Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QCU1_LEIMA

TriTrypDb:

LmjF.20.1050 , LMJLV39_200015900 , LMJSD75_200015700

Length:

946

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCU1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.703
CLV_C14_Caspase3-7	370	374	PF00656	0.713
CLV_C14_Caspase3-7	496	500	PF00656	0.691
CLV_C14_Caspase3-7	527	531	PF00656	0.744
CLV_C14_Caspase3-7	532	536	PF00656	0.711
CLV_C14_Caspase3-7	540	544	PF00656	0.611
CLV_C14_Caspase3-7	805	809	PF00656	0.643
CLV_NRD_NRD_1	291	293	PF00675	0.707
CLV_NRD_NRD_1	294	296	PF00675	0.689
CLV_NRD_NRD_1	317	319	PF00675	0.745
CLV_NRD_NRD_1	388	390	PF00675	0.713
CLV_NRD_NRD_1	395	397	PF00675	0.667
CLV_NRD_NRD_1	552	554	PF00675	0.723
CLV_NRD_NRD_1	692	694	PF00675	0.820
CLV_NRD_NRD_1	750	752	PF00675	0.693
CLV_NRD_NRD_1	883	885	PF00675	0.720
CLV_NRD_NRD_1	913	915	PF00675	0.695
CLV_PCSK_FUR_1	292	296	PF00082	0.660
CLV_PCSK_FUR_1	393	397	PF00082	0.616
CLV_PCSK_KEX2_1	293	295	PF00082	0.719
CLV_PCSK_KEX2_1	317	319	PF00082	0.745
CLV_PCSK_KEX2_1	395	397	PF00082	0.646
CLV_PCSK_KEX2_1	552	554	PF00082	0.792
CLV_PCSK_KEX2_1	692	694	PF00082	0.828
CLV_PCSK_KEX2_1	750	752	PF00082	0.693
CLV_PCSK_KEX2_1	913	915	PF00082	0.695
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.719
CLV_PCSK_SKI1_1	224	228	PF00082	0.698
CLV_PCSK_SKI1_1	568	572	PF00082	0.762
CLV_PCSK_SKI1_1	884	888	PF00082	0.644
CLV_PCSK_SKI1_1	934	938	PF00082	0.674
CLV_Separin_Metazoa	221	225	PF03568	0.692
DEG_Nend_UBRbox_3	1	3	PF02207	0.672
DEG_SCF_FBW7_1	897	903	PF00400	0.741
DEG_SCF_FBW7_2	72	77	PF00400	0.730
DEG_SPOP_SBC_1	362	366	PF00917	0.723
DEG_SPOP_SBC_1	487	491	PF00917	0.767
DEG_SPOP_SBC_1	66	70	PF00917	0.637
DEG_SPOP_SBC_1	718	722	PF00917	0.608
DOC_ANK_TNKS_1	316	323	PF00023	0.681
DOC_CKS1_1	897	902	PF01111	0.742
DOC_PP4_FxxP_1	279	282	PF00568	0.732
DOC_USP7_MATH_1	261	265	PF00917	0.713
DOC_USP7_MATH_1	282	286	PF00917	0.705
DOC_USP7_MATH_1	33	37	PF00917	0.792
DOC_USP7_MATH_1	362	366	PF00917	0.723
DOC_USP7_MATH_1	487	491	PF00917	0.782
DOC_USP7_MATH_1	508	512	PF00917	0.594
DOC_USP7_MATH_1	537	541	PF00917	0.706
DOC_USP7_MATH_1	545	549	PF00917	0.657
DOC_USP7_MATH_1	560	564	PF00917	0.562
DOC_USP7_MATH_1	597	601	PF00917	0.738
DOC_USP7_MATH_1	64	68	PF00917	0.722
DOC_USP7_MATH_1	655	659	PF00917	0.772
DOC_USP7_MATH_1	670	674	PF00917	0.670
