Tubulin nucleotide-binding domain-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tubulin/FtsZ family, putative

Species:

Leishmania major

UniProt:

Q4QCW8_LEIMA

TriTrypDb:

LmjF.20.0780 , LMJLV39_200013200 , LMJSD75_200013000

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.717
CLV_C14_Caspase3-7	265	269	PF00656	0.479
CLV_C14_Caspase3-7	287	291	PF00656	0.398
CLV_C14_Caspase3-7	680	684	PF00656	0.547
CLV_C14_Caspase3-7	91	95	PF00656	0.676
CLV_NRD_NRD_1	182	184	PF00675	0.806
CLV_NRD_NRD_1	200	202	PF00675	0.538
CLV_NRD_NRD_1	271	273	PF00675	0.494
CLV_NRD_NRD_1	341	343	PF00675	0.418
CLV_NRD_NRD_1	608	610	PF00675	0.393
CLV_NRD_NRD_1	80	82	PF00675	0.572
CLV_PCSK_FUR_1	198	202	PF00082	0.497
CLV_PCSK_FUR_1	339	343	PF00082	0.524
CLV_PCSK_KEX2_1	182	184	PF00082	0.768
CLV_PCSK_KEX2_1	200	202	PF00082	0.434
CLV_PCSK_KEX2_1	271	273	PF00082	0.494
CLV_PCSK_KEX2_1	341	343	PF00082	0.404
CLV_PCSK_KEX2_1	608	610	PF00082	0.393
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.523
CLV_PCSK_SKI1_1	129	133	PF00082	0.542
CLV_PCSK_SKI1_1	201	205	PF00082	0.557
CLV_PCSK_SKI1_1	551	555	PF00082	0.444
CLV_PCSK_SKI1_1	608	612	PF00082	0.646
CLV_PCSK_SKI1_1	61	65	PF00082	0.335
CLV_PCSK_SKI1_1	660	664	PF00082	0.453
DEG_APCC_DBOX_1	607	615	PF00400	0.594
DOC_CDC14_PxL_1	320	328	PF14671	0.290
DOC_CDC14_PxL_1	474	482	PF14671	0.599
DOC_CDC14_PxL_1	624	632	PF14671	0.407
DOC_CKS1_1	310	315	PF01111	0.518
DOC_CYCLIN_RxL_1	195	206	PF00134	0.524
DOC_CYCLIN_RxL_1	56	66	PF00134	0.493
DOC_MAPK_DCC_7	56	64	PF00069	0.469
DOC_MAPK_gen_1	339	348	PF00069	0.384
DOC_MAPK_gen_1	437	447	PF00069	0.487
DOC_MAPK_gen_1	56	65	PF00069	0.483
DOC_MAPK_gen_1	608	616	PF00069	0.342
DOC_MAPK_MEF2A_6	359	368	PF00069	0.428
DOC_MAPK_MEF2A_6	440	447	PF00069	0.493
DOC_MAPK_MEF2A_6	5	12	PF00069	0.320
DOC_MAPK_MEF2A_6	56	64	PF00069	0.487
DOC_MAPK_NFAT4_5	5	13	PF00069	0.462
DOC_PP2B_LxvP_1	65	68	PF13499	0.362
DOC_PP4_FxxP_1	582	585	PF00568	0.467
DOC_USP7_MATH_1	243	247	PF00917	0.487
DOC_USP7_MATH_1	32	36	PF00917	0.377
DOC_USP7_MATH_1	441	445	PF00917	0.431
DOC_USP7_MATH_1	487	491	PF00917	0.734
DOC_USP7_MATH_1	595	599	PF00917	0.612
DOC_USP7_MATH_1	68	72	PF00917	0.553
DOC_USP7_UBL2_3	84	88	PF12436	0.473
DOC_WW_Pin1_4	100	105	PF00397	0.745
DOC_WW_Pin1_4	309	314	PF00397	0.509
DOC_WW_Pin1_4	382	387	PF00397	0.612
LIG_14-3-3_CanoR_1	259	266	PF00244	0.443
LIG_14-3-3_CanoR_1	359	368	PF00244	0.456
LIG_14-3-3_CanoR_1	397	403	PF00244	0.472
LIG_14-3-3_CanoR_1	557	562	PF00244	0.501
LIG_14-3-3_CanoR_1	609	615	PF00244	0.500
LIG_Actin_WH2_2	399	417	PF00022	0.400
LIG_Actin_WH2_2	535	553	PF00022	0.452
LIG_APCC_ABBA_1	667	672	PF00400	0.504
LIG_APCC_ABBAyCdc20_2	200	206	PF00400	0.536
