Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCU8_LEIMA

TriTrypDb:

LmjF.20.0980 , LMJLV39_200015200 , LMJSD75_200015000

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCU8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.590
CLV_NRD_NRD_1	226	228	PF00675	0.437
CLV_NRD_NRD_1	304	306	PF00675	0.393
CLV_NRD_NRD_1	335	337	PF00675	0.422
CLV_NRD_NRD_1	35	37	PF00675	0.621
CLV_NRD_NRD_1	350	352	PF00675	0.613
CLV_NRD_NRD_1	353	355	PF00675	0.525
CLV_NRD_NRD_1	435	437	PF00675	0.384
CLV_NRD_NRD_1	465	467	PF00675	0.407
CLV_NRD_NRD_1	468	470	PF00675	0.461
CLV_PCSK_FUR_1	351	355	PF00082	0.450
CLV_PCSK_FUR_1	433	437	PF00082	0.378
CLV_PCSK_FUR_1	466	470	PF00082	0.430
CLV_PCSK_KEX2_1	11	13	PF00082	0.592
CLV_PCSK_KEX2_1	304	306	PF00082	0.405
CLV_PCSK_KEX2_1	35	37	PF00082	0.621
CLV_PCSK_KEX2_1	350	352	PF00082	0.515
CLV_PCSK_KEX2_1	353	355	PF00082	0.547
CLV_PCSK_KEX2_1	435	437	PF00082	0.473
CLV_PCSK_KEX2_1	465	467	PF00082	0.405
CLV_PCSK_KEX2_1	468	470	PF00082	0.464
CLV_PCSK_KEX2_1	88	90	PF00082	0.416
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.416
CLV_PCSK_PC7_1	461	467	PF00082	0.435
CLV_PCSK_SKI1_1	155	159	PF00082	0.396
CLV_PCSK_SKI1_1	179	183	PF00082	0.495
CLV_PCSK_SKI1_1	202	206	PF00082	0.324
CLV_PCSK_SKI1_1	405	409	PF00082	0.424
CLV_PCSK_SKI1_1	448	452	PF00082	0.458
CLV_PCSK_SKI1_1	481	485	PF00082	0.457
CLV_PCSK_SKI1_1	592	596	PF00082	0.500
CLV_Separin_Metazoa	339	343	PF03568	0.460
DEG_APCC_DBOX_1	591	599	PF00400	0.488
DEG_Nend_Nbox_1	1	3	PF02207	0.570
DEG_SPOP_SBC_1	364	368	PF00917	0.572
DEG_SPOP_SBC_1	37	41	PF00917	0.593
DEG_SPOP_SBC_1	526	530	PF00917	0.507
DEG_SPOP_SBC_1	98	102	PF00917	0.530
DOC_CKS1_1	632	637	PF01111	0.602
DOC_CKS1_1	653	658	PF01111	0.553
DOC_CYCLIN_RxL_1	176	185	PF00134	0.469
DOC_CYCLIN_RxL_1	478	487	PF00134	0.458
DOC_CYCLIN_yCln2_LP_2	632	638	PF00134	0.590
DOC_MAPK_gen_1	353	363	PF00069	0.444
DOC_MAPK_gen_1	405	413	PF00069	0.401
DOC_MAPK_gen_1	642	650	PF00069	0.593
DOC_MAPK_MEF2A_6	642	650	PF00069	0.593
DOC_PP1_RVXF_1	177	184	PF00149	0.466
DOC_PP1_RVXF_1	396	403	PF00149	0.500
DOC_PP2B_LxvP_1	361	364	PF13499	0.665
DOC_PP4_FxxP_1	194	197	PF00568	0.416
DOC_USP7_MATH_1	238	242	PF00917	0.450
DOC_USP7_MATH_1	25	29	PF00917	0.697
DOC_USP7_MATH_1	294	298	PF00917	0.502
