Phosphopantetheinyl transferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphopantetheinyl transferase-like protein

Species:

Leishmania major

UniProt:

Q4QCW3_LEIMA

TriTrypDb:

LmjF.20.0830 , LMJLV39_200013700 , LMJSD75_200013500

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCW3

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006520	amino acid metabolic process	3	2
GO:0006553	lysine metabolic process	6	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008652	amino acid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009066	aspartate family amino acid metabolic process	5	2
GO:0009067	aspartate family amino acid biosynthetic process	6	2
GO:0009085	lysine biosynthetic process	7	2
GO:0009987	cellular process	1	2
GO:0016053	organic acid biosynthetic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0019878	lysine biosynthetic process via aminoadipic acid	8	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901605	alpha-amino acid metabolic process	4	2
GO:1901607	alpha-amino acid biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0008897	holo-[acyl-carrier-protein] synthase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	33	35	PF00675	0.476
CLV_NRD_NRD_1	79	81	PF00675	0.368
CLV_PCSK_KEX2_1	33	35	PF00082	0.443
CLV_PCSK_KEX2_1	78	80	PF00082	0.533
CLV_PCSK_KEX2_1	83	85	PF00082	0.585
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.531
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.585
CLV_PCSK_PC7_1	79	85	PF00082	0.479
CLV_PCSK_SKI1_1	62	66	PF00082	0.403
CLV_PCSK_SKI1_1	87	91	PF00082	0.428
CLV_PCSK_SKI1_1	95	99	PF00082	0.419
DOC_CYCLIN_RxL_1	171	184	PF00134	0.470
DOC_CYCLIN_RxL_1	56	70	PF00134	0.422
DOC_MAPK_gen_1	217	224	PF00069	0.423
DOC_MAPK_gen_1	78	88	PF00069	0.379
DOC_MAPK_MEF2A_6	217	224	PF00069	0.569
DOC_PP2B_LxvP_1	97	100	PF13499	0.435
DOC_PP4_FxxP_1	237	240	PF00568	0.416
DOC_PP4_FxxP_1	264	267	PF00568	0.415
DOC_USP7_MATH_1	35	39	PF00917	0.497
DOC_USP7_MATH_1	7	11	PF00917	0.351
DOC_WW_Pin1_4	12	17	PF00397	0.444
DOC_WW_Pin1_4	134	139	PF00397	0.421
DOC_WW_Pin1_4	263	268	PF00397	0.429
LIG_14-3-3_CanoR_1	219	225	PF00244	0.409
LIG_14-3-3_CanoR_1	45	51	PF00244	0.469
LIG_14-3-3_CanoR_1	87	97	PF00244	0.518
LIG_BRCT_BRCA1_1	136	140	PF00533	0.516
LIG_FHA_2	167	173	PF00498	0.566
LIG_LIR_Apic_2	211	216	PF02991	0.483
LIG_LIR_Apic_2	235	240	PF02991	0.412
LIG_LIR_Apic_2	261	267	PF02991	0.419
LIG_LIR_Apic_2	90	96	PF02991	0.412
LIG_LIR_Gen_1	162	170	PF02991	0.503
LIG_LIR_Nem_3	162	167	PF02991	0.487
LIG_PAM2_1	159	171	PF00658	0.483
LIG_Pex14_2	164	168	PF04695	0.503
LIG_SH2_CRK	213	217	PF00017	0.538
LIG_SH2_CRK	93	97	PF00017	0.402
LIG_SH2_STAT5	213	216	PF00017	0.542
LIG_SH3_3	237	243	PF00018	0.437
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.473
LIG_TRAF2_1	145	148	PF00917	0.519
LIG_UBA3_1	163	171	PF00899	0.367
LIG_UBA3_1	220	229	PF00899	0.409
MOD_CK1_1	202	208	PF00069	0.375
MOD_CK1_1	211	217	PF00069	0.327
MOD_CK1_1	266	272	PF00069	0.376
MOD_CK2_1	142	148	PF00069	0.321
MOD_CK2_1	166	172	PF00069	0.439
MOD_CK2_1	18	24	PF00069	0.439
MOD_CK2_1	202	208	PF00069	0.228
MOD_GlcNHglycan	20	23	PF01048	0.439
MOD_GlcNHglycan	247	250	PF01048	0.273
MOD_GlcNHglycan	37	40	PF01048	0.359
MOD_GlcNHglycan	41	44	PF01048	0.525
MOD_GlcNHglycan	9	12	PF01048	0.406
MOD_GlcNHglycan	90	93	PF01048	0.417
MOD_GSK3_1	134	141	PF00069	0.340
MOD_GSK3_1	35	42	PF00069	0.516
MOD_N-GLC_1	104	109	PF02516	0.374
MOD_N-GLC_1	199	204	PF02516	0.369
MOD_N-GLC_1	7	12	PF02516	0.346
MOD_NEK2_1	142	147	PF00069	0.439
MOD_NEK2_1	166	171	PF00069	0.423
MOD_NEK2_1	180	185	PF00069	0.308
MOD_NEK2_1	220	225	PF00069	0.438
MOD_NEK2_1	88	93	PF00069	0.391
MOD_NEK2_2	192	197	PF00069	0.323
MOD_NEK2_2	232	237	PF00069	0.403
MOD_PK_1	28	34	PF00069	0.478
MOD_PKA_2	39	45	PF00069	0.515
MOD_Plk_1	104	110	PF00069	0.376
MOD_Plk_1	199	205	PF00069	0.352
MOD_Plk_1	28	34	PF00069	0.432
MOD_Plk_1	7	13	PF00069	0.354
MOD_Plk_4	159	165	PF00069	0.360
MOD_Plk_4	199	205	PF00069	0.323
MOD_Plk_4	208	214	PF00069	0.259
MOD_ProDKin_1	12	18	PF00069	0.448
MOD_ProDKin_1	134	140	PF00069	0.236
MOD_ProDKin_1	263	269	PF00069	0.434
MOD_SUMO_for_1	196	199	PF00179	0.347
MOD_SUMO_rev_2	48	57	PF00179	0.531
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.382
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.410
TRG_ER_diArg_1	32	34	PF00400	0.426
TRG_ER_diArg_1	79	81	PF00400	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I553	Leptomonas seymouri	39%	100%
A0A3S7WW00	Leishmania donovani	89%	100%
A4HYS5	Leishmania infantum	90%	100%
E9AID4	Leishmania braziliensis	63%	100%
E9AUM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%