DOC_USP7_MATH_1	677	681	PF00917	0.676
DOC_USP7_MATH_1	687	691	PF00917	0.651
DOC_USP7_MATH_1	718	722	PF00917	0.696
DOC_USP7_MATH_1	740	744	PF00917	0.708
DOC_USP7_MATH_1	756	760	PF00917	0.575
DOC_USP7_MATH_1	785	789	PF00917	0.780
DOC_USP7_MATH_1	858	862	PF00917	0.704
DOC_USP7_MATH_1	879	883	PF00917	0.611
DOC_WW_Pin1_4	216	221	PF00397	0.666
DOC_WW_Pin1_4	225	230	PF00397	0.702
DOC_WW_Pin1_4	345	350	PF00397	0.751
DOC_WW_Pin1_4	363	368	PF00397	0.554
DOC_WW_Pin1_4	400	405	PF00397	0.723
DOC_WW_Pin1_4	422	427	PF00397	0.715
DOC_WW_Pin1_4	456	461	PF00397	0.730
DOC_WW_Pin1_4	648	653	PF00397	0.740
DOC_WW_Pin1_4	70	75	PF00397	0.795
DOC_WW_Pin1_4	781	786	PF00397	0.714
DOC_WW_Pin1_4	809	814	PF00397	0.656
DOC_WW_Pin1_4	844	849	PF00397	0.637
DOC_WW_Pin1_4	896	901	PF00397	0.757
DOC_WW_Pin1_4	921	926	PF00397	0.703
LIG_14-3-3_CanoR_1	20	27	PF00244	0.592
LIG_14-3-3_CanoR_1	224	229	PF00244	0.689
LIG_14-3-3_CanoR_1	245	250	PF00244	0.725
LIG_14-3-3_CanoR_1	396	406	PF00244	0.724
LIG_14-3-3_CanoR_1	662	668	PF00244	0.791
LIG_14-3-3_CanoR_1	701	711	PF00244	0.675
LIG_14-3-3_CanoR_1	750	755	PF00244	0.787
LIG_14-3-3_CanoR_1	821	827	PF00244	0.648
LIG_14-3-3_CanoR_1	838	844	PF00244	0.539
LIG_Actin_WH2_2	326	343	PF00022	0.557
LIG_APCC_ABBA_1	800	805	PF00400	0.689
LIG_BRCT_BRCA1_1	402	406	PF00533	0.717
LIG_BRCT_BRCA1_1	515	519	PF00533	0.838
LIG_EH_1	178	182	PF12763	0.739
LIG_FHA_1	139	145	PF00498	0.772
LIG_FHA_1	217	223	PF00498	0.764
LIG_FHA_1	272	278	PF00498	0.674
LIG_FHA_1	683	689	PF00498	0.772
LIG_FHA_1	822	828	PF00498	0.598
LIG_FHA_1	897	903	PF00498	0.706
LIG_FHA_1	922	928	PF00498	0.630
LIG_FHA_2	186	192	PF00498	0.705
LIG_FHA_2	225	231	PF00498	0.719
LIG_FHA_2	301	307	PF00498	0.651
LIG_FHA_2	755	761	PF00498	0.769
LIG_GSK3_LRP6_1	648	653	PF00069	0.682
LIG_LIR_Apic_2	22	27	PF02991	0.720
LIG_LIR_Apic_2	278	282	PF02991	0.725
LIG_LIR_Apic_2	36	41	PF02991	0.630
LIG_LIR_Apic_2	938	944	PF02991	0.722
LIG_LIR_Gen_1	248	253	PF02991	0.751
LIG_LIR_Gen_1	331	340	PF02991	0.666
LIG_LIR_Gen_1	573	584	PF02991	0.748
LIG_LIR_Gen_1	766	775	PF02991	0.639
LIG_LIR_Gen_1	824	830	PF02991	0.567
LIG_LIR_Gen_1	935	944	PF02991	0.724
LIG_LIR_Nem_3	248	252	PF02991	0.750
LIG_LIR_Nem_3	278	283	PF02991	0.730
LIG_LIR_Nem_3	331	337	PF02991	0.667
LIG_LIR_Nem_3	53	57	PF02991	0.758
LIG_LIR_Nem_3	766	770	PF02991	0.679
LIG_LIR_Nem_3	824	829	PF02991	0.714
LIG_LIR_Nem_3	935	939	PF02991	0.728
