Putative nuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative nuclease

Gene product:

RNA-editing nuclease 1

Species:

Leishmania major

UniProt:

Q4QCV6_LEIMA

TriTrypDb:

LmjF.20.0900 , LMJLV39_200014400 , LMJSD75_200014200

Length:

890

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCV6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004521	RNA endonuclease activity	5	7
GO:0004525	ribonuclease III activity	6	7
GO:0004540	RNA nuclease activity	4	7
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	7
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	7
GO:0032296	double-stranded RNA-specific ribonuclease activity	5	7
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2
GO:0140098	catalytic activity, acting on RNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	515	519	PF00656	0.693
CLV_C14_Caspase3-7	89	93	PF00656	0.607
CLV_NRD_NRD_1	254	256	PF00675	0.484
CLV_NRD_NRD_1	3	5	PF00675	0.804
CLV_NRD_NRD_1	688	690	PF00675	0.703
CLV_NRD_NRD_1	870	872	PF00675	0.595
CLV_PCSK_FUR_1	252	256	PF00082	0.493
CLV_PCSK_KEX2_1	213	215	PF00082	0.390
CLV_PCSK_KEX2_1	226	228	PF00082	0.437
CLV_PCSK_KEX2_1	254	256	PF00082	0.487
CLV_PCSK_KEX2_1	3	5	PF00082	0.804
CLV_PCSK_KEX2_1	411	413	PF00082	0.569
CLV_PCSK_KEX2_1	425	427	PF00082	0.550
CLV_PCSK_KEX2_1	688	690	PF00082	0.703
CLV_PCSK_KEX2_1	869	871	PF00082	0.590
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.390
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.437
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.569
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.550
CLV_PCSK_PC7_1	250	256	PF00082	0.524
CLV_PCSK_SKI1_1	202	206	PF00082	0.564
CLV_PCSK_SKI1_1	223	227	PF00082	0.533
CLV_PCSK_SKI1_1	255	259	PF00082	0.578
CLV_PCSK_SKI1_1	276	280	PF00082	0.504
CLV_PCSK_SKI1_1	457	461	PF00082	0.675
CLV_PCSK_SKI1_1	586	590	PF00082	0.711
CLV_PCSK_SKI1_1	688	692	PF00082	0.593
CLV_PCSK_SKI1_1	702	706	PF00082	0.569
CLV_PCSK_SKI1_1	793	797	PF00082	0.580
DEG_APCC_DBOX_1	687	695	PF00400	0.586
DEG_APCC_DBOX_1	701	709	PF00400	0.576
DEG_SCF_FBW7_1	742	749	PF00400	0.783
DEG_SPOP_SBC_1	66	70	PF00917	0.715
DOC_ANK_TNKS_1	771	778	PF00023	0.609
DOC_CDC14_PxL_1	351	359	PF14671	0.684
DOC_CDC14_PxL_1	581	589	PF14671	0.598
DOC_CKS1_1	561	566	PF01111	0.653
DOC_CKS1_1	823	828	PF01111	0.593
