Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCU2_LEIMA

TriTrypDb:

LmjF.20.1040 , LMJLV39_200015800 , LMJSD75_200015600

Length:

892

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.667
CLV_C14_Caspase3-7	422	426	PF00656	0.697
CLV_C14_Caspase3-7	49	53	PF00656	0.621
CLV_C14_Caspase3-7	494	498	PF00656	0.615
CLV_NRD_NRD_1	131	133	PF00675	0.654
CLV_NRD_NRD_1	156	158	PF00675	0.830
CLV_NRD_NRD_1	177	179	PF00675	0.634
CLV_NRD_NRD_1	357	359	PF00675	0.606
CLV_NRD_NRD_1	542	544	PF00675	0.773
CLV_NRD_NRD_1	634	636	PF00675	0.632
CLV_NRD_NRD_1	685	687	PF00675	0.559
CLV_NRD_NRD_1	785	787	PF00675	0.605
CLV_NRD_NRD_1	82	84	PF00675	0.713
CLV_NRD_NRD_1	842	844	PF00675	0.532
CLV_PCSK_FUR_1	783	787	PF00082	0.580
CLV_PCSK_KEX2_1	131	133	PF00082	0.654
CLV_PCSK_KEX2_1	310	312	PF00082	0.628
CLV_PCSK_KEX2_1	357	359	PF00082	0.615
CLV_PCSK_KEX2_1	634	636	PF00082	0.632
CLV_PCSK_KEX2_1	685	687	PF00082	0.559
CLV_PCSK_KEX2_1	785	787	PF00082	0.605
CLV_PCSK_KEX2_1	826	828	PF00082	0.471
CLV_PCSK_KEX2_1	842	844	PF00082	0.590
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.704
CLV_PCSK_PC1ET2_1	826	828	PF00082	0.466
CLV_PCSK_PC7_1	781	787	PF00082	0.585
CLV_PCSK_SKI1_1	220	224	PF00082	0.769
CLV_PCSK_SKI1_1	302	306	PF00082	0.653
CLV_PCSK_SKI1_1	329	333	PF00082	0.699
CLV_PCSK_SKI1_1	390	394	PF00082	0.643
CLV_PCSK_SKI1_1	543	547	PF00082	0.702
CLV_PCSK_SKI1_1	551	555	PF00082	0.615
CLV_PCSK_SKI1_1	605	609	PF00082	0.689
CLV_PCSK_SKI1_1	665	669	PF00082	0.628
CLV_PCSK_SKI1_1	686	690	PF00082	0.480
CLV_PCSK_SKI1_1	807	811	PF00082	0.517
DEG_Nend_Nbox_1	1	3	PF02207	0.691
DEG_SCF_FBW7_1	626	632	PF00400	0.711
DEG_SPOP_SBC_1	117	121	PF00917	0.657
DEG_SPOP_SBC_1	201	205	PF00917	0.720
DEG_SPOP_SBC_1	336	340	PF00917	0.626
DOC_CKS1_1	448	453	PF01111	0.609
DOC_CKS1_1	626	631	PF01111	0.714
DOC_CKS1_1	73	78	PF01111	0.662
DOC_CKS1_1	787	792	PF01111	0.581
DOC_CYCLIN_yCln2_LP_2	720	726	PF00134	0.487
DOC_MAPK_gen_1	83	90	PF00069	0.667
DOC_PP2B_LxvP_1	2	5	PF13499	0.679
DOC_PP2B_LxvP_1	231	234	PF13499	0.681
DOC_PP4_FxxP_1	546	549	PF00568	0.649
DOC_USP7_MATH_1	101	105	PF00917	0.699
DOC_USP7_MATH_1	136	140	PF00917	0.688
DOC_USP7_MATH_1	191	195	PF00917	0.703
DOC_USP7_MATH_1	196	200	PF00917	0.661
DOC_USP7_MATH_1	201	205	PF00917	0.808
DOC_USP7_MATH_1	234	238	PF00917	0.635
DOC_USP7_MATH_1	240	244	PF00917	0.598
DOC_USP7_MATH_1	280	284	PF00917	0.633
DOC_USP7_MATH_1	336	340	PF00917	0.657
DOC_USP7_MATH_1	363	367	PF00917	0.674
DOC_USP7_MATH_1	383	387	PF00917	0.700
DOC_USP7_MATH_1	409	413	PF00917	0.578
DOC_USP7_MATH_1	495	499	PF00917	0.738
DOC_USP7_MATH_1	524	528	PF00917	0.693