LIG_MLH1_MIPbox_1	404	408	PF16413	0.709
LIG_MYND_1	349	353	PF01753	0.716
LIG_Pex14_1	402	406	PF04695	0.542
LIG_PTAP_UEV_1	196	201	PF05743	0.637
LIG_RPA_C_Fungi	384	396	PF08784	0.640
LIG_SH2_CRK	24	28	PF00017	0.702
LIG_SH2_CRK	280	284	PF00017	0.718
LIG_SH2_NCK_1	941	945	PF00017	0.657
LIG_SH2_STAP1	249	253	PF00017	0.752
LIG_SH2_STAP1	754	758	PF00017	0.712
LIG_SH2_STAT5	407	410	PF00017	0.705
LIG_SH2_STAT5	54	57	PF00017	0.773
LIG_SH2_STAT5	82	85	PF00017	0.678
LIG_SH2_STAT5	894	897	PF00017	0.734
LIG_SH3_1	894	900	PF00018	0.735
LIG_SH3_3	157	163	PF00018	0.677
LIG_SH3_3	194	200	PF00018	0.723
LIG_SH3_3	217	223	PF00018	0.659
LIG_SH3_3	343	349	PF00018	0.730
LIG_SH3_3	433	439	PF00018	0.659
LIG_SH3_3	60	66	PF00018	0.839
LIG_SH3_3	643	649	PF00018	0.757
LIG_SH3_3	851	857	PF00018	0.624
LIG_SH3_3	894	900	PF00018	0.735
LIG_SUMO_SIM_anti_2	336	341	PF11976	0.612
LIG_SUMO_SIM_par_1	684	690	PF11976	0.580
LIG_SUMO_SIM_par_1	872	877	PF11976	0.636
LIG_TRAF2_1	41	44	PF00917	0.690
LIG_TRAF2_1	74	77	PF00917	0.734
LIG_TRAF2_2	74	79	PF00917	0.615
MOD_CDC14_SPxK_1	228	231	PF00782	0.597
MOD_CDK_SPK_2	345	350	PF00069	0.692
MOD_CDK_SPK_2	70	75	PF00069	0.760
MOD_CDK_SPK_2	900	905	PF00069	0.696
MOD_CDK_SPxK_1	225	231	PF00069	0.602
MOD_CK1_1	127	133	PF00069	0.771
MOD_CK1_1	143	149	PF00069	0.641
MOD_CK1_1	192	198	PF00069	0.703
MOD_CK1_1	361	367	PF00069	0.773
MOD_CK1_1	400	406	PF00069	0.720
MOD_CK1_1	488	494	PF00069	0.779
MOD_CK1_1	528	534	PF00069	0.772
MOD_CK1_1	563	569	PF00069	0.711
MOD_CK1_1	587	593	PF00069	0.736
MOD_CK1_1	653	659	PF00069	0.779
MOD_CK1_1	67	73	PF00069	0.795
MOD_CK1_1	695	701	PF00069	0.788
MOD_CK1_1	784	790	PF00069	0.677
MOD_CK1_1	806	812	PF00069	0.720
MOD_CK1_1	842	848	PF00069	0.786
MOD_CK1_1	921	927	PF00069	0.720
MOD_CK1_1	935	941	PF00069	0.728
MOD_CK2_1	185	191	PF00069	0.706
MOD_CK2_1	224	230	PF00069	0.718
MOD_CK2_1	300	306	PF00069	0.659
MOD_CK2_1	508	514	PF00069	0.742
MOD_Cter_Amidation	882	885	PF01082	0.558
MOD_GlcNHglycan	129	132	PF01048	0.697
MOD_GlcNHglycan	134	137	PF01048	0.692
MOD_GlcNHglycan	148	151	PF01048	0.684
MOD_GlcNHglycan	197	200	PF01048	0.632
MOD_GlcNHglycan	263	266	PF01048	0.741
MOD_GlcNHglycan	300	303	PF01048	0.717
MOD_GlcNHglycan	359	363	PF01048	0.757
MOD_GlcNHglycan	426	429	PF01048	0.727
MOD_GlcNHglycan	492	495	PF01048	0.797
MOD_GlcNHglycan	506	509	PF01048	0.779
