Putative serine/threonine protein phosphatase 2A regulatory subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase 2A regulatory subunit, putative

Species:

Leishmania major

UniProt:

Q4QCX5_LEIMA

TriTrypDb:

LmjF.20.0660 , LMJLV39_200012400 , LMJSD75_200012200

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	2
GO:0005737	cytoplasm	2	2
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	2
GO:0008287	protein serine/threonine phosphatase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0036064	ciliary basal body	3	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2
GO:1902494	catalytic complex	2	2
GO:1903293	phosphatase complex	3	2

Expansion

Sequence features

Q4QCX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCX5

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	2
GO:0019888	protein phosphatase regulator activity	4	2
GO:0030234	enzyme regulator activity	2	2
GO:0098772	molecular function regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.663
CLV_C14_Caspase3-7	229	233	PF00656	0.334
CLV_NRD_NRD_1	131	133	PF00675	0.638
CLV_NRD_NRD_1	148	150	PF00675	0.401
CLV_NRD_NRD_1	196	198	PF00675	0.354
CLV_PCSK_KEX2_1	131	133	PF00082	0.638
CLV_PCSK_KEX2_1	148	150	PF00082	0.401
CLV_PCSK_KEX2_1	196	198	PF00082	0.341
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.582
CLV_PCSK_SKI1_1	273	277	PF00082	0.408
CLV_PCSK_SKI1_1	327	331	PF00082	0.406
CLV_PCSK_SKI1_1	333	337	PF00082	0.345
CLV_PCSK_SKI1_1	390	394	PF00082	0.340
CLV_PCSK_SKI1_1	565	569	PF00082	0.464
CLV_Separin_Metazoa	58	62	PF03568	0.369
DEG_APCC_DBOX_1	176	184	PF00400	0.503
DEG_APCC_DBOX_1	504	512	PF00400	0.439
DEG_Nend_UBRbox_2	1	3	PF02207	0.608
DEG_ODPH_VHL_1	409	420	PF01847	0.402
DOC_ANK_TNKS_1	147	154	PF00023	0.523
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.436
DOC_MAPK_gen_1	40	49	PF00069	0.454
DOC_MAPK_gen_1	425	433	PF00069	0.383
DOC_MAPK_MEF2A_6	40	49	PF00069	0.499
DOC_MAPK_NFAT4_5	42	50	PF00069	0.500
DOC_PP2B_LxvP_1	287	290	PF13499	0.384
DOC_PP2B_LxvP_1	83	86	PF13499	0.468
DOC_USP7_MATH_1	102	106	PF00917	0.341
DOC_USP7_MATH_1	172	176	PF00917	0.370
DOC_USP7_MATH_1	260	264	PF00917	0.359
DOC_USP7_MATH_1	392	396	PF00917	0.361
DOC_USP7_MATH_1	421	425	PF00917	0.517
DOC_USP7_MATH_1	469	473	PF00917	0.351
DOC_USP7_MATH_1	591	595	PF00917	0.635
DOC_USP7_UBL2_3	182	186	PF12436	0.474
DOC_WW_Pin1_4	112	117	PF00397	0.532
DOC_WW_Pin1_4	285	290	PF00397	0.356
DOC_WW_Pin1_4	400	405	PF00397	0.459
LIG_14-3-3_CanoR_1	158	165	PF00244	0.341
LIG_14-3-3_CanoR_1	22	27	PF00244	0.384
LIG_14-3-3_CanoR_1	262	272	PF00244	0.419
LIG_14-3-3_CanoR_1	273	280	PF00244	0.419
LIG_14-3-3_CanoR_1	312	319	PF00244	0.291
LIG_14-3-3_CanoR_1	341	350	PF00244	0.458
LIG_14-3-3_CanoR_1	351	355	PF00244	0.418
