Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QCU4_LEIMA

TriTrypDb:

LmjF.20.1020 , LMJLV39_200015600 , LMJSD75_200015400

Length:

1020

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCU4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.679
CLV_C14_Caspase3-7	879	883	PF00656	0.600
CLV_NRD_NRD_1	147	149	PF00675	0.621
CLV_NRD_NRD_1	165	167	PF00675	0.553
CLV_NRD_NRD_1	299	301	PF00675	0.734
CLV_NRD_NRD_1	358	360	PF00675	0.763
CLV_NRD_NRD_1	40	42	PF00675	0.706
CLV_NRD_NRD_1	676	678	PF00675	0.602
CLV_NRD_NRD_1	835	837	PF00675	0.631
CLV_NRD_NRD_1	851	853	PF00675	0.526
CLV_NRD_NRD_1	902	904	PF00675	0.721
CLV_NRD_NRD_1	983	985	PF00675	0.666
CLV_PCSK_FUR_1	297	301	PF00082	0.585
CLV_PCSK_KEX2_1	147	149	PF00082	0.770
CLV_PCSK_KEX2_1	165	167	PF00082	0.525
CLV_PCSK_KEX2_1	299	301	PF00082	0.712
CLV_PCSK_KEX2_1	358	360	PF00082	0.763
CLV_PCSK_KEX2_1	40	42	PF00082	0.706
CLV_PCSK_KEX2_1	676	678	PF00082	0.602
CLV_PCSK_KEX2_1	834	836	PF00082	0.682
CLV_PCSK_KEX2_1	851	853	PF00082	0.516
CLV_PCSK_KEX2_1	902	904	PF00082	0.718
CLV_PCSK_KEX2_1	985	987	PF00082	0.658
CLV_PCSK_PC1ET2_1	834	836	PF00082	0.682
CLV_PCSK_PC1ET2_1	985	987	PF00082	0.658
CLV_PCSK_PC7_1	36	42	PF00082	0.708
CLV_PCSK_SKI1_1	165	169	PF00082	0.755
CLV_PCSK_SKI1_1	638	642	PF00082	0.736
CLV_PCSK_SKI1_1	739	743	PF00082	0.770
CLV_PCSK_SKI1_1	930	934	PF00082	0.647
DEG_APCC_DBOX_1	298	306	PF00400	0.695
DEG_Kelch_Keap1_1	770	775	PF01344	0.740
DEG_SCF_FBW7_2	463	470	PF00400	0.672
DEG_SPOP_SBC_1	325	329	PF00917	0.769
DEG_SPOP_SBC_1	767	771	PF00917	0.614
DEG_SPOP_SBC_1	876	880	PF00917	0.701
DOC_CDC14_PxL_1	309	317	PF14671	0.605
DOC_CKS1_1	730	735	PF01111	0.790
DOC_CYCLIN_RxL_1	162	172	PF00134	0.750
DOC_CYCLIN_yCln2_LP_2	305	311	PF00134	0.693
DOC_CYCLIN_yCln2_LP_2	803	809	PF00134	0.630
DOC_MAPK_gen_1	297	307	PF00069	0.587
DOC_MAPK_MEF2A_6	174	182	PF00069	0.743
DOC_MAPK_MEF2A_6	300	309	PF00069	0.583
DOC_MAPK_RevD_3	345	359	PF00069	0.641
DOC_PP1_RVXF_1	636	642	PF00149	0.737
DOC_PP2B_LxvP_1	136	139	PF13499	0.764
DOC_PP2B_LxvP_1	168	171	PF13499	0.719
DOC_PP2B_LxvP_1	305	308	PF13499	0.764
DOC_PP2B_LxvP_1	388	391	PF13499	0.699
DOC_PP2B_LxvP_1	728	731	PF13499	0.645
DOC_PP2B_LxvP_1	803	806	PF13499	0.628