MOD_GlcNHglycan	510	513	PF01048	0.759
MOD_GlcNHglycan	514	518	PF01048	0.713
MOD_GlcNHglycan	524	530	PF01048	0.588
MOD_GlcNHglycan	558	561	PF01048	0.755
MOD_GlcNHglycan	562	565	PF01048	0.741
MOD_GlcNHglycan	635	638	PF01048	0.673
MOD_GlcNHglycan	672	675	PF01048	0.817
MOD_GlcNHglycan	677	680	PF01048	0.748
MOD_GlcNHglycan	7	10	PF01048	0.726
MOD_GlcNHglycan	754	757	PF01048	0.737
MOD_GlcNHglycan	793	799	PF01048	0.690
MOD_GlcNHglycan	87	93	PF01048	0.713
MOD_GlcNHglycan	881	884	PF01048	0.581
MOD_GlcNHglycan	920	923	PF01048	0.670
MOD_GSK3_1	125	132	PF00069	0.744
MOD_GSK3_1	136	143	PF00069	0.656
MOD_GSK3_1	146	153	PF00069	0.724
MOD_GSK3_1	185	192	PF00069	0.656
MOD_GSK3_1	195	202	PF00069	0.679
MOD_GSK3_1	271	278	PF00069	0.769
MOD_GSK3_1	358	365	PF00069	0.729
MOD_GSK3_1	367	374	PF00069	0.660
MOD_GSK3_1	398	405	PF00069	0.666
MOD_GSK3_1	450	457	PF00069	0.750
MOD_GSK3_1	485	492	PF00069	0.772
MOD_GSK3_1	493	500	PF00069	0.645
MOD_GSK3_1	504	511	PF00069	0.798
MOD_GSK3_1	556	563	PF00069	0.770
MOD_GSK3_1	64	71	PF00069	0.808
MOD_GSK3_1	675	682	PF00069	0.703
MOD_GSK3_1	697	704	PF00069	0.741
MOD_GSK3_1	746	753	PF00069	0.755
MOD_GSK3_1	781	788	PF00069	0.704
MOD_GSK3_1	803	810	PF00069	0.677
MOD_GSK3_1	817	824	PF00069	0.581
MOD_GSK3_1	834	841	PF00069	0.656
MOD_GSK3_1	858	865	PF00069	0.713
MOD_GSK3_1	896	903	PF00069	0.763
MOD_GSK3_1	914	921	PF00069	0.579
MOD_LATS_1	183	189	PF00433	0.704
MOD_LATS_1	860	866	PF00433	0.680
MOD_N-GLC_1	146	151	PF02516	0.722
MOD_N-GLC_1	497	502	PF02516	0.806
MOD_N-GLC_1	579	584	PF02516	0.698
MOD_N-GLC_1	695	700	PF02516	0.771
MOD_N-GLC_1	763	768	PF02516	0.562
MOD_N-GLC_1	838	843	PF02516	0.649
MOD_N-GLC_1	918	923	PF02516	0.663
MOD_NEK2_1	116	121	PF00069	0.680
MOD_NEK2_1	124	129	PF00069	0.689
MOD_NEK2_1	486	491	PF00069	0.599
MOD_NEK2_1	578	583	PF00069	0.758
MOD_NEK2_1	584	589	PF00069	0.656
MOD_NEK2_1	816	821	PF00069	0.717
MOD_NEK2_1	927	932	PF00069	0.737
MOD_NEK2_2	275	280	PF00069	0.743
MOD_PIKK_1	129	135	PF00454	0.697
MOD_PIKK_1	136	142	PF00454	0.647
MOD_PIKK_1	237	243	PF00454	0.717
MOD_PIKK_1	254	260	PF00454	0.529
MOD_PIKK_1	328	334	PF00454	0.668
MOD_PIKK_1	653	659	PF00454	0.761
MOD_PIKK_1	687	693	PF00454	0.582
MOD_PIKK_1	80	86	PF00454	0.603
MOD_PIKK_1	839	845	PF00454	0.763
MOD_PKA_1	555	561	PF00069	0.753
MOD_PKA_1	692	698	PF00069	0.779
MOD_PKA_1	750	756	PF00069	0.702
MOD_PKA_2	19	25	PF00069	0.596
