Putative ATP-dependent RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase, putative

Species:

Leishmania major

UniProt:

Q4QCV9_LEIMA

TriTrypDb:

LmjF.20.0870 , LMJLV39_200014100 , LMJSD75_200013900

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCV9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004386	helicase activity	2	10
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016787	hydrolase activity	2	9
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:0140657	ATP-dependent activity	1	10
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.583
CLV_C14_Caspase3-7	174	178	PF00656	0.669
CLV_C14_Caspase3-7	180	184	PF00656	0.618
CLV_C14_Caspase3-7	449	453	PF00656	0.656
CLV_MEL_PAP_1	148	154	PF00089	0.665
CLV_NRD_NRD_1	145	147	PF00675	0.513
CLV_NRD_NRD_1	270	272	PF00675	0.364
CLV_NRD_NRD_1	366	368	PF00675	0.593
CLV_NRD_NRD_1	434	436	PF00675	0.552
CLV_NRD_NRD_1	443	445	PF00675	0.530
CLV_NRD_NRD_1	531	533	PF00675	0.268
CLV_NRD_NRD_1	689	691	PF00675	0.587
CLV_NRD_NRD_1	739	741	PF00675	0.648
CLV_PCSK_KEX2_1	145	147	PF00082	0.513
CLV_PCSK_KEX2_1	270	272	PF00082	0.349
CLV_PCSK_KEX2_1	436	438	PF00082	0.589
CLV_PCSK_KEX2_1	443	445	PF00082	0.564
CLV_PCSK_KEX2_1	530	532	PF00082	0.261
CLV_PCSK_KEX2_1	621	623	PF00082	0.525
CLV_PCSK_KEX2_1	689	691	PF00082	0.574
CLV_PCSK_KEX2_1	741	743	PF00082	0.654
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.578
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.548
CLV_PCSK_PC1ET2_1	741	743	PF00082	0.654
CLV_PCSK_PC7_1	141	147	PF00082	0.572
CLV_PCSK_SKI1_1	146	150	PF00082	0.483
CLV_PCSK_SKI1_1	531	535	PF00082	0.275
CLV_PCSK_SKI1_1	625	629	PF00082	0.509
CLV_PCSK_SKI1_1	637	641	PF00082	0.472
CLV_PCSK_SKI1_1	73	77	PF00082	0.331
CLV_Separin_Metazoa	142	146	PF03568	0.562
DOC_CKS1_1	213	218	PF01111	0.461
DOC_CKS1_1	722	727	PF01111	0.686
DOC_CYCLIN_RxL_1	221	233	PF00134	0.541
DOC_CYCLIN_RxL_1	529	538	PF00134	0.491
DOC_CYCLIN_RxL_1	621	630	PF00134	0.457
DOC_CYCLIN_RxL_1	85	95	PF00134	0.493
DOC_MAPK_DCC_7	23	33	PF00069	0.531
DOC_MAPK_gen_1	227	236	PF00069	0.541
DOC_MAPK_gen_1	343	352	PF00069	0.616
DOC_MAPK_gen_1	592	601	PF00069	0.552
DOC_MAPK_MEF2A_6	204	213	PF00069	0.564
DOC_MAPK_MEF2A_6	230	238	PF00069	0.541
DOC_MAPK_MEF2A_6	414	421	PF00069	0.357
DOC_MAPK_MEF2A_6	595	603	PF00069	0.424
DOC_PP2B_LxvP_1	55	58	PF13499	0.461
DOC_PP4_FxxP_1	291	294	PF00568	0.425
DOC_PP4_FxxP_1	396	399	PF00568	0.403
DOC_USP7_MATH_1	166	170	PF00917	0.780
DOC_USP7_MATH_1	286	290	PF00917	0.522
DOC_USP7_MATH_1	294	298	PF00917	0.511
DOC_USP7_MATH_1	385	389	PF00917	0.579
DOC_USP7_MATH_1	424	428	PF00917	0.511
DOC_USP7_MATH_1	44	48	PF00917	0.508
