Cytochrome c oxidase assembly factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

electron transport protein SCO1/2, putative

Species:

Leishmania major

UniProt:

Q4QCW2_LEIMA

TriTrypDb:

LmjF.20.0840 , LMJLV39_200013800 , LMJSD75_200013600

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	2

Expansion

Sequence features

Q4QCW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCW2

Function

Biological processes
Term	Name	Level	Count
GO:0008535	respiratory chain complex IV assembly	7	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0017004	cytochrome complex assembly	6	2
GO:0022607	cellular component assembly	4	2
GO:0033108	mitochondrial respiratory chain complex assembly	6	2
GO:0033617	mitochondrial cytochrome c oxidase assembly	7	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016491	oxidoreductase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.409
CLV_NRD_NRD_1	123	125	PF00675	0.401
CLV_NRD_NRD_1	6	8	PF00675	0.642
CLV_PCSK_SKI1_1	196	200	PF00082	0.403
CLV_PCSK_SKI1_1	45	49	PF00082	0.398
DEG_MDM2_SWIB_1	53	60	PF02201	0.304
DEG_Nend_UBRbox_3	1	3	PF02207	0.707
DEG_ODPH_VHL_1	14	26	PF01847	0.562
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.304
DOC_MAPK_MEF2A_6	100	109	PF00069	0.307
LIG_BRCT_BRCA1_1	107	111	PF00533	0.390
LIG_FHA_2	134	140	PF00498	0.390
LIG_FHA_2	155	161	PF00498	0.320
LIG_FHA_2	46	52	PF00498	0.294
LIG_LIR_Gen_1	17	26	PF02991	0.589
LIG_LIR_Nem_3	58	64	PF02991	0.310
LIG_MYND_1	12	16	PF01753	0.529
LIG_Pex14_1	147	151	PF04695	0.304
LIG_Pex14_1	57	61	PF04695	0.304
LIG_Pex14_2	53	57	PF04695	0.304
LIG_REV1ctd_RIR_1	196	205	PF16727	0.434
LIG_SH2_GRB2like	4	7	PF00017	0.661
LIG_SH2_NCK_1	151	155	PF00017	0.320
LIG_SH2_NCK_1	216	220	PF00017	0.547
LIG_SH2_STAP1	216	220	PF00017	0.547
LIG_SH2_STAT5	187	190	PF00017	0.316
LIG_SH2_STAT5	46	49	PF00017	0.316
LIG_SH2_STAT5	61	64	PF00017	0.269
LIG_SH3_3	166	172	PF00018	0.390
LIG_SH3_4	27	34	PF00018	0.644
LIG_TRAF2_1	136	139	PF00917	0.425
LIG_TRAF2_1	157	160	PF00917	0.321
LIG_TRAF2_1	96	99	PF00917	0.427
LIG_TYR_ITIM	149	154	PF00017	0.320
LIG_TYR_ITIM	214	219	PF00017	0.535
MOD_CK1_1	20	26	PF00069	0.586
MOD_CK1_1	65	71	PF00069	0.368
MOD_CK2_1	133	139	PF00069	0.369
MOD_CK2_1	150	156	PF00069	0.188
MOD_CK2_1	45	51	PF00069	0.308
MOD_GlcNHglycan	183	186	PF01048	0.320
MOD_GSK3_1	150	157	PF00069	0.304
MOD_GSK3_1	220	227	PF00069	0.514
MOD_N-GLC_1	205	210	PF02516	0.409
MOD_NEK2_1	180	185	PF00069	0.327
MOD_NEK2_1	205	210	PF00069	0.534
MOD_NEK2_1	222	227	PF00069	0.517
MOD_NEK2_1	38	43	PF00069	0.317
MOD_NEK2_1	62	67	PF00069	0.304
MOD_PIKK_1	27	33	PF00454	0.611
MOD_PKA_2	38	44	PF00069	0.320
MOD_Plk_1	174	180	PF00069	0.305
MOD_Plk_1	205	211	PF00069	0.411
MOD_SUMO_rev_2	92	102	PF00179	0.362
TRG_ENDOCYTIC_2	151	154	PF00928	0.320
TRG_ENDOCYTIC_2	216	219	PF00928	0.543
TRG_ENDOCYTIC_2	61	64	PF00928	0.304
TRG_ER_diArg_1	128	131	PF00400	0.320
TRG_ER_diArg_1	36	39	PF00400	0.339
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R3	Leptomonas seymouri	30%	75%
A0A0N1I6S1	Leptomonas seymouri	78%	82%
A0A0S4J8R8	Bodo saltans	31%	78%
A0A0S4KH84	Bodo saltans	60%	71%
A0A1X0NLN8	Trypanosomatidae	31%	86%
A0A1X0NWD3	Trypanosomatidae	69%	77%
A0A3R7L4G0	Trypanosoma rangeli	69%	80%
A0A3R7RML7	Trypanosoma rangeli	32%	100%
A0A3S5H5E9	Leishmania donovani	30%	75%
A0A3S5H786	Leishmania donovani	96%	100%
A1A4J8	Bos taurus	34%	76%
A4H427	Leishmania braziliensis	29%	78%
A4HF41	Leishmania braziliensis	32%	81%
A4HSB1	Leishmania infantum	30%	75%
A4HYS6	Leishmania infantum	97%	100%
A6H784	Bos taurus	33%	87%
C9ZI98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	77%
C9ZYA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	85%
E9AID5	Leishmania braziliensis	87%	100%
E9AK94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	78%
E9AUM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AYH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	81%
O42899	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	88%
O43819	Homo sapiens	31%	87%
O75880	Homo sapiens	35%	77%
O97196	Leishmania major	31%	100%
P23833	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	78%
P38072	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	77%
P47206	Pseudonocardia sediminis	25%	100%
Q1RIN4	Rickettsia bellii (strain RML369-C)	30%	100%
Q4Q8Z5	Leishmania major	32%	100%
Q4UKW2	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	28%	100%
Q52720	Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)	31%	100%
Q5RH02	Danio rerio	34%	83%
Q5SUC9	Mus musculus	34%	81%
Q68WF1	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	24%	100%
Q8LAL0	Arabidopsis thaliana	28%	84%
Q8VCL2	Mus musculus	34%	91%
Q8VYP0	Arabidopsis thaliana	32%	69%
Q92H76	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	27%	100%
Q9ZCW7	Rickettsia prowazekii (strain Madrid E)	27%	100%
V5BI84	Trypanosoma cruzi	31%	86%
V5BQS4	Trypanosoma cruzi	68%	69%