ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QCU7_LEIMA

TriTrypDb:

LmjF.20.0990 , LMJLV39_200015300 , LMJSD75_200015100

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.593
CLV_NRD_NRD_1	198	200	PF00675	0.506
CLV_NRD_NRD_1	335	337	PF00675	0.570
CLV_NRD_NRD_1	348	350	PF00675	0.430
CLV_NRD_NRD_1	46	48	PF00675	0.609
CLV_NRD_NRD_1	65	67	PF00675	0.434
CLV_PCSK_KEX2_1	198	200	PF00082	0.529
CLV_PCSK_KEX2_1	294	296	PF00082	0.578
CLV_PCSK_KEX2_1	335	337	PF00082	0.570
CLV_PCSK_KEX2_1	348	350	PF00082	0.430
CLV_PCSK_KEX2_1	415	417	PF00082	0.682
CLV_PCSK_KEX2_1	46	48	PF00082	0.609
CLV_PCSK_KEX2_1	65	67	PF00082	0.434
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.578
CLV_PCSK_PC1ET2_1	415	417	PF00082	0.557
CLV_PCSK_PC7_1	331	337	PF00082	0.550
CLV_PCSK_SKI1_1	24	28	PF00082	0.591
CLV_PCSK_SKI1_1	331	335	PF00082	0.539
CLV_PCSK_SKI1_1	348	352	PF00082	0.451
DEG_APCC_DBOX_1	330	338	PF00400	0.547
DEG_APCC_DBOX_1	436	444	PF00400	0.531
DEG_Nend_UBRbox_1	1	4	PF02207	0.569
DEG_SCF_FBW7_2	277	283	PF00400	0.529
DEG_SPOP_SBC_1	464	468	PF00917	0.616
DEG_SPOP_SBC_1	85	89	PF00917	0.526
DOC_CKS1_1	277	282	PF01111	0.553
DOC_CYCLIN_RxL_1	92	100	PF00134	0.392
DOC_MAPK_gen_1	434	443	PF00069	0.499
DOC_MAPK_JIP1_4	164	170	PF00069	0.411
DOC_MAPK_MEF2A_6	164	172	PF00069	0.402
DOC_MAPK_MEF2A_6	364	372	PF00069	0.544
DOC_MAPK_MEF2A_6	437	445	PF00069	0.501
DOC_PP2B_LxvP_1	274	277	PF13499	0.624
DOC_PP2B_LxvP_1	288	291	PF13499	0.563
DOC_USP7_MATH_1	278	282	PF00917	0.639
DOC_USP7_MATH_1	397	401	PF00917	0.603
DOC_USP7_MATH_1	421	425	PF00917	0.692
DOC_USP7_MATH_1	462	466	PF00917	0.762
DOC_USP7_MATH_1	53	57	PF00917	0.594
DOC_USP7_MATH_1	79	83	PF00917	0.539
DOC_USP7_MATH_1	84	88	PF00917	0.521
DOC_WW_Pin1_4	19	24	PF00397	0.522
DOC_WW_Pin1_4	276	281	PF00397	0.688
DOC_WW_Pin1_4	460	465	PF00397	0.644
LIG_14-3-3_CanoR_1	198	204	PF00244	0.546
LIG_14-3-3_CanoR_1	437	441	PF00244	0.541
LIG_Actin_WH2_2	322	337	PF00022	0.549
LIG_APCC_ABBA_1	252	257	PF00400	0.469
LIG_BRCT_BRCA1_1	455	459	PF00533	0.628
LIG_CaM_IQ_9	370	385	PF13499	0.513
LIG_CaM_IQ_9	474	490	PF13499	0.519
LIG_DLG_GKlike_1	164	172	PF00625	0.514
LIG_FHA_1	122	128	PF00498	0.542
LIG_FHA_1	219	225	PF00498	0.469
LIG_FHA_1	277	283	PF00498	0.642
LIG_FHA_1	352	358	PF00498	0.486
LIG_FHA_1	38	44	PF00498	0.453
LIG_FHA_1	406	412	PF00498	0.701
LIG_FHA_1	437	443	PF00498	0.556
LIG_FHA_1	87	93	PF00498	0.624
LIG_FHA_2	198	204	PF00498	0.612
LIG_FHA_2	67	73	PF00498	0.507
LIG_LIR_Gen_1	307	316	PF02991	0.470
LIG_LIR_Gen_1	365	373	PF02991	0.506
LIG_LIR_Nem_3	307	313	PF02991	0.463
LIG_LIR_Nem_3	365	369	PF02991	0.447
LIG_RPA_C_Fungi	42	54	PF08784	0.567
LIG_SH2_NCK_1	155	159	PF00017	0.524
LIG_SH2_PTP2	310	313	PF00017	0.529
LIG_SH2_SRC	155	158	PF00017	0.514
LIG_SH2_STAP1	353	357	PF00017	0.510
LIG_SH2_STAP1	59	63	PF00017	0.595
LIG_SH2_STAT5	130	133	PF00017	0.421
LIG_SH2_STAT5	174	177	PF00017	0.452
LIG_SH2_STAT5	262	265	PF00017	0.436
LIG_SH2_STAT5	310	313	PF00017	0.466
LIG_SH2_STAT5	353	356	PF00017	0.441
LIG_SH2_STAT5	361	364	PF00017	0.436
LIG_SH3_3	1	7	PF00018	0.600
LIG_SH3_3	274	280	PF00018	0.546
LIG_SH3_3	354	360	PF00018	0.492
LIG_SUMO_SIM_anti_2	221	226	PF11976	0.412
