LeishMANIAdb
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rRNA biogenesis protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
rRNA biogenesis protein-like protein
Gene product:
rRNA biogenesis protein-like protein
Species:
Leishmania major
UniProt:
Q4QCX6_LEIMA
TriTrypDb:
LmjF.20.0650 , LMJLV39_200012300 * , LMJSD75_200012100 *
Length:
738

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 2
GO:0030684 preribosome 3 2
GO:0032040 small-subunit processome 4 2
GO:0032991 protein-containing complex 1 2
GO:0043226 organelle 2 2
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2
GO:1990904 ribonucleoprotein complex 2 2

Expansion

Sequence features

Q4QCX6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCX6

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006364 rRNA processing 8 12
GO:0006396 RNA processing 6 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0016072 rRNA metabolic process 7 12
GO:0034470 ncRNA processing 7 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034660 ncRNA metabolic process 6 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0003723 RNA binding 4 2
GO:0005488 binding 1 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 438 442 PF00656 0.580
CLV_NRD_NRD_1 101 103 PF00675 0.468
CLV_NRD_NRD_1 108 110 PF00675 0.382
CLV_NRD_NRD_1 403 405 PF00675 0.605
CLV_NRD_NRD_1 427 429 PF00675 0.612
CLV_NRD_NRD_1 433 435 PF00675 0.583
CLV_NRD_NRD_1 532 534 PF00675 0.473
CLV_NRD_NRD_1 555 557 PF00675 0.439
CLV_NRD_NRD_1 576 578 PF00675 0.484
CLV_NRD_NRD_1 639 641 PF00675 0.538
CLV_NRD_NRD_1 661 663 PF00675 0.491
CLV_PCSK_FUR_1 430 434 PF00082 0.671
CLV_PCSK_KEX2_1 101 103 PF00082 0.537
CLV_PCSK_KEX2_1 403 405 PF00082 0.607
CLV_PCSK_KEX2_1 427 429 PF00082 0.622
CLV_PCSK_KEX2_1 432 434 PF00082 0.586
CLV_PCSK_KEX2_1 532 534 PF00082 0.413
CLV_PCSK_KEX2_1 54 56 PF00082 0.486
CLV_PCSK_KEX2_1 576 578 PF00082 0.476
CLV_PCSK_KEX2_1 591 593 PF00082 0.341
CLV_PCSK_KEX2_1 596 598 PF00082 0.435
CLV_PCSK_KEX2_1 607 609 PF00082 0.446
CLV_PCSK_KEX2_1 644 646 PF00082 0.523
CLV_PCSK_PC1ET2_1 54 56 PF00082 0.490
CLV_PCSK_PC1ET2_1 591 593 PF00082 0.442
CLV_PCSK_PC1ET2_1 596 598 PF00082 0.451
CLV_PCSK_PC1ET2_1 607 609 PF00082 0.461
CLV_PCSK_PC1ET2_1 644 646 PF00082 0.538
CLV_PCSK_PC7_1 428 434 PF00082 0.651
CLV_PCSK_PC7_1 592 598 PF00082 0.440
CLV_PCSK_PC7_1 640 646 PF00082 0.542
CLV_PCSK_SKI1_1 110 114 PF00082 0.443
CLV_PCSK_SKI1_1 386 390 PF00082 0.628
CLV_PCSK_SKI1_1 460 464 PF00082 0.469
CLV_PCSK_SKI1_1 54 58 PF00082 0.426
CLV_PCSK_SKI1_1 566 570 PF00082 0.500
CLV_PCSK_SKI1_1 597 601 PF00082 0.427
CLV_PCSK_SKI1_1 632 636 PF00082 0.398
CLV_PCSK_SKI1_1 673 677 PF00082 0.400
CLV_PCSK_SKI1_1 80 84 PF00082 0.530