DOC_USP7_MATH_1	583	587	PF00917	0.679
DOC_USP7_MATH_1	595	599	PF00917	0.619
DOC_USP7_MATH_1	601	605	PF00917	0.553
DOC_USP7_MATH_1	607	611	PF00917	0.647
DOC_WW_Pin1_4	106	111	PF00397	0.704
DOC_WW_Pin1_4	259	264	PF00397	0.629
DOC_WW_Pin1_4	369	374	PF00397	0.655
DOC_WW_Pin1_4	38	43	PF00397	0.621
DOC_WW_Pin1_4	415	420	PF00397	0.660
DOC_WW_Pin1_4	44	49	PF00397	0.619
DOC_WW_Pin1_4	442	447	PF00397	0.665
DOC_WW_Pin1_4	462	467	PF00397	0.464
DOC_WW_Pin1_4	479	484	PF00397	0.501
DOC_WW_Pin1_4	503	508	PF00397	0.703
DOC_WW_Pin1_4	529	534	PF00397	0.695
DOC_WW_Pin1_4	537	542	PF00397	0.662
DOC_WW_Pin1_4	597	602	PF00397	0.606
DOC_WW_Pin1_4	625	630	PF00397	0.706
DOC_WW_Pin1_4	655	660	PF00397	0.776
DOC_WW_Pin1_4	705	710	PF00397	0.555
DOC_WW_Pin1_4	72	77	PF00397	0.679
DOC_WW_Pin1_4	786	791	PF00397	0.585
DOC_WW_Pin1_4	815	820	PF00397	0.530
DOC_WW_Pin1_4	858	863	PF00397	0.651
DOC_WW_Pin1_4	88	93	PF00397	0.800
LIG_14-3-3_CanoR_1	157	161	PF00244	0.613
LIG_14-3-3_CanoR_1	178	186	PF00244	0.705
LIG_14-3-3_CanoR_1	190	196	PF00244	0.589
LIG_14-3-3_CanoR_1	302	309	PF00244	0.648
LIG_14-3-3_CanoR_1	788	794	PF00244	0.559
LIG_APCC_ABBAyCdc20_2	157	163	PF00400	0.701
LIG_BIR_III_4	274	278	PF00653	0.583
LIG_DCNL_PONY_1	1	4	PF03556	0.690
LIG_FHA_1	391	397	PF00498	0.574
LIG_FHA_1	442	448	PF00498	0.643
LIG_FHA_1	463	469	PF00498	0.599
LIG_FHA_1	565	571	PF00498	0.642
LIG_FHA_1	626	632	PF00498	0.640
LIG_FHA_2	47	53	PF00498	0.628
LIG_FHA_2	492	498	PF00498	0.609
LIG_Integrin_RGD_1	16	18	PF01839	0.624
LIG_Integrin_RGD_1	374	376	PF01839	0.657
LIG_LIR_Gen_1	470	481	PF02991	0.731
LIG_LIR_Gen_1	690	700	PF02991	0.521
LIG_LIR_Nem_3	18	24	PF02991	0.602
LIG_LIR_Nem_3	470	476	PF02991	0.644
LIG_LIR_Nem_3	690	695	PF02991	0.516
LIG_MYND_1	259	263	PF01753	0.628
LIG_NBox_RRM_1	806	816	PF00076	0.501
LIG_PCNA_yPIPBox_3	749	762	PF02747	0.453
LIG_Pex14_1	456	460	PF04695	0.605
LIG_PTAP_UEV_1	622	627	PF05743	0.634
LIG_SH2_CRK	24	28	PF00017	0.584
LIG_SH2_CRK	256	260	PF00017	0.677
LIG_SH2_CRK	61	65	PF00017	0.670
LIG_SH2_CRK	730	734	PF00017	0.572
LIG_SH2_GRB2like	322	325	PF00017	0.686
LIG_SH2_NCK_1	460	464	PF00017	0.676
LIG_SH2_NCK_1	730	734	PF00017	0.620
LIG_SH2_SRC	19	22	PF00017	0.599
LIG_SH2_SRC	730	733	PF00017	0.552
LIG_SH2_STAP1	246	250	PF00017	0.676
LIG_SH2_STAT3	853	856	PF00017	0.639
LIG_SH2_STAT5	246	249	PF00017	0.646
LIG_SH2_STAT5	454	457	PF00017	0.633
LIG_SH3_1	79	85	PF00018	0.712
LIG_SH3_2	82	87	PF14604	0.721
LIG_SH3_3	163	169	PF00018	0.626
LIG_SH3_3	257	263	PF00018	0.624
LIG_SH3_3	445	451	PF00018	0.592
LIG_SH3_3	473	479	PF00018	0.641
LIG_SH3_3	546	552	PF00018	0.646
LIG_SH3_3	568	574	PF00018	0.638