LIG_BIR_III_2	307	311	PF00653	0.319
LIG_BIR_III_4	148	152	PF00653	0.530
LIG_BIR_III_4	236	240	PF00653	0.503
LIG_BRCT_BRCA1_1	572	576	PF00533	0.456
LIG_CAP-Gly_1	688	692	PF01302	0.685
LIG_Clathr_ClatBox_1	62	66	PF01394	0.340
LIG_deltaCOP1_diTrp_1	372	377	PF00928	0.439
LIG_deltaCOP1_diTrp_1	463	467	PF00928	0.375
LIG_FHA_1	216	222	PF00498	0.508
LIG_FHA_1	310	316	PF00498	0.483
LIG_FHA_1	352	358	PF00498	0.339
LIG_FHA_1	359	365	PF00498	0.360
LIG_FHA_1	397	403	PF00498	0.401
LIG_FHA_1	576	582	PF00498	0.425
LIG_FHA_2	285	291	PF00498	0.439
LIG_GBD_Chelix_1	403	411	PF00786	0.238
LIG_Integrin_isoDGR_2	54	56	PF01839	0.369
LIG_Integrin_RGD_1	109	111	PF01839	0.490
LIG_LIR_Apic_2	579	585	PF02991	0.443
LIG_LIR_Gen_1	117	127	PF02991	0.507
LIG_LIR_Gen_1	319	328	PF02991	0.480
LIG_LIR_Gen_1	371	381	PF02991	0.464
LIG_LIR_Gen_1	433	443	PF02991	0.491
LIG_LIR_Gen_1	462	473	PF02991	0.377
LIG_LIR_Gen_1	71	80	PF02991	0.600
LIG_LIR_Nem_3	117	123	PF02991	0.529
LIG_LIR_Nem_3	210	216	PF02991	0.537
LIG_LIR_Nem_3	319	323	PF02991	0.334
LIG_LIR_Nem_3	362	368	PF02991	0.442
LIG_LIR_Nem_3	371	376	PF02991	0.455
LIG_LIR_Nem_3	433	438	PF02991	0.495
LIG_LIR_Nem_3	462	468	PF02991	0.366
LIG_LIR_Nem_3	558	564	PF02991	0.376
LIG_LIR_Nem_3	71	76	PF02991	0.622
LIG_LIR_Nem_3	9	15	PF02991	0.405
LIG_NRBOX	347	353	PF00104	0.323
LIG_Pex14_1	373	377	PF04695	0.356
LIG_Pex14_1	79	83	PF04695	0.593
LIG_SH2_CRK	15	19	PF00017	0.311
LIG_SH2_CRK	552	556	PF00017	0.365
LIG_SH2_NCK_1	624	628	PF00017	0.423
LIG_SH2_NCK_1	673	677	PF00017	0.526
LIG_SH2_NCK_1	69	73	PF00017	0.522
LIG_SH2_PTP2	365	368	PF00017	0.386
LIG_SH2_SRC	365	368	PF00017	0.489
LIG_SH2_STAP1	15	19	PF00017	0.311
LIG_SH2_STAP1	69	73	PF00017	0.589
LIG_SH2_STAT5	216	219	PF00017	0.410
LIG_SH2_STAT5	253	256	PF00017	0.490
LIG_SH2_STAT5	365	368	PF00017	0.337
LIG_SH2_STAT5	561	564	PF00017	0.337
LIG_SH2_STAT5	648	651	PF00017	0.464
LIG_SH2_STAT5	652	655	PF00017	0.449
LIG_SH3_3	307	313	PF00018	0.455
LIG_SH3_3	324	330	PF00018	0.340
LIG_SH3_3	361	367	PF00018	0.311
LIG_SH3_3	435	441	PF00018	0.457
LIG_SH3_3	469	475	PF00018	0.517
LIG_SH3_3	54	60	PF00018	0.458
LIG_SH3_3	565	571	PF00018	0.538
LIG_SUMO_SIM_par_1	260	268	PF11976	0.306
LIG_SUMO_SIM_par_1	61	66	PF11976	0.328
LIG_TRAF2_1	112	115	PF00917	0.705
LIG_TRAF2_2	231	236	PF00917	0.613
LIG_UBA3_1	629	636	PF00899	0.423
LIG_WRC_WIRS_1	244	249	PF05994	0.399
MOD_CDK_SPxxK_3	102	109	PF00069	0.638
MOD_CK1_1	100	106	PF00069	0.746
MOD_CK1_1	225	231	PF00069	0.505
MOD_CK1_1	358	364	PF00069	0.333
MOD_CK1_1	418	424	PF00069	0.595
MOD_CK1_1	459	465	PF00069	0.517
MOD_CK1_1	514	520	PF00069	0.583
MOD_CK1_1	598	604	PF00069	0.631
MOD_CK2_1	382	388	PF00069	0.548