DOC_CYCLIN_RxL_1	597	608	PF00134	0.651
DOC_MAPK_FxFP_2	50	53	PF00069	0.640
DOC_MAPK_gen_1	213	220	PF00069	0.357
DOC_MAPK_gen_1	223	233	PF00069	0.474
DOC_MAPK_gen_1	250	258	PF00069	0.597
DOC_MAPK_gen_1	549	557	PF00069	0.671
DOC_MAPK_MEF2A_6	213	222	PF00069	0.338
DOC_MAPK_MEF2A_6	226	235	PF00069	0.507
DOC_MAPK_MEF2A_6	299	308	PF00069	0.396
DOC_PP1_RVXF_1	252	259	PF00149	0.595
DOC_PP1_RVXF_1	30	36	PF00149	0.754
DOC_PP4_FxxP_1	193	196	PF00568	0.476
DOC_PP4_FxxP_1	35	38	PF00568	0.707
DOC_PP4_FxxP_1	420	423	PF00568	0.707
DOC_PP4_FxxP_1	467	470	PF00568	0.579
DOC_PP4_FxxP_1	50	53	PF00568	0.438
DOC_PP4_FxxP_1	561	564	PF00568	0.655
DOC_PP4_FxxP_1	588	591	PF00568	0.597
DOC_USP7_MATH_1	13	17	PF00917	0.763
DOC_USP7_MATH_1	38	42	PF00917	0.596
DOC_USP7_MATH_1	443	447	PF00917	0.749
DOC_USP7_MATH_1	477	481	PF00917	0.753
DOC_USP7_MATH_1	524	528	PF00917	0.720
DOC_USP7_MATH_1	609	613	PF00917	0.576
DOC_USP7_MATH_1	64	68	PF00917	0.704
DOC_USP7_MATH_1	716	720	PF00917	0.692
DOC_USP7_MATH_1	744	748	PF00917	0.629
DOC_USP7_MATH_1	833	837	PF00917	0.724
DOC_USP7_MATH_1	841	845	PF00917	0.670
DOC_USP7_MATH_1	850	854	PF00917	0.576
DOC_WW_Pin1_4	2	7	PF00397	0.697
DOC_WW_Pin1_4	488	493	PF00397	0.740
DOC_WW_Pin1_4	555	560	PF00397	0.627
DOC_WW_Pin1_4	646	651	PF00397	0.687
DOC_WW_Pin1_4	711	716	PF00397	0.626
DOC_WW_Pin1_4	721	726	PF00397	0.665
DOC_WW_Pin1_4	742	747	PF00397	0.691
DOC_WW_Pin1_4	819	824	PF00397	0.692
DOC_WW_Pin1_4	846	851	PF00397	0.769
LIG_14-3-3_CanoR_1	147	153	PF00244	0.635
LIG_14-3-3_CanoR_1	157	162	PF00244	0.456
LIG_14-3-3_CanoR_1	200	205	PF00244	0.434
LIG_14-3-3_CanoR_1	291	296	PF00244	0.550
LIG_14-3-3_CanoR_1	586	591	PF00244	0.714
LIG_14-3-3_CanoR_1	626	632	PF00244	0.516
LIG_14-3-3_CanoR_1	689	695	PF00244	0.664
LIG_14-3-3_CanoR_1	763	769	PF00244	0.708
LIG_14-3-3_CanoR_1	812	821	PF00244	0.548
LIG_14-3-3_CanoR_1	869	876	PF00244	0.622
LIG_Actin_WH2_2	378	394	PF00022	0.482
LIG_APCC_ABBA_1	278	283	PF00400	0.413
LIG_BRCT_BRCA1_1	128	132	PF00533	0.613
LIG_BRCT_BRCA1_1	557	561	PF00533	0.729
LIG_BRCT_BRCA1_1	620	624	PF00533	0.619
LIG_CtBP_PxDLS_1	564	568	PF00389	0.651
LIG_EH1_1	178	186	PF00400	0.402
LIG_eIF4E_1	631	637	PF01652	0.518
LIG_eIF4E_2	773	779	PF01652	0.612
LIG_EVH1_2	8	12	PF00568	0.760
LIG_FHA_1	101	107	PF00498	0.788
LIG_FHA_1	111	117	PF00498	0.627
