Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCW4_LEIMA

TriTrypDb:

LmjF.20.0820 , LMJLV39_200013600 , LMJSD75_200013400

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QCW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCW4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.501
CLV_PCSK_FUR_1	260	264	PF00082	0.500
CLV_PCSK_KEX2_1	259	261	PF00082	0.480
CLV_PCSK_KEX2_1	262	264	PF00082	0.532
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.480
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.532
CLV_PCSK_SKI1_1	199	203	PF00082	0.409
DEG_APCC_KENBOX_2	72	76	PF00400	0.574
DOC_CKS1_1	13	18	PF01111	0.592
DOC_CYCLIN_RxL_1	196	204	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.568
DOC_PP1_RVXF_1	142	148	PF00149	0.504
DOC_PP1_RVXF_1	197	203	PF00149	0.489
DOC_PP2B_PxIxI_1	279	285	PF00149	0.463
DOC_USP7_MATH_1	125	129	PF00917	0.619
DOC_USP7_MATH_1	173	177	PF00917	0.610
DOC_USP7_MATH_1	180	184	PF00917	0.722
DOC_USP7_MATH_1	261	265	PF00917	0.526
DOC_USP7_MATH_1	44	48	PF00917	0.597
DOC_USP7_MATH_1	80	84	PF00917	0.744
DOC_WW_Pin1_4	12	17	PF00397	0.683
DOC_WW_Pin1_4	218	223	PF00397	0.539
DOC_WW_Pin1_4	6	11	PF00397	0.692
LIG_14-3-3_CanoR_1	199	209	PF00244	0.491
LIG_eIF4E_1	99	105	PF01652	0.551
LIG_FHA_1	128	134	PF00498	0.480
LIG_FHA_1	219	225	PF00498	0.530
LIG_FHA_1	239	245	PF00498	0.532
LIG_FHA_1	48	54	PF00498	0.528
LIG_FHA_1	7	13	PF00498	0.592
LIG_FHA_1	99	105	PF00498	0.551
LIG_LIR_Gen_1	289	298	PF02991	0.418
LIG_LIR_Gen_1	302	312	PF02991	0.366
LIG_LIR_Gen_1	51	62	PF02991	0.477
LIG_LIR_Nem_3	289	293	PF02991	0.429
LIG_LIR_Nem_3	302	308	PF02991	0.379
LIG_LIR_Nem_3	51	57	PF02991	0.452
LIG_Pex14_2	112	116	PF04695	0.487
LIG_Pex14_2	147	151	PF04695	0.412
LIG_SH2_SRC	331	334	PF00017	0.606
LIG_SH2_STAT5	158	161	PF00017	0.350
LIG_SH2_STAT5	195	198	PF00017	0.512
LIG_SH3_1	23	29	PF00018	0.639
LIG_SH3_3	228	234	PF00018	0.568
LIG_SH3_3	23	29	PF00018	0.480
LIG_SH3_3	255	261	PF00018	0.408
LIG_SH3_3	7	13	PF00018	0.647
LIG_Sin3_3	54	61	PF02671	0.564
LIG_SUMO_SIM_par_1	126	134	PF11976	0.539
LIG_TRAF2_1	124	127	PF00917	0.559
LIG_TRAF2_1	275	278	PF00917	0.622
MOD_CK1_1	299	305	PF00069	0.376
MOD_CK1_1	47	53	PF00069	0.520
MOD_CK1_1	6	12	PF00069	0.702
MOD_CK1_1	78	84	PF00069	0.637
MOD_CK2_1	121	127	PF00069	0.686
MOD_CK2_1	261	267	PF00069	0.600
MOD_CMANNOS	310	313	PF00535	0.414
MOD_GlcNHglycan	123	126	PF01048	0.629
MOD_GlcNHglycan	140	143	PF01048	0.527
MOD_GlcNHglycan	182	185	PF01048	0.672
MOD_GlcNHglycan	263	266	PF01048	0.632
MOD_GlcNHglycan	5	8	PF01048	0.610
MOD_GlcNHglycan	77	80	PF01048	0.700
MOD_GSK3_1	121	128	PF00069	0.667
MOD_GSK3_1	146	153	PF00069	0.349
MOD_GSK3_1	2	9	PF00069	0.703
MOD_GSK3_1	200	207	PF00069	0.392
MOD_GSK3_1	238	245	PF00069	0.523
MOD_GSK3_1	74	81	PF00069	0.767
MOD_N-GLC_1	74	79	PF02516	0.616
MOD_NEK2_1	138	143	PF00069	0.431
MOD_NEK2_1	150	155	PF00069	0.303
MOD_NEK2_1	3	8	PF00069	0.635
MOD_OFUCOSY	155	162	PF10250	0.426
MOD_PKA_1	84	90	PF00069	0.652
MOD_Plk_1	126	132	PF00069	0.549
MOD_Plk_4	127	133	PF00069	0.497
MOD_Plk_4	146	152	PF00069	0.230
MOD_Plk_4	204	210	PF00069	0.356
MOD_Plk_4	243	249	PF00069	0.433
MOD_Plk_4	84	90	PF00069	0.604
MOD_ProDKin_1	218	224	PF00069	0.533
MOD_ProDKin_1	6	12	PF00069	0.689
TRG_NES_CRM1_1	111	126	PF08389	0.612
TRG_NLS_MonoCore_2	258	263	PF00514	0.469
TRG_NLS_MonoExtC_3	258	263	PF00514	0.469
TRG_Pf-PMV_PEXEL_1	199	204	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P7	Leptomonas seymouri	54%	100%
A0A1X0NWT5	Trypanosomatidae	33%	100%
A0A3R7NTG5	Trypanosoma rangeli	34%	100%
A0A3S7WW35	Leishmania donovani	94%	100%
A4HYS4	Leishmania infantum	94%	100%
E9AID3	Leishmania braziliensis	75%	100%
E9AUM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BA94	Trypanosoma cruzi	34%	92%