LIG_SUMO_SIM_anti_2	439	444	PF11976	0.507
LIG_SUMO_SIM_par_1	265	271	PF11976	0.507
LIG_SUMO_SIM_par_1	353	358	PF11976	0.392
LIG_SUMO_SIM_par_1	87	93	PF11976	0.553
LIG_TRAF2_1	387	390	PF00917	0.486
LIG_TYR_ITIM	153	158	PF00017	0.516
LIG_TYR_ITIM	308	313	PF00017	0.522
LIG_WRC_WIRS_1	363	368	PF05994	0.501
MOD_CDK_SPK_2	19	24	PF00069	0.581
MOD_CK1_1	116	122	PF00069	0.673
MOD_CK1_1	183	189	PF00069	0.588
MOD_CK1_1	315	321	PF00069	0.567
MOD_CK1_1	32	38	PF00069	0.604
MOD_CK1_1	395	401	PF00069	0.632
MOD_CK1_1	404	410	PF00069	0.607
MOD_CK1_1	453	459	PF00069	0.572
MOD_CK1_1	460	466	PF00069	0.613
MOD_CK1_1	467	473	PF00069	0.769
MOD_CK2_1	119	125	PF00069	0.580
MOD_CK2_1	66	72	PF00069	0.522
MOD_GlcNHglycan	148	151	PF01048	0.523
MOD_GlcNHglycan	159	162	PF01048	0.454
MOD_GlcNHglycan	185	188	PF01048	0.553
MOD_GlcNHglycan	208	211	PF01048	0.619
MOD_GlcNHglycan	27	30	PF01048	0.541
MOD_GlcNHglycan	314	317	PF01048	0.559
MOD_GlcNHglycan	394	397	PF01048	0.589
MOD_GlcNHglycan	403	406	PF01048	0.611
MOD_GlcNHglycan	423	426	PF01048	0.669
MOD_GlcNHglycan	459	462	PF01048	0.700
MOD_GlcNHglycan	494	497	PF01048	0.667
MOD_GlcNHglycan	82	85	PF01048	0.557
MOD_GSK3_1	110	117	PF00069	0.573
MOD_GSK3_1	15	22	PF00069	0.555
MOD_GSK3_1	164	171	PF00069	0.518
MOD_GSK3_1	214	221	PF00069	0.530
MOD_GSK3_1	25	32	PF00069	0.508
MOD_GSK3_1	351	358	PF00069	0.525
MOD_GSK3_1	397	404	PF00069	0.677
MOD_GSK3_1	453	460	PF00069	0.597
MOD_GSK3_1	462	469	PF00069	0.761
MOD_GSK3_1	492	499	PF00069	0.552
MOD_GSK3_1	80	87	PF00069	0.657
MOD_GSK3_1	93	100	PF00069	0.588
MOD_LATS_1	162	168	PF00433	0.521
MOD_N-GLC_1	318	323	PF02516	0.555
MOD_N-GLC_1	401	406	PF02516	0.566
MOD_NEK2_1	168	173	PF00069	0.449
MOD_NEK2_1	180	185	PF00069	0.512
MOD_NEK2_1	204	209	PF00069	0.737
MOD_NEK2_1	218	223	PF00069	0.387
MOD_NEK2_1	351	356	PF00069	0.451
MOD_NEK2_1	392	397	PF00069	0.562
MOD_NEK2_1	42	47	PF00069	0.527
MOD_NEK2_1	451	456	PF00069	0.485
MOD_NEK2_1	8	13	PF00069	0.572
MOD_NEK2_1	90	95	PF00069	0.539
MOD_NEK2_1	97	102	PF00069	0.485
MOD_NEK2_2	256	261	PF00069	0.504
MOD_PIKK_1	110	116	PF00454	0.630
MOD_PIKK_1	467	473	PF00454	0.613
MOD_PKA_1	415	421	PF00069	0.612
MOD_PKA_2	197	203	PF00069	0.502
MOD_PKA_2	400	406	PF00069	0.610
MOD_PKA_2	415	421	PF00069	0.612
MOD_PKA_2	436	442	PF00069	0.549
MOD_Plk_1	214	220	PF00069	0.428
MOD_Plk_1	256	262	PF00069	0.422
MOD_Plk_4	218	224	PF00069	0.373
MOD_Plk_4	304	310	PF00069	0.510
MOD_Plk_4	436	442	PF00069	0.616
MOD_Plk_4	93	99	PF00069	0.446
MOD_ProDKin_1	19	25	PF00069	0.525
MOD_ProDKin_1	276	282	PF00069	0.692
MOD_ProDKin_1	460	466	PF00069	0.642
MOD_SUMO_for_1	293	296	PF00179	0.581
TRG_ENDOCYTIC_2	139	142	PF00928	0.527
TRG_ENDOCYTIC_2	155	158	PF00928	0.473
TRG_ENDOCYTIC_2	310	313	PF00928	0.466
TRG_ER_diArg_1	334	336	PF00400	0.562
TRG_ER_diArg_1	347	349	PF00400	0.441
TRG_ER_diArg_1	46	48	PF00400	0.609
TRG_ER_diArg_1	65	67	PF00400	0.434
TRG_NLS_MonoExtN_4	412	418	PF00514	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P496	Leptomonas seymouri	40%	90%
A0A3S7WVY4	Leishmania donovani	85%	99%
E9AGU1	Leishmania infantum	85%	99%
E9AUN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%