DOC_USP7_MATH_1	450	454	PF00917	0.585
DOC_USP7_MATH_1	476	480	PF00917	0.662
DOC_USP7_MATH_1	513	517	PF00917	0.564
DOC_USP7_MATH_1	548	552	PF00917	0.531
DOC_USP7_MATH_1	58	62	PF00917	0.399
DOC_USP7_MATH_1	644	648	PF00917	0.592
DOC_USP7_MATH_1	650	654	PF00917	0.699
DOC_USP7_MATH_1	703	707	PF00917	0.534
DOC_USP7_MATH_1	710	714	PF00917	0.649
DOC_USP7_MATH_1	729	733	PF00917	0.678
DOC_USP7_MATH_1	757	761	PF00917	0.629
DOC_USP7_MATH_2	576	582	PF00917	0.541
DOC_WW_Pin1_4	212	217	PF00397	0.461
DOC_WW_Pin1_4	290	295	PF00397	0.514
DOC_WW_Pin1_4	302	307	PF00397	0.472
DOC_WW_Pin1_4	721	726	PF00397	0.690
LIG_14-3-3_CanoR_1	197	206	PF00244	0.591
LIG_14-3-3_CanoR_1	23	28	PF00244	0.527
LIG_14-3-3_CanoR_1	230	235	PF00244	0.564
LIG_14-3-3_CanoR_1	353	358	PF00244	0.454
LIG_14-3-3_CanoR_1	435	445	PF00244	0.558
LIG_14-3-3_CanoR_1	586	596	PF00244	0.461
LIG_14-3-3_CanoR_1	622	628	PF00244	0.510
LIG_14-3-3_CanoR_1	631	636	PF00244	0.559
LIG_14-3-3_CanoR_1	689	695	PF00244	0.542
LIG_14-3-3_CanoR_1	716	725	PF00244	0.745
LIG_14-3-3_CanoR_1	73	82	PF00244	0.531
LIG_Actin_WH2_2	216	232	PF00022	0.541
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BRCT_BRCA1_1	287	291	PF00533	0.509
LIG_CaM_NSCaTE_8	691	698	PF13499	0.562
LIG_Clathr_ClatBox_1	236	240	PF01394	0.491
LIG_deltaCOP1_diTrp_1	670	679	PF00928	0.533
LIG_DLG_GKlike_1	230	237	PF00625	0.509
LIG_DLG_GKlike_1	353	360	PF00625	0.522
LIG_eIF4E_1	413	419	PF01652	0.376
LIG_FHA_1	224	230	PF00498	0.478
LIG_FHA_1	282	288	PF00498	0.540
LIG_FHA_1	489	495	PF00498	0.514
LIG_FHA_1	628	634	PF00498	0.487
LIG_FHA_1	717	723	PF00498	0.520
LIG_FHA_1	93	99	PF00498	0.467
LIG_FHA_2	129	135	PF00498	0.654
LIG_FHA_2	399	405	PF00498	0.467
LIG_FHA_2	4	10	PF00498	0.527
LIG_FHA_2	447	453	PF00498	0.443
LIG_FHA_2	473	479	PF00498	0.672
LIG_FHA_2	497	503	PF00498	0.484
LIG_FHA_2	660	666	PF00498	0.464
LIG_LIR_Apic_2	26	30	PF02991	0.597
LIG_LIR_Apic_2	288	294	PF02991	0.425
LIG_LIR_Apic_2	394	399	PF02991	0.455
LIG_LIR_Apic_2	64	70	PF02991	0.449
LIG_LIR_Gen_1	520	528	PF02991	0.477
LIG_LIR_Nem_3	356	360	PF02991	0.516
LIG_LIR_Nem_3	479	485	PF02991	0.628
LIG_LIR_Nem_3	520	524	PF02991	0.477
LIG_LIR_Nem_3	636	642	PF02991	0.450
LIG_LYPXL_yS_3	482	485	PF13949	0.584
LIG_NRP_CendR_1	765	768	PF00754	0.636
LIG_PCNA_yPIPBox_3	270	283	PF02747	0.547
LIG_PTB_Apo_2	351	358	PF02174	0.522
LIG_PTB_Phospho_1	351	357	PF10480	0.525
LIG_REV1ctd_RIR_1	637	645	PF16727	0.587
LIG_RPA_C_Fungi	423	435	PF08784	0.563
LIG_RPA_C_Fungi	439	451	PF08784	0.516
LIG_RPA_C_Fungi	499	511	PF08784	0.426
LIG_SH2_CRK	620	624	PF00017	0.535
LIG_SH2_SRC	67	70	PF00017	0.459
LIG_SH2_STAP1	261	265	PF00017	0.426
LIG_SH2_STAT5	205	208	PF00017	0.421
