Vesicle-fusing ATPase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vesicular-fusion protein nsf, putative

Species:

Leishmania major

UniProt:

Q4QCW5_LEIMA

TriTrypDb:

LmjF.20.0810 , LMJLV39_200013500 , LMJSD75_200013300

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005795	Golgi stack	4	2
GO:0016020	membrane	2	1
GO:0031984	organelle subcompartment	2	2
GO:0098791	Golgi apparatus subcompartment	3	2
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

Q4QCW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCW5

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006891	intra-Golgi vesicle-mediated transport	6	2
GO:0006892	post-Golgi vesicle-mediated transport	6	2
GO:0006893	Golgi to plasma membrane transport	5	2
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016043	cellular component organization	3	12
GO:0016192	vesicle-mediated transport	4	2
GO:0022411	cellular component disassembly	4	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	355	359	PF00656	0.324
CLV_C14_Caspase3-7	505	509	PF00656	0.508
CLV_C14_Caspase3-7	647	651	PF00656	0.343
CLV_NRD_NRD_1	231	233	PF00675	0.423
CLV_NRD_NRD_1	269	271	PF00675	0.309
CLV_NRD_NRD_1	301	303	PF00675	0.357
CLV_NRD_NRD_1	374	376	PF00675	0.301
CLV_NRD_NRD_1	499	501	PF00675	0.594
CLV_NRD_NRD_1	518	520	PF00675	0.523
CLV_NRD_NRD_1	582	584	PF00675	0.309

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P640	Leptomonas seymouri	83%	100%
A0A0N0P6X6	Leptomonas seymouri	33%	72%
A0A0S4JAU3	Bodo saltans	26%	100%
A0A0S4JTC3	Bodo saltans	57%	100%
A0A1X0NXR8	Trypanosomatidae	64%	100%
A0A1X0P437	Trypanosomatidae	28%	79%
A0A3Q8IKK0	Leishmania donovani	98%	100%
A0A3S7X0L3	Leishmania donovani	26%	100%
A0A422MWC2	Trypanosoma rangeli	28%	83%
A0A422NPR7	Trypanosoma rangeli	63%	100%

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