Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCU3_LEIMA

TriTrypDb:

LmjF.20.1030 , LMJLV39_200015700 , LMJSD75_200015500

Length:

217

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCU3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.640
CLV_NRD_NRD_1	126	128	PF00675	0.627
CLV_NRD_NRD_1	135	137	PF00675	0.683
CLV_NRD_NRD_1	182	184	PF00675	0.662
CLV_NRD_NRD_1	195	197	PF00675	0.613
CLV_PCSK_KEX2_1	135	137	PF00082	0.695
CLV_PCSK_KEX2_1	181	183	PF00082	0.652
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.686
CLV_PCSK_SKI1_1	142	146	PF00082	0.659
CLV_PCSK_SKI1_1	156	160	PF00082	0.549
CLV_PCSK_SKI1_1	213	217	PF00082	0.596
CLV_PCSK_SKI1_1	94	98	PF00082	0.627
DOC_PP4_FxxP_1	116	119	PF00568	0.621
DOC_PP4_MxPP_1	2	5	PF00568	0.650
DOC_USP7_MATH_1	119	123	PF00917	0.652
DOC_USP7_MATH_1	80	84	PF00917	0.525
DOC_USP7_UBL2_3	121	125	PF12436	0.567
DOC_USP7_UBL2_3	181	185	PF12436	0.723
DOC_USP7_UBL2_3	94	98	PF12436	0.594
DOC_WW_Pin1_4	163	168	PF00397	0.646
LIG_14-3-3_CanoR_1	14	23	PF00244	0.566
LIG_14-3-3_CanoR_1	72	77	PF00244	0.636
LIG_FHA_1	203	209	PF00498	0.607
LIG_FHA_2	160	166	PF00498	0.639
LIG_LIR_Apic_2	115	119	PF02991	0.642
LIG_MYND_1	4	8	PF01753	0.787
LIG_SH2_STAP1	160	164	PF00017	0.755
LIG_SH2_STAT5	114	117	PF00017	0.569
LIG_SH3_2	42	47	PF14604	0.555
LIG_SH3_3	1	7	PF00018	0.640
LIG_SH3_3	161	167	PF00018	0.724
LIG_SH3_3	17	23	PF00018	0.729
LIG_SH3_3	27	33	PF00018	0.640
LIG_SH3_3	39	45	PF00018	0.726
LIG_WW_2	4	7	PF00397	0.634
MOD_CDK_SPK_2	163	168	PF00069	0.646
MOD_CK1_1	15	21	PF00069	0.654
MOD_CK2_1	80	86	PF00069	0.610
MOD_Cter_Amidation	194	197	PF01082	0.680
MOD_Cter_Amidation	92	95	PF01082	0.621
MOD_GlcNHglycan	121	124	PF01048	0.589
MOD_GlcNHglycan	14	17	PF01048	0.682
MOD_GlcNHglycan	42	45	PF01048	0.674
MOD_GlcNHglycan	54	57	PF01048	0.608
MOD_GSK3_1	159	166	PF00069	0.621
MOD_GSK3_1	32	39	PF00069	0.673
MOD_GSK3_1	57	64	PF00069	0.607
MOD_GSK3_1	81	88	PF00069	0.655
MOD_N-GLC_1	12	17	PF02516	0.636
MOD_N-GLC_1	149	154	PF02516	0.490
MOD_N-GLC_1	36	41	PF02516	0.715
MOD_NEK2_1	12	17	PF00069	0.579
MOD_NEK2_1	158	163	PF00069	0.630
MOD_NEK2_1	202	207	PF00069	0.667
MOD_NEK2_1	36	41	PF00069	0.712
MOD_NEK2_2	167	172	PF00069	0.670
MOD_PIKK_1	101	107	PF00454	0.652
MOD_PIKK_1	62	68	PF00454	0.818
MOD_PK_1	72	78	PF00069	0.540
MOD_PKA_2	195	201	PF00069	0.794
MOD_PKA_2	40	46	PF00069	0.563
MOD_Plk_1	149	155	PF00069	0.623
MOD_Plk_1	36	42	PF00069	0.756
MOD_Plk_4	150	156	PF00069	0.621
MOD_Plk_4	159	165	PF00069	0.640
MOD_Plk_4	203	209	PF00069	0.740
MOD_ProDKin_1	163	169	PF00069	0.646
TRG_ER_diArg_1	182	184	PF00400	0.622
TRG_NLS_Bipartite_1	181	200	PF00514	0.816
TRG_NLS_MonoExtC_3	180	185	PF00514	0.709
TRG_NLS_MonoExtC_3	93	98	PF00514	0.590
TRG_NLS_MonoExtN_4	179	185	PF00514	0.738
TRG_NLS_MonoExtN_4	194	200	PF00514	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I456	Leptomonas seymouri	48%	68%
E9AIF3	Leishmania braziliensis	60%	100%
E9AUP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%