CLV_Separin_Metazoa 98 102 PF03568 0.583
DEG_SCF_FBW7_1 237 244 PF00400 0.578
DEG_SCF_TRCP1_1 729 735 PF00400 0.463
DOC_CYCLIN_RxL_1 51 61 PF00134 0.510
DOC_CYCLIN_RxL_1 692 700 PF00134 0.475
DOC_MAPK_gen_1 106 116 PF00069 0.435
DOC_MAPK_gen_1 556 564 PF00069 0.421
DOC_MAPK_gen_1 576 584 PF00069 0.504
DOC_MAPK_gen_1 607 615 PF00069 0.413
DOC_MAPK_MEF2A_6 109 116 PF00069 0.440
DOC_MAPK_MEF2A_6 577 586 PF00069 0.466
DOC_PP1_RVXF_1 693 700 PF00149 0.478
DOC_USP7_MATH_1 129 133 PF00917 0.586
DOC_USP7_MATH_1 279 283 PF00917 0.631
DOC_USP7_MATH_1 287 291 PF00917 0.573
DOC_USP7_MATH_1 365 369 PF00917 0.746
DOC_USP7_MATH_1 405 409 PF00917 0.721
DOC_USP7_MATH_1 466 470 PF00917 0.459
DOC_USP7_MATH_1 643 647 PF00917 0.409
DOC_USP7_MATH_1 665 669 PF00917 0.491
DOC_USP7_MATH_1 70 74 PF00917 0.502
DOC_USP7_MATH_1 8 12 PF00917 0.693
DOC_USP7_UBL2_3 596 600 PF12436 0.471
DOC_WW_Pin1_4 10 15 PF00397 0.637
DOC_WW_Pin1_4 237 242 PF00397 0.458
DOC_WW_Pin1_4 378 383 PF00397 0.703
DOC_WW_Pin1_4 451 456 PF00397 0.504
DOC_WW_Pin1_4 624 629 PF00397 0.518
DOC_WW_Pin1_4 702 707 PF00397 0.441
LIG_14-3-3_CanoR_1 139 146 PF00244 0.568
LIG_14-3-3_CanoR_1 41 47 PF00244 0.496
LIG_14-3-3_CanoR_1 55 61 PF00244 0.412
LIG_14-3-3_CanoR_1 576 580 PF00244 0.485
LIG_14-3-3_CanoR_1 695 700 PF00244 0.441
LIG_14-3-3_CanoR_1 80 85 PF00244 0.467
LIG_Actin_WH2_2 580 598 PF00022 0.489
LIG_BIR_II_1 1 5 PF00653 0.780
LIG_BIR_III_4 75 79 PF00653 0.580
LIG_BRCT_BRCA1_1 12 16 PF00533 0.591
LIG_BRCT_BRCA1_1 527 531 PF00533 0.451
LIG_Clathr_ClatBox_1 81 85 PF01394 0.528
LIG_DLG_GKlike_1 695 702 PF00625 0.528
LIG_FHA_1 211 217 PF00498 0.501
LIG_FHA_1 24 30 PF00498 0.524
LIG_FHA_1 261 267 PF00498 0.398
LIG_FHA_1 42 48 PF00498 0.336
LIG_FHA_1 496 502 PF00498 0.437
LIG_FHA_1 610 616 PF00498 0.516
LIG_FHA_1 667 673 PF00498 0.509
LIG_FHA_1 692 698 PF00498 0.469
LIG_FHA_1 81 87 PF00498 0.517
LIG_FHA_2 116 122 PF00498 0.354
LIG_FHA_2 238 244 PF00498 0.480
LIG_FHA_2 44 50 PF00498 0.552
LIG_FHA_2 451 457 PF00498 0.621
LIG_FHA_2 541 547 PF00498 0.348
LIG_FHA_2 596 602 PF00498 0.552
LIG_FHA_2 651 657 PF00498 0.515
LIG_FHA_2 703 709 PF00498 0.491
LIG_FHA_2 716 722 PF00498 0.494
LIG_FHA_2 93 99 PF00498 0.599
LIG_GBD_Chelix_1 52 60 PF00786 0.461
LIG_Integrin_isoDGR_2 630 632 PF01839 0.408
LIG_LIR_Apic_2 95 99 PF02991 0.465
LIG_LIR_Gen_1 456 466 PF02991 0.474
LIG_LIR_Gen_1 468 478 PF02991 0.383
LIG_LIR_Gen_1 543 553 PF02991 0.423
LIG_LIR_Gen_1 578 587 PF02991 0.416
LIG_LIR_Gen_1 694 702 PF02991 0.425
LIG_LIR_Gen_1 88 97 PF02991 0.484
LIG_LIR_Nem_3 13 19 PF02991 0.503
LIG_LIR_Nem_3 36 42 PF02991 0.530
LIG_LIR_Nem_3 456 461 PF02991 0.474
LIG_LIR_Nem_3 469 475 PF02991 0.399
LIG_LIR_Nem_3 543 548 PF02991 0.417
LIG_LIR_Nem_3 578 582 PF02991 0.402