DOC_PP2B_LxvP_1	873	876	PF13499	0.704
DOC_PP4_FxxP_1	193	196	PF00568	0.733
DOC_PP4_FxxP_1	220	223	PF00568	0.729
DOC_PP4_FxxP_1	565	568	PF00568	0.583
DOC_USP7_MATH_1	1013	1017	PF00917	0.506
DOC_USP7_MATH_1	128	132	PF00917	0.585
DOC_USP7_MATH_1	252	256	PF00917	0.746
DOC_USP7_MATH_1	267	271	PF00917	0.556
DOC_USP7_MATH_1	326	330	PF00917	0.745
DOC_USP7_MATH_1	346	350	PF00917	0.485
DOC_USP7_MATH_1	423	427	PF00917	0.774
DOC_USP7_MATH_1	428	432	PF00917	0.715
DOC_USP7_MATH_1	659	663	PF00917	0.719
DOC_USP7_MATH_1	75	79	PF00917	0.720
DOC_USP7_MATH_1	763	767	PF00917	0.761
DOC_USP7_MATH_1	817	821	PF00917	0.737
DOC_USP7_MATH_1	861	865	PF00917	0.758
DOC_USP7_MATH_1	876	880	PF00917	0.548
DOC_USP7_MATH_1	958	962	PF00917	0.651
DOC_USP7_MATH_1	994	998	PF00917	0.636
DOC_USP7_UBL2_3	830	834	PF12436	0.772
DOC_WW_Pin1_4	1008	1013	PF00397	0.655
DOC_WW_Pin1_4	273	278	PF00397	0.762
DOC_WW_Pin1_4	280	285	PF00397	0.676
DOC_WW_Pin1_4	327	332	PF00397	0.776
DOC_WW_Pin1_4	333	338	PF00397	0.692
DOC_WW_Pin1_4	386	391	PF00397	0.660
DOC_WW_Pin1_4	398	403	PF00397	0.622
DOC_WW_Pin1_4	411	416	PF00397	0.578
DOC_WW_Pin1_4	463	468	PF00397	0.687
DOC_WW_Pin1_4	536	541	PF00397	0.720
DOC_WW_Pin1_4	547	552	PF00397	0.569
DOC_WW_Pin1_4	585	590	PF00397	0.605
DOC_WW_Pin1_4	643	648	PF00397	0.729
DOC_WW_Pin1_4	661	666	PF00397	0.499
DOC_WW_Pin1_4	686	691	PF00397	0.703
DOC_WW_Pin1_4	694	699	PF00397	0.643
DOC_WW_Pin1_4	717	722	PF00397	0.776
DOC_WW_Pin1_4	729	734	PF00397	0.635
DOC_WW_Pin1_4	775	780	PF00397	0.706
DOC_WW_Pin1_4	94	99	PF00397	0.730
DOC_WW_Pin1_4	956	961	PF00397	0.664
LIG_14-3-3_CanoR_1	122	126	PF00244	0.618
LIG_14-3-3_CanoR_1	147	152	PF00244	0.730
LIG_14-3-3_CanoR_1	266	275	PF00244	0.738
LIG_14-3-3_CanoR_1	317	326	PF00244	0.637
LIG_14-3-3_CanoR_1	367	373	PF00244	0.661
LIG_14-3-3_CanoR_1	451	456	PF00244	0.596
LIG_14-3-3_CanoR_1	46	52	PF00244	0.756
LIG_14-3-3_CanoR_1	670	674	PF00244	0.736
LIG_14-3-3_CanoR_1	743	748	PF00244	0.775
LIG_14-3-3_CanoR_1	79	84	PF00244	0.777
LIG_14-3-3_CanoR_1	804	810	PF00244	0.670
LIG_14-3-3_CanoR_1	877	882	PF00244	0.704
LIG_14-3-3_CanoR_1	911	919	PF00244	0.650
LIG_BRCT_BRCA1_1	159	163	PF00533	0.757
LIG_BRCT_BRCA1_1	216	220	PF00533	0.756
LIG_EH1_1	894	902	PF00400	0.631
LIG_EVH1_1	193	197	PF00568	0.732