LIG_SH2_STAT5	358	361	PF00017	0.522
LIG_SH2_STAT5	583	586	PF00017	0.330
LIG_SH2_STAT5	67	70	PF00017	0.314
LIG_SH3_3	144	150	PF00018	0.557
LIG_SH3_3	210	216	PF00018	0.357
LIG_SUMO_SIM_anti_2	207	215	PF11976	0.387
LIG_SUMO_SIM_par_1	235	241	PF11976	0.333
LIG_SUMO_SIM_par_1	89	95	PF11976	0.314
LIG_TRAF2_1	401	404	PF00917	0.491
LIG_TRAF2_1	499	502	PF00917	0.357
LIG_TRAF2_1	662	665	PF00917	0.682
LIG_TRFH_1	396	400	PF08558	0.403
MOD_CDK_SPxK_1	212	218	PF00069	0.314
MOD_CDK_SPxK_1	721	727	PF00069	0.685
MOD_CK1_1	295	301	PF00069	0.386
MOD_CK1_1	3	9	PF00069	0.537
MOD_CK1_1	477	483	PF00069	0.539
MOD_CK1_1	61	67	PF00069	0.318
MOD_CK1_1	649	655	PF00069	0.650
MOD_CK1_1	706	712	PF00069	0.559
MOD_CK1_1	745	751	PF00069	0.690
MOD_CK1_1	760	766	PF00069	0.640
MOD_CK2_1	130	136	PF00069	0.576
MOD_CK2_1	162	168	PF00069	0.716
MOD_CK2_1	290	296	PF00069	0.439
MOD_CK2_1	359	365	PF00069	0.525
MOD_CK2_1	398	404	PF00069	0.471
MOD_CK2_1	472	478	PF00069	0.625
MOD_CK2_1	496	502	PF00069	0.333
MOD_CK2_1	514	520	PF00069	0.426
MOD_CK2_1	523	529	PF00069	0.314
MOD_CK2_1	659	665	PF00069	0.475
MOD_CK2_1	690	696	PF00069	0.510
MOD_CK2_1	729	735	PF00069	0.718
MOD_Cter_Amidation	738	741	PF01082	0.760
MOD_GlcNHglycan	158	161	PF01048	0.740
MOD_GlcNHglycan	164	167	PF01048	0.693
MOD_GlcNHglycan	299	302	PF01048	0.375
MOD_GlcNHglycan	318	321	PF01048	0.403
MOD_GlcNHglycan	336	339	PF01048	0.228
MOD_GlcNHglycan	387	390	PF01048	0.601
MOD_GlcNHglycan	438	441	PF01048	0.525
MOD_GlcNHglycan	452	455	PF01048	0.579
MOD_GlcNHglycan	46	49	PF01048	0.322
MOD_GlcNHglycan	60	63	PF01048	0.291
MOD_GlcNHglycan	608	611	PF01048	0.503
MOD_GlcNHglycan	646	649	PF01048	0.613
MOD_GlcNHglycan	652	655	PF01048	0.662
MOD_GlcNHglycan	667	670	PF01048	0.556
MOD_GlcNHglycan	696	699	PF01048	0.520
MOD_GlcNHglycan	759	762	PF01048	0.752
MOD_GSK3_1	107	114	PF00069	0.314
MOD_GSK3_1	152	159	PF00069	0.687
MOD_GSK3_1	162	169	PF00069	0.682
MOD_GSK3_1	195	202	PF00069	0.550
MOD_GSK3_1	281	288	PF00069	0.401
MOD_GSK3_1	290	297	PF00069	0.371
MOD_GSK3_1	334	341	PF00069	0.321
MOD_GSK3_1	446	453	PF00069	0.489
MOD_GSK3_1	472	479	PF00069	0.628
MOD_GSK3_1	519	526	PF00069	0.322
MOD_GSK3_1	623	630	PF00069	0.454
MOD_GSK3_1	646	653	PF00069	0.587
MOD_GSK3_1	690	697	PF00069	0.518
MOD_GSK3_1	706	713	PF00069	0.595
MOD_GSK3_1	716	723	PF00069	0.636
MOD_N-GLC_1	199	204	PF02516	0.623
MOD_N-GLC_1	353	358	PF02516	0.523
MOD_NEK2_1	223	228	PF00069	0.421
MOD_NEK2_1	372	377	PF00069	0.731
MOD_NEK2_1	601	606	PF00069	0.509
MOD_NEK2_1	623	628	PF00069	0.528
MOD_NEK2_1	680	685	PF00069	0.460
MOD_NEK2_1	734	739	PF00069	0.607
MOD_NEK2_1	75	80	PF00069	0.326
MOD_OFUCOSY	280	285	PF10250	0.264
