AATF-Che1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AATF protein, putative

Species:

Leishmania major

UniProt:

Q4QCV4_LEIMA

TriTrypDb:

LmjF.20.0920 , LMJLV39_200014600 , LMJSD75_200014400

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	7
GO:0005634	nucleus	5	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5

Expansion

Sequence features

Q4QCV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.788
CLV_C14_Caspase3-7	186	190	PF00656	0.743
CLV_C14_Caspase3-7	51	55	PF00656	0.766
CLV_C14_Caspase3-7	64	68	PF00656	0.670
CLV_NRD_NRD_1	18	20	PF00675	0.710
CLV_NRD_NRD_1	192	194	PF00675	0.608
CLV_NRD_NRD_1	196	198	PF00675	0.579
CLV_NRD_NRD_1	224	226	PF00675	0.645
CLV_NRD_NRD_1	381	383	PF00675	0.470
CLV_NRD_NRD_1	523	525	PF00675	0.413
CLV_NRD_NRD_1	550	552	PF00675	0.449
CLV_NRD_NRD_1	82	84	PF00675	0.791
CLV_PCSK_FUR_1	193	197	PF00082	0.708
CLV_PCSK_KEX2_1	194	196	PF00082	0.599
CLV_PCSK_KEX2_1	20	22	PF00082	0.614
CLV_PCSK_KEX2_1	224	226	PF00082	0.617
CLV_PCSK_KEX2_1	381	383	PF00082	0.470
CLV_PCSK_KEX2_1	523	525	PF00082	0.344
CLV_PCSK_KEX2_1	82	84	PF00082	0.745
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.578
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.683
CLV_PCSK_PC7_1	519	525	PF00082	0.344
CLV_PCSK_SKI1_1	196	200	PF00082	0.684
CLV_PCSK_SKI1_1	303	307	PF00082	0.413
CLV_PCSK_SKI1_1	322	326	PF00082	0.220
CLV_PCSK_SKI1_1	33	37	PF00082	0.710
CLV_PCSK_SKI1_1	399	403	PF00082	0.475
CLV_PCSK_SKI1_1	534	538	PF00082	0.359
CLV_PCSK_SKI1_1	541	545	PF00082	0.444
CLV_PCSK_SKI1_1	591	595	PF00082	0.382
CLV_Separin_Metazoa	520	524	PF03568	0.413
DOC_CYCLIN_RxL_1	319	329	PF00134	0.428
DOC_CYCLIN_RxL_1	535	548	PF00134	0.437
DOC_MAPK_gen_1	381	391	PF00069	0.483
DOC_MAPK_gen_1	399	409	PF00069	0.475
DOC_MAPK_gen_1	469	479	PF00069	0.536
DOC_MAPK_MEF2A_6	402	411	PF00069	0.423
DOC_PP1_RVXF_1	568	575	PF00149	0.328
DOC_PP2B_LxvP_1	407	410	PF13499	0.475
DOC_PP4_FxxP_1	574	577	PF00568	0.363
DOC_USP7_MATH_1	105	109	PF00917	0.767
DOC_USP7_MATH_1	337	341	PF00917	0.475
DOC_USP7_MATH_1	377	381	PF00917	0.492
DOC_USP7_MATH_1	393	397	PF00917	0.145
DOC_USP7_MATH_1	488	492	PF00917	0.576
DOC_USP7_MATH_1	527	531	PF00917	0.475
DOC_USP7_UBL2_3	91	95	PF12436	0.788
DOC_WW_Pin1_4	125	130	PF00397	0.587
LIG_14-3-3_CanoR_1	19	24	PF00244	0.594
LIG_14-3-3_CanoR_1	224	230	PF00244	0.709
LIG_14-3-3_CanoR_1	250	258	PF00244	0.612
LIG_14-3-3_CanoR_1	3	13	PF00244	0.645
LIG_14-3-3_CanoR_1	385	391	PF00244	0.242
LIG_Actin_WH2_2	408	426	PF00022	0.281
LIG_APCC_ABBA_1	409	414	PF00400	0.281
LIG_BIR_III_4	149	153	PF00653	0.734
LIG_BIR_III_4	189	193	PF00653	0.739
LIG_BRCT_BRCA1_1	67	71	PF00533	0.790
LIG_eIF4E_1	319	325	PF01652	0.415
LIG_eIF4E_1	432	438	PF01652	0.385
LIG_FHA_1	283	289	PF00498	0.649
LIG_FHA_1	309	315	PF00498	0.449
LIG_FHA_2	200	206	PF00498	0.592
LIG_FHA_2	24	30	PF00498	0.672
LIG_FHA_2	401	407	PF00498	0.452
LIG_FHA_2	426	432	PF00498	0.475
LIG_FHA_2	488	494	PF00498	0.642
LIG_LIR_Gen_1	356	366	PF02991	0.451
LIG_LIR_Gen_1	60	71	PF02991	0.729
LIG_LIR_Nem_3	137	143	PF02991	0.588
LIG_LIR_Nem_3	356	362	PF02991	0.451
LIG_LIR_Nem_3	60	66	PF02991	0.683
LIG_NRBOX	301	307	PF00104	0.449
LIG_PCNA_yPIPBox_3	357	370	PF02747	0.451
LIG_SH2_CRK	296	300	PF00017	0.319
LIG_SH2_NCK_1	374	378	PF00017	0.432
LIG_SH2_NCK_1	512	516	PF00017	0.557
LIG_SH2_NCK_1	63	67	PF00017	0.615
LIG_SH2_SRC	512	515	PF00017	0.537
LIG_SH2_SRC	52	55	PF00017	0.743
LIG_SH2_SRC	63	66	PF00017	0.743