LIG_14-3-3_CanoR_1	457	465	PF00244	0.461
LIG_14-3-3_CanoR_1	505	509	PF00244	0.324
LIG_14-3-3_CanoR_1	572	580	PF00244	0.527
LIG_Actin_WH2_2	347	362	PF00022	0.376
LIG_APCC_ABBA_1	535	540	PF00400	0.515
LIG_BIR_III_2	540	544	PF00653	0.480
LIG_BIR_III_4	328	332	PF00653	0.496
LIG_BRCT_BRCA1_1	110	114	PF00533	0.439
LIG_BRCT_BRCA1_1	313	317	PF00533	0.311
LIG_FHA_1	338	344	PF00498	0.485
LIG_FHA_1	370	376	PF00498	0.368
LIG_FHA_1	377	383	PF00498	0.332
LIG_FHA_1	457	463	PF00498	0.478
LIG_FHA_1	48	54	PF00498	0.381
LIG_FHA_1	537	543	PF00498	0.282
LIG_FHA_1	78	84	PF00498	0.491
LIG_FHA_2	174	180	PF00498	0.491
LIG_FHA_2	39	45	PF00498	0.383
LIG_FHA_2	7	13	PF00498	0.560
LIG_FHA_2	95	101	PF00498	0.372
LIG_LIR_Gen_1	142	150	PF02991	0.348
LIG_LIR_Gen_1	2	11	PF02991	0.466
LIG_LIR_Gen_1	395	404	PF02991	0.410
LIG_LIR_Nem_3	2	7	PF02991	0.457
LIG_LIR_Nem_3	528	534	PF02991	0.446
LIG_MYND_1	411	415	PF01753	0.382
LIG_Pex14_1	270	274	PF04695	0.315
LIG_SH2_CRK	295	299	PF00017	0.419
LIG_SH2_CRK	512	516	PF00017	0.404
LIG_SH2_STAP1	512	516	PF00017	0.331
LIG_SH2_STAP1	79	83	PF00017	0.468
LIG_SH2_STAT5	438	441	PF00017	0.491
LIG_SH2_STAT5	48	51	PF00017	0.384
LIG_SH2_STAT5	502	505	PF00017	0.362
LIG_SH2_STAT5	52	55	PF00017	0.386
LIG_SH2_STAT5	79	82	PF00017	0.498
LIG_SH3_3	494	500	PF00018	0.444
LIG_SH3_3	563	569	PF00018	0.440
LIG_SH3_3	584	590	PF00018	0.497
LIG_SUMO_SIM_par_1	257	263	PF11976	0.419
LIG_SUMO_SIM_par_1	414	419	PF11976	0.398
LIG_SUMO_SIM_par_1	533	540	PF11976	0.515
LIG_UBA3_1	180	186	PF00899	0.429
LIG_UBA3_1	553	561	PF00899	0.418
LIG_WRC_WIRS_1	592	597	PF05994	0.456
MOD_CDK_SPxxK_3	400	407	PF00069	0.458
MOD_CK1_1	115	121	PF00069	0.560
MOD_CK1_1	123	129	PF00069	0.677
MOD_CK1_1	163	169	PF00069	0.367
MOD_CK1_1	263	269	PF00069	0.353
MOD_CK1_1	353	359	PF00069	0.446
MOD_CK1_1	395	401	PF00069	0.395
MOD_CK1_1	6	12	PF00069	0.470
MOD_CK2_1	304	310	PF00069	0.355
MOD_CK2_1	38	44	PF00069	0.390
MOD_CK2_1	89	95	PF00069	0.384
MOD_Cter_Amidation	330	333	PF01082	0.494
MOD_GlcNHglycan	122	125	PF01048	0.699
MOD_GlcNHglycan	126	129	PF01048	0.635
MOD_GlcNHglycan	254	257	PF01048	0.375
MOD_GlcNHglycan	313	316	PF01048	0.291
MOD_GlcNHglycan	355	358	PF01048	0.340
MOD_GlcNHglycan	394	397	PF01048	0.367
MOD_GlcNHglycan	445	448	PF01048	0.485
MOD_GlcNHglycan	481	484	PF01048	0.397
MOD_GlcNHglycan	527	530	PF01048	0.507
MOD_GSK3_1	108	115	PF00069	0.411
MOD_GSK3_1	119	126	PF00069	0.631
MOD_GSK3_1	156	163	PF00069	0.437
MOD_GSK3_1	210	217	PF00069	0.441
MOD_GSK3_1	262	269	PF00069	0.378
MOD_GSK3_1	337	344	PF00069	0.459
MOD_GSK3_1	392	399	PF00069	0.375
MOD_GSK3_1	439	446	PF00069	0.438
MOD_NEK2_1	108	113	PF00069	0.438
MOD_NEK2_1	164	169	PF00069	0.383
MOD_NEK2_1	31	36	PF00069	0.399
MOD_NEK2_1	369	374	PF00069	0.366
MOD_NEK2_1	554	559	PF00069	0.454
