Protein YIF1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein YIF1

Gene product:

protein transport protein YIF1, putative

Species:

Leishmania major

UniProt:

Q4QCT2_LEIMA

TriTrypDb:

LmjF.20.1140 , LMJLV39_200017000 , LMJSD75_200016800

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	12
GO:0016020	membrane	2	12
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	2
GO:0030135	coated vesicle	7	2
GO:0031090	organelle membrane	3	12
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	12
GO:0000139	Golgi membrane	5	10
GO:0098588	bounding membrane of organelle	4	10

Expansion

Sequence features

Q4QCT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCT2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0048193	Golgi vesicle transport	5	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	81	83	PF00675	0.240
CLV_NRD_NRD_1	96	98	PF00675	0.187
CLV_PCSK_KEX2_1	81	83	PF00082	0.240
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.245
CLV_PCSK_SKI1_1	242	246	PF00082	0.263
CLV_PCSK_SKI1_1	298	302	PF00082	0.367
DEG_Nend_UBRbox_3	1	3	PF02207	0.672
DEG_SPOP_SBC_1	137	141	PF00917	0.530
DOC_CKS1_1	1	6	PF01111	0.638
DOC_MAPK_gen_1	81	87	PF00069	0.412
DOC_MAPK_MEF2A_6	242	250	PF00069	0.276
DOC_MAPK_MEF2A_6	81	89	PF00069	0.422
DOC_MAPK_NFAT4_5	82	90	PF00069	0.463
DOC_PP2B_LxvP_1	167	170	PF13499	0.412
DOC_PP2B_LxvP_1	225	228	PF13499	0.430
DOC_PP2B_LxvP_1	87	90	PF13499	0.514
DOC_PP4_FxxP_1	123	126	PF00568	0.509
DOC_PP4_FxxP_1	152	155	PF00568	0.463
DOC_USP7_MATH_1	170	174	PF00917	0.319
DOC_USP7_MATH_1	190	194	PF00917	0.266
DOC_USP7_UBL2_3	94	98	PF12436	0.533
DOC_WW_Pin1_4	126	131	PF00397	0.459
DOC_WW_Pin1_4	16	21	PF00397	0.664
DOC_WW_Pin1_4	186	191	PF00397	0.315
DOC_WW_Pin1_4	3	8	PF00397	0.649
DOC_WW_Pin1_4	96	101	PF00397	0.507
LIG_14-3-3_CanoR_1	298	303	PF00244	0.568
LIG_Actin_WH2_2	205	220	PF00022	0.291
LIG_BRCT_BRCA1_1	262	266	PF00533	0.394
LIG_eIF4E_1	79	85	PF01652	0.479
LIG_FHA_1	174	180	PF00498	0.263
LIG_FHA_1	189	195	PF00498	0.222
LIG_FHA_1	200	206	PF00498	0.272
LIG_FHA_1	276	282	PF00498	0.425
LIG_FHA_1	4	10	PF00498	0.672
LIG_FHA_1	91	97	PF00498	0.491
LIG_LIR_Apic_2	120	126	PF02991	0.509
LIG_LIR_Apic_2	150	155	PF02991	0.458
LIG_LIR_Gen_1	176	185	PF02991	0.249
LIG_LIR_Gen_1	312	320	PF02991	0.397
LIG_LIR_Nem_3	132	137	PF02991	0.507
LIG_LIR_Nem_3	165	171	PF02991	0.416
LIG_LIR_Nem_3	176	180	PF02991	0.249
LIG_LIR_Nem_3	259	265	PF02991	0.255
LIG_LIR_Nem_3	275	279	PF02991	0.301
LIG_LIR_Nem_3	312	317	PF02991	0.351
LIG_LYPXL_S_1	133	137	PF13949	0.180
LIG_LYPXL_yS_3	134	137	PF13949	0.380
LIG_PCNA_yPIPBox_3	229	242	PF02747	0.512
LIG_REV1ctd_RIR_1	24	31	PF16727	0.642
LIG_REV1ctd_RIR_1	274	284	PF16727	0.307
LIG_SH2_CRK	222	226	PF00017	0.435
LIG_SH2_CRK	241	245	PF00017	0.168
LIG_SH2_CRK	262	266	PF00017	0.392
LIG_SH2_CRK	269	273	PF00017	0.392
LIG_SH2_PTP2	168	171	PF00017	0.307
LIG_SH2_PTP2	177	180	PF00017	0.248
