Transcription elongation factor 1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transcription elongation factor 1 domain-containing protein

Species:

Leishmania major

UniProt:

Q4QCV7_LEIMA

TriTrypDb:

LmjF.20.0890 , LMJLV39_200014300 , LMJSD75_200014100

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	6
GO:0005634	nucleus	5	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4

Expansion

Sequence features

Q4QCV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCV7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003746	translation elongation factor activity	4	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.631
CLV_C14_Caspase3-7	269	273	PF00656	0.568
CLV_NRD_NRD_1	11	13	PF00675	0.673
CLV_NRD_NRD_1	154	156	PF00675	0.659
CLV_NRD_NRD_1	17	19	PF00675	0.588
CLV_NRD_NRD_1	44	46	PF00675	0.606
CLV_PCSK_KEX2_1	11	13	PF00082	0.673
CLV_PCSK_KEX2_1	156	158	PF00082	0.670
CLV_PCSK_KEX2_1	44	46	PF00082	0.618
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.670
DOC_CKS1_1	232	237	PF01111	0.700
DOC_MAPK_MEF2A_6	69	76	PF00069	0.385
DOC_PP4_FxxP_1	61	64	PF00568	0.385
DOC_USP7_MATH_1	101	105	PF00917	0.385
DOC_USP7_UBL2_3	156	160	PF12436	0.652
DOC_WW_Pin1_4	231	236	PF00397	0.826
LIG_14-3-3_CanoR_1	73	77	PF00244	0.385
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_BIR_III_2	223	227	PF00653	0.632
LIG_FHA_1	2	8	PF00498	0.628
LIG_FHA_1	202	208	PF00498	0.676
LIG_FHA_1	50	56	PF00498	0.562
LIG_FHA_1	69	75	PF00498	0.250
LIG_FHA_2	218	224	PF00498	0.631
LIG_HCF-1_HBM_1	38	41	PF13415	0.633
LIG_LIR_Apic_2	60	64	PF02991	0.385
LIG_LIR_Gen_1	124	130	PF02991	0.495
LIG_LIR_Gen_1	247	257	PF02991	0.709
LIG_LIR_Nem_3	117	122	PF02991	0.218
LIG_LIR_Nem_3	124	129	PF02991	0.425
LIG_LIR_Nem_3	247	253	PF02991	0.797
LIG_LIR_Nem_3	99	105	PF02991	0.385
LIG_LYPXL_yS_3	102	105	PF13949	0.385
LIG_MYND_3	109	113	PF01753	0.385
LIG_REV1ctd_RIR_1	117	125	PF16727	0.385
LIG_SH2_CRK	126	130	PF00017	0.448
LIG_SH2_STAP1	126	130	PF00017	0.491
LIG_SH2_STAT5	89	92	PF00017	0.385
LIG_SH3_3	223	229	PF00018	0.678
LIG_SH3_3	232	238	PF00018	0.635
LIG_SH3_3	4	10	PF00018	0.627
LIG_SH3_3	92	98	PF00018	0.342
LIG_TYR_ITIM	100	105	PF00017	0.385
LIG_WRC_WIRS_1	58	63	PF05994	0.385
LIG_WW_3	236	240	PF00397	0.666
MOD_CDC14_SPxK_1	236	239	PF00782	0.666
MOD_CDK_SPxK_1	233	239	PF00069	0.674
MOD_CK1_1	14	20	PF00069	0.568
MOD_CK1_1	233	239	PF00069	0.827
MOD_CK1_1	27	33	PF00069	0.643
MOD_CK1_1	68	74	PF00069	0.385
MOD_CK2_1	173	179	PF00069	0.607
MOD_GlcNHglycan	164	167	PF01048	0.662
MOD_GSK3_1	138	145	PF00069	0.628
MOD_GSK3_1	147	154	PF00069	0.582
MOD_GSK3_1	24	31	PF00069	0.683
MOD_GSK3_1	68	75	PF00069	0.385
MOD_GSK3_1	81	88	PF00069	0.264
MOD_NEK2_2	89	94	PF00069	0.385
MOD_PKA_1	11	17	PF00069	0.537
MOD_PKA_2	11	17	PF00069	0.537
MOD_PKA_2	72	78	PF00069	0.372
MOD_Plk_1	37	43	PF00069	0.621
MOD_ProDKin_1	231	237	PF00069	0.823
MOD_SUMO_rev_2	62	71	PF00179	0.320
TRG_ENDOCYTIC_2	102	105	PF00928	0.442
TRG_ENDOCYTIC_2	126	129	PF00928	0.576
TRG_ER_diArg_1	10	12	PF00400	0.661
TRG_ER_diArg_1	44	46	PF00400	0.618
TRG_NLS_MonoExtC_3	17	23	PF00514	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBM0	Leishmania donovani	89%	100%
A4HYT1	Leishmania infantum	90%	100%
E9AIE0	Leishmania braziliensis	69%	100%
E9AUM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%