Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCU6_LEIMA

TriTrypDb:

LmjF.20.1000 , LMJLV39_200015400 , LMJSD75_200015200

Length:

722

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCU6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.780
CLV_C14_Caspase3-7	466	470	PF00656	0.638
CLV_C14_Caspase3-7	56	60	PF00656	0.739
CLV_NRD_NRD_1	201	203	PF00675	0.659
CLV_NRD_NRD_1	209	211	PF00675	0.658
CLV_NRD_NRD_1	214	216	PF00675	0.686
CLV_NRD_NRD_1	313	315	PF00675	0.758
CLV_NRD_NRD_1	43	45	PF00675	0.700
CLV_NRD_NRD_1	435	437	PF00675	0.785
CLV_NRD_NRD_1	482	484	PF00675	0.854
CLV_NRD_NRD_1	485	487	PF00675	0.834
CLV_PCSK_FUR_1	386	390	PF00082	0.860
CLV_PCSK_FUR_1	73	77	PF00082	0.544
CLV_PCSK_KEX2_1	214	216	PF00082	0.755
CLV_PCSK_KEX2_1	313	315	PF00082	0.738
CLV_PCSK_KEX2_1	388	390	PF00082	0.861
CLV_PCSK_KEX2_1	43	45	PF00082	0.700
CLV_PCSK_KEX2_1	435	437	PF00082	0.785
CLV_PCSK_KEX2_1	574	576	PF00082	0.802
CLV_PCSK_KEX2_1	75	77	PF00082	0.772
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.861
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.700
CLV_PCSK_PC1ET2_1	574	576	PF00082	0.802
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.772
CLV_PCSK_PC7_1	210	216	PF00082	0.821
CLV_PCSK_SKI1_1	111	115	PF00082	0.659
CLV_PCSK_SKI1_1	12	16	PF00082	0.644
CLV_PCSK_SKI1_1	18	22	PF00082	0.587
CLV_PCSK_SKI1_1	214	218	PF00082	0.750
CLV_PCSK_SKI1_1	286	290	PF00082	0.702
CLV_PCSK_SKI1_1	29	33	PF00082	0.379
CLV_PCSK_SKI1_1	44	48	PF00082	0.491
CLV_PCSK_SKI1_1	457	461	PF00082	0.727
CLV_PCSK_SKI1_1	529	533	PF00082	0.786
DEG_Nend_UBRbox_2	1	3	PF02207	0.714
DEG_SCF_FBW7_1	413	418	PF00400	0.684
DEG_SCF_FBW7_1	424	431	PF00400	0.712
DEG_SCF_FBW7_1	512	518	PF00400	0.651
DEG_SPOP_SBC_1	112	116	PF00917	0.634
DEG_SPOP_SBC_1	183	187	PF00917	0.794
DEG_SPOP_SBC_1	632	636	PF00917	0.834
DOC_CKS1_1	275	280	PF01111	0.699
DOC_CKS1_1	412	417	PF01111	0.667
DOC_CKS1_1	425	430	PF01111	0.702
DOC_CKS1_1	512	517	PF01111	0.709
DOC_CKS1_1	597	602	PF01111	0.613
DOC_CYCLIN_yCln2_LP_2	233	239	PF00134	0.612
DOC_CYCLIN_yCln2_LP_2	275	281	PF00134	0.739
DOC_MAPK_gen_1	313	322	PF00069	0.780
DOC_MAPK_gen_1	432	440	PF00069	0.783
DOC_MAPK_MEF2A_6	286	295	PF00069	0.589
DOC_PP1_RVXF_1	10	16	PF00149	0.647
DOC_PP2B_LxvP_1	461	464	PF13499	0.716
DOC_PP2B_LxvP_1	517	520	PF13499	0.610
DOC_USP7_MATH_1	112	116	PF00917	0.670
DOC_USP7_MATH_1	123	127	PF00917	0.678
DOC_USP7_MATH_1	143	147	PF00917	0.553
DOC_USP7_MATH_1	148	152	PF00917	0.750
DOC_USP7_MATH_1	183	187	PF00917	0.769
DOC_USP7_MATH_1	196	200	PF00917	0.620
DOC_USP7_MATH_1	374	378	PF00917	0.862
DOC_USP7_MATH_1	415	419	PF00917	0.685
DOC_USP7_MATH_1	428	432	PF00917	0.632
DOC_USP7_MATH_1	450	454	PF00917	0.830
DOC_USP7_MATH_1	462	466	PF00917	0.630