LIG_SH2_PTP2	243	246	PF00017	0.282
LIG_SH2_STAP1	222	226	PF00017	0.319
LIG_SH2_STAP1	269	273	PF00017	0.411
LIG_SH2_STAT5	168	171	PF00017	0.248
LIG_SH2_STAT5	177	180	PF00017	0.248
LIG_SH2_STAT5	183	186	PF00017	0.248
LIG_SH2_STAT5	243	246	PF00017	0.253
LIG_SH2_STAT5	72	75	PF00017	0.440
LIG_SH2_STAT5	79	82	PF00017	0.438
LIG_SH2_STAT5	95	98	PF00017	0.412
LIG_SH3_3	1	7	PF00018	0.634
LIG_SH3_3	152	158	PF00018	0.483
LIG_SH3_3	225	231	PF00018	0.459
LIG_SH3_3	291	297	PF00018	0.479
LIG_SUMO_SIM_anti_2	213	218	PF11976	0.341
LIG_SUMO_SIM_par_1	83	88	PF11976	0.514
LIG_TYR_ITIM	175	180	PF00017	0.248
LIG_TYR_ITIM	220	225	PF00017	0.249
LIG_UBA3_1	235	242	PF00899	0.326
LIG_UBA3_1	85	94	PF00899	0.510
LIG_WW_3	293	297	PF00397	0.467
MOD_CK1_1	129	135	PF00069	0.456
MOD_CK1_1	173	179	PF00069	0.400
MOD_CK1_1	189	195	PF00069	0.302
MOD_CK1_1	198	204	PF00069	0.278
MOD_CK1_1	275	281	PF00069	0.392
MOD_GlcNHglycan	16	19	PF01048	0.569
MOD_GlcNHglycan	262	265	PF01048	0.374
MOD_GlcNHglycan	281	284	PF01048	0.339
MOD_GSK3_1	102	109	PF00069	0.543
MOD_GSK3_1	186	193	PF00069	0.300
MOD_GSK3_1	195	202	PF00069	0.224
MOD_GSK3_1	256	263	PF00069	0.230
MOD_GSK3_1	275	282	PF00069	0.313
MOD_NEK2_1	107	112	PF00069	0.431
MOD_NEK2_1	138	143	PF00069	0.370
MOD_NEK2_1	199	204	PF00069	0.258
MOD_NEK2_1	250	255	PF00069	0.305
MOD_NEK2_1	272	277	PF00069	0.308
MOD_NEK2_1	39	44	PF00069	0.479
MOD_PIKK_1	250	256	PF00454	0.319
MOD_PKA_2	279	285	PF00069	0.409
MOD_PKB_1	296	304	PF00069	0.463
MOD_Plk_1	75	81	PF00069	0.514
MOD_Plk_4	129	135	PF00069	0.537
MOD_Plk_4	170	176	PF00069	0.395
MOD_Plk_4	195	201	PF00069	0.270
MOD_Plk_4	272	278	PF00069	0.346
MOD_Plk_4	309	315	PF00069	0.346
MOD_Plk_4	75	81	PF00069	0.455
MOD_ProDKin_1	126	132	PF00069	0.459
MOD_ProDKin_1	16	22	PF00069	0.665
MOD_ProDKin_1	186	192	PF00069	0.315
MOD_ProDKin_1	3	9	PF00069	0.649
MOD_ProDKin_1	96	102	PF00069	0.507
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.363
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.463
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.400
TRG_ENDOCYTIC_2	134	137	PF00928	0.407
TRG_ENDOCYTIC_2	168	171	PF00928	0.279
TRG_ENDOCYTIC_2	177	180	PF00928	0.260
TRG_ENDOCYTIC_2	222	225	PF00928	0.435
TRG_ENDOCYTIC_2	241	244	PF00928	0.168
TRG_ENDOCYTIC_2	262	265	PF00928	0.273
TRG_ENDOCYTIC_2	269	272	PF00928	0.237
TRG_ENDOCYTIC_2	62	65	PF00928	0.459
TRG_ENDOCYTIC_2	72	75	PF00928	0.418
TRG_ER_diArg_1	295	298	PF00400	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEI6	Leptomonas seymouri	60%	99%
A0A0S4KG55	Bodo saltans	34%	100%
A0A1X0NW97	Trypanosomatidae	38%	100%
A0A3Q8IDN8	Leishmania donovani	93%	100%
A0A3R7RL55	Trypanosoma rangeli	35%	100%
A4HYV6	Leishmania infantum	93%	100%
C9ZID7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AIG3	Leishmania braziliensis	82%	99%
E9AUQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q5U3G6	Danio rerio	24%	100%
V5C052	Trypanosoma cruzi	37%	100%