rRNA biogenesis protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rRNA biogenesis protein-like protein

Species:

Leishmania major

UniProt:

Q4QCX6_LEIMA

TriTrypDb:

LmjF.20.0650 , LMJLV39_200012300 , LMJSD75_200012100

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0030684	preribosome	3	2
GO:0032040	small-subunit processome	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QCX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCX6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	438	442	PF00656	0.580
CLV_NRD_NRD_1	101	103	PF00675	0.468
CLV_NRD_NRD_1	108	110	PF00675	0.382
CLV_NRD_NRD_1	403	405	PF00675	0.605
CLV_NRD_NRD_1	427	429	PF00675	0.612
CLV_NRD_NRD_1	433	435	PF00675	0.583
CLV_NRD_NRD_1	532	534	PF00675	0.473
CLV_NRD_NRD_1	555	557	PF00675	0.439
CLV_NRD_NRD_1	576	578	PF00675	0.484
CLV_NRD_NRD_1	639	641	PF00675	0.538
CLV_NRD_NRD_1	661	663	PF00675	0.491
CLV_PCSK_FUR_1	430	434	PF00082	0.671
CLV_PCSK_KEX2_1	101	103	PF00082	0.537
CLV_PCSK_KEX2_1	403	405	PF00082	0.607
CLV_PCSK_KEX2_1	427	429	PF00082	0.622
CLV_PCSK_KEX2_1	432	434	PF00082	0.586
CLV_PCSK_KEX2_1	532	534	PF00082	0.413
CLV_PCSK_KEX2_1	54	56	PF00082	0.486
CLV_PCSK_KEX2_1	576	578	PF00082	0.476
CLV_PCSK_KEX2_1	591	593	PF00082	0.341
CLV_PCSK_KEX2_1	596	598	PF00082	0.435
CLV_PCSK_KEX2_1	607	609	PF00082	0.446
CLV_PCSK_KEX2_1	644	646	PF00082	0.523
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.490
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.442
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.451
CLV_PCSK_PC1ET2_1	607	609	PF00082	0.461
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.538
CLV_PCSK_PC7_1	428	434	PF00082	0.651
CLV_PCSK_PC7_1	592	598	PF00082	0.440
CLV_PCSK_PC7_1	640	646	PF00082	0.542
CLV_PCSK_SKI1_1	110	114	PF00082	0.443
CLV_PCSK_SKI1_1	386	390	PF00082	0.628
CLV_PCSK_SKI1_1	460	464	PF00082	0.469
CLV_PCSK_SKI1_1	54	58	PF00082	0.426
CLV_PCSK_SKI1_1	566	570	PF00082	0.500
CLV_PCSK_SKI1_1	597	601	PF00082	0.427
CLV_PCSK_SKI1_1	632	636	PF00082	0.398
CLV_PCSK_SKI1_1	673	677	PF00082	0.400
CLV_PCSK_SKI1_1	80	84	PF00082	0.530
CLV_Separin_Metazoa	98	102	PF03568	0.583
DEG_SCF_FBW7_1	237	244	PF00400	0.578
DEG_SCF_TRCP1_1	729	735	PF00400	0.463
DOC_CYCLIN_RxL_1	51	61	PF00134	0.510
DOC_CYCLIN_RxL_1	692	700	PF00134	0.475
DOC_MAPK_gen_1	106	116	PF00069	0.435
DOC_MAPK_gen_1	556	564	PF00069	0.421
DOC_MAPK_gen_1	576	584	PF00069	0.504
DOC_MAPK_gen_1	607	615	PF00069	0.413
DOC_MAPK_MEF2A_6	109	116	PF00069	0.440
DOC_MAPK_MEF2A_6	577	586	PF00069	0.466
DOC_PP1_RVXF_1	693	700	PF00149	0.478
