	159	162	PF00017	0.250
LIG_SH2_STAP1	276	280	PF00017	0.293
LIG_SH2_STAT5	159	162	PF00017	0.252
LIG_SH2_STAT5	244	247	PF00017	0.306
LIG_SH2_STAT5	298	301	PF00017	0.449
LIG_SH2_STAT5	345	348	PF00017	0.293
LIG_SH3_3	169	175	PF00018	0.302
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.386
LIG_SUMO_SIM_anti_2	263	268	PF11976	0.269
LIG_SUMO_SIM_par_1	35	41	PF11976	0.413
LIG_TRAF2_1	319	322	PF00917	0.413
LIG_TRFH_1	223	227	PF08558	0.371
LIG_WRC_WIRS_1	180	185	PF05994	0.274
LIG_WRC_WIRS_1	220	225	PF05994	0.444
LIG_WRC_WIRS_1	402	407	PF05994	0.434
LIG_WW_1	226	229	PF00397	0.352
MOD_CK1_1	19	25	PF00069	0.409
MOD_CK1_1	309	315	PF00069	0.531
MOD_CK1_1	54	60	PF00069	0.288
MOD_CK2_1	204	210	PF00069	0.364
MOD_CK2_1	316	322	PF00069	0.576
MOD_CK2_1	397	403	PF00069	0.596
MOD_CK2_1	77	83	PF00069	0.365
MOD_Cter_Amidation	3	6	PF01082	0.439
MOD_Cter_Amidation	348	351	PF01082	0.306
MOD_GlcNHglycan	124	127	PF01048	0.377
MOD_GlcNHglycan	294	298	PF01048	0.383
MOD_GlcNHglycan	79	82	PF01048	0.354
MOD_GSK3_1	16	23	PF00069	0.393
MOD_GSK3_1	175	182	PF00069	0.305
MOD_GSK3_1	306	313	PF00069	0.570
MOD_GSK3_1	316	323	PF00069	0.530
MOD_GSK3_1	397	404	PF00069	0.616
MOD_GSK3_1	54	61	PF00069	0.439
MOD_GSK3_1	73	80	PF00069	0.490
MOD_N-GLC_1	260	265	PF02516	0.368
MOD_N-GLC_1	375	380	PF02516	0.485
MOD_N-GLC_1	395	400	PF02516	0.460
MOD_N-GLC_1	73	78	PF02516	0.356
MOD_N-GLC_2	112	114	PF02516	0.311
MOD_NEK2_1	179	184	PF00069	0.291
MOD_NEK2_1	320	325	PF00069	0.423
MOD_NEK2_1	383	388	PF00069	0.433
MOD_NEK2_1	51	56	PF00069	0.301
MOD_NEK2_1	59	64	PF00069	0.312
MOD_NEK2_1	68	73	PF00069	0.206
MOD_NEK2_2	175	180	PF00069	0.343
MOD_NEK2_2	375	380	PF00069	0.376
MOD_PIKK_1	16	22	PF00454	0.386
MOD_PKA_2	16	22	PF00069	0.323
MOD_PKA_2	355	361	PF00069	0.407
MOD_Plk_1	129	135	PF00069	0.273
MOD_Plk_1	175	181	PF00069	0.309
MOD_Plk_1	209	215	PF00069	0.337
MOD_Plk_1	293	299	PF00069	0.463
MOD_Plk_1	320	326	PF00069	0.406
MOD_Plk_1	375	381	PF00069	0.539
MOD_Plk_1	66	72	PF00069	0.265
MOD_Plk_4	175	181	PF00069	0.480
MOD_Plk_4	186	192	PF00069	0.331
MOD_Plk_4	262	268	PF00069	0.284
MOD_ProDKin_1	73	79	PF00069	0.389
MOD_SUMO_rev_2	358	367	PF00179	0.465
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.253
TRG_ENDOCYTIC_2	159	162	PF00928	0.250
TRG_ENDOCYTIC_2	208	211	PF00928	0.347
TRG_ENDOCYTIC_2	229	232	PF00928	0.323
TRG_ENDOCYTIC_2	244	247	PF00928	0.305
TRG_ENDOCYTIC_2	254	257	PF00928	0.320
TRG_ENDOCYTIC_2	276	279	PF00928	0.298
TRG_ENDOCYTIC_2	368	371	PF00928	0.436
TRG_ER_diArg_1	269	271	PF00400	0.299
TRG_ER_diArg_1	32	35	PF00400	0.277
TRG_ER_diArg_1	350	352	PF00400	0.366
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.292
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.265

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7H1	Leptomonas seymouri	64%	100%
A0A0S4J0S6	Bodo saltans	56%	100%
A0A1X0NX27	Trypanosomatidae	55%	100%
A0A3Q8IDK5	Leishmania donovani	96%	100%
A0A422NJM7	Trypanosoma rangeli	54%	88%
A4HYQ1	Leishmania infantum	96%	100%
C7AJA4	Trypanosoma brucei brucei	52%	100%
C9ZI80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AUK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q6DFA8	Xenopus laevis	25%	80%