Putative cyclophilin 15

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 15, putative

Species:

Leishmania major

UniProt:

Q4QCV2_LEIMA

TriTrypDb:

LmjF.20.0940 , LMJLV39_200014800 , LMJSD75_200014600

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCV2

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018208	peptidyl-proline modification	6	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	12
GO:0016859	cis-trans isomerase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.674
CLV_NRD_NRD_1	286	288	PF00675	0.715
CLV_NRD_NRD_1	300	302	PF00675	0.702
CLV_NRD_NRD_1	346	348	PF00675	0.686
CLV_NRD_NRD_1	407	409	PF00675	0.503
CLV_NRD_NRD_1	411	413	PF00675	0.490
CLV_NRD_NRD_1	417	419	PF00675	0.510
CLV_PCSK_FUR_1	283	287	PF00082	0.748
CLV_PCSK_KEX2_1	212	214	PF00082	0.544
CLV_PCSK_KEX2_1	285	287	PF00082	0.700
CLV_PCSK_KEX2_1	300	302	PF00082	0.707
CLV_PCSK_KEX2_1	344	346	PF00082	0.606
CLV_PCSK_KEX2_1	411	413	PF00082	0.486
CLV_PCSK_KEX2_1	417	419	PF00082	0.532
CLV_PCSK_KEX2_1	460	462	PF00082	0.631
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.450
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.566
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.779
CLV_PCSK_SKI1_1	127	131	PF00082	0.382
CLV_PCSK_SKI1_1	300	304	PF00082	0.564
CLV_PCSK_SKI1_1	412	416	PF00082	0.556
DEG_APCC_DBOX_1	15	23	PF00400	0.585
DEG_SCF_FBW7_1	14	21	PF00400	0.464
DEG_SPOP_SBC_1	421	425	PF00917	0.598
DOC_CKS1_1	186	191	PF01111	0.462
DOC_CKS1_1	91	96	PF01111	0.493
DOC_CYCLIN_yCln2_LP_2	72	78	PF00134	0.404
DOC_MAPK_FxFP_2	36	39	PF00069	0.321
DOC_MAPK_gen_1	112	121	PF00069	0.343
DOC_MAPK_gen_1	57	66	PF00069	0.382
DOC_PP2B_LxvP_1	169	172	PF13499	0.541
DOC_PP2B_LxvP_1	4	7	PF13499	0.481
DOC_PP2B_LxvP_1	72	75	PF13499	0.491
DOC_PP4_FxxP_1	36	39	PF00568	0.321
DOC_PP4_FxxP_1	49	52	PF00568	0.372
DOC_USP7_MATH_1	154	158	PF00917	0.553
DOC_USP7_MATH_1	251	255	PF00917	0.655
DOC_USP7_MATH_1	316	320	PF00917	0.719
DOC_USP7_MATH_1	339	343	PF00917	0.763
DOC_USP7_MATH_1	419	423	PF00917	0.590
DOC_USP7_MATH_1	52	56	PF00917	0.533
DOC_USP7_MATH_2	75	81	PF00917	0.367
DOC_USP7_UBL2_3	451	455	PF12436	0.646
DOC_USP7_UBL2_3	456	460	PF12436	0.586
DOC_WW_Pin1_4	14	19	PF00397	0.516
DOC_WW_Pin1_4	185	190	PF00397	0.550
DOC_WW_Pin1_4	6	11	PF00397	0.551
DOC_WW_Pin1_4	90	95	PF00397	0.523
LIG_14-3-3_CanoR_1	138	142	PF00244	0.532
LIG_14-3-3_CanoR_1	213	222	PF00244	0.518
