DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved protein, unknown function

Species:

Leishmania major

UniProt:

Q4QCV1_LEIMA

TriTrypDb:

LmjF.20.0950 , LMJLV39_200014900 , LMJSD75_200014700

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCV1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	451	455	PF00656	0.624
CLV_C14_Caspase3-7	586	590	PF00656	0.478
CLV_C14_Caspase3-7	628	632	PF00656	0.611
CLV_NRD_NRD_1	229	231	PF00675	0.475
CLV_NRD_NRD_1	334	336	PF00675	0.705
CLV_NRD_NRD_1	364	366	PF00675	0.702
CLV_NRD_NRD_1	473	475	PF00675	0.653
CLV_NRD_NRD_1	556	558	PF00675	0.651
CLV_NRD_NRD_1	577	579	PF00675	0.622
CLV_NRD_NRD_1	609	611	PF00675	0.685
CLV_NRD_NRD_1	634	636	PF00675	0.651
CLV_NRD_NRD_1	641	643	PF00675	0.618
CLV_NRD_NRD_1	657	659	PF00675	0.555
CLV_NRD_NRD_1	684	686	PF00675	0.595
CLV_NRD_NRD_1	691	693	PF00675	0.615
CLV_PCSK_FUR_1	639	643	PF00082	0.674
CLV_PCSK_FUR_1	689	693	PF00082	0.691
CLV_PCSK_KEX2_1	229	231	PF00082	0.475
CLV_PCSK_KEX2_1	334	336	PF00082	0.673
CLV_PCSK_KEX2_1	364	366	PF00082	0.658
CLV_PCSK_KEX2_1	473	475	PF00082	0.642
CLV_PCSK_KEX2_1	556	558	PF00082	0.651
CLV_PCSK_KEX2_1	576	578	PF00082	0.631
CLV_PCSK_KEX2_1	609	611	PF00082	0.685
CLV_PCSK_KEX2_1	634	636	PF00082	0.651
CLV_PCSK_KEX2_1	641	643	PF00082	0.618
CLV_PCSK_KEX2_1	656	658	PF00082	0.570
CLV_PCSK_KEX2_1	691	693	PF00082	0.635
CLV_PCSK_PC7_1	572	578	PF00082	0.634
CLV_PCSK_SKI1_1	194	198	PF00082	0.552
CLV_PCSK_SKI1_1	323	327	PF00082	0.618
CLV_PCSK_SKI1_1	349	353	PF00082	0.677
DEG_APCC_DBOX_1	193	201	PF00400	0.497
DEG_APCC_DBOX_1	373	381	PF00400	0.611
DEG_COP1_1	51	60	PF00400	0.323
DEG_SPOP_SBC_1	385	389	PF00917	0.528
DEG_SPOP_SBC_1	604	608	PF00917	0.664
DOC_CKS1_1	487	492	PF01111	0.681
DOC_CKS1_1	681	686	PF01111	0.659
DOC_CYCLIN_RxL_1	320	329	PF00134	0.652
DOC_MAPK_DCC_7	239	247	PF00069	0.560
DOC_MAPK_gen_1	38	47	PF00069	0.566
DOC_MAPK_gen_1	639	647	PF00069	0.754
DOC_MAPK_MEF2A_6	239	247	PF00069	0.597
DOC_MAPK_MEF2A_6	38	47	PF00069	0.583
DOC_PP1_RVXF_1	172	179	PF00149	0.519
DOC_PP2B_LxvP_1	645	648	PF13499	0.607
DOC_PP4_FxxP_1	196	199	PF00568	0.412
DOC_PP4_FxxP_1	678	681	PF00568	0.673
DOC_USP7_MATH_1	116	120	PF00917	0.643
DOC_USP7_MATH_1	192	196	PF00917	0.528
DOC_USP7_MATH_1	269	273	PF00917	0.646
DOC_USP7_MATH_1	31	35	PF00917	0.666
DOC_USP7_MATH_1	310	314	PF00917	0.757
DOC_USP7_MATH_1	336	340	PF00917	0.716
DOC_USP7_MATH_1	343	347	PF00917	0.554
DOC_USP7_MATH_1	386	390	PF00917	0.625
DOC_USP7_MATH_1	393	397	PF00917	0.597
DOC_USP7_MATH_1	604	608	PF00917	0.742
DOC_USP7_MATH_1	627	631	PF00917	0.601
DOC_USP7_MATH_1	667	671	PF00917	0.786
DOC_WW_Pin1_4	186	191	PF00397	0.551
DOC_WW_Pin1_4	206	211	PF00397	0.571
DOC_WW_Pin1_4	326	331	PF00397	0.701