LIG_FHA_1	2	8	PF00498	0.721
LIG_FHA_1	203	209	PF00498	0.628
LIG_FHA_1	263	269	PF00498	0.715
LIG_FHA_1	368	374	PF00498	0.766
LIG_FHA_1	438	444	PF00498	0.743
LIG_FHA_1	634	640	PF00498	0.717
LIG_FHA_1	817	823	PF00498	0.768
LIG_FHA_2	147	153	PF00498	0.651
LIG_FHA_2	23	29	PF00498	0.554
LIG_FHA_2	473	479	PF00498	0.633
LIG_FHA_2	517	523	PF00498	0.707
LIG_FHA_2	617	623	PF00498	0.766
LIG_FHA_2	9	15	PF00498	0.726
LIG_FHA_2	943	949	PF00498	0.653
LIG_LIR_Apic_2	190	196	PF02991	0.730
LIG_LIR_Apic_2	217	223	PF02991	0.720
LIG_LIR_Apic_2	276	281	PF02991	0.605
LIG_LIR_Gen_1	121	130	PF02991	0.601
LIG_LIR_Gen_1	14	21	PF02991	0.621
LIG_LIR_Gen_1	496	505	PF02991	0.731
LIG_LIR_Gen_1	684	690	PF02991	0.629
LIG_LIR_Nem_3	121	126	PF02991	0.615
LIG_LIR_Nem_3	14	19	PF02991	0.685
LIG_LIR_Nem_3	23	29	PF02991	0.689
LIG_LIR_Nem_3	496	501	PF02991	0.727
LIG_LIR_Nem_3	775	780	PF02991	0.800
LIG_LIR_Nem_3	868	873	PF02991	0.763
LIG_LIR_Nem_3	916	922	PF02991	0.638
LIG_LIR_Nem_3	927	932	PF02991	0.539
LIG_MYND_1	463	467	PF01753	0.771
LIG_PDZ_Class_3	1015	1020	PF00595	0.621
LIG_PTB_Apo_2	880	887	PF02174	0.687
LIG_SH2_GRB2like	609	612	PF00017	0.617
LIG_SH2_SRC	498	501	PF00017	0.731
LIG_SH2_SRC	520	523	PF00017	0.546
LIG_SH2_STAT5	520	523	PF00017	0.546
LIG_SH2_STAT5	941	944	PF00017	0.651
LIG_SH3_1	191	197	PF00018	0.732
LIG_SH3_3	122	128	PF00018	0.761
LIG_SH3_3	136	142	PF00018	0.575
LIG_SH3_3	191	197	PF00018	0.774
LIG_SH3_3	220	226	PF00018	0.623
LIG_SH3_3	271	277	PF00018	0.718
LIG_SH3_3	278	284	PF00018	0.644
LIG_SH3_3	305	311	PF00018	0.790
LIG_SH3_3	388	394	PF00018	0.743
LIG_SH3_3	588	594	PF00018	0.684
LIG_SH3_3	641	647	PF00018	0.673
LIG_SH3_3	695	701	PF00018	0.640
LIG_SH3_4	603	610	PF00018	0.596
LIG_SUMO_SIM_par_1	166	172	PF11976	0.724
LIG_TRAF2_1	781	784	PF00917	0.736
LIG_TYR_ITSM	22	29	PF00017	0.741
LIG_WRC_WIRS_1	170	175	PF05994	0.734
LIG_WRC_WIRS_1	919	924	PF05994	0.629
LIG_WRC_WIRS_1	926	931	PF05994	0.562
MOD_CDK_SPK_2	694	699	PF00069	0.660
MOD_CDK_SPxxK_3	398	405	PF00069	0.723
MOD_CDK_SPxxK_3	775	782	PF00069	0.641
MOD_CK1_1	121	127	PF00069	0.762
MOD_CK1_1	181	187	PF00069	0.597
MOD_CK1_1	207	213	PF00069	0.755
MOD_CK1_1	22	28	PF00069	0.588
MOD_CK1_1	238	244	PF00069	0.761