DOC_USP7_MATH_1	364	368	PF00917	0.612
DOC_USP7_MATH_1	370	374	PF00917	0.618
DOC_USP7_MATH_1	526	530	PF00917	0.629
DOC_USP7_MATH_1	80	84	PF00917	0.548
DOC_WW_Pin1_4	103	108	PF00397	0.506
DOC_WW_Pin1_4	124	129	PF00397	0.409
DOC_WW_Pin1_4	137	142	PF00397	0.365
DOC_WW_Pin1_4	281	286	PF00397	0.497
DOC_WW_Pin1_4	374	379	PF00397	0.662
DOC_WW_Pin1_4	531	536	PF00397	0.641
DOC_WW_Pin1_4	563	568	PF00397	0.548
DOC_WW_Pin1_4	582	587	PF00397	0.701
DOC_WW_Pin1_4	631	636	PF00397	0.761
DOC_WW_Pin1_4	652	657	PF00397	0.616
DOC_WW_Pin1_4	683	688	PF00397	0.601
LIG_14-3-3_CanoR_1	11	15	PF00244	0.659
LIG_14-3-3_CanoR_1	216	226	PF00244	0.340
LIG_14-3-3_CanoR_1	26	34	PF00244	0.636
LIG_14-3-3_CanoR_1	461	465	PF00244	0.527
LIG_14-3-3_CanoR_1	628	633	PF00244	0.635
LIG_Actin_WH2_2	317	335	PF00022	0.426
LIG_BRCT_BRCA1_1	222	226	PF00533	0.444
LIG_BRCT_BRCA1_1	266	270	PF00533	0.401
LIG_BRCT_BRCA1_1	74	78	PF00533	0.464
LIG_BRCT_BRCA1_2	222	228	PF00533	0.461
LIG_CaM_IQ_9	661	677	PF13499	0.556
LIG_CSL_BTD_1	3	6	PF09270	0.462
LIG_FHA_1	25	31	PF00498	0.521
LIG_FHA_1	314	320	PF00498	0.404
LIG_FHA_1	384	390	PF00498	0.348
LIG_FHA_1	438	444	PF00498	0.493
LIG_FHA_1	528	534	PF00498	0.632
LIG_FHA_2	421	427	PF00498	0.407
LIG_FHA_2	620	626	PF00498	0.755
LIG_HCF-1_HBM_1	151	154	PF13415	0.422
LIG_IRF3_LxIS_1	527	534	PF10401	0.476
LIG_LIR_Apic_2	122	128	PF02991	0.385
LIG_LIR_Apic_2	191	197	PF02991	0.428
LIG_LIR_Apic_2	65	71	PF02991	0.391
LIG_LIR_Gen_1	127	138	PF02991	0.453
LIG_LIR_Gen_1	241	250	PF02991	0.502
LIG_LIR_Gen_1	273	283	PF02991	0.369
LIG_LIR_Gen_1	335	345	PF02991	0.460
LIG_LIR_Gen_1	376	387	PF02991	0.310
LIG_LIR_Gen_1	426	434	PF02991	0.488
LIG_LIR_Gen_1	645	653	PF02991	0.634
LIG_LIR_LC3C_4	359	363	PF02991	0.449
LIG_LIR_Nem_3	127	133	PF02991	0.428
LIG_LIR_Nem_3	151	157	PF02991	0.351
LIG_LIR_Nem_3	223	229	PF02991	0.416
LIG_LIR_Nem_3	241	246	PF02991	0.370
LIG_LIR_Nem_3	273	278	PF02991	0.492
LIG_LIR_Nem_3	335	341	PF02991	0.457
LIG_LIR_Nem_3	376	382	PF02991	0.361
LIG_LIR_Nem_3	521	525	PF02991	0.560
LIG_LIR_Nem_3	645	650	PF02991	0.555
LIG_MYND_1	281	285	PF01753	0.439
LIG_NRBOX	200	206	PF00104	0.298
LIG_NRBOX	479	485	PF00104	0.486
LIG_Rb_LxCxE_1	392	409	PF01857	0.398
LIG_SH2_CRK	154	158	PF00017	0.458
LIG_SH2_CRK	327	331	PF00017	0.433