DOC_WW_Pin1_4	375	380	PF00397	0.727
DOC_WW_Pin1_4	400	405	PF00397	0.587
DOC_WW_Pin1_4	474	479	PF00397	0.804
DOC_WW_Pin1_4	486	491	PF00397	0.660
DOC_WW_Pin1_4	680	685	PF00397	0.679
LIG_14-3-3_CanoR_1	374	378	PF00244	0.540
LIG_14-3-3_CanoR_1	457	467	PF00244	0.631
LIG_14-3-3_CanoR_1	557	567	PF00244	0.656
LIG_14-3-3_CanoR_1	642	648	PF00244	0.699
LIG_14-3-3_CanoR_1	80	88	PF00244	0.467
LIG_CSL_BTD_1	177	180	PF09270	0.494
LIG_FHA_1	171	177	PF00498	0.441
LIG_FHA_1	182	188	PF00498	0.576
LIG_FHA_1	345	351	PF00498	0.582
LIG_FHA_1	35	41	PF00498	0.684
LIG_FHA_1	376	382	PF00498	0.644
LIG_FHA_1	524	530	PF00498	0.653
LIG_FHA_1	616	622	PF00498	0.723
LIG_FHA_1	72	78	PF00498	0.396
LIG_FHA_2	145	151	PF00498	0.549
LIG_FHA_2	449	455	PF00498	0.713
LIG_FHA_2	526	532	PF00498	0.797
LIG_Integrin_RGD_1	137	139	PF01839	0.518
LIG_LIR_Apic_2	195	199	PF02991	0.424
LIG_LIR_Gen_1	403	412	PF02991	0.643
LIG_LIR_Nem_3	221	225	PF02991	0.532
LIG_LIR_Nem_3	403	409	PF02991	0.580
LIG_Pex14_1	406	410	PF04695	0.540
LIG_RPA_C_Fungi	573	585	PF08784	0.489
LIG_SH2_NCK_1	205	209	PF00017	0.478
LIG_SH2_PTP2	422	425	PF00017	0.593
LIG_SH2_SRC	422	425	PF00017	0.593
LIG_SH2_STAT5	356	359	PF00017	0.560
LIG_SH2_STAT5	422	425	PF00017	0.618
LIG_SH2_STAT5	430	433	PF00017	0.595
LIG_SH3_2	681	686	PF14604	0.582
LIG_SH3_3	130	136	PF00018	0.735
LIG_SH3_3	44	50	PF00018	0.430
LIG_SH3_3	469	475	PF00018	0.642
LIG_SH3_3	516	522	PF00018	0.669
LIG_SH3_3	678	684	PF00018	0.577
LIG_SUMO_SIM_par_1	243	249	PF11976	0.639
LIG_TRAF2_1	209	212	PF00917	0.497
LIG_TRAF2_1	693	696	PF00917	0.684
MOD_CDK_SPK_2	474	479	PF00069	0.811
MOD_CDK_SPK_2	680	685	PF00069	0.596
MOD_CDK_SPxK_1	680	686	PF00069	0.600
MOD_CDK_SPxxK_3	474	481	PF00069	0.676
MOD_CK1_1	166	172	PF00069	0.544
MOD_CK1_1	249	255	PF00069	0.537
MOD_CK1_1	272	278	PF00069	0.742
MOD_CK1_1	312	318	PF00069	0.803
MOD_CK1_1	329	335	PF00069	0.708
MOD_CK1_1	339	345	PF00069	0.456
MOD_CK1_1	34	40	PF00069	0.722
MOD_CK1_1	387	393	PF00069	0.600
MOD_CK1_1	448	454	PF00069	0.651
MOD_CK1_1	461	467	PF00069	0.519
MOD_CK1_1	629	635	PF00069	0.721
MOD_CK2_1	206	212	PF00069	0.475
MOD_CK2_1	367	373	PF00069	0.755
MOD_CK2_1	525	531	PF00069	0.697
MOD_CK2_1	597	603	PF00069	0.625
MOD_CK2_1	66	72	PF00069	0.362
MOD_DYRK1A_RPxSP_1	474	478	PF00069	0.668
MOD_GlcNHglycan	110	113	PF01048	0.640
MOD_GlcNHglycan	115	119	PF01048	0.690
MOD_GlcNHglycan	120	123	PF01048	0.676
MOD_GlcNHglycan	206	209	PF01048	0.501
MOD_GlcNHglycan	248	251	PF01048	0.697
MOD_GlcNHglycan	263	266	PF01048	0.684
MOD_GlcNHglycan	295	298	PF01048	0.563
MOD_GlcNHglycan	312	315	PF01048	0.685
MOD_GlcNHglycan	338	341	PF01048	0.634
MOD_GlcNHglycan	395	398	PF01048	0.552
MOD_GlcNHglycan	415	418	PF01048	0.584