DOC_USP7_MATH_1	129	133	PF00917	0.586
DOC_USP7_MATH_1	279	283	PF00917	0.631
DOC_USP7_MATH_1	287	291	PF00917	0.573
DOC_USP7_MATH_1	365	369	PF00917	0.746
DOC_USP7_MATH_1	405	409	PF00917	0.721
DOC_USP7_MATH_1	466	470	PF00917	0.459
DOC_USP7_MATH_1	643	647	PF00917	0.409
DOC_USP7_MATH_1	665	669	PF00917	0.491
DOC_USP7_MATH_1	70	74	PF00917	0.502
DOC_USP7_MATH_1	8	12	PF00917	0.693
DOC_USP7_UBL2_3	596	600	PF12436	0.471
DOC_WW_Pin1_4	10	15	PF00397	0.637
DOC_WW_Pin1_4	237	242	PF00397	0.458
DOC_WW_Pin1_4	378	383	PF00397	0.703
DOC_WW_Pin1_4	451	456	PF00397	0.504
DOC_WW_Pin1_4	624	629	PF00397	0.518
DOC_WW_Pin1_4	702	707	PF00397	0.441
LIG_14-3-3_CanoR_1	139	146	PF00244	0.568
LIG_14-3-3_CanoR_1	41	47	PF00244	0.496
LIG_14-3-3_CanoR_1	55	61	PF00244	0.412
LIG_14-3-3_CanoR_1	576	580	PF00244	0.485
LIG_14-3-3_CanoR_1	695	700	PF00244	0.441
LIG_14-3-3_CanoR_1	80	85	PF00244	0.467
LIG_Actin_WH2_2	580	598	PF00022	0.489
LIG_BIR_II_1	1	5	PF00653	0.780
LIG_BIR_III_4	75	79	PF00653	0.580
LIG_BRCT_BRCA1_1	12	16	PF00533	0.591
LIG_BRCT_BRCA1_1	527	531	PF00533	0.451
LIG_Clathr_ClatBox_1	81	85	PF01394	0.528
LIG_DLG_GKlike_1	695	702	PF00625	0.528
LIG_FHA_1	211	217	PF00498	0.501
LIG_FHA_1	24	30	PF00498	0.524
LIG_FHA_1	261	267	PF00498	0.398
LIG_FHA_1	42	48	PF00498	0.336
LIG_FHA_1	496	502	PF00498	0.437
LIG_FHA_1	610	616	PF00498	0.516
LIG_FHA_1	667	673	PF00498	0.509
LIG_FHA_1	692	698	PF00498	0.469
LIG_FHA_1	81	87	PF00498	0.517
LIG_FHA_2	116	122	PF00498	0.354
LIG_FHA_2	238	244	PF00498	0.480
LIG_FHA_2	44	50	PF00498	0.552
LIG_FHA_2	451	457	PF00498	0.621
LIG_FHA_2	541	547	PF00498	0.348
LIG_FHA_2	596	602	PF00498	0.552
LIG_FHA_2	651	657	PF00498	0.515
LIG_FHA_2	703	709	PF00498	0.491
LIG_FHA_2	716	722	PF00498	0.494
LIG_FHA_2	93	99	PF00498	0.599
LIG_GBD_Chelix_1	52	60	PF00786	0.461
LIG_Integrin_isoDGR_2	630	632	PF01839	0.408
LIG_LIR_Apic_2	95	99	PF02991	0.465
LIG_LIR_Gen_1	456	466	PF02991	0.474
LIG_LIR_Gen_1	468	478	PF02991	0.383
LIG_LIR_Gen_1	543	553	PF02991	0.423
LIG_LIR_Gen_1	578	587	PF02991	0.416
LIG_LIR_Gen_1	694	702	PF02991	0.425
LIG_LIR_Gen_1	88	97	PF02991	0.484
LIG_LIR_Nem_3	13	19	PF02991	0.503
LIG_LIR_Nem_3	36	42	PF02991	0.530
LIG_LIR_Nem_3	456	461	PF02991	0.474
LIG_LIR_Nem_3	469	475	PF02991	0.399
LIG_LIR_Nem_3	543	548	PF02991	0.417
LIG_LIR_Nem_3	578	582	PF02991	0.402
LIG_LIR_Nem_3	646	652	PF02991	0.393
LIG_LIR_Nem_3	694	699	PF02991	0.417
LIG_LIR_Nem_3	88	93	PF02991	0.512
LIG_PCNA_PIPBox_1	690	699	PF02747	0.486
LIG_PCNA_yPIPBox_3	502	511	PF02747	0.527
LIG_PCNA_yPIPBox_3	687	697	PF02747	0.456
LIG_Pex14_1	394	398	PF04695	0.611