LIG_SH2_NCK_1	473	477	PF00017	0.442
LIG_SH2_PTP2	647	650	PF00017	0.553
LIG_SH2_STAP1	174	178	PF00017	0.324
LIG_SH2_STAP1	259	263	PF00017	0.336
LIG_SH2_STAT5	117	120	PF00017	0.451
LIG_SH2_STAT5	218	221	PF00017	0.326
LIG_SH2_STAT5	245	248	PF00017	0.306
LIG_SH2_STAT5	647	650	PF00017	0.553
LIG_SH2_STAT5	689	692	PF00017	0.571
LIG_SH3_3	472	478	PF00018	0.536
LIG_SH3_3	581	587	PF00018	0.550
LIG_SH3_3	604	610	PF00018	0.533
LIG_SH3_3	61	67	PF00018	0.432
LIG_SH3_3	632	638	PF00018	0.706
LIG_SUMO_SIM_par_1	528	534	PF11976	0.479
LIG_TRAF2_1	189	192	PF00917	0.418
LIG_TRAF2_1	41	44	PF00917	0.505
LIG_TRAF2_1	452	455	PF00917	0.473
LIG_TRAF2_1	637	640	PF00917	0.616
LIG_UBA3_1	329	337	PF00899	0.459
MOD_CK1_1	100	106	PF00069	0.646
MOD_CK1_1	13	19	PF00069	0.651
MOD_CK1_1	38	44	PF00069	0.595
MOD_CK1_1	529	535	PF00069	0.642
MOD_CK1_1	566	572	PF00069	0.735
MOD_CK1_1	631	637	PF00069	0.691
MOD_CK1_1	657	663	PF00069	0.641
MOD_CK2_1	370	376	PF00069	0.680
MOD_CK2_1	38	44	PF00069	0.606
MOD_CK2_1	449	455	PF00069	0.409
MOD_CK2_1	602	608	PF00069	0.392
MOD_CK2_1	619	625	PF00069	0.708
MOD_GlcNHglycan	103	106	PF01048	0.581
MOD_GlcNHglycan	18	21	PF01048	0.756
MOD_GlcNHglycan	220	223	PF01048	0.480
MOD_GlcNHglycan	236	239	PF01048	0.262
MOD_GlcNHglycan	240	243	PF01048	0.256
MOD_GlcNHglycan	27	30	PF01048	0.602
MOD_GlcNHglycan	358	361	PF01048	0.539
MOD_GlcNHglycan	372	375	PF01048	0.472
MOD_GlcNHglycan	451	454	PF01048	0.434
MOD_GlcNHglycan	48	51	PF01048	0.598
MOD_GlcNHglycan	489	492	PF01048	0.686
MOD_GlcNHglycan	498	501	PF01048	0.600
MOD_GlcNHglycan	52	55	PF01048	0.539
MOD_GlcNHglycan	570	573	PF01048	0.752
MOD_GlcNHglycan	58	62	PF01048	0.528
MOD_GlcNHglycan	615	618	PF01048	0.807
MOD_GlcNHglycan	659	662	PF01048	0.687
MOD_GlcNHglycan	81	85	PF01048	0.415
MOD_GSK3_1	234	241	PF00069	0.350
MOD_GSK3_1	25	32	PF00069	0.663
MOD_GSK3_1	328	335	PF00069	0.461
MOD_GSK3_1	35	42	PF00069	0.590
MOD_GSK3_1	370	377	PF00069	0.678
MOD_GSK3_1	442	449	PF00069	0.415
MOD_GSK3_1	46	53	PF00069	0.530
MOD_GSK3_1	525	532	PF00069	0.586
MOD_GSK3_1	619	626	PF00069	0.745
MOD_GSK3_1	97	104	PF00069	0.601
MOD_N-GLC_1	623	628	PF02516	0.651
MOD_NEK2_1	181	186	PF00069	0.510
MOD_NEK2_1	217	222	PF00069	0.460
MOD_NEK2_1	332	337	PF00069	0.398
MOD_NEK2_1	389	394	PF00069	0.447