LIG_FHA_1	168	174	PF00498	0.405
LIG_FHA_1	292	298	PF00498	0.540
LIG_FHA_1	312	318	PF00498	0.239
LIG_FHA_1	397	403	PF00498	0.586
LIG_FHA_1	576	582	PF00498	0.615
LIG_FHA_1	816	822	PF00498	0.675
LIG_FHA_2	149	155	PF00498	0.652
LIG_FHA_2	481	487	PF00498	0.628
LIG_FHA_2	617	623	PF00498	0.541
LIG_FHA_2	747	753	PF00498	0.774
LIG_FHA_2	812	818	PF00498	0.674
LIG_GBD_Chelix_1	338	346	PF00786	0.489
LIG_LIR_Apic_2	190	196	PF02991	0.409
LIG_LIR_Apic_2	417	423	PF02991	0.689
LIG_LIR_Apic_2	464	470	PF02991	0.579
LIG_LIR_Apic_2	49	53	PF02991	0.642
LIG_LIR_Apic_2	558	564	PF02991	0.658
LIG_LIR_Apic_2	771	776	PF02991	0.601
LIG_LIR_Gen_1	129	140	PF02991	0.453
LIG_LIR_Gen_1	186	196	PF02991	0.521
LIG_LIR_Gen_1	293	301	PF02991	0.415
LIG_LIR_Gen_1	309	320	PF02991	0.458
LIG_LIR_Gen_1	383	394	PF02991	0.360
LIG_LIR_Gen_1	621	631	PF02991	0.498
LIG_LIR_Nem_3	129	135	PF02991	0.454
LIG_LIR_Nem_3	186	191	PF02991	0.516
LIG_LIR_Nem_3	293	298	PF02991	0.420
LIG_LIR_Nem_3	309	315	PF02991	0.451
LIG_LIR_Nem_3	316	321	PF02991	0.427
LIG_LIR_Nem_3	340	346	PF02991	0.489
LIG_LIR_Nem_3	383	389	PF02991	0.370
LIG_LIR_Nem_3	630	634	PF02991	0.559
LIG_NRBOX	316	322	PF00104	0.528
LIG_OCRL_FandH_1	342	354	PF00620	0.536
LIG_Rb_pABgroove_1	380	388	PF01858	0.357
LIG_Rb_pABgroove_1	482	490	PF01858	0.731
LIG_RPA_C_Fungi	390	402	PF08784	0.474
LIG_SH2_CRK	351	355	PF00017	0.598
LIG_SH2_CRK	386	390	PF00017	0.373
LIG_SH2_NCK_1	88	92	PF00017	0.701
LIG_SH2_PTP2	773	776	PF00017	0.719
LIG_SH2_SRC	20	23	PF00017	0.643
LIG_SH2_SRC	773	776	PF00017	0.672
LIG_SH2_SRC	88	91	PF00017	0.700
LIG_SH2_STAP1	386	390	PF00017	0.356
LIG_SH2_STAP1	463	467	PF00017	0.561
LIG_SH2_STAP1	857	861	PF00017	0.609
LIG_SH2_STAT3	281	284	PF00017	0.418
LIG_SH2_STAT5	263	266	PF00017	0.421
LIG_SH2_STAT5	363	366	PF00017	0.639
LIG_SH2_STAT5	463	466	PF00017	0.557
LIG_SH2_STAT5	615	618	PF00017	0.530
LIG_SH2_STAT5	646	649	PF00017	0.572
LIG_SH2_STAT5	700	703	PF00017	0.582
LIG_SH2_STAT5	773	776	PF00017	0.719
LIG_SH3_1	3	9	PF00018	0.783
LIG_SH3_1	579	585	PF00018	0.600
LIG_SH3_3	156	162	PF00018	0.606
LIG_SH3_3	193	199	PF00018	0.425
LIG_SH3_3	3	9	PF00018	0.754
LIG_SH3_3	553	559	PF00018	0.662
LIG_SH3_3	579	585	PF00018	0.600
LIG_SH3_3	595	601	PF00018	0.561
LIG_SH3_3	644	650	PF00018	0.635
LIG_SH3_3	670	676	PF00018	0.658