MOD_PIKK_1	108	114	PF00454	0.436
MOD_PIKK_1	249	255	PF00454	0.370
MOD_PKA_1	132	138	PF00069	0.531
MOD_PKA_2	157	163	PF00069	0.335
MOD_PKA_2	21	27	PF00069	0.407
MOD_PKA_2	311	317	PF00069	0.291
MOD_PKA_2	350	356	PF00069	0.455
MOD_PKA_2	456	462	PF00069	0.459
MOD_PKA_2	504	510	PF00069	0.351
MOD_PKB_1	271	279	PF00069	0.408
MOD_Plk_1	266	272	PF00069	0.299
MOD_Plk_1	345	351	PF00069	0.446
MOD_Plk_1	94	100	PF00069	0.382
MOD_Plk_2-3	94	100	PF00069	0.382
MOD_Plk_4	160	166	PF00069	0.333
MOD_Plk_4	241	247	PF00069	0.367
MOD_Plk_4	370	376	PF00069	0.380
MOD_Plk_4	409	415	PF00069	0.495
MOD_Plk_4	485	491	PF00069	0.408
MOD_Plk_4	492	498	PF00069	0.446
MOD_Plk_4	591	597	PF00069	0.454
MOD_Plk_4	6	12	PF00069	0.448
MOD_Plk_4	66	72	PF00069	0.354
MOD_Plk_4	79	85	PF00069	0.367
MOD_ProDKin_1	112	118	PF00069	0.536
MOD_ProDKin_1	285	291	PF00069	0.356
MOD_ProDKin_1	400	406	PF00069	0.454
MOD_SUMO_for_1	227	230	PF00179	0.446
MOD_SUMO_rev_2	399	409	PF00179	0.548
TRG_ENDOCYTIC_2	512	515	PF00928	0.336
TRG_ER_diArg_1	147	149	PF00400	0.500
TRG_ER_diArg_1	195	197	PF00400	0.344
TRG_ER_diArg_1	270	273	PF00400	0.299
TRG_ER_diArg_1	426	429	PF00400	0.357
TRG_NES_CRM1_1	88	101	PF08389	0.453
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	262	267	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	572	576	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHR7	Leptomonas seymouri	23%	82%
A0A0N1IM26	Leptomonas seymouri	83%	100%
A0A0S4IUU5	Bodo saltans	26%	95%
A0A0S4J1S0	Bodo saltans	24%	97%
A0A0S4J2C5	Bodo saltans	53%	100%
A0A1X0NWU2	Trypanosomatidae	59%	100%
A0A1X0P6U3	Trypanosomatidae	24%	100%
A0A3Q8IBL0	Leishmania donovani	97%	100%
A0A3Q8IDF8	Leishmania donovani	24%	72%
A0A3R7MGY7	Trypanosoma rangeli	58%	100%
A0A3S7WUV3	Leishmania donovani	23%	84%
A4H9H6	Leishmania braziliensis	23%	84%
A4HWJ0	Leishmania infantum	24%	72%
A4HXU2	Leishmania infantum	23%	84%
A4HYP6	Leishmania infantum	97%	100%
C9ZI85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AIC2	Leishmania braziliensis	90%	100%
E9AUK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P30153	Homo sapiens	36%	100%
P30154	Homo sapiens	35%	100%
P31383	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	94%
P36179	Drosophila melanogaster	33%	100%
P54612	Sus scrofa	36%	100%
P54613	Sus scrofa	35%	100%
Q09543	Caenorhabditis elegans	33%	100%
Q32PI5	Bos taurus	36%	100%
Q38845	Arabidopsis thaliana	34%	100%
Q38950	Arabidopsis thaliana	34%	100%
Q38951	Arabidopsis thaliana	33%	100%
Q4QDX5	Leishmania major	23%	84%
Q4QQT4	Rattus norvegicus	35%	100%
Q54QR9	Dictyostelium discoideum	34%	100%
Q76MZ3	Mus musculus	36%	100%
Q7TNP2	Mus musculus	35%	100%
Q9UT08	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
V5C089	Trypanosoma cruzi	56%	100%