LIG_SH3_3	620	626	PF00018	0.596
LIG_SH3_3	70	76	PF00018	0.738
LIG_SH3_3	769	775	PF00018	0.683
LIG_SH3_3	79	85	PF00018	0.776
LIG_SH3_3	813	819	PF00018	0.609
LIG_SUMO_SIM_anti_2	694	699	PF11976	0.551
LIG_SUMO_SIM_par_1	338	346	PF11976	0.607
LIG_SUMO_SIM_par_1	694	699	PF11976	0.594
LIG_UBA3_1	1	8	PF00899	0.684
LIG_WW_3	770	774	PF00397	0.617
MOD_CDK_SPK_2	369	374	PF00069	0.655
MOD_CDK_SPK_2	447	452	PF00069	0.675
MOD_CDK_SPK_2	479	484	PF00069	0.638
MOD_CDK_SPK_2	786	791	PF00069	0.593
MOD_CDK_SPxK_1	537	543	PF00069	0.609
MOD_CDK_SPxxK_3	537	544	PF00069	0.688
MOD_CDK_SPxxK_3	705	712	PF00069	0.545
MOD_CDK_SPxxK_3	72	79	PF00069	0.664
MOD_CK1_1	105	111	PF00069	0.620
MOD_CK1_1	148	154	PF00069	0.674
MOD_CK1_1	204	210	PF00069	0.726
MOD_CK1_1	221	227	PF00069	0.640
MOD_CK1_1	262	268	PF00069	0.761
MOD_CK1_1	314	320	PF00069	0.795
MOD_CK1_1	366	372	PF00069	0.722
MOD_CK1_1	386	392	PF00069	0.685
MOD_CK1_1	410	416	PF00069	0.655
MOD_CK1_1	527	533	PF00069	0.614
MOD_CK1_1	534	540	PF00069	0.658
MOD_CK1_1	585	591	PF00069	0.627
MOD_GlcNHglycan	10	13	PF01048	0.729
MOD_GlcNHglycan	104	107	PF01048	0.740
MOD_GlcNHglycan	138	141	PF01048	0.691
MOD_GlcNHglycan	146	150	PF01048	0.648
MOD_GlcNHglycan	193	196	PF01048	0.707
MOD_GlcNHglycan	223	226	PF01048	0.671
MOD_GlcNHglycan	278	281	PF01048	0.704
MOD_GlcNHglycan	282	285	PF01048	0.754
MOD_GlcNHglycan	363	366	PF01048	0.776
MOD_GlcNHglycan	414	417	PF01048	0.693
MOD_GlcNHglycan	419	422	PF01048	0.705
MOD_GlcNHglycan	425	428	PF01048	0.803
MOD_GlcNHglycan	501	504	PF01048	0.705
MOD_GlcNHglycan	518	521	PF01048	0.527
MOD_GlcNHglycan	526	529	PF01048	0.691
MOD_GlcNHglycan	536	539	PF01048	0.550
MOD_GlcNHglycan	556	559	PF01048	0.739
MOD_GlcNHglycan	593	596	PF01048	0.718
MOD_GlcNHglycan	623	626	PF01048	0.656
MOD_GlcNHglycan	99	102	PF01048	0.709
MOD_GSK3_1	141	148	PF00069	0.701
MOD_GSK3_1	196	203	PF00069	0.640
MOD_GSK3_1	205	212	PF00069	0.801
MOD_GSK3_1	214	221	PF00069	0.596
MOD_GSK3_1	240	247	PF00069	0.665
MOD_GSK3_1	276	283	PF00069	0.792
MOD_GSK3_1	286	293	PF00069	0.674
MOD_GSK3_1	332	339	PF00069	0.636
MOD_GSK3_1	34	41	PF00069	0.646
MOD_GSK3_1	341	348	PF00069	0.645
MOD_GSK3_1	382	389	PF00069	0.575
MOD_GSK3_1	4	11	PF00069	0.749
MOD_GSK3_1	407	414	PF00069	0.664
MOD_GSK3_1	42	49	PF00069	0.690
MOD_GSK3_1	467	474	PF00069	0.753
MOD_GSK3_1	491	498	PF00069	0.624
MOD_GSK3_1	499	506	PF00069	0.651
MOD_GSK3_1	527	534	PF00069	0.662
MOD_GSK3_1	579	586	PF00069	0.708
MOD_GSK3_1	591	598	PF00069	0.607
MOD_GSK3_1	603	610	PF00069	0.569
MOD_GSK3_1	621	628	PF00069	0.679
MOD_GSK3_1	639	646	PF00069	0.573
MOD_GSK3_1	657	664	PF00069	0.625
MOD_GSK3_1	97	104	PF00069	0.687