MOD_CK1_1	255	261	PF00069	0.525
MOD_CK1_1	283	289	PF00069	0.694
MOD_CK1_1	292	298	PF00069	0.660
MOD_CK1_1	327	333	PF00069	0.711
MOD_CK1_1	349	355	PF00069	0.744
MOD_CK1_1	437	443	PF00069	0.741
MOD_CK1_1	454	460	PF00069	0.542
MOD_CK1_1	539	545	PF00069	0.761
MOD_CK1_1	584	590	PF00069	0.797
MOD_CK1_1	616	622	PF00069	0.736
MOD_CK1_1	689	695	PF00069	0.709
MOD_CK1_1	724	730	PF00069	0.797
MOD_CK1_1	762	768	PF00069	0.763
MOD_CK1_1	770	776	PF00069	0.667
MOD_CK1_1	78	84	PF00069	0.684
MOD_CK1_1	820	826	PF00069	0.666
MOD_CK1_1	855	861	PF00069	0.770
MOD_CK1_1	862	868	PF00069	0.667
MOD_CK1_1	896	902	PF00069	0.679
MOD_CK1_1	925	931	PF00069	0.616
MOD_CK1_1	94	100	PF00069	0.552
MOD_CK1_1	950	956	PF00069	0.670
MOD_CK1_1	997	1003	PF00069	0.638
MOD_CK2_1	146	152	PF00069	0.645
MOD_CK2_1	22	28	PF00069	0.557
MOD_CK2_1	237	243	PF00069	0.766
MOD_CK2_1	472	478	PF00069	0.634
MOD_CK2_1	616	622	PF00069	0.775
MOD_CK2_1	668	674	PF00069	0.753
MOD_CK2_1	766	772	PF00069	0.766
MOD_CK2_1	8	14	PF00069	0.726
MOD_CK2_1	862	868	PF00069	0.759
MOD_CK2_1	928	934	PF00069	0.626
MOD_Cter_Amidation	145	148	PF01082	0.764
MOD_Cter_Amidation	297	300	PF01082	0.718
MOD_Cter_Amidation	356	359	PF01082	0.757
MOD_GlcNHglycan	129	133	PF01048	0.670
MOD_GlcNHglycan	237	240	PF01048	0.774
MOD_GlcNHglycan	254	257	PF01048	0.524
MOD_GlcNHglycan	260	263	PF01048	0.673
MOD_GlcNHglycan	285	288	PF01048	0.748
MOD_GlcNHglycan	292	295	PF01048	0.654
MOD_GlcNHglycan	355	358	PF01048	0.720
MOD_GlcNHglycan	374	377	PF01048	0.519
MOD_GlcNHglycan	425	428	PF01048	0.763
MOD_GlcNHglycan	456	459	PF01048	0.704
MOD_GlcNHglycan	49	52	PF01048	0.695
MOD_GlcNHglycan	493	496	PF01048	0.651
MOD_GlcNHglycan	59	62	PF01048	0.678
MOD_GlcNHglycan	613	616	PF01048	0.677
MOD_GlcNHglycan	761	764	PF01048	0.769
MOD_GlcNHglycan	81	84	PF01048	0.650
MOD_GlcNHglycan	812	815	PF01048	0.732
MOD_GlcNHglycan	853	857	PF01048	0.763
MOD_GlcNHglycan	948	952	PF01048	0.662
MOD_GlcNHglycan	956	959	PF01048	0.611
MOD_GlcNHglycan	962	965	PF01048	0.553
MOD_GlcNHglycan	996	999	PF01048	0.635
MOD_GSK3_1	169	176	PF00069	0.670
MOD_GSK3_1	2	9	PF00069	0.674
MOD_GSK3_1	200	207	PF00069	0.712
MOD_GSK3_1	251	258	PF00069	0.744
MOD_GSK3_1	289	296	PF00069	0.732
MOD_GSK3_1	320	327	PF00069	0.813