LIG_SH3_3	709	715	PF00018	0.731
LIG_SH3_3	820	826	PF00018	0.696
LIG_SUMO_SIM_anti_2	169	175	PF11976	0.407
LIG_SUMO_SIM_anti_2	387	392	PF11976	0.360
LIG_SUMO_SIM_anti_2	521	527	PF11976	0.677
LIG_SUMO_SIM_par_1	373	379	PF11976	0.545
LIG_SUMO_SIM_par_1	563	568	PF11976	0.646
LIG_SxIP_EBH_1	603	616	PF03271	0.637
LIG_UBA3_1	221	226	PF00899	0.391
LIG_UBA3_1	388	392	PF00899	0.480
LIG_WW_3	27	31	PF00397	0.763
LIG_WW_3	651	655	PF00397	0.446
MOD_CDK_SPK_2	846	851	PF00069	0.674
MOD_CDK_SPxK_1	648	654	PF00069	0.475
MOD_CDK_SPxK_1	742	748	PF00069	0.719
MOD_CK1_1	148	154	PF00069	0.511
MOD_CK1_1	246	252	PF00069	0.528
MOD_CK1_1	293	299	PF00069	0.532
MOD_CK1_1	480	486	PF00069	0.660
MOD_CK1_1	491	497	PF00069	0.766
MOD_CK1_1	57	63	PF00069	0.605
MOD_CK1_1	67	73	PF00069	0.734
MOD_CK1_1	758	764	PF00069	0.676
MOD_CK1_1	76	82	PF00069	0.590
MOD_CK1_1	822	828	PF00069	0.720
MOD_CK1_1	872	878	PF00069	0.623
MOD_CK1_1	880	886	PF00069	0.625
MOD_CK2_1	832	838	PF00069	0.775
MOD_DYRK1A_RPxSP_1	4	8	PF00069	0.720
MOD_GlcNHglycan	116	119	PF01048	0.663
MOD_GlcNHglycan	330	333	PF01048	0.518
MOD_GlcNHglycan	399	402	PF01048	0.493
MOD_GlcNHglycan	445	448	PF01048	0.664
MOD_GlcNHglycan	449	452	PF01048	0.628
MOD_GlcNHglycan	502	506	PF01048	0.804
MOD_GlcNHglycan	509	512	PF01048	0.651
MOD_GlcNHglycan	528	531	PF01048	0.663
MOD_GlcNHglycan	569	572	PF01048	0.756
MOD_GlcNHglycan	607	610	PF01048	0.567
MOD_GlcNHglycan	683	686	PF01048	0.699
MOD_GlcNHglycan	742	745	PF01048	0.777
MOD_GlcNHglycan	75	78	PF01048	0.713
MOD_GlcNHglycan	759	763	PF01048	0.618
MOD_GlcNHglycan	835	838	PF01048	0.702
MOD_GlcNHglycan	843	846	PF01048	0.674
MOD_GlcNHglycan	852	855	PF01048	0.541
MOD_GlcNHglycan	879	882	PF01048	0.657
MOD_GlcNHglycan	96	99	PF01048	0.682
MOD_GSK3_1	110	117	PF00069	0.690
MOD_GSK3_1	122	129	PF00069	0.725
MOD_GSK3_1	234	241	PF00069	0.489
MOD_GSK3_1	286	293	PF00069	0.538
MOD_GSK3_1	320	327	PF00069	0.548
MOD_GSK3_1	38	45	PF00069	0.600
MOD_GSK3_1	443	450	PF00069	0.760
MOD_GSK3_1	457	464	PF00069	0.718
MOD_GSK3_1	469	476	PF00069	0.586
MOD_GSK3_1	526	533	PF00069	0.787
MOD_GSK3_1	563	570	PF00069	0.675
MOD_GSK3_1	605	612	PF00069	0.637
MOD_GSK3_1	64	71	PF00069	0.746
MOD_GSK3_1	677	684	PF00069	0.580
MOD_GSK3_1	72	79	PF00069	0.646
MOD_GSK3_1	740	747	PF00069	0.591
MOD_GSK3_1	754	761	PF00069	0.660