MOD_PIKK_1	249	255	PF00454	0.403
MOD_PIKK_1	372	378	PF00454	0.768
MOD_PIKK_1	391	397	PF00454	0.646
MOD_PIKK_1	578	584	PF00454	0.378
MOD_PIKK_1	680	686	PF00454	0.464
MOD_PIKK_1	729	735	PF00454	0.700
MOD_PIKK_1	92	98	PF00454	0.371
MOD_PK_1	111	117	PF00069	0.387
MOD_PK_1	690	696	PF00069	0.602
MOD_PK_1	742	748	PF00069	0.760
MOD_PKA_1	436	442	PF00069	0.530
MOD_PKA_1	621	627	PF00069	0.538
MOD_PKA_2	107	113	PF00069	0.303
MOD_PKA_2	128	134	PF00069	0.672
MOD_PKA_2	198	204	PF00069	0.571
MOD_PKA_2	345	351	PF00069	0.460
MOD_PKA_2	436	442	PF00069	0.567
MOD_PKA_2	621	627	PF00069	0.538
MOD_PKA_2	715	721	PF00069	0.681
MOD_PKB_1	197	205	PF00069	0.567
MOD_PKB_1	629	637	PF00069	0.342
MOD_PKB_1	740	748	PF00069	0.725
MOD_Plk_1	199	205	PF00069	0.412
MOD_Plk_1	295	301	PF00069	0.432
MOD_Plk_1	353	359	PF00069	0.495
MOD_Plk_1	409	415	PF00069	0.541
MOD_Plk_1	477	483	PF00069	0.538
MOD_Plk_1	51	57	PF00069	0.426
MOD_Plk_1	519	525	PF00069	0.319
MOD_Plk_1	548	554	PF00069	0.352
MOD_Plk_1	729	735	PF00069	0.681
MOD_Plk_1	742	748	PF00069	0.760
MOD_Plk_4	353	359	PF00069	0.521
MOD_Plk_4	37	43	PF00069	0.459
MOD_Plk_4	514	520	PF00069	0.426
MOD_Plk_4	690	696	PF00069	0.602
MOD_ProDKin_1	212	218	PF00069	0.314
MOD_ProDKin_1	290	296	PF00069	0.389
MOD_ProDKin_1	302	308	PF00069	0.330
MOD_ProDKin_1	721	727	PF00069	0.689
TRG_DiLeu_BaEn_1	139	144	PF01217	0.459
TRG_DiLeu_BaEn_2	403	409	PF01217	0.392
TRG_DiLeu_BaEn_3	170	176	PF01217	0.687
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.314
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.128
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.380
TRG_ENDOCYTIC_2	357	360	PF00928	0.517
TRG_ENDOCYTIC_2	482	485	PF00928	0.584
TRG_ENDOCYTIC_2	620	623	PF00928	0.537
TRG_ER_diArg_1	144	146	PF00400	0.496
TRG_ER_diArg_1	425	428	PF00400	0.537
TRG_ER_diArg_1	443	445	PF00400	0.554
TRG_ER_diArg_1	530	532	PF00400	0.315
TRG_ER_diArg_1	628	631	PF00400	0.543
TRG_ER_diArg_1	689	691	PF00400	0.608
TRG_ER_diArg_1	766	768	PF00400	0.614
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.314
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	443	448	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKF6	Leptomonas seymouri	65%	100%
A0A0S4JIC9	Bodo saltans	37%	100%
A0A3R7NJH7	Trypanosoma rangeli	44%	100%
A0A3S7WVZ5	Leishmania donovani	92%	100%
A4HYS9	Leishmania infantum	92%	100%
A4QX49	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	22%	93%
C9ZIA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AID8	Leishmania braziliensis	79%	97%
E9AUM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q6BKH3	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	21%	96%
V5DS01	Trypanosoma cruzi	43%	100%