LIG_14-3-3_CanoR_1	362	368	PF00244	0.678
LIG_14-3-3_CanoR_1	57	62	PF00244	0.345
LIG_Actin_WH2_2	197	214	PF00022	0.513
LIG_BRCT_BRCA1_1	318	322	PF00533	0.624
LIG_BRCT_BRCA1_1	325	329	PF00533	0.586
LIG_BRCT_BRCA1_1	34	38	PF00533	0.428
LIG_BRCT_BRCA1_2	318	324	PF00533	0.652
LIG_BRCT_BRCA1_2	325	331	PF00533	0.612
LIG_FHA_1	124	130	PF00498	0.379
LIG_FHA_1	19	25	PF00498	0.452
LIG_FHA_1	203	209	PF00498	0.425
LIG_FHA_1	361	367	PF00498	0.588
LIG_FHA_2	185	191	PF00498	0.536
LIG_FHA_2	262	268	PF00498	0.533
LIG_FHA_2	83	89	PF00498	0.500
LIG_LIR_Apic_2	33	39	PF02991	0.315
LIG_LIR_Apic_2	48	52	PF02991	0.476
LIG_LIR_Apic_2	88	94	PF02991	0.477
LIG_LIR_Gen_1	177	186	PF02991	0.361
LIG_LIR_Gen_1	379	386	PF02991	0.508
LIG_LIR_Nem_3	128	133	PF02991	0.335
LIG_LIR_Nem_3	163	169	PF02991	0.431
LIG_LIR_Nem_3	177	183	PF02991	0.323
LIG_LIR_Nem_3	194	198	PF02991	0.477
LIG_LIR_Nem_3	241	245	PF02991	0.487
LIG_LIR_Nem_3	319	325	PF02991	0.516
LIG_LIR_Nem_3	379	384	PF02991	0.522
LIG_LIR_Nem_3	48	53	PF02991	0.490
LIG_MLH1_MIPbox_1	319	323	PF16413	0.615
LIG_PTB_Apo_2	60	67	PF02174	0.299
LIG_REV1ctd_RIR_1	320	328	PF16727	0.567
LIG_REV1ctd_RIR_1	381	389	PF16727	0.616
LIG_SH2_CRK	166	170	PF00017	0.503
LIG_SH2_CRK	242	246	PF00017	0.409
LIG_SH2_CRK	91	95	PF00017	0.490
LIG_SH2_NCK_1	91	95	PF00017	0.487
LIG_SH2_PTP2	180	183	PF00017	0.368
LIG_SH2_STAT5	180	183	PF00017	0.368
LIG_SH2_STAT5	242	245	PF00017	0.547
LIG_SH3_1	270	276	PF00018	0.617
LIG_SH3_3	136	142	PF00018	0.388
LIG_SH3_3	183	189	PF00018	0.483
LIG_SH3_3	21	27	PF00018	0.447
LIG_SH3_3	270	276	PF00018	0.711
LIG_SH3_3	4	10	PF00018	0.516
LIG_TYR_ITIM	164	169	PF00017	0.481
LIG_TYR_ITIM	240	245	PF00017	0.477
MOD_CDK_SPxxK_3	185	192	PF00069	0.403
MOD_CK1_1	123	129	PF00069	0.363
MOD_CK1_1	246	252	PF00069	0.661
MOD_CK1_1	422	428	PF00069	0.666
MOD_CK1_1	436	442	PF00069	0.551
MOD_CK2_1	114	120	PF00069	0.481
MOD_CK2_1	184	190	PF00069	0.485
MOD_CK2_1	244	250	PF00069	0.451
MOD_CK2_1	82	88	PF00069	0.478
MOD_GlcNHglycan	107	110	PF01048	0.374
MOD_GlcNHglycan	233	236	PF01048	0.340
MOD_GlcNHglycan	250	254	PF01048	0.668
MOD_GlcNHglycan	319	322	PF01048	0.618
MOD_GlcNHglycan	325	328	PF01048	0.568
MOD_GlcNHglycan	336	339	PF01048	0.620
MOD_GlcNHglycan	425	428	PF01048	0.626
MOD_GlcNHglycan	438	441	PF01048	0.733
MOD_GlcNHglycan	445	448	PF01048	0.733
MOD_GlcNHglycan	68	71	PF01048	0.479
MOD_GlcNHglycan	79	82	PF01048	0.395
