Putative glutaredoxin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutaredoxin, putative

Species:

Leishmania major

UniProt:

Q4QCU5_LEIMA

TriTrypDb:

LmjF.20.1010 , LMJLV39_200015500 , LMJSD75_200015300

Length:

107

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCU5

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	2
GO:0006979	response to oxidative stress	3	2
GO:0009987	cellular process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034599	cellular response to oxidative stress	4	2
GO:0042221	response to chemical	2	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0062197	cellular response to chemical stress	4	2
GO:0070887	cellular response to chemical stimulus	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0015035	protein-disulfide reductase activity	3	12
GO:0015036	disulfide oxidoreductase activity	4	12
GO:0015038	glutathione disulfide oxidoreductase activity	5	2
GO:0016491	oxidoreductase activity	2	12
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	12
GO:0097573	obsolete glutathione oxidoreductase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0003756	protein disulfide isomerase activity	3	1
GO:0016853	isomerase activity	2	1
GO:0016860	intramolecular oxidoreductase activity	3	1
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.394
CLV_PCSK_KEX2_1	19	21	PF00082	0.428
CLV_PCSK_KEX2_1	97	99	PF00082	0.485
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.477
CLV_PCSK_SKI1_1	22	26	PF00082	0.402
CLV_PCSK_SKI1_1	38	42	PF00082	0.312
CLV_PCSK_SKI1_1	60	64	PF00082	0.312
DEG_Nend_UBRbox_3	1	3	PF02207	0.579
DOC_CYCLIN_RxL_1	35	43	PF00134	0.312
DOC_MAPK_gen_1	19	26	PF00069	0.355
DOC_MAPK_gen_1	36	44	PF00069	0.338
DOC_MAPK_gen_1	45	53	PF00069	0.309
DOC_MAPK_MEF2A_6	36	44	PF00069	0.327
DOC_MAPK_MEF2A_6	45	53	PF00069	0.327
DOC_MIT_MIM_1	43	51	PF04212	0.347
LIG_14-3-3_CanoR_1	47	52	PF00244	0.312
LIG_Integrin_isoDGR_2	58	60	PF01839	0.312
LIG_LIR_Gen_1	27	37	PF02991	0.327
LIG_LIR_Gen_1	61	68	PF02991	0.312
LIG_LIR_Nem_3	27	33	PF02991	0.312
LIG_LIR_Nem_3	61	66	PF02991	0.312
LIG_NRBOX	36	42	PF00104	0.312
LIG_NRP_CendR_1	106	107	PF00754	0.569
LIG_PTB_Apo_2	78	85	PF02174	0.402
LIG_PTB_Phospho_1	78	84	PF10480	0.402
LIG_SH2_STAP1	88	92	PF00017	0.362
LIG_SH2_STAT5	30	33	PF00017	0.312
LIG_SH2_STAT5	84	87	PF00017	0.380
LIG_SH3_3	1	7	PF00018	0.465
LIG_SUMO_SIM_anti_2	52	57	PF11976	0.327
LIG_SUMO_SIM_par_1	22	27	PF11976	0.312
LIG_SUMO_SIM_par_1	38	43	PF11976	0.312
LIG_UBA3_1	39	45	PF00899	0.327
LIG_UBA3_1	91	97	PF00899	0.439
MOD_GlcNHglycan	26	29	PF01048	0.317
MOD_GSK3_1	67	74	PF00069	0.325
MOD_LATS_1	96	102	PF00433	0.462
MOD_NEK2_1	13	18	PF00069	0.450
MOD_Plk_4	13	19	PF00069	0.455
TRG_ENDOCYTIC_2	30	33	PF00928	0.327
TRG_ENDOCYTIC_2	88	91	PF00928	0.365
TRG_ER_diArg_1	18	20	PF00400	0.419
TRG_NES_CRM1_1	43	54	PF08389	0.347
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIF5	Leptomonas seymouri	27%	100%
A0A0N1PD78	Leptomonas seymouri	94%	100%
A0A0S4JTJ5	Bodo saltans	35%	86%
A0A0S4JUD4	Bodo saltans	35%	100%
A0A0S4JWT8	Bodo saltans	82%	100%
A0A0S4KNN2	Bodo saltans	80%	100%
A0A1X0NXP8	Trypanosomatidae	85%	100%
A0A3Q8IG95	Leishmania donovani	29%	99%
A0A3S7WVZ7	Leishmania donovani	99%	100%
A0A422NLI8	Trypanosoma rangeli	80%	100%
A4HYU2	Leishmania infantum	99%	100%
B7ZFT1	Rhizophagus irregularis (strain DAOM 181602 / DAOM 197198 / MUCL 43194)	29%	100%
C9ZIB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	100%
E9AD58	Leishmania major	28%	100%
E9AHF3	Leishmania infantum	29%	99%
E9AIF1	Leishmania braziliensis	92%	100%
E9AIS6	Leishmania braziliensis	28%	100%
E9AUN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9AYY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	98%
O36032	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
O81187	Vernicia fordii	33%	100%
P17695	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	75%
P25373	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	97%
P55142	Oryza sativa subsp. japonica	38%	96%
P55143	Ricinus communis	35%	100%
Q0DAE4	Oryza sativa subsp. japonica	32%	79%
Q19297	Caenorhabditis elegans	35%	73%
Q32L67	Bos taurus	30%	68%
Q54GP8	Dictyostelium discoideum	30%	100%
Q5RC53	Pongo abelii	30%	66%
Q6H628	Oryza sativa subsp. japonica	37%	82%
Q6K953	Oryza sativa subsp. japonica	33%	80%
Q8L8T2	Arabidopsis thaliana	35%	86%
Q8LFQ6	Arabidopsis thaliana	33%	79%
Q923X4	Mus musculus	27%	69%
Q9FNE2	Arabidopsis thaliana	31%	96%
Q9FVX1	Arabidopsis thaliana	35%	82%
Q9ZR41	Solanum lycopersicum	35%	99%