MgtE_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QCW6_LEIMA

TriTrypDb:

LmjF.20.0800 , LMJLV39_200013400 , LMJSD75_200013200

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCW6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.565
CLV_NRD_NRD_1	23	25	PF00675	0.634
CLV_NRD_NRD_1	303	305	PF00675	0.532
CLV_NRD_NRD_1	32	34	PF00675	0.706
CLV_NRD_NRD_1	44	46	PF00675	0.595
CLV_NRD_NRD_1	70	72	PF00675	0.649
CLV_PCSK_KEX2_1	23	25	PF00082	0.633
CLV_PCSK_KEX2_1	43	45	PF00082	0.439
CLV_PCSK_KEX2_1	72	74	PF00082	0.676
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.636
CLV_PCSK_SKI1_1	165	169	PF00082	0.581
CLV_PCSK_SKI1_1	273	277	PF00082	0.484
CLV_PCSK_SKI1_1	64	68	PF00082	0.618
CLV_PCSK_SKI1_1	75	79	PF00082	0.502
DEG_APCC_DBOX_1	32	40	PF00400	0.496
DOC_CYCLIN_RxL_1	270	278	PF00134	0.456
DOC_MAPK_JIP1_4	317	323	PF00069	0.576
DOC_USP7_MATH_1	198	202	PF00917	0.706
DOC_USP7_UBL2_3	346	350	PF12436	0.570
DOC_WW_Pin1_4	16	21	PF00397	0.666
DOC_WW_Pin1_4	165	170	PF00397	0.627
DOC_WW_Pin1_4	278	283	PF00397	0.630
DOC_WW_Pin1_4	6	11	PF00397	0.790
LIG_14-3-3_CanoR_1	159	163	PF00244	0.535
LIG_14-3-3_CanoR_1	304	310	PF00244	0.545
LIG_14-3-3_CanoR_1	33	37	PF00244	0.494
LIG_Clathr_ClatBox_1	152	156	PF01394	0.533
LIG_eIF4E_1	207	213	PF01652	0.553
LIG_FHA_1	290	296	PF00498	0.588
LIG_FHA_2	46	52	PF00498	0.556
LIG_MYND_1	6	10	PF01753	0.569
LIG_RPA_C_Fungi	125	137	PF08784	0.563
LIG_SH2_STAT5	248	251	PF00017	0.605
LIG_SUMO_SIM_anti_2	319	326	PF11976	0.576
LIG_SUMO_SIM_par_1	149	156	PF11976	0.530
LIG_SUMO_SIM_par_1	292	298	PF11976	0.451
LIG_TRAF2_1	120	123	PF00917	0.720
LIG_TRAF2_1	208	211	PF00917	0.672
LIG_TRAF2_1	258	261	PF00917	0.569
LIG_WRC_WIRS_1	138	143	PF05994	0.543
MOD_CDK_SPK_2	6	11	PF00069	0.698
MOD_CDK_SPxK_1	278	284	PF00069	0.627
MOD_CDK_SPxxK_3	16	23	PF00069	0.586
MOD_CK1_1	201	207	PF00069	0.574
MOD_CK1_1	308	314	PF00069	0.529
MOD_CK1_1	4	10	PF00069	0.797
MOD_CK2_1	329	335	PF00069	0.570
MOD_CK2_1	351	357	PF00069	0.576
MOD_CK2_1	45	51	PF00069	0.562
MOD_GlcNHglycan	104	107	PF01048	0.574
MOD_GlcNHglycan	185	188	PF01048	0.662
MOD_GlcNHglycan	3	6	PF01048	0.654
MOD_GSK3_1	137	144	PF00069	0.510
MOD_GSK3_1	179	186	PF00069	0.609
MOD_GSK3_1	198	205	PF00069	0.588
MOD_N-GLC_1	198	203	PF02516	0.724
MOD_N-GLC_1	337	342	PF02516	0.386
MOD_NEK2_1	1	6	PF00069	0.824
MOD_NEK2_1	141	146	PF00069	0.527
MOD_NEK2_1	300	305	PF00069	0.559
MOD_NEK2_1	32	37	PF00069	0.495
MOD_NEK2_2	198	203	PF00069	0.711
MOD_PIKK_1	329	335	PF00454	0.608
MOD_PIKK_1	9	15	PF00454	0.740
MOD_PK_1	305	311	PF00069	0.484
MOD_PKA_2	158	164	PF00069	0.534
MOD_PKA_2	32	38	PF00069	0.701
MOD_PKB_1	43	51	PF00069	0.546
MOD_Plk_1	198	204	PF00069	0.592
MOD_Plk_1	337	343	PF00069	0.390
MOD_Plk_2-3	151	157	PF00069	0.594
MOD_Plk_4	137	143	PF00069	0.583
MOD_Plk_4	158	164	PF00069	0.735
MOD_Plk_4	319	325	PF00069	0.575
MOD_ProDKin_1	16	22	PF00069	0.661
MOD_ProDKin_1	165	171	PF00069	0.627
MOD_ProDKin_1	278	284	PF00069	0.627
MOD_ProDKin_1	6	12	PF00069	0.790
MOD_SUMO_for_1	344	347	PF00179	0.516
TRG_DiLeu_BaEn_1	296	301	PF01217	0.444
TRG_DiLeu_BaEn_4	121	127	PF01217	0.596
TRG_ER_diArg_1	42	45	PF00400	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL3	Leptomonas seymouri	55%	100%
A0A3Q8IAT4	Leishmania donovani	93%	100%
A4HYN8	Leishmania infantum	93%	100%
E9AID1	Leishmania braziliensis	74%	100%
E9AUL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%