MOD_Cter_Amidation	180	183	PF01082	0.543
MOD_GlcNHglycan	184	187	PF01048	0.711
MOD_GlcNHglycan	361	364	PF01048	0.374
MOD_GlcNHglycan	42	45	PF01048	0.543
MOD_GlcNHglycan	420	423	PF01048	0.670
MOD_GlcNHglycan	458	461	PF01048	0.538
MOD_GlcNHglycan	489	492	PF01048	0.737
MOD_GlcNHglycan	496	499	PF01048	0.750
MOD_GlcNHglycan	51	54	PF01048	0.532
MOD_GlcNHglycan	595	598	PF01048	0.676
MOD_GlcNHglycan	70	73	PF01048	0.613
MOD_GSK3_1	184	191	PF00069	0.701
MOD_GSK3_1	32	39	PF00069	0.473
MOD_GSK3_1	351	358	PF00069	0.307
MOD_GSK3_1	418	425	PF00069	0.617
MOD_GSK3_1	454	461	PF00069	0.545
MOD_GSK3_1	507	514	PF00069	0.415
MOD_GSK3_1	566	573	PF00069	0.396
MOD_GSK3_1	598	605	PF00069	0.647
MOD_GSK3_1	619	626	PF00069	0.382
MOD_N-GLC_1	13	18	PF02516	0.354
MOD_N-GLC_1	207	212	PF02516	0.580
MOD_N-GLC_1	24	29	PF02516	0.343
MOD_N-GLC_1	487	492	PF02516	0.683
MOD_NEK2_1	119	124	PF00069	0.548
MOD_NEK2_1	351	356	PF00069	0.309
MOD_NEK2_1	509	514	PF00069	0.425
MOD_NEK2_1	556	561	PF00069	0.438
MOD_NEK2_2	603	608	PF00069	0.597
MOD_PIKK_1	422	428	PF00454	0.549
MOD_PKA_1	182	188	PF00069	0.576
MOD_PKA_2	182	188	PF00069	0.742
MOD_PKA_2	258	264	PF00069	0.441
MOD_PKA_2	358	364	PF00069	0.463
MOD_PKA_2	396	402	PF00069	0.497
MOD_PKA_2	418	424	PF00069	0.638
MOD_PKA_2	556	562	PF00069	0.495
MOD_Plk_1	13	19	PF00069	0.408
MOD_Plk_1	207	213	PF00069	0.540
MOD_Plk_1	566	572	PF00069	0.487
MOD_Plk_4	119	125	PF00069	0.425
MOD_Plk_4	14	20	PF00069	0.323
MOD_Plk_4	33	39	PF00069	0.505
MOD_Plk_4	538	544	PF00069	0.514
MOD_Plk_4	557	563	PF00069	0.497
MOD_ProDKin_1	100	106	PF00069	0.744
MOD_ProDKin_1	309	315	PF00069	0.503
MOD_ProDKin_1	382	388	PF00069	0.612
MOD_SUMO_rev_2	85	89	PF00179	0.622
TRG_DiLeu_BaEn_2	462	468	PF01217	0.491
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.404
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.442
TRG_ENDOCYTIC_2	15	18	PF00928	0.311
TRG_ENDOCYTIC_2	365	368	PF00928	0.348
TRG_ENDOCYTIC_2	561	564	PF00928	0.337
TRG_ER_diArg_1	270	272	PF00400	0.489
TRG_ER_diArg_1	341	343	PF00400	0.448
TRG_ER_diArg_1	56	59	PF00400	0.516
TRG_ER_diArg_1	607	609	PF00400	0.400
TRG_NLS_Bipartite_1	182	204	PF00514	0.540
TRG_NLS_MonoExtC_3	199	205	PF00514	0.640
TRG_NLS_MonoExtN_4	198	204	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U7	Leptomonas seymouri	53%	94%
A0A0S4J688	Bodo saltans	32%	100%
A0A1X0NWM5	Trypanosomatidae	40%	100%
A0A3R7MKD9	Trypanosoma rangeli	42%	100%
A0A3S7WVZ9	Leishmania donovani	91%	99%
A4HYP0	Leishmania infantum	92%	100%
C9ZI95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AIC9	Leishmania braziliensis	78%	99%
E9AUL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5C080	Trypanosoma cruzi	39%	100%