Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCW0_LEIMA

TriTrypDb:

LmjF.20.0860 , LMJLV39_200014000 , LMJSD75_200013800

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.557
CLV_NRD_NRD_1	206	208	PF00675	0.739
CLV_NRD_NRD_1	45	47	PF00675	0.468
CLV_PCSK_FUR_1	43	47	PF00082	0.606
CLV_PCSK_KEX2_1	15	17	PF00082	0.557
CLV_PCSK_KEX2_1	240	242	PF00082	0.729
CLV_PCSK_KEX2_1	302	304	PF00082	0.510
CLV_PCSK_KEX2_1	45	47	PF00082	0.471
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.689
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.564
CLV_PCSK_PC7_1	11	17	PF00082	0.665
CLV_PCSK_SKI1_1	240	244	PF00082	0.641
CLV_PCSK_SKI1_1	46	50	PF00082	0.444
CLV_PCSK_SKI1_1	73	77	PF00082	0.578
DEG_APCC_DBOX_1	317	325	PF00400	0.517
DEG_Kelch_Keap1_1	199	204	PF01344	0.575
DEG_Nend_UBRbox_3	1	3	PF02207	0.607
DEG_SPOP_SBC_1	195	199	PF00917	0.634
DOC_CDC14_PxL_1	85	93	PF14671	0.428
DOC_CYCLIN_RxL_1	42	53	PF00134	0.522
DOC_CYCLIN_RxL_1	82	94	PF00134	0.432
DOC_MAPK_gen_1	15	22	PF00069	0.494
DOC_MAPK_gen_1	316	324	PF00069	0.574
DOC_MAPK_gen_1	59	69	PF00069	0.592
DOC_PP2B_LxvP_1	150	153	PF13499	0.563
DOC_USP7_MATH_1	194	198	PF00917	0.781
DOC_USP7_UBL2_3	239	243	PF12436	0.650
DOC_WW_Pin1_4	104	109	PF00397	0.479
DOC_WW_Pin1_4	142	147	PF00397	0.495
DOC_WW_Pin1_4	176	181	PF00397	0.691
DOC_WW_Pin1_4	50	55	PF00397	0.560
LIG_14-3-3_CanoR_1	308	315	PF00244	0.580
LIG_eIF4E_1	85	91	PF01652	0.430
LIG_FHA_1	154	160	PF00498	0.521
LIG_FHA_1	180	186	PF00498	0.683
LIG_FHA_1	250	256	PF00498	0.458
LIG_FHA_1	325	331	PF00498	0.351
LIG_FHA_2	111	117	PF00498	0.465
LIG_FHA_2	143	149	PF00498	0.547
LIG_FHA_2	249	255	PF00498	0.399
LIG_LIR_Gen_1	273	284	PF02991	0.482
LIG_LIR_Gen_1	4	13	PF02991	0.584
LIG_LIR_Gen_1	74	83	PF02991	0.469
LIG_LIR_Gen_1	96	106	PF02991	0.422
LIG_LIR_Nem_3	273	279	PF02991	0.465
LIG_LIR_Nem_3	36	42	PF02991	0.500
LIG_LIR_Nem_3	4	9	PF02991	0.589
LIG_LIR_Nem_3	74	78	PF02991	0.457
LIG_REV1ctd_RIR_1	138	145	PF16727	0.581
LIG_SH2_CRK	6	10	PF00017	0.590
LIG_SH2_CRK	85	89	PF00017	0.430
LIG_SH2_NCK_1	333	337	PF00017	0.503
LIG_SH2_SRC	341	344	PF00017	0.499
LIG_SH2_STAP1	341	345	PF00017	0.580
LIG_SH2_STAP1	6	10	PF00017	0.590
LIG_SH2_STAT5	144	147	PF00017	0.608
LIG_SH3_3	105	111	PF00018	0.598
LIG_SH3_3	55	61	PF00018	0.602
LIG_SH3_3	7	13	PF00018	0.627
LIG_TRAF2_1	146	149	PF00917	0.620
LIG_TRFH_1	85	89	PF08558	0.430
LIG_WRC_WIRS_1	72	77	PF05994	0.574
MOD_CDK_SPK_2	142	147	PF00069	0.380
MOD_CK1_1	107	113	PF00069	0.482
MOD_CK1_1	197	203	PF00069	0.730
MOD_CK1_1	5	11	PF00069	0.636
MOD_CK2_1	142	148	PF00069	0.474
MOD_CK2_1	198	204	PF00069	0.605
MOD_CK2_1	288	294	PF00069	0.564
MOD_CK2_1	334	340	PF00069	0.509
MOD_CK2_1	90	96	PF00069	0.481
MOD_Cter_Amidation	205	208	PF01082	0.739
MOD_GlcNHglycan	153	156	PF01048	0.558
MOD_GlcNHglycan	204	207	PF01048	0.768
MOD_GlcNHglycan	209	212	PF01048	0.758
MOD_GlcNHglycan	282	285	PF01048	0.463
MOD_GSK3_1	175	182	PF00069	0.638
MOD_GSK3_1	183	190	PF00069	0.706
MOD_GSK3_1	194	201	PF00069	0.733
MOD_GSK3_1	229	236	PF00069	0.751
MOD_NEK2_1	234	239	PF00069	0.691
MOD_NEK2_1	324	329	PF00069	0.434
MOD_PIKK_1	117	123	PF00454	0.530
MOD_PIKK_1	259	265	PF00454	0.560
MOD_PIKK_1	324	330	PF00454	0.584
MOD_PK_1	288	294	PF00069	0.593
MOD_PKA_1	207	213	PF00069	0.704
MOD_PKA_2	125	131	PF00069	0.524
MOD_PKA_2	2	8	PF00069	0.647
MOD_Plk_2-3	334	340	PF00069	0.509
MOD_Plk_4	5	11	PF00069	0.599
MOD_Plk_4	71	77	PF00069	0.504
MOD_ProDKin_1	104	110	PF00069	0.479
MOD_ProDKin_1	142	148	PF00069	0.499
MOD_ProDKin_1	176	182	PF00069	0.696
MOD_ProDKin_1	50	56	PF00069	0.567
TRG_DiLeu_BaEn_2	293	299	PF01217	0.571
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.426
TRG_ENDOCYTIC_2	276	279	PF00928	0.455
TRG_ENDOCYTIC_2	333	336	PF00928	0.495
TRG_ENDOCYTIC_2	6	9	PF00928	0.588
TRG_ENDOCYTIC_2	72	75	PF00928	0.489
TRG_ENDOCYTIC_2	85	88	PF00928	0.422
TRG_ER_diArg_1	315	318	PF00400	0.616
TRG_ER_diArg_1	42	45	PF00400	0.487
TRG_NLS_MonoExtC_3	238	243	PF00514	0.658
TRG_NLS_MonoExtN_4	239	244	PF00514	0.630
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD57	Leptomonas seymouri	48%	100%
A0A1X0NWC4	Trypanosomatidae	37%	100%
A0A3S7WVX4	Leishmania donovani	94%	100%
A4HYS8	Leishmania infantum	94%	100%
E9AID7	Leishmania braziliensis	80%	100%
E9AUM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%