DOC_USP7_MATH_1	482	486	PF00917	0.616
DOC_USP7_MATH_1	490	494	PF00917	0.725
DOC_USP7_MATH_1	498	502	PF00917	0.593
DOC_USP7_MATH_1	60	64	PF00917	0.743
DOC_USP7_MATH_1	632	636	PF00917	0.788
DOC_USP7_MATH_1	659	663	PF00917	0.799
DOC_USP7_UBL2_3	43	47	PF12436	0.719
DOC_USP7_UBL2_3	570	574	PF12436	0.629
DOC_WD40_RPTOR_TOS_1	700	706	PF00400	0.804
DOC_WW_Pin1_4	134	139	PF00397	0.713
DOC_WW_Pin1_4	168	173	PF00397	0.624
DOC_WW_Pin1_4	187	192	PF00397	0.571
DOC_WW_Pin1_4	240	245	PF00397	0.850
DOC_WW_Pin1_4	274	279	PF00397	0.699
DOC_WW_Pin1_4	295	300	PF00397	0.704
DOC_WW_Pin1_4	363	368	PF00397	0.733
DOC_WW_Pin1_4	411	416	PF00397	0.736
DOC_WW_Pin1_4	420	425	PF00397	0.802
DOC_WW_Pin1_4	446	451	PF00397	0.616
DOC_WW_Pin1_4	477	482	PF00397	0.840
DOC_WW_Pin1_4	511	516	PF00397	0.803
DOC_WW_Pin1_4	530	535	PF00397	0.583
DOC_WW_Pin1_4	536	541	PF00397	0.778
DOC_WW_Pin1_4	573	578	PF00397	0.847
DOC_WW_Pin1_4	582	587	PF00397	0.697
DOC_WW_Pin1_4	596	601	PF00397	0.613
DOC_WW_Pin1_4	616	621	PF00397	0.861
DOC_WW_Pin1_4	640	645	PF00397	0.826
DOC_WW_Pin1_4	681	686	PF00397	0.815
LIG_14-3-3_CanoR_1	18	28	PF00244	0.646
LIG_14-3-3_CanoR_1	197	201	PF00244	0.629
LIG_14-3-3_CanoR_1	254	258	PF00244	0.793
LIG_14-3-3_CanoR_1	407	416	PF00244	0.779
LIG_14-3-3_CanoR_1	529	534	PF00244	0.663
LIG_14-3-3_CanoR_1	575	581	PF00244	0.869
LIG_14-3-3_CanoR_1	630	640	PF00244	0.801
LIG_14-3-3_CanoR_1	81	89	PF00244	0.645
LIG_BIR_III_4	335	339	PF00653	0.743
LIG_BRCT_BRCA1_1	676	680	PF00533	0.621
LIG_Clathr_ClatBox_1	292	296	PF01394	0.595
LIG_FHA_1	20	26	PF00498	0.462
LIG_FHA_1	211	217	PF00498	0.745
LIG_FHA_1	228	234	PF00498	0.611
LIG_FHA_1	287	293	PF00498	0.700
LIG_FHA_1	420	426	PF00498	0.760
LIG_FHA_1	458	464	PF00498	0.721
LIG_FHA_1	512	518	PF00498	0.752
LIG_FHA_1	545	551	PF00498	0.860
LIG_FHA_1	583	589	PF00498	0.844
LIG_FHA_1	6	12	PF00498	0.637
LIG_FHA_1	632	638	PF00498	0.833
LIG_FHA_2	169	175	PF00498	0.611
LIG_FHA_2	188	194	PF00498	0.544
LIG_FHA_2	230	236	PF00498	0.723
LIG_FHA_2	394	400	PF00498	0.856
LIG_FHA_2	464	470	PF00498	0.830
LIG_FHA_2	54	60	PF00498	0.739
LIG_FHA_2	599	605	PF00498	0.788
LIG_FHA_2	693	699	PF00498	0.798
LIG_Integrin_RGD_1	57	59	PF01839	0.699
LIG_LIR_Nem_3	650	655	PF02991	0.753
LIG_MLH1_MIPbox_1	676	680	PF16413	0.601
LIG_MYND_1	401	405	PF01753	0.661
LIG_MYND_1	515	519	PF01753	0.780
LIG_MYND_1	520	524	PF01753	0.727
LIG_MYND_1	640	644	PF01753	0.748
LIG_NRBOX	27	33	PF00104	0.644
LIG_SH2_GRB2like	590	593	PF00017	0.851
LIG_SH2_STAP1	212	216	PF00017	0.590
LIG_SH2_STAT5	212	215	PF00017	0.575
LIG_SH2_STAT5	38	41	PF00017	0.598
LIG_SH2_STAT5	716	719	PF00017	0.811
LIG_SH2_STAT5	94	97	PF00017	0.597
LIG_SH3_2	478	483	PF14604	0.743
LIG_SH3_3	377	383	PF00018	0.777
LIG_SH3_3	398	404	PF00018	0.851