MOD_GlcNHglycan	439	442	PF01048	0.686
MOD_GlcNHglycan	495	498	PF01048	0.676
MOD_GlcNHglycan	503	507	PF01048	0.705
MOD_GlcNHglycan	545	551	PF01048	0.639
MOD_GlcNHglycan	589	592	PF01048	0.593
MOD_GlcNHglycan	631	634	PF01048	0.596
MOD_GlcNHglycan	668	672	PF01048	0.688
MOD_GlcNHglycan	698	701	PF01048	0.665
MOD_GSK3_1	114	121	PF00069	0.653
MOD_GSK3_1	140	147	PF00069	0.517
MOD_GSK3_1	166	173	PF00069	0.495
MOD_GSK3_1	339	346	PF00069	0.616
MOD_GSK3_1	368	375	PF00069	0.672
MOD_GSK3_1	380	387	PF00069	0.714
MOD_GSK3_1	400	407	PF00069	0.418
MOD_GSK3_1	448	455	PF00069	0.766
MOD_GSK3_1	583	590	PF00069	0.715
MOD_GSK3_1	615	622	PF00069	0.764
MOD_GSK3_1	625	632	PF00069	0.603
MOD_N-GLC_1	604	609	PF02516	0.553
MOD_N-GLC_2	499	501	PF02516	0.522
MOD_NEK2_1	144	149	PF00069	0.435
MOD_NEK2_1	456	461	PF00069	0.617
MOD_NEK2_1	523	528	PF00069	0.661
MOD_NEK2_1	587	592	PF00069	0.608
MOD_NEK2_1	625	630	PF00069	0.808
MOD_NEK2_1	643	648	PF00069	0.529
MOD_NEK2_2	344	349	PF00069	0.571
MOD_PIKK_1	458	464	PF00454	0.551
MOD_PKA_2	272	278	PF00069	0.637
MOD_PKA_2	293	299	PF00069	0.718
MOD_PKA_2	373	379	PF00069	0.538
MOD_PKA_2	413	419	PF00069	0.565
MOD_PKA_2	456	462	PF00069	0.598
MOD_PKA_2	558	564	PF00069	0.623
MOD_PKA_2	633	639	PF00069	0.630
MOD_PKA_2	643	649	PF00069	0.576
MOD_PKA_2	79	85	PF00069	0.469
MOD_Plk_1	372	378	PF00069	0.616
MOD_Plk_1	502	508	PF00069	0.621
MOD_Plk_1	71	77	PF00069	0.368
MOD_Plk_2-3	597	603	PF00069	0.650
MOD_Plk_4	463	469	PF00069	0.647
MOD_Plk_4	583	589	PF00069	0.643
MOD_Plk_4	72	78	PF00069	0.387
MOD_ProDKin_1	186	192	PF00069	0.546
MOD_ProDKin_1	206	212	PF00069	0.569
MOD_ProDKin_1	326	332	PF00069	0.698
MOD_ProDKin_1	375	381	PF00069	0.725
MOD_ProDKin_1	400	406	PF00069	0.587
MOD_ProDKin_1	474	480	PF00069	0.805
MOD_ProDKin_1	486	492	PF00069	0.661
MOD_ProDKin_1	680	686	PF00069	0.682
MOD_SUMO_for_1	299	302	PF00179	0.531
MOD_SUMO_rev_2	302	310	PF00179	0.594
TRG_DiLeu_BaEn_1	72	77	PF01217	0.362
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.513
TRG_ENDOCYTIC_2	356	359	PF00928	0.487
TRG_ER_diArg_1	228	230	PF00400	0.466
TRG_ER_diArg_1	472	474	PF00400	0.646
TRG_ER_diArg_1	478	481	PF00400	0.649
TRG_ER_diArg_1	556	559	PF00400	0.628
TRG_ER_diArg_1	576	578	PF00400	0.506
TRG_ER_diArg_1	609	611	PF00400	0.567
TRG_ER_diArg_1	639	642	PF00400	0.650
TRG_ER_diArg_1	655	658	PF00400	0.525
TRG_ER_diArg_1	689	692	PF00400	0.695
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYJ6	Leptomonas seymouri	35%	86%
A0A1X0NWB7	Trypanosomatidae	29%	99%
A0A3Q8IEV0	Leishmania donovani	90%	100%
A0A3R7M1N2	Trypanosoma rangeli	29%	100%
A4HYT7	Leishmania infantum	90%	100%
E9AIE6	Leishmania braziliensis	70%	96%
E9AUN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%