MOD_NEK2_1	442	447	PF00069	0.598
MOD_NEK2_1	460	465	PF00069	0.582
MOD_NEK2_1	515	520	PF00069	0.548
MOD_NEK2_1	623	628	PF00069	0.704
MOD_PIKK_1	308	314	PF00454	0.452
MOD_PIKK_1	39	45	PF00454	0.780
MOD_PKA_1	35	41	PF00069	0.586
MOD_PKA_2	10	16	PF00069	0.662
MOD_PKA_2	25	31	PF00069	0.581
MOD_PKA_2	332	338	PF00069	0.461
MOD_PKA_2	35	41	PF00069	0.653
MOD_PKA_2	460	466	PF00069	0.540
MOD_PKA_2	602	608	PF00069	0.553
MOD_PKA_2	613	619	PF00069	0.615
MOD_PKA_2	72	78	PF00069	0.564
MOD_PKB_1	354	362	PF00069	0.508
MOD_Plk_1	73	79	PF00069	0.467
MOD_Plk_2-3	602	608	PF00069	0.539
MOD_Plk_4	389	395	PF00069	0.448
MOD_Plk_4	602	608	PF00069	0.592
MOD_Plk_4	73	79	PF00069	0.467
MOD_ProDKin_1	103	109	PF00069	0.506
MOD_ProDKin_1	124	130	PF00069	0.410
MOD_ProDKin_1	137	143	PF00069	0.369
MOD_ProDKin_1	281	287	PF00069	0.504
MOD_ProDKin_1	374	380	PF00069	0.644
MOD_ProDKin_1	531	537	PF00069	0.643
MOD_ProDKin_1	563	569	PF00069	0.547
MOD_ProDKin_1	582	588	PF00069	0.688
MOD_ProDKin_1	631	637	PF00069	0.755
MOD_ProDKin_1	652	658	PF00069	0.615
MOD_ProDKin_1	683	689	PF00069	0.603
TRG_DiLeu_BaEn_1	455	460	PF01217	0.457
TRG_DiLeu_BaEn_2	408	414	PF01217	0.531
TRG_DiLeu_BaEn_4	191	197	PF01217	0.385
TRG_DiLeu_BaEn_4	671	677	PF01217	0.546
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.445
TRG_ENDOCYTIC_2	130	133	PF00928	0.395
TRG_ENDOCYTIC_2	154	157	PF00928	0.404
TRG_ENDOCYTIC_2	174	177	PF00928	0.177
TRG_ENDOCYTIC_2	327	330	PF00928	0.374
TRG_ENDOCYTIC_2	379	382	PF00928	0.298
TRG_ENDOCYTIC_2	647	650	PF00928	0.553
TRG_ER_diArg_1	304	306	PF00400	0.393
TRG_ER_diArg_1	34	36	PF00400	0.621
TRG_ER_diArg_1	350	353	PF00400	0.441
TRG_ER_diArg_1	432	435	PF00400	0.375
TRG_ER_diArg_1	464	466	PF00400	0.446
TRG_Pf-PMV_PEXEL_1	155	160	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.320
TRG_Pf-PMV_PEXEL_1	304	309	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P3	Leptomonas seymouri	54%	94%
A0A0S4JGL0	Bodo saltans	31%	100%
A0A1X0NTL4	Trypanosomatidae	39%	100%
A0A3S7WW17	Leishmania donovani	93%	100%
A0A422N5G0	Trypanosoma rangeli	38%	100%
A4HYU0	Leishmania infantum	93%	100%
C9ZQ69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AIE9	Leishmania braziliensis	78%	100%
E9AUN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%