LIG_SH3_3	475	481	PF00018	0.856
LIG_SH3_3	510	516	PF00018	0.847
LIG_SH3_3	518	524	PF00018	0.718
LIG_SH3_3	594	600	PF00018	0.779
LIG_SH3_4	570	577	PF00018	0.633
LIG_TRAF2_1	218	221	PF00917	0.783
LIG_TRAF2_1	244	247	PF00917	0.864
LIG_TRAF2_1	294	297	PF00917	0.836
LIG_TRAF2_1	580	583	PF00917	0.743
LIG_WW_3	553	557	PF00397	0.737
MOD_CDC14_SPxK_1	480	483	PF00782	0.664
MOD_CDK_SPxK_1	424	430	PF00069	0.769
MOD_CDK_SPxK_1	477	483	PF00069	0.666
MOD_CDK_SPxxK_3	477	484	PF00069	0.784
MOD_CDK_SPxxK_3	530	537	PF00069	0.666
MOD_CDK_SPxxK_3	596	603	PF00069	0.614
MOD_CDK_SPxxK_3	616	623	PF00069	0.746
MOD_CK1_1	187	193	PF00069	0.637
MOD_CK1_1	342	348	PF00069	0.805
MOD_CK1_1	485	491	PF00069	0.626
MOD_CK1_1	493	499	PF00069	0.664
MOD_CK1_1	576	582	PF00069	0.866
MOD_CK1_1	591	597	PF00069	0.595
MOD_CK1_1	618	624	PF00069	0.845
MOD_CK1_1	631	637	PF00069	0.631
MOD_CK1_1	650	656	PF00069	0.517
MOD_CK1_1	674	680	PF00069	0.683
MOD_CK1_1	69	75	PF00069	0.718
MOD_CK1_1	711	717	PF00069	0.801
MOD_CK2_1	143	149	PF00069	0.832
MOD_CK2_1	168	174	PF00069	0.612
MOD_CK2_1	415	421	PF00069	0.842
MOD_CK2_1	467	473	PF00069	0.775
MOD_CK2_1	692	698	PF00069	0.798
MOD_CK2_1	702	708	PF00069	0.636
MOD_Cter_Amidation	386	389	PF01082	0.856
MOD_Cter_Amidation	535	538	PF01082	0.753
MOD_DYRK1A_RPxSP_1	477	481	PF00069	0.623
MOD_GlcNHglycan	123	126	PF01048	0.817
MOD_GlcNHglycan	145	148	PF01048	0.615
MOD_GlcNHglycan	186	189	PF01048	0.590
MOD_GlcNHglycan	341	344	PF01048	0.781
MOD_GlcNHglycan	452	455	PF01048	0.778
MOD_GlcNHglycan	473	476	PF01048	0.805
MOD_GlcNHglycan	488	491	PF01048	0.608
MOD_GlcNHglycan	492	495	PF01048	0.544
MOD_GlcNHglycan	578	581	PF01048	0.809
MOD_GlcNHglycan	594	597	PF01048	0.592
MOD_GlcNHglycan	630	633	PF01048	0.659
MOD_GlcNHglycan	652	655	PF01048	0.685
MOD_GlcNHglycan	656	659	PF01048	0.697
MOD_GlcNHglycan	67	71	PF01048	0.751
MOD_GlcNHglycan	673	676	PF01048	0.663
MOD_GlcNHglycan	710	713	PF01048	0.814
MOD_GSK3_1	112	119	PF00069	0.702
MOD_GSK3_1	123	130	PF00069	0.727
MOD_GSK3_1	164	171	PF00069	0.633
MOD_GSK3_1	179	186	PF00069	0.722
MOD_GSK3_1	227	234	PF00069	0.764
MOD_GSK3_1	339	346	PF00069	0.845
MOD_GSK3_1	389	396	PF00069	0.794
MOD_GSK3_1	407	414	PF00069	0.577
MOD_GSK3_1	415	422	PF00069	0.784
MOD_GSK3_1	424	431	PF00069	0.624
MOD_GSK3_1	445	452	PF00069	0.844
MOD_GSK3_1	463	470	PF00069	0.559
MOD_GSK3_1	482	489	PF00069	0.571
MOD_GSK3_1	493	500	PF00069	0.678
MOD_GSK3_1	507	514	PF00069	0.678
MOD_GSK3_1	538	545	PF00069	0.834
MOD_GSK3_1	588	595	PF00069	0.774
MOD_GSK3_1	615	622	PF00069	0.826
MOD_GSK3_1	628	635	PF00069	0.592
MOD_GSK3_1	650	657	PF00069	0.600
MOD_GSK3_1	687	694	PF00069	0.762
MOD_GSK3_1	698	705	PF00069	0.666
MOD_GSK3_1	707	714	PF00069	0.520
MOD_N-GLC_1	591	596	PF02516	0.842