MOD_PKA_2	195	201	PF00069	0.694
MOD_PKA_2	271	277	PF00069	0.695
MOD_PKA_2	298	304	PF00069	0.667
MOD_PKA_2	313	319	PF00069	0.598
MOD_PKA_2	537	543	PF00069	0.764
MOD_PKA_2	661	667	PF00069	0.829
MOD_PKA_2	670	676	PF00069	0.720
MOD_PKA_2	692	698	PF00069	0.781
MOD_PKA_2	750	756	PF00069	0.702
MOD_PKA_2	806	812	PF00069	0.647
MOD_PKA_2	837	843	PF00069	0.592
MOD_PKB_1	187	195	PF00069	0.596
MOD_Plk_1	125	131	PF00069	0.692
MOD_Plk_1	335	341	PF00069	0.633
MOD_Plk_1	43	49	PF00069	0.697
MOD_Plk_1	579	585	PF00069	0.771
MOD_Plk_1	763	769	PF00069	0.561
MOD_Plk_1	794	800	PF00069	0.687
MOD_Plk_1	807	813	PF00069	0.635
MOD_Plk_4	247	253	PF00069	0.751
MOD_Plk_4	275	281	PF00069	0.740
MOD_Plk_4	335	341	PF00069	0.613
MOD_Plk_4	402	408	PF00069	0.714
MOD_Plk_4	450	456	PF00069	0.699
MOD_Plk_4	50	56	PF00069	0.755
MOD_Plk_4	579	585	PF00069	0.728
MOD_Plk_4	597	603	PF00069	0.666
MOD_Plk_4	768	774	PF00069	0.576
MOD_Plk_4	785	791	PF00069	0.654
MOD_Plk_4	822	828	PF00069	0.558
MOD_ProDKin_1	216	222	PF00069	0.669
MOD_ProDKin_1	225	231	PF00069	0.705
MOD_ProDKin_1	345	351	PF00069	0.755
MOD_ProDKin_1	363	369	PF00069	0.552
MOD_ProDKin_1	400	406	PF00069	0.720
MOD_ProDKin_1	422	428	PF00069	0.715
MOD_ProDKin_1	456	462	PF00069	0.730
MOD_ProDKin_1	648	654	PF00069	0.744
MOD_ProDKin_1	70	76	PF00069	0.795
MOD_ProDKin_1	781	787	PF00069	0.718
MOD_ProDKin_1	809	815	PF00069	0.659
MOD_ProDKin_1	844	850	PF00069	0.637
MOD_ProDKin_1	896	902	PF00069	0.761
MOD_ProDKin_1	921	927	PF00069	0.705
TRG_ENDOCYTIC_2	249	252	PF00928	0.751
TRG_ENDOCYTIC_2	280	283	PF00928	0.726
TRG_ENDOCYTIC_2	54	57	PF00928	0.762
TRG_ENDOCYTIC_2	576	579	PF00928	0.808
TRG_ENDOCYTIC_2	95	98	PF00928	0.764
TRG_ER_diArg_1	184	187	PF00400	0.704
TRG_ER_diArg_1	292	295	PF00400	0.664
TRG_ER_diArg_1	317	319	PF00400	0.745
TRG_ER_diArg_1	392	395	PF00400	0.613
TRG_ER_diArg_1	551	553	PF00400	0.705
TRG_ER_diArg_1	692	694	PF00400	0.832
TRG_ER_diArg_1	912	914	PF00400	0.691
TRG_NLS_MonoCore_2	291	296	PF00514	0.658
TRG_NLS_MonoExtC_3	292	298	PF00514	0.711
TRG_NLS_MonoExtC_3	388	393	PF00514	0.646
TRG_NLS_MonoExtN_4	292	297	PF00514	0.654
TRG_NLS_MonoExtN_4	389	394	PF00514	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBR5	Leishmania donovani	86%	99%
A4HYU6	Leishmania infantum	86%	99%
E9AIF4	Leishmania braziliensis	58%	92%
E9AUP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%