MOD_LATS_1	439	445	PF00433	0.662
MOD_N-GLC_1	234	239	PF02516	0.541
MOD_N-GLC_1	275	280	PF02516	0.651
MOD_N-GLC_1	390	395	PF02516	0.621
MOD_N-GLC_1	442	447	PF02516	0.622
MOD_N-GLC_1	471	476	PF02516	0.696
MOD_N-GLC_1	499	504	PF02516	0.639
MOD_N-GLC_1	554	559	PF02516	0.825
MOD_N-GLC_1	705	710	PF02516	0.567
MOD_N-GLC_1	88	93	PF02516	0.687
MOD_N-GLC_1	97	102	PF02516	0.651
MOD_N-GLC_2	566	568	PF02516	0.557
MOD_NEK2_1	34	39	PF00069	0.657
MOD_NEK2_1	554	559	PF00069	0.559
MOD_NEK2_1	608	613	PF00069	0.574
MOD_NEK2_1	696	701	PF00069	0.570
MOD_NEK2_1	716	721	PF00069	0.537
MOD_NEK2_2	383	388	PF00069	0.611
MOD_PIKK_1	395	401	PF00454	0.653
MOD_PIKK_1	707	713	PF00454	0.511
MOD_PK_1	311	317	PF00069	0.648
MOD_PKA_1	179	185	PF00069	0.641
MOD_PKA_1	83	89	PF00069	0.714
MOD_PKA_2	156	162	PF00069	0.632
MOD_PKA_2	361	367	PF00069	0.706
MOD_PKA_2	423	429	PF00069	0.825
MOD_PKB_1	300	308	PF00069	0.656
MOD_Plk_1	145	151	PF00069	0.709
MOD_Plk_1	471	477	PF00069	0.690
MOD_Plk_1	97	103	PF00069	0.579
MOD_Plk_2-3	820	826	PF00069	0.490
MOD_Plk_4	801	807	PF00069	0.413
MOD_ProDKin_1	106	112	PF00069	0.704
MOD_ProDKin_1	259	265	PF00069	0.633
MOD_ProDKin_1	369	375	PF00069	0.655
MOD_ProDKin_1	38	44	PF00069	0.618
MOD_ProDKin_1	415	421	PF00069	0.658
MOD_ProDKin_1	442	448	PF00069	0.659
MOD_ProDKin_1	462	468	PF00069	0.468
MOD_ProDKin_1	479	485	PF00069	0.499
MOD_ProDKin_1	503	509	PF00069	0.705
MOD_ProDKin_1	529	535	PF00069	0.694
MOD_ProDKin_1	537	543	PF00069	0.667
MOD_ProDKin_1	597	603	PF00069	0.602
MOD_ProDKin_1	625	631	PF00069	0.706
MOD_ProDKin_1	655	661	PF00069	0.778
MOD_ProDKin_1	705	711	PF00069	0.553
MOD_ProDKin_1	72	78	PF00069	0.681
MOD_ProDKin_1	786	792	PF00069	0.583
MOD_ProDKin_1	815	821	PF00069	0.527
MOD_ProDKin_1	858	864	PF00069	0.653
MOD_ProDKin_1	88	94	PF00069	0.801
MOD_SUMO_for_1	352	355	PF00179	0.612
TRG_DiLeu_BaEn_2	827	833	PF01217	0.484
TRG_DiLeu_BaEn_4	354	360	PF01217	0.691
TRG_ENDOCYTIC_2	24	27	PF00928	0.616
TRG_ENDOCYTIC_2	61	64	PF00928	0.605
TRG_ENDOCYTIC_2	730	733	PF00928	0.565
TRG_ER_diArg_1	299	302	PF00400	0.557
TRG_ER_diArg_1	357	359	PF00400	0.619
TRG_ER_diArg_1	634	636	PF00400	0.632
TRG_ER_diArg_1	759	762	PF00400	0.505
TRG_ER_diArg_1	780	783	PF00400	0.612
TRG_ER_diArg_1	784	786	PF00400	0.614
TRG_ER_diArg_1	842	845	PF00400	0.542
TRG_NES_CRM1_1	747	758	PF08389	0.448
TRG_NLS_MonoExtC_3	177	183	PF00514	0.710

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2V0	Leptomonas seymouri	34%	100%
A0A3S5H787	Leishmania donovani	92%	100%
A4HYU5	Leishmania infantum	93%	100%
E9AIP3	Leishmania braziliensis	71%	100%
E9AUP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%