Transcription elongation factor 1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription elongation factor 1 homolog

Species:

Leishmania major

UniProt:

Q4QCV8_LEIMA

TriTrypDb:

LmjF.20.0880 , LMJLV39_200014200 , LMJSD75_200014000

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0008023	transcription elongation factor complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	7
GO:0140513	nuclear protein-containing complex	2	2
GO:0005634	nucleus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5

Expansion

Sequence features

Q4QCV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCV8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006354	DNA-templated transcription elongation	6	2
GO:0006368	transcription elongation by RNA polymerase II	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0032774	RNA biosynthetic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000993	RNA polymerase II complex binding	5	2
GO:0001098	basal transcription machinery binding	3	2
GO:0001099	basal RNA polymerase II transcription machinery binding	4	2
GO:0005488	binding	1	7
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0043175	RNA polymerase core enzyme binding	5	2
GO:0046872	metal ion binding	4	7
GO:0070063	RNA polymerase binding	4	2
GO:0003676	nucleic acid binding	3	1
GO:0003746	translation elongation factor activity	4	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.567
CLV_NRD_NRD_1	4	6	PF00675	0.339
CLV_PCSK_KEX2_1	4	6	PF00082	0.339
CLV_PCSK_KEX2_1	60	62	PF00082	0.335
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.335
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.335
CLV_PCSK_SKI1_1	161	165	PF00082	0.660
DOC_CYCLIN_yCln2_LP_2	67	73	PF00134	0.335
DOC_MAPK_gen_1	60	67	PF00069	0.335
DOC_MAPK_MEF2A_6	33	40	PF00069	0.354
DOC_MAPK_MEF2A_6	66	75	PF00069	0.335
DOC_PP2B_LxvP_1	163	166	PF13499	0.689
DOC_PP4_FxxP_1	25	28	PF00568	0.354
DOC_USP7_MATH_1	142	146	PF00917	0.606
DOC_USP7_MATH_1	175	179	PF00917	0.567
DOC_USP7_MATH_1	32	36	PF00917	0.262
DOC_USP7_UBL2_3	14	18	PF12436	0.335
DOC_WW_Pin1_4	119	124	PF00397	0.637
LIG_14-3-3_CanoR_1	161	166	PF00244	0.628
LIG_14-3-3_CanoR_1	42	49	PF00244	0.349
LIG_14-3-3_CanoR_1	99	103	PF00244	0.483
LIG_FHA_2	21	27	PF00498	0.335
LIG_LIR_Apic_2	16	22	PF02991	0.347
LIG_LIR_Apic_2	23	28	PF02991	0.361
LIG_LIR_Gen_1	212	219	PF02991	0.573
LIG_LIR_Gen_1	59	70	PF02991	0.453
LIG_LIR_Nem_3	212	218	PF02991	0.575
LIG_LIR_Nem_3	59	65	PF02991	0.504
LIG_LIR_Nem_3	72	77	PF02991	0.337
LIG_REV1ctd_RIR_1	72	80	PF16727	0.354
LIG_RPA_C_Fungi	128	140	PF08784	0.629
LIG_SH2_CRK	19	23	PF00017	0.335
LIG_SH2_CRK	215	219	PF00017	0.566
LIG_SH2_STAP1	215	219	PF00017	0.684
LIG_SH2_STAT5	198	201	PF00017	0.585
LIG_SH3_3	99	105	PF00018	0.616
LIG_TRAF2_1	201	204	PF00917	0.714
MOD_CK1_1	112	118	PF00069	0.595
MOD_CK1_1	145	151	PF00069	0.685
MOD_CK1_1	45	51	PF00069	0.429
MOD_CK2_1	152	158	PF00069	0.575
MOD_Cter_Amidation	2	5	PF01082	0.335
MOD_GlcNHglycan	136	139	PF01048	0.597
MOD_GlcNHglycan	144	147	PF01048	0.643
MOD_GlcNHglycan	168	171	PF01048	0.540
MOD_GlcNHglycan	206	209	PF01048	0.581
MOD_GSK3_1	166	173	PF00069	0.536
MOD_GSK3_1	41	48	PF00069	0.346
MOD_NEK2_1	109	114	PF00069	0.580
MOD_NEK2_1	134	139	PF00069	0.689
MOD_PIKK_1	109	115	PF00454	0.572
MOD_PIKK_1	147	153	PF00454	0.644
MOD_PKA_1	14	20	PF00069	0.335
MOD_PKA_1	161	167	PF00069	0.688
MOD_PKA_1	5	11	PF00069	0.335
MOD_PKA_2	41	47	PF00069	0.349
MOD_PKA_2	98	104	PF00069	0.515
MOD_Plk_1	45	51	PF00069	0.335
MOD_Plk_4	32	38	PF00069	0.335
MOD_ProDKin_1	119	125	PF00069	0.639
MOD_SUMO_for_1	13	16	PF00179	0.335
MOD_SUMO_rev_2	26	35	PF00179	0.354
TRG_ENDOCYTIC_2	215	218	PF00928	0.567
TRG_NLS_MonoCore_2	3	8	PF00514	0.335
TRG_NLS_MonoExtN_4	4	9	PF00514	0.335
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWX8	Leptomonas seymouri	62%	94%
A0A3Q8IBQ8	Leishmania donovani	94%	100%
A4HYT0	Leishmania infantum	94%	100%
E9AID9	Leishmania braziliensis	83%	100%
E9AUM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%