LIG_LIR_Nem_3 646 652 PF02991 0.393
LIG_LIR_Nem_3 694 699 PF02991 0.417
LIG_LIR_Nem_3 88 93 PF02991 0.512
LIG_PCNA_PIPBox_1 690 699 PF02747 0.486
LIG_PCNA_yPIPBox_3 502 511 PF02747 0.527
LIG_PCNA_yPIPBox_3 687 697 PF02747 0.456
LIG_Pex14_1 394 398 PF04695 0.611
LIG_SH2_CRK 79 83 PF00017 0.431
LIG_SH2_GRB2like 514 517 PF00017 0.363
LIG_SH2_SRC 514 517 PF00017 0.448
LIG_SH2_SRC 719 722 PF00017 0.435
LIG_SH2_STAP1 221 225 PF00017 0.516
LIG_SH2_STAP1 398 402 PF00017 0.673
LIG_SH2_STAT3 652 655 PF00017 0.406
LIG_SH2_STAT5 301 304 PF00017 0.386
LIG_SH2_STAT5 470 473 PF00017 0.397
LIG_SH2_STAT5 514 517 PF00017 0.448
LIG_SH2_STAT5 652 655 PF00017 0.406
LIG_SH2_STAT5 719 722 PF00017 0.435
LIG_SH3_3 273 279 PF00018 0.411
LIG_SH3_3 28 34 PF00018 0.424
LIG_SH3_3 308 314 PF00018 0.598
LIG_SH3_3 376 382 PF00018 0.735
LIG_SH3_3 449 455 PF00018 0.530
LIG_SUMO_SIM_anti_2 612 617 PF11976 0.458
LIG_SUMO_SIM_par_1 261 271 PF11976 0.418
LIG_SUMO_SIM_par_1 583 588 PF11976 0.442
LIG_SUMO_SIM_par_1 80 85 PF11976 0.507
LIG_TRAF2_1 454 457 PF00917 0.512
LIG_TRAF2_1 653 656 PF00917 0.537
LIG_TYR_ITIM 512 517 PF00017 0.364
LIG_UBA3_1 634 641 PF00899 0.467
LIG_WRC_WIRS_1 158 163 PF05994 0.765
LIG_WRC_WIRS_1 696 701 PF05994 0.435
MOD_CDK_SPxxK_3 10 17 PF00069 0.468
MOD_CK1_1 132 138 PF00069 0.598
MOD_CK1_1 154 160 PF00069 0.726
MOD_CK1_1 2 8 PF00069 0.768
MOD_CK1_1 372 378 PF00069 0.770
MOD_CK2_1 115 121 PF00069 0.483
MOD_CK2_1 358 364 PF00069 0.689
MOD_CK2_1 450 456 PF00069 0.516
MOD_CK2_1 540 546 PF00069 0.438
MOD_CK2_1 58 64 PF00069 0.561
MOD_CK2_1 650 656 PF00069 0.540
MOD_CK2_1 715 721 PF00069 0.445
MOD_CK2_1 92 98 PF00069 0.604
MOD_Cter_Amidation 589 592 PF01082 0.541
MOD_GlcNHglycan 10 13 PF01048 0.643
MOD_GlcNHglycan 127 130 PF01048 0.617
MOD_GlcNHglycan 154 157 PF01048 0.718
MOD_GlcNHglycan 161 164 PF01048 0.724
MOD_GlcNHglycan 177 180 PF01048 0.766
MOD_GlcNHglycan 246 249 PF01048 0.494
MOD_GlcNHglycan 291 294 PF01048 0.638
MOD_GlcNHglycan 367 370 PF01048 0.787
MOD_GlcNHglycan 373 377 PF01048 0.772
MOD_GlcNHglycan 418 421 PF01048 0.779
MOD_GlcNHglycan 422 425 PF01048 0.723
MOD_GlcNHglycan 527 530 PF01048 0.453
MOD_GlcNHglycan 6 9 PF01048 0.737
MOD_GlcNHglycan 60 63 PF01048 0.527
MOD_GlcNHglycan 684 687 PF01048 0.506
MOD_GlcNHglycan 729 732 PF01048 0.538
MOD_GlcNHglycan 90 93 PF01048 0.531
MOD_GSK3_1 125 132 PF00069 0.558
MOD_GSK3_1 147 154 PF00069 0.628
MOD_GSK3_1 171 178 PF00069 0.795
MOD_GSK3_1 194 201 PF00069 0.719
MOD_GSK3_1 237 244 PF00069 0.558
MOD_GSK3_1 260 267 PF00069 0.407
MOD_GSK3_1 289 296 PF00069 0.608
MOD_GSK3_1 3 10 PF00069 0.762
MOD_GSK3_1 359 366 PF00069 0.665
MOD_GSK3_1 416 423 PF00069 0.731
MOD_GSK3_1 446 453 PF00069 0.605
MOD_GSK3_1 571 578 PF00069 0.530