LIG_SH2_STAP1	206	210	PF00017	0.602
LIG_SH2_STAP1	320	324	PF00017	0.398
LIG_SUMO_SIM_anti_2	475	481	PF11976	0.534
LIG_TRAF2_1	163	166	PF00917	0.725
LIG_TRAF2_1	202	205	PF00917	0.634
MOD_CK1_1	103	109	PF00069	0.763
MOD_CK1_1	12	18	PF00069	0.728
MOD_CK1_1	277	283	PF00069	0.629
MOD_CK1_1	461	467	PF00069	0.654
MOD_CK2_1	116	122	PF00069	0.642
MOD_CK2_1	19	25	PF00069	0.683
MOD_CK2_1	199	205	PF00069	0.603
MOD_CK2_1	5	11	PF00069	0.761
MOD_CK2_1	527	533	PF00069	0.475
MOD_Cter_Amidation	191	194	PF01082	0.656
MOD_GlcNHglycan	103	106	PF01048	0.687
MOD_GlcNHglycan	233	236	PF01048	0.647
MOD_GlcNHglycan	269	272	PF01048	0.704
MOD_GlcNHglycan	276	279	PF01048	0.676
MOD_GlcNHglycan	391	394	PF01048	0.474
MOD_GlcNHglycan	441	444	PF01048	0.596
MOD_GlcNHglycan	460	463	PF01048	0.650
MOD_GlcNHglycan	489	493	PF01048	0.570
MOD_GlcNHglycan	7	10	PF01048	0.643
MOD_GlcNHglycan	87	90	PF01048	0.775
MOD_GSK3_1	100	107	PF00069	0.737
MOD_GSK3_1	19	26	PF00069	0.616
MOD_GSK3_1	308	315	PF00069	0.437
MOD_GSK3_1	353	360	PF00069	0.359
MOD_GSK3_1	389	396	PF00069	0.454
MOD_GSK3_1	461	468	PF00069	0.565
MOD_GSK3_1	5	12	PF00069	0.661
MOD_GSK3_1	78	85	PF00069	0.777
MOD_LATS_1	485	491	PF00433	0.631
MOD_N-GLC_1	211	216	PF02516	0.589
MOD_N-GLC_1	4	9	PF02516	0.709
MOD_N-GLC_1	472	477	PF02516	0.577
MOD_NEK2_1	116	121	PF00069	0.579
MOD_NEK2_1	223	228	PF00069	0.715
MOD_NEK2_1	23	28	PF00069	0.378
MOD_NEK2_1	258	263	PF00069	0.598
MOD_NEK2_1	4	9	PF00069	0.658
MOD_NEK2_2	320	325	PF00069	0.460
MOD_PIKK_1	527	533	PF00454	0.492
MOD_PKA_1	19	25	PF00069	0.601
MOD_PKA_1	82	88	PF00069	0.768
MOD_PKA_1	91	97	PF00069	0.628
MOD_PKA_2	223	229	PF00069	0.676
MOD_PKA_2	384	390	PF00069	0.368
MOD_PKA_2	5	11	PF00069	0.700
MOD_PKA_2	555	561	PF00069	0.328
MOD_PKA_2	82	88	PF00069	0.812
MOD_Plk_1	116	122	PF00069	0.596
MOD_Plk_1	472	478	PF00069	0.577
MOD_Plk_4	258	264	PF00069	0.611
MOD_Plk_4	369	375	PF00069	0.396
MOD_Plk_4	9	15	PF00069	0.727
MOD_ProDKin_1	125	131	PF00069	0.584
MOD_SUMO_for_1	241	244	PF00179	0.435
MOD_SUMO_for_1	401	404	PF00179	0.457
MOD_SUMO_rev_2	117	126	PF00179	0.705
MOD_SUMO_rev_2	205	215	PF00179	0.626
MOD_SUMO_rev_2	277	285	PF00179	0.662
MOD_SUMO_rev_2	489	496	PF00179	0.545
MOD_SUMO_rev_2	530	536	PF00179	0.490
TRG_DiLeu_BaEn_4	244	250	PF01217	0.567
TRG_ENDOCYTIC_2	296	299	PF00928	0.361
TRG_ENDOCYTIC_2	359	362	PF00928	0.449
TRG_ENDOCYTIC_2	412	415	PF00928	0.413
TRG_ENDOCYTIC_2	63	66	PF00928	0.653
TRG_ER_diArg_1	110	113	PF00400	0.703
TRG_ER_diArg_1	193	196	PF00400	0.673
TRG_ER_diArg_1	223	225	PF00400	0.649
TRG_ER_diArg_1	300	303	PF00400	0.330
TRG_ER_diArg_1	522	524	PF00400	0.413
TRG_NLS_Bipartite_1	381	403	PF00514	0.242
TRG_NLS_MonoCore_2	192	197	PF00514	0.620
TRG_NLS_MonoExtC_3	192	197	PF00514	0.642
TRG_NLS_MonoExtC_3	398	404	PF00514	0.450
TRG_NLS_MonoExtN_4	17	23	PF00514	0.634
TRG_NLS_MonoExtN_4	193	198	PF00514	0.615
TRG_NLS_MonoExtN_4	397	403	PF00514	0.473
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	322	327	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P4	Leptomonas seymouri	60%	98%
A0A0S4JJ09	Bodo saltans	33%	100%
A0A1X0NXQ8	Trypanosomatidae	41%	100%
A0A3Q8IA20	Leishmania donovani	91%	99%
A0A3R7KQ11	Trypanosoma rangeli	40%	100%
A4HYT4	Leishmania infantum	90%	85%
C9ZIB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AIE3	Leishmania braziliensis	77%	99%
E9AUN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
V5BQR9	Trypanosoma cruzi	37%	100%