MOD_GSK3_1	121	128	PF00069	0.351
MOD_GSK3_1	14	21	PF00069	0.611
MOD_GSK3_1	148	155	PF00069	0.547
MOD_GSK3_1	240	247	PF00069	0.520
MOD_GSK3_1	249	256	PF00069	0.649
MOD_GSK3_1	357	364	PF00069	0.628
MOD_GSK3_1	419	426	PF00069	0.690
MOD_GSK3_1	429	436	PF00069	0.606
MOD_GSK3_1	443	450	PF00069	0.619
MOD_N-GLC_1	307	312	PF02516	0.661
MOD_NEK2_1	105	110	PF00069	0.343
MOD_NEK2_1	240	245	PF00069	0.529
MOD_NEK2_1	317	322	PF00069	0.571
MOD_NEK2_1	323	328	PF00069	0.496
MOD_NEK2_1	361	366	PF00069	0.623
MOD_NEK2_1	449	454	PF00069	0.742
MOD_NEK2_1	66	71	PF00069	0.382
MOD_PIKK_1	171	177	PF00454	0.484
MOD_PIKK_1	213	219	PF00454	0.572
MOD_PIKK_1	429	435	PF00454	0.757
MOD_PIKK_1	52	58	PF00454	0.367
MOD_PK_1	148	154	PF00069	0.568
MOD_PKA_2	137	143	PF00069	0.544
MOD_PKA_2	271	277	PF00069	0.739
MOD_PKA_2	361	367	PF00069	0.580
MOD_Plk_1	240	246	PF00069	0.434
MOD_Plk_1	32	38	PF00069	0.419
MOD_Plk_2-3	114	120	PF00069	0.481
MOD_Plk_4	114	120	PF00069	0.423
MOD_Plk_4	125	131	PF00069	0.262
MOD_Plk_4	160	166	PF00069	0.363
MOD_Plk_4	240	246	PF00069	0.353
MOD_Plk_4	32	38	PF00069	0.444
MOD_Plk_4	45	51	PF00069	0.461
MOD_ProDKin_1	14	20	PF00069	0.515
MOD_ProDKin_1	185	191	PF00069	0.549
MOD_ProDKin_1	6	12	PF00069	0.549
MOD_ProDKin_1	90	96	PF00069	0.522
MOD_SUMO_rev_2	288	297	PF00179	0.533
TRG_ENDOCYTIC_2	166	169	PF00928	0.424
TRG_ENDOCYTIC_2	179	182	PF00928	0.280
TRG_ENDOCYTIC_2	242	245	PF00928	0.488
TRG_ER_diArg_1	283	286	PF00400	0.630
TRG_ER_diArg_1	299	301	PF00400	0.663
TRG_ER_diArg_1	345	347	PF00400	0.720
TRG_ER_diArg_1	411	413	PF00400	0.538
TRG_ER_diLys_1	458	462	PF00400	0.528
TRG_NLS_Bipartite_1	212	232	PF00514	0.459
TRG_NLS_MonoCore_2	343	348	PF00514	0.623
TRG_NLS_MonoExtC_3	343	349	PF00514	0.560
TRG_NLS_MonoExtC_3	407	412	PF00514	0.574
TRG_NLS_MonoExtC_3	454	459	PF00514	0.724
TRG_NLS_MonoExtN_4	227	232	PF00514	0.446
TRG_NLS_MonoExtN_4	341	348	PF00514	0.596
TRG_NLS_MonoExtN_4	405	412	PF00514	0.502
TRG_Pf-PMV_PEXEL_1	301	306	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC45	Leptomonas seymouri	60%	100%
A0A0S4KRJ3	Bodo saltans	32%	100%
A0A1X0NWC9	Trypanosomatidae	33%	100%
A0A3S7WVY2	Leishmania donovani	90%	100%
A0A422NPI7	Trypanosoma rangeli	37%	100%
A4HYT6	Leishmania infantum	88%	100%
C9ZIB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AIE5	Leishmania braziliensis	77%	100%
E9AUN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DRZ7	Trypanosoma cruzi	38%	100%