MOD_N-GLC_1	628	633	PF02516	0.729
MOD_NEK2_1	127	132	PF00069	0.777
MOD_NEK2_1	141	146	PF00069	0.663
MOD_NEK2_1	158	163	PF00069	0.567
MOD_NEK2_1	228	233	PF00069	0.844
MOD_NEK2_1	48	53	PF00069	0.798
MOD_NEK2_1	665	670	PF00069	0.729
MOD_NEK2_1	687	692	PF00069	0.805
MOD_PIKK_1	118	124	PF00454	0.745
MOD_PIKK_1	127	133	PF00454	0.769
MOD_PIKK_1	205	211	PF00454	0.573
MOD_PIKK_1	242	248	PF00454	0.790
MOD_PIKK_1	374	380	PF00454	0.860
MOD_PIKK_1	408	414	PF00454	0.791
MOD_PIKK_1	647	653	PF00454	0.745
MOD_PIKK_1	687	693	PF00454	0.805
MOD_PK_1	75	81	PF00069	0.712
MOD_PKA_1	210	216	PF00069	0.821
MOD_PKA_1	315	321	PF00069	0.773
MOD_PKA_1	486	492	PF00069	0.860
MOD_PKA_1	75	81	PF00069	0.712
MOD_PKA_2	159	165	PF00069	0.650
MOD_PKA_2	196	202	PF00069	0.629
MOD_PKA_2	253	259	PF00069	0.793
MOD_PKA_2	339	345	PF00069	0.743
MOD_PKA_2	346	352	PF00069	0.740
MOD_PKA_2	482	488	PF00069	0.797
MOD_PKA_2	592	598	PF00069	0.842
MOD_PKA_2	75	81	PF00069	0.712
MOD_Plk_1	457	463	PF00069	0.763
MOD_Plk_1	698	704	PF00069	0.807
MOD_Plk_2-3	698	704	PF00069	0.807
MOD_Plk_4	123	129	PF00069	0.807
MOD_Plk_4	463	469	PF00069	0.616
MOD_Plk_4	633	639	PF00069	0.828
MOD_Plk_4	665	671	PF00069	0.729
MOD_Plk_4	75	81	PF00069	0.712
MOD_ProDKin_1	134	140	PF00069	0.709
MOD_ProDKin_1	168	174	PF00069	0.626
MOD_ProDKin_1	187	193	PF00069	0.574
MOD_ProDKin_1	240	246	PF00069	0.850
MOD_ProDKin_1	274	280	PF00069	0.699
MOD_ProDKin_1	295	301	PF00069	0.695
MOD_ProDKin_1	363	369	PF00069	0.734
MOD_ProDKin_1	411	417	PF00069	0.737
MOD_ProDKin_1	420	426	PF00069	0.801
MOD_ProDKin_1	446	452	PF00069	0.617
MOD_ProDKin_1	477	483	PF00069	0.843
MOD_ProDKin_1	511	517	PF00069	0.806
MOD_ProDKin_1	530	536	PF00069	0.582
MOD_ProDKin_1	573	579	PF00069	0.846
MOD_ProDKin_1	582	588	PF00069	0.698
MOD_ProDKin_1	596	602	PF00069	0.613
MOD_ProDKin_1	616	622	PF00069	0.861
MOD_ProDKin_1	640	646	PF00069	0.824
MOD_ProDKin_1	681	687	PF00069	0.813
MOD_SUMO_rev_2	323	332	PF00179	0.752
MOD_SUMO_rev_2	443	448	PF00179	0.622
MOD_SUMO_rev_2	567	572	PF00179	0.629
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.714
TRG_DiLeu_BaLyEn_6	637	642	PF01217	0.812
TRG_ENDOCYTIC_2	101	104	PF00928	0.593
TRG_ER_diArg_1	214	216	PF00400	0.784
TRG_NLS_MonoExtC_3	387	393	PF00514	0.776
TRG_NLS_MonoExtC_3	482	487	PF00514	0.752
TRG_NLS_MonoExtN_4	313	318	PF00514	0.745
TRG_NLS_MonoExtN_4	386	392	PF00514	0.855
TRG_NLS_MonoExtN_4	43	48	PF00514	0.727
TRG_NLS_MonoExtN_4	481	487	PF00514	0.745
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.742

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WW49	Leishmania donovani	84%	100%
A4HYU1	Leishmania infantum	84%	100%
E9AIF0	Leishmania braziliensis	61%	99%
E9AUN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%