MOD_GSK3_1	346	353	PF00069	0.737
MOD_GSK3_1	363	370	PF00069	0.544
MOD_GSK3_1	435	442	PF00069	0.691
MOD_GSK3_1	55	62	PF00069	0.757
MOD_GSK3_1	575	582	PF00069	0.611
MOD_GSK3_1	607	614	PF00069	0.771
MOD_GSK3_1	653	660	PF00069	0.793
MOD_GSK3_1	717	724	PF00069	0.819
MOD_GSK3_1	75	82	PF00069	0.545
MOD_GSK3_1	755	762	PF00069	0.776
MOD_GSK3_1	763	770	PF00069	0.672
MOD_GSK3_1	816	823	PF00069	0.738
MOD_GSK3_1	851	858	PF00069	0.762
MOD_GSK3_1	882	889	PF00069	0.728
MOD_GSK3_1	914	921	PF00069	0.632
MOD_GSK3_1	92	99	PF00069	0.586
MOD_GSK3_1	943	950	PF00069	0.654
MOD_GSK3_1	952	959	PF00069	0.602
MOD_GSK3_1	975	982	PF00069	0.670
MOD_GSK3_1	997	1004	PF00069	0.640
MOD_N-GLC_1	363	368	PF02516	0.734
MOD_N-GLC_1	429	434	PF02516	0.758
MOD_N-GLC_1	435	440	PF02516	0.653
MOD_N-GLC_1	820	825	PF02516	0.650
MOD_N-GLC_1	862	867	PF02516	0.759
MOD_N-GLC_1	882	887	PF02516	0.492
MOD_N-GLC_1	943	948	PF02516	0.652
MOD_NEK2_1	1	6	PF00069	0.735
MOD_NEK2_1	180	185	PF00069	0.736
MOD_NEK2_1	19	24	PF00069	0.501
MOD_NEK2_1	213	218	PF00069	0.678
MOD_NEK2_1	315	320	PF00069	0.659
MOD_NEK2_1	332	337	PF00069	0.687
MOD_NEK2_1	363	368	PF00069	0.766
MOD_NEK2_1	493	498	PF00069	0.706
MOD_NEK2_1	579	584	PF00069	0.604
MOD_NEK2_1	8	13	PF00069	0.625
MOD_NEK2_1	859	864	PF00069	0.704
MOD_NEK2_1	886	891	PF00069	0.708
MOD_NEK2_1	942	947	PF00069	0.653
MOD_NEK2_2	100	105	PF00069	0.601
MOD_NEK2_2	346	351	PF00069	0.595
MOD_PIKK_1	157	163	PF00454	0.763
MOD_PIKK_1	173	179	PF00454	0.529
MOD_PIKK_1	214	220	PF00454	0.753
MOD_PIKK_1	429	435	PF00454	0.704
MOD_PIKK_1	472	478	PF00454	0.634
MOD_PIKK_1	734	740	PF00454	0.792
MOD_PIKK_1	952	958	PF00454	0.629
MOD_PIKK_1	979	985	PF00454	0.671
MOD_PK_1	451	457	PF00069	0.599
MOD_PK_1	743	749	PF00069	0.775
MOD_PK_1	843	849	PF00069	0.779
MOD_PK_1	893	899	PF00069	0.618
MOD_PKA_1	147	153	PF00069	0.782
MOD_PKA_1	358	364	PF00069	0.766
MOD_PKA_1	834	840	PF00069	0.675
MOD_PKA_1	851	857	PF00069	0.522
MOD_PKA_1	985	991	PF00069	0.657
MOD_PKA_2	118	124	PF00069	0.612
MOD_PKA_2	146	152	PF00069	0.768
MOD_PKA_2	173	179	PF00069	0.739
MOD_PKA_2	289	295	PF00069	0.764
MOD_PKA_2	318	324	PF00069	0.639
MOD_PKA_2	358	364	PF00069	0.722
MOD_PKA_2	366	372	PF00069	0.623
MOD_PKA_2	45	51	PF00069	0.755
MOD_PKA_2	628	634	PF00069	0.747