MOD_GSK3_1 643 650 PF00069 0.395
MOD_GSK3_1 691 698 PF00069 0.455
MOD_GSK3_1 715 722 PF00069 0.493
MOD_GSK3_1 88 95 PF00069 0.500
MOD_LATS_1 191 197 PF00433 0.580
MOD_N-GLC_1 228 233 PF02516 0.419
MOD_N-GLC_1 466 471 PF02516 0.412
MOD_N-GLC_1 682 687 PF02516 0.486
MOD_NEK2_1 1 6 PF00069 0.782
MOD_NEK2_1 358 363 PF00069 0.728
MOD_NEK2_1 56 61 PF00069 0.546
MOD_NEK2_1 595 600 PF00069 0.547
MOD_NEK2_1 666 671 PF00069 0.569
MOD_NEK2_1 676 681 PF00069 0.513
MOD_NEK2_1 682 687 PF00069 0.521
MOD_NEK2_1 727 732 PF00069 0.686
MOD_NEK2_2 250 255 PF00069 0.509
MOD_PKA_2 125 131 PF00069 0.603
MOD_PKA_2 138 144 PF00069 0.518
MOD_PKA_2 2 8 PF00069 0.703
MOD_PKA_2 40 46 PF00069 0.455
MOD_PKA_2 575 581 PF00069 0.472
MOD_Plk_1 193 199 PF00069 0.578
MOD_Plk_1 466 472 PF00069 0.407
MOD_Plk_1 523 529 PF00069 0.542
MOD_Plk_1 609 615 PF00069 0.503
MOD_Plk_2-3 210 216 PF00069 0.491
MOD_Plk_2-3 575 581 PF00069 0.463
MOD_Plk_4 129 135 PF00069 0.538
MOD_Plk_4 260 266 PF00069 0.428
MOD_Plk_4 293 299 PF00069 0.489
MOD_Plk_4 466 472 PF00069 0.407
MOD_Plk_4 540 546 PF00069 0.508
MOD_ProDKin_1 10 16 PF00069 0.624
MOD_ProDKin_1 237 243 PF00069 0.462
MOD_ProDKin_1 378 384 PF00069 0.701
MOD_ProDKin_1 451 457 PF00069 0.500
MOD_ProDKin_1 624 630 PF00069 0.514
MOD_ProDKin_1 702 708 PF00069 0.438
TRG_DiLeu_BaEn_1 457 462 PF01217 0.459
TRG_DiLeu_BaEn_1 503 508 PF01217 0.508
TRG_DiLeu_BaLyEn_6 103 108 PF01217 0.537
TRG_DiLeu_BaLyEn_6 52 57 PF01217 0.492
TRG_DiLeu_BaLyEn_6 77 82 PF01217 0.471
TRG_DiLeu_LyEn_5 457 462 PF01217 0.475
TRG_ENDOCYTIC_2 470 473 PF00928 0.328
TRG_ENDOCYTIC_2 514 517 PF00928 0.363
TRG_ENDOCYTIC_2 79 82 PF00928 0.421
TRG_ER_diArg_1 100 102 PF00400 0.536
TRG_ER_diArg_1 427 430 PF00400 0.614
TRG_ER_diArg_1 432 434 PF00400 0.573
TRG_ER_diArg_1 531 533 PF00400 0.480
TRG_ER_diArg_1 71 74 PF00400 0.530
TRG_NES_CRM1_1 506 518 PF08389 0.370
TRG_Pf-PMV_PEXEL_1 101 105 PF00026 0.544
TRG_Pf-PMV_PEXEL_1 217 222 PF00026 0.408
TRG_Pf-PMV_PEXEL_1 434 438 PF00026 0.588
TRG_Pf-PMV_PEXEL_1 537 541 PF00026 0.550
TRG_Pf-PMV_PEXEL_1 597 601 PF00026 0.470
TRG_Pf-PMV_PEXEL_1 632 636 PF00026 0.406
TRG_Pf-PMV_PEXEL_1 673 677 PF00026 0.405
TRG_Pf-PMV_PEXEL_1 695 700 PF00026 0.476
TRG_Pf-PMV_PEXEL_1 80 85 PF00026 0.429

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9P1 Leptomonas seymouri 69% 100%
A0A0S4J3E1 Bodo saltans 42% 100%
A0A1X0NXS8 Trypanosomatidae 44% 100%
A0A3Q8IBQ3 Leishmania donovani 94% 100%
A0A3R7KD39 Trypanosoma rangeli 49% 100%
A4HYP7 Leishmania infantum 94% 100%
C9ZI84 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 100%
E9AIC1 Leishmania braziliensis 84% 99%
E9AUK8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
V5BQT5 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS