DUF775 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF775), putative

Species:

Leishmania major

UniProt:

Q4QCX3_LEIMA

TriTrypDb:

LmjF.20.0680 , LMJLV39_200012600 , LMJSD75_200012400

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCX3

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0034504	protein localization to nucleus	6	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051169	nuclear transport	4	2
GO:0051170	import into nucleus	6	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0072594	establishment of protein localization to organelle	4	2

Molecular functions
Term	Name	Level	Count
GO:0061608	nuclear import signal receptor activity	3	2
GO:0140104	molecular carrier activity	1	2
GO:0140142	nucleocytoplasmic carrier activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	115	119	PF00082	0.228
CLV_PCSK_SKI1_1	167	171	PF00082	0.269
DEG_MDM2_SWIB_1	195	203	PF02201	0.428
DEG_Nend_UBRbox_3	1	3	PF02207	0.664
DEG_SPOP_SBC_1	17	21	PF00917	0.504
DOC_MAPK_MEF2A_6	115	122	PF00069	0.494
DOC_MAPK_MEF2A_6	46	53	PF00069	0.509
DOC_MAPK_NFAT4_5	115	123	PF00069	0.509
DOC_PP1_RVXF_1	127	134	PF00149	0.417
DOC_PP2B_LxvP_1	10	13	PF13499	0.576
DOC_WW_Pin1_4	18	23	PF00397	0.647
DOC_WW_Pin1_4	37	42	PF00397	0.473
LIG_14-3-3_CanoR_1	167	172	PF00244	0.471
LIG_14-3-3_CanoR_1	96	100	PF00244	0.465
LIG_EVH1_2	22	26	PF00568	0.454
LIG_FHA_1	166	172	PF00498	0.452
LIG_FHA_1	191	197	PF00498	0.495
LIG_FHA_2	179	185	PF00498	0.466
LIG_FHA_2	61	67	PF00498	0.511
LIG_GBD_Chelix_1	150	158	PF00786	0.246
LIG_LIR_Gen_1	187	196	PF02991	0.509
LIG_LIR_Gen_1	56	64	PF02991	0.504
LIG_LIR_Gen_1	83	92	PF02991	0.432
LIG_LIR_Nem_3	156	162	PF02991	0.428
LIG_LIR_Nem_3	56	61	PF02991	0.473
LIG_LIR_Nem_3	83	89	PF02991	0.432
LIG_PDZ_Class_2	210	215	PF00595	0.400
LIG_PDZ_Wminus1_1	213	215	PF00595	0.366
LIG_Pex14_2	195	199	PF04695	0.428
LIG_PTB_Apo_2	127	134	PF02174	0.435
LIG_SH2_CRK	159	163	PF00017	0.428
LIG_SH2_STAP1	165	169	PF00017	0.479
LIG_SH2_STAT5	188	191	PF00017	0.509
LIG_SH2_STAT5	88	91	PF00017	0.436
LIG_SH3_3	186	192	PF00018	0.428
LIG_SH3_3	25	31	PF00018	0.486
LIG_SH3_3	64	70	PF00018	0.467
LIG_SH3_3	98	104	PF00018	0.515
MOD_CK1_1	175	181	PF00069	0.451
MOD_CK1_1	205	211	PF00069	0.549
MOD_CK2_1	178	184	PF00069	0.509
MOD_CK2_1	60	66	PF00069	0.509
MOD_GlcNHglycan	174	177	PF01048	0.329
MOD_GSK3_1	13	20	PF00069	0.713
MOD_GSK3_1	139	146	PF00069	0.564
MOD_GSK3_1	161	168	PF00069	0.463
MOD_GSK3_1	174	181	PF00069	0.469
MOD_GSK3_1	37	44	PF00069	0.506
MOD_N-GLC_1	37	42	PF02516	0.275
MOD_NEK2_1	139	144	PF00069	0.486
MOD_NEK2_1	161	166	PF00069	0.439
MOD_PIKK_1	139	145	PF00454	0.495
MOD_PIKK_1	90	96	PF00454	0.484
MOD_PKA_2	95	101	PF00069	0.429
MOD_PKB_1	200	208	PF00069	0.471
MOD_Plk_1	178	184	PF00069	0.469
MOD_Plk_1	80	86	PF00069	0.509
MOD_Plk_2-3	179	185	PF00069	0.412
MOD_Plk_4	191	197	PF00069	0.471
MOD_Plk_4	54	60	PF00069	0.414
MOD_Plk_4	95	101	PF00069	0.421
MOD_ProDKin_1	18	24	PF00069	0.638
MOD_ProDKin_1	37	43	PF00069	0.473
MOD_SUMO_rev_2	123	131	PF00179	0.417
TRG_DiLeu_BaEn_4	126	132	PF01217	0.509
TRG_ENDOCYTIC_2	159	162	PF00928	0.415
TRG_ENDOCYTIC_2	188	191	PF00928	0.509
TRG_ER_diArg_1	199	202	PF00400	0.499
TRG_NES_CRM1_1	112	126	PF08389	0.504
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.273

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILS8	Leptomonas seymouri	71%	93%
A0A0S4J2E1	Bodo saltans	38%	100%
A0A1X0NWD7	Trypanosomatidae	45%	91%
A0A3Q8IBJ8	Leishmania donovani	94%	100%
A0A422NJN3	Trypanosoma rangeli	50%	100%
A4HYP4	Leishmania infantum	95%	100%
C9ZI87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AIC4	Leishmania braziliensis	82%	100%
E9AUL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O60175	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%