LIG_SH2_CRK	79	83	PF00017	0.431
LIG_SH2_GRB2like	514	517	PF00017	0.363
LIG_SH2_SRC	514	517	PF00017	0.448
LIG_SH2_SRC	719	722	PF00017	0.435
LIG_SH2_STAP1	221	225	PF00017	0.516
LIG_SH2_STAP1	398	402	PF00017	0.673
LIG_SH2_STAT3	652	655	PF00017	0.406
LIG_SH2_STAT5	301	304	PF00017	0.386
LIG_SH2_STAT5	470	473	PF00017	0.397
LIG_SH2_STAT5	514	517	PF00017	0.448
LIG_SH2_STAT5	652	655	PF00017	0.406
LIG_SH2_STAT5	719	722	PF00017	0.435
LIG_SH3_3	273	279	PF00018	0.411
LIG_SH3_3	28	34	PF00018	0.424
LIG_SH3_3	308	314	PF00018	0.598
LIG_SH3_3	376	382	PF00018	0.735
LIG_SH3_3	449	455	PF00018	0.530
LIG_SUMO_SIM_anti_2	612	617	PF11976	0.458
LIG_SUMO_SIM_par_1	261	271	PF11976	0.418
LIG_SUMO_SIM_par_1	583	588	PF11976	0.442
LIG_SUMO_SIM_par_1	80	85	PF11976	0.507
LIG_TRAF2_1	454	457	PF00917	0.512
LIG_TRAF2_1	653	656	PF00917	0.537
LIG_TYR_ITIM	512	517	PF00017	0.364
LIG_UBA3_1	634	641	PF00899	0.467
LIG_WRC_WIRS_1	158	163	PF05994	0.765
LIG_WRC_WIRS_1	696	701	PF05994	0.435
MOD_CDK_SPxxK_3	10	17	PF00069	0.468
MOD_CK1_1	132	138	PF00069	0.598
MOD_CK1_1	154	160	PF00069	0.726
MOD_CK1_1	2	8	PF00069	0.768
MOD_CK1_1	372	378	PF00069	0.770
MOD_CK2_1	115	121	PF00069	0.483
MOD_CK2_1	358	364	PF00069	0.689
MOD_CK2_1	450	456	PF00069	0.516
MOD_CK2_1	540	546	PF00069	0.438
MOD_CK2_1	58	64	PF00069	0.561
MOD_CK2_1	650	656	PF00069	0.540
MOD_CK2_1	715	721	PF00069	0.445
MOD_CK2_1	92	98	PF00069	0.604
MOD_Cter_Amidation	589	592	PF01082	0.541
MOD_GlcNHglycan	10	13	PF01048	0.643
MOD_GlcNHglycan	127	130	PF01048	0.617
MOD_GlcNHglycan	154	157	PF01048	0.718
MOD_GlcNHglycan	161	164	PF01048	0.724
MOD_GlcNHglycan	177	180	PF01048	0.766
MOD_GlcNHglycan	246	249	PF01048	0.494
MOD_GlcNHglycan	291	294	PF01048	0.638
MOD_GlcNHglycan	367	370	PF01048	0.787
MOD_GlcNHglycan	373	377	PF01048	0.772
MOD_GlcNHglycan	418	421	PF01048	0.779
MOD_GlcNHglycan	422	425	PF01048	0.723
MOD_GlcNHglycan	527	530	PF01048	0.453
MOD_GlcNHglycan	6	9	PF01048	0.737
MOD_GlcNHglycan	60	63	PF01048	0.527
MOD_GlcNHglycan	684	687	PF01048	0.506
MOD_GlcNHglycan	729	732	PF01048	0.538
MOD_GlcNHglycan	90	93	PF01048	0.531
MOD_GSK3_1	125	132	PF00069	0.558
MOD_GSK3_1	147	154	PF00069	0.628
MOD_GSK3_1	171	178	PF00069	0.795
MOD_GSK3_1	194	201	PF00069	0.719
MOD_GSK3_1	237	244	PF00069	0.558
MOD_GSK3_1	260	267	PF00069	0.407
MOD_GSK3_1	289	296	PF00069	0.608
MOD_GSK3_1	3	10	PF00069	0.762
MOD_GSK3_1	359	366	PF00069	0.665
MOD_GSK3_1	416	423	PF00069	0.731
MOD_GSK3_1	446	453	PF00069	0.605
MOD_GSK3_1	571	578	PF00069	0.530
MOD_GSK3_1	643	650	PF00069	0.395
MOD_GSK3_1	691	698	PF00069	0.455
MOD_GSK3_1	715	722	PF00069	0.493