MOD_PKA_2	669	675	PF00069	0.749
MOD_PKA_2	78	84	PF00069	0.772
MOD_PKA_2	834	840	PF00069	0.692
MOD_PKA_2	851	857	PF00069	0.631
MOD_PKA_2	876	882	PF00069	0.704
MOD_PKA_2	985	991	PF00069	0.657
MOD_PKB_1	53	61	PF00069	0.602
MOD_Plk_1	363	369	PF00069	0.622
MOD_Plk_1	435	441	PF00069	0.689
MOD_Plk_1	843	849	PF00069	0.779
MOD_Plk_1	882	888	PF00069	0.688
MOD_Plk_4	100	106	PF00069	0.750
MOD_Plk_4	439	445	PF00069	0.695
MOD_Plk_4	743	749	PF00069	0.775
MOD_Plk_4	855	861	PF00069	0.726
MOD_Plk_4	896	902	PF00069	0.679
MOD_Plk_4	918	924	PF00069	0.688
MOD_Plk_4	936	942	PF00069	0.510
MOD_ProDKin_1	1008	1014	PF00069	0.651
MOD_ProDKin_1	273	279	PF00069	0.757
MOD_ProDKin_1	280	286	PF00069	0.675
MOD_ProDKin_1	327	333	PF00069	0.777
MOD_ProDKin_1	386	392	PF00069	0.661
MOD_ProDKin_1	398	404	PF00069	0.622
MOD_ProDKin_1	411	417	PF00069	0.578
MOD_ProDKin_1	463	469	PF00069	0.690
MOD_ProDKin_1	536	542	PF00069	0.724
MOD_ProDKin_1	547	553	PF00069	0.568
MOD_ProDKin_1	585	591	PF00069	0.600
MOD_ProDKin_1	643	649	PF00069	0.728
MOD_ProDKin_1	661	667	PF00069	0.500
MOD_ProDKin_1	686	692	PF00069	0.703
MOD_ProDKin_1	694	700	PF00069	0.643
MOD_ProDKin_1	717	723	PF00069	0.775
MOD_ProDKin_1	729	735	PF00069	0.633
MOD_ProDKin_1	775	781	PF00069	0.702
MOD_ProDKin_1	94	100	PF00069	0.730
MOD_ProDKin_1	956	962	PF00069	0.664
MOD_SUMO_for_1	781	784	PF00179	0.780
MOD_SUMO_rev_2	481	489	PF00179	0.582
TRG_DiLeu_BaEn_2	132	138	PF01217	0.603
TRG_DiLeu_BaEn_4	14	20	PF01217	0.753
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.649
TRG_ENDOCYTIC_2	26	29	PF00928	0.748
TRG_ENDOCYTIC_2	498	501	PF00928	0.731
TRG_ER_diArg_1	165	167	PF00400	0.652
TRG_ER_diArg_1	297	300	PF00400	0.586
TRG_ER_diArg_1	39	41	PF00400	0.706
TRG_ER_diArg_1	52	55	PF00400	0.570
TRG_ER_diArg_1	675	677	PF00400	0.617
TRG_ER_diArg_1	835	838	PF00400	0.630
TRG_ER_diArg_1	850	852	PF00400	0.525
TRG_ER_diArg_1	901	903	PF00400	0.727
TRG_ER_diArg_1	965	968	PF00400	0.600
TRG_NLS_MonoExtC_3	833	838	PF00514	0.683
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.755

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IAU5	Leishmania donovani	81%	100%
A4HYU3	Leishmania infantum	80%	100%
E9AUP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%