RAWUL domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCV5_LEIMA

TriTrypDb:

LmjF.20.0910 , LMJLV39_200014500 , LMJSD75_200014300

Length:

283

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.605
CLV_C14_Caspase3-7	259	263	PF00656	0.681
CLV_NRD_NRD_1	75	77	PF00675	0.472
CLV_PCSK_KEX2_1	103	105	PF00082	0.451
CLV_PCSK_KEX2_1	75	77	PF00082	0.472
CLV_PCSK_KEX2_1	84	86	PF00082	0.422
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.365
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.488
CLV_PCSK_SKI1_1	81	85	PF00082	0.469
DEG_APCC_DBOX_1	84	92	PF00400	0.427
DEG_SPOP_SBC_1	179	183	PF00917	0.692
DEG_SPOP_SBC_1	256	260	PF00917	0.646
DOC_ANK_TNKS_1	198	205	PF00023	0.573
DOC_MAPK_MEF2A_6	55	62	PF00069	0.500
DOC_USP7_MATH_1	137	141	PF00917	0.660
DOC_USP7_MATH_1	155	159	PF00917	0.482
DOC_USP7_MATH_1	179	183	PF00917	0.685
DOC_USP7_MATH_1	192	196	PF00917	0.569
DOC_USP7_MATH_1	256	260	PF00917	0.651
DOC_USP7_UBL2_3	235	239	PF12436	0.558
DOC_WW_Pin1_4	107	112	PF00397	0.528
DOC_WW_Pin1_4	181	186	PF00397	0.636
DOC_WW_Pin1_4	252	257	PF00397	0.678
LIG_14-3-3_CanoR_1	177	185	PF00244	0.621
LIG_14-3-3_CanoR_1	31	40	PF00244	0.539
LIG_FHA_1	111	117	PF00498	0.526
LIG_FHA_1	267	273	PF00498	0.659
LIG_LIR_Gen_1	26	34	PF02991	0.465
LIG_LIR_Nem_3	26	30	PF02991	0.465
LIG_SH2_CRK	80	84	PF00017	0.458
LIG_SH2_STAT3	109	112	PF00017	0.494
LIG_SH2_STAT3	69	72	PF00017	0.440
LIG_SH2_STAT5	24	27	PF00017	0.446
LIG_SH2_STAT5	78	81	PF00017	0.455
LIG_SH3_3	159	165	PF00018	0.606
LIG_SH3_3	182	188	PF00018	0.661
LIG_SUMO_SIM_par_1	58	65	PF11976	0.483
LIG_WRC_WIRS_1	24	29	PF05994	0.460
MOD_CDC14_SPxK_1	184	187	PF00782	0.639
MOD_CDK_SPxK_1	181	187	PF00069	0.639
MOD_CK1_1	107	113	PF00069	0.620
MOD_CK1_1	178	184	PF00069	0.685
MOD_CK1_1	228	234	PF00069	0.610
MOD_CK1_1	255	261	PF00069	0.700
MOD_CK1_1	4	10	PF00069	0.512
MOD_CK1_1	61	67	PF00069	0.491
MOD_CK2_1	141	147	PF00069	0.729
MOD_CK2_1	192	198	PF00069	0.633
MOD_CK2_1	7	13	PF00069	0.491
MOD_GlcNHglycan	132	136	PF01048	0.643
MOD_GlcNHglycan	173	176	PF01048	0.679
MOD_GlcNHglycan	177	180	PF01048	0.685
MOD_GlcNHglycan	194	197	PF01048	0.524
MOD_GlcNHglycan	269	272	PF01048	0.750
MOD_GlcNHglycan	3	6	PF01048	0.622
MOD_GlcNHglycan	9	12	PF01048	0.564
MOD_GSK3_1	137	144	PF00069	0.635
MOD_GSK3_1	171	178	PF00069	0.675
MOD_GSK3_1	179	186	PF00069	0.630
MOD_GSK3_1	225	232	PF00069	0.639
MOD_GSK3_1	252	259	PF00069	0.634
MOD_GSK3_1	32	39	PF00069	0.588
MOD_N-GLC_1	116	121	PF02516	0.474
MOD_N-GLC_1	175	180	PF02516	0.679
MOD_N-GLC_2	154	156	PF02516	0.533
MOD_NEK2_1	116	121	PF00069	0.553
MOD_NEK2_1	225	230	PF00069	0.646
MOD_NEK2_1	25	30	PF00069	0.523
MOD_PIKK_1	225	231	PF00454	0.642
MOD_PIKK_1	238	244	PF00454	0.545
MOD_PIKK_1	68	74	PF00454	0.468
MOD_PKA_2	121	127	PF00069	0.576
MOD_Plk_1	116	122	PF00069	0.512
MOD_Plk_1	40	46	PF00069	0.444
MOD_Plk_4	116	122	PF00069	0.530
MOD_Plk_4	58	64	PF00069	0.478
MOD_ProDKin_1	107	113	PF00069	0.529
MOD_ProDKin_1	181	187	PF00069	0.639
MOD_ProDKin_1	252	258	PF00069	0.679
MOD_SUMO_for_1	272	275	PF00179	0.530
MOD_SUMO_for_1	83	86	PF00179	0.477
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.458
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.511
TRG_ENDOCYTIC_2	24	27	PF00928	0.446
TRG_ENDOCYTIC_2	80	83	PF00928	0.515
TRG_ER_diArg_1	29	32	PF00400	0.466
TRG_ER_diArg_1	75	77	PF00400	0.472
TRG_ER_diArg_1	94	97	PF00400	0.311
TRG_NLS_MonoExtN_4	100	107	PF00514	0.485
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBK6	Leishmania donovani	87%	100%
A4HYT3	Leishmania infantum	87%	100%
E9AIE2	Leishmania braziliensis	66%	100%
E9AUM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%