MOD_GSK3_1	88	95	PF00069	0.500
MOD_LATS_1	191	197	PF00433	0.580
MOD_N-GLC_1	228	233	PF02516	0.419
MOD_N-GLC_1	466	471	PF02516	0.412
MOD_N-GLC_1	682	687	PF02516	0.486
MOD_NEK2_1	1	6	PF00069	0.782
MOD_NEK2_1	358	363	PF00069	0.728
MOD_NEK2_1	56	61	PF00069	0.546
MOD_NEK2_1	595	600	PF00069	0.547
MOD_NEK2_1	666	671	PF00069	0.569
MOD_NEK2_1	676	681	PF00069	0.513
MOD_NEK2_1	682	687	PF00069	0.521
MOD_NEK2_1	727	732	PF00069	0.686
MOD_NEK2_2	250	255	PF00069	0.509
MOD_PKA_2	125	131	PF00069	0.603
MOD_PKA_2	138	144	PF00069	0.518
MOD_PKA_2	2	8	PF00069	0.703
MOD_PKA_2	40	46	PF00069	0.455
MOD_PKA_2	575	581	PF00069	0.472
MOD_Plk_1	193	199	PF00069	0.578
MOD_Plk_1	466	472	PF00069	0.407
MOD_Plk_1	523	529	PF00069	0.542
MOD_Plk_1	609	615	PF00069	0.503
MOD_Plk_2-3	210	216	PF00069	0.491
MOD_Plk_2-3	575	581	PF00069	0.463
MOD_Plk_4	129	135	PF00069	0.538
MOD_Plk_4	260	266	PF00069	0.428
MOD_Plk_4	293	299	PF00069	0.489
MOD_Plk_4	466	472	PF00069	0.407
MOD_Plk_4	540	546	PF00069	0.508
MOD_ProDKin_1	10	16	PF00069	0.624
MOD_ProDKin_1	237	243	PF00069	0.462
MOD_ProDKin_1	378	384	PF00069	0.701
MOD_ProDKin_1	451	457	PF00069	0.500
MOD_ProDKin_1	624	630	PF00069	0.514
MOD_ProDKin_1	702	708	PF00069	0.438
TRG_DiLeu_BaEn_1	457	462	PF01217	0.459
TRG_DiLeu_BaEn_1	503	508	PF01217	0.508
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.537
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.492
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.471
TRG_DiLeu_LyEn_5	457	462	PF01217	0.475
TRG_ENDOCYTIC_2	470	473	PF00928	0.328
TRG_ENDOCYTIC_2	514	517	PF00928	0.363
TRG_ENDOCYTIC_2	79	82	PF00928	0.421
TRG_ER_diArg_1	100	102	PF00400	0.536
TRG_ER_diArg_1	427	430	PF00400	0.614
TRG_ER_diArg_1	432	434	PF00400	0.573
TRG_ER_diArg_1	531	533	PF00400	0.480
TRG_ER_diArg_1	71	74	PF00400	0.530
TRG_NES_CRM1_1	506	518	PF08389	0.370
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	597	601	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	673	677	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	695	700	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	80	85	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9P1	Leptomonas seymouri	69%	100%
A0A0S4J3E1	Bodo saltans	42%	100%
A0A1X0NXS8	Trypanosomatidae	44%	100%
A0A3Q8IBQ3	Leishmania donovani	94%	100%
A0A3R7KD39	Trypanosoma rangeli	49%	100%
A4HYP7	Leishmania infantum	94%	100%
C9ZI84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AIC1	Leishmania braziliensis	84%	99%
E9AUK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BQT5	Trypanosoma cruzi	50%	100%