MOD_GSK3_1	764	771	PF00069	0.685
MOD_GSK3_1	811	818	PF00069	0.708
MOD_GSK3_1	828	835	PF00069	0.556
MOD_GSK3_1	846	853	PF00069	0.744
MOD_GSK3_1	871	878	PF00069	0.608
MOD_GSK3_1	880	887	PF00069	0.655
MOD_LATS_1	326	332	PF00433	0.504
MOD_N-GLC_1	271	276	PF02516	0.512
MOD_N-GLC_1	477	482	PF02516	0.777
MOD_N-GLC_1	57	62	PF02516	0.713
MOD_N-GLC_1	64	69	PF02516	0.703
MOD_N-GLC_2	790	792	PF02516	0.572
MOD_NEK2_1	320	325	PF00069	0.613
MOD_NEK2_1	397	402	PF00069	0.405
MOD_NEK2_1	565	570	PF00069	0.606
MOD_NEK2_1	575	580	PF00069	0.565
MOD_NEK2_1	658	663	PF00069	0.503
MOD_PIKK_1	869	875	PF00454	0.657
MOD_PKA_1	869	875	PF00069	0.585
MOD_PKA_2	136	142	PF00069	0.522
MOD_PKA_2	207	213	PF00069	0.547
MOD_PKA_2	290	296	PF00069	0.562
MOD_PKA_2	811	817	PF00069	0.529
MOD_PKA_2	833	839	PF00069	0.792
MOD_PKA_2	869	875	PF00069	0.664
MOD_PKB_1	155	163	PF00069	0.609
MOD_PKB_1	200	208	PF00069	0.556
MOD_PKB_1	431	439	PF00069	0.773
MOD_PKB_1	869	877	PF00069	0.630
MOD_Plk_1	477	483	PF00069	0.734
MOD_Plk_1	57	63	PF00069	0.548
MOD_Plk_1	884	890	PF00069	0.693
MOD_Plk_4	169	175	PF00069	0.507
MOD_Plk_4	183	189	PF00069	0.308
MOD_Plk_4	658	664	PF00069	0.628
MOD_ProDKin_1	2	8	PF00069	0.693
MOD_ProDKin_1	488	494	PF00069	0.740
MOD_ProDKin_1	555	561	PF00069	0.627
MOD_ProDKin_1	646	652	PF00069	0.684
MOD_ProDKin_1	711	717	PF00069	0.630
MOD_ProDKin_1	721	727	PF00069	0.664
MOD_ProDKin_1	742	748	PF00069	0.783
MOD_ProDKin_1	819	825	PF00069	0.695
MOD_ProDKin_1	846	852	PF00069	0.763
TRG_DiLeu_BaEn_1	169	174	PF01217	0.525
TRG_DiLeu_BaEn_1	316	321	PF01217	0.523
TRG_DiLeu_BaEn_1	384	389	PF01217	0.354
TRG_DiLeu_BaEn_1	632	637	PF01217	0.637
TRG_DiLeu_BaEn_1	686	691	PF01217	0.651
TRG_DiLeu_BaLyEn_6	600	605	PF01217	0.639
TRG_DiLeu_LyEn_5	686	691	PF01217	0.651
TRG_ENDOCYTIC_2	351	354	PF00928	0.589
TRG_ENDOCYTIC_2	386	389	PF00928	0.371
TRG_ENDOCYTIC_2	631	634	PF00928	0.530
TRG_ER_diArg_1	199	202	PF00400	0.550
TRG_ER_diArg_1	251	254	PF00400	0.503
TRG_ER_diArg_1	416	419	PF00400	0.674
TRG_ER_diArg_1	688	690	PF00400	0.703
TRG_ER_diArg_1	868	871	PF00400	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEA0	Leptomonas seymouri	42%	86%
A0A3S7WW37	Leishmania donovani	92%	100%
A4HYT2	Leishmania infantum	93%	100%
E9AIE1	Leishmania braziliensis	75%	95%
E9AUM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%