Pre-mRNA-splicing factor 38

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pre-mRNA-splicing factor 38, putative

Species:

Leishmania major

UniProt:

Q4QCT1_LEIMA

TriTrypDb:

LmjF.20.1150 , LMJLV39_200017100 , LMJSD75_200016900

Length:

269

Annotations

LeishMANIAdb annotations

A conserved eukaryotic pre-mRNA-splicing factor 38 protein. Non-TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0071011	precatalytic spliceosome	4	7
GO:0140513	nuclear protein-containing complex	2	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

Q4QCT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCT1

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008380	RNA splicing	7	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016071	mRNA metabolic process	6	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.346
CLV_PCSK_KEX2_1	166	168	PF00082	0.561
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.561
CLV_PCSK_SKI1_1	34	38	PF00082	0.536
CLV_PCSK_SKI1_1	80	84	PF00082	0.346
DEG_SPOP_SBC_1	134	138	PF00917	0.687
DOC_CKS1_1	241	246	PF01111	0.718
DOC_CYCLIN_RxL_1	30	41	PF00134	0.346
DOC_CYCLIN_yCln2_LP_2	262	268	PF00134	0.668
DOC_MAPK_gen_1	89	99	PF00069	0.546
DOC_MAPK_MEF2A_6	30	39	PF00069	0.343
DOC_MAPK_MEF2A_6	92	101	PF00069	0.546
DOC_PP1_RVXF_1	111	117	PF00149	0.530
DOC_PP1_RVXF_1	32	39	PF00149	0.346
DOC_PP2B_LxvP_1	14	17	PF13499	0.419
DOC_USP7_MATH_1	10	14	PF00917	0.370
DOC_USP7_MATH_1	149	153	PF00917	0.761
DOC_USP7_MATH_1	219	223	PF00917	0.763
DOC_USP7_MATH_1	242	246	PF00917	0.797
DOC_WW_Pin1_4	217	222	PF00397	0.594
DOC_WW_Pin1_4	236	241	PF00397	0.839
LIG_14-3-3_CanoR_1	113	122	PF00244	0.563
LIG_14-3-3_CanoR_1	153	162	PF00244	0.818
LIG_Actin_WH2_2	76	94	PF00022	0.450
LIG_BIR_II_1	1	5	PF00653	0.410
LIG_FHA_1	210	216	PF00498	0.587
LIG_FHA_1	51	57	PF00498	0.330
LIG_GSK3_LRP6_1	240	246	PF00069	0.764
LIG_LIR_Nem_3	117	122	PF02991	0.546
LIG_LIR_Nem_3	18	23	PF02991	0.402
LIG_LIR_Nem_3	208	214	PF02991	0.586
LIG_LIR_Nem_3	258	262	PF02991	0.682
LIG_PDZ_Class_2	264	269	PF00595	0.630
LIG_SH2_CRK	119	123	PF00017	0.546
LIG_SH2_CRK	20	24	PF00017	0.363
LIG_SH2_STAT5	214	217	PF00017	0.587
LIG_SH2_STAT5	48	51	PF00017	0.363
LIG_SH2_STAT5	61	64	PF00017	0.411
LIG_SH2_STAT5	90	93	PF00017	0.619
LIG_SH3_2	230	235	PF14604	0.690
LIG_SH3_3	194	200	PF00018	0.737
LIG_SH3_3	215	221	PF00018	0.560
LIG_SH3_3	227	233	PF00018	0.643
LIG_SH3_3	234	240	PF00018	0.778
LIG_SUMO_SIM_anti_2	75	80	PF11976	0.436
LIG_TRAF2_1	129	132	PF00917	0.623
LIG_UBA3_1	159	166	PF00899	0.752
LIG_WW_1	200	203	PF00397	0.676
MOD_CK1_1	136	142	PF00069	0.737
MOD_CK1_1	165	171	PF00069	0.739
MOD_CK1_1	187	193	PF00069	0.794
MOD_CK1_1	220	226	PF00069	0.813
MOD_CK1_1	250	256	PF00069	0.722
MOD_CK2_1	165	171	PF00069	0.774
MOD_GlcNHglycan	186	189	PF01048	0.576
MOD_GSK3_1	133	140	PF00069	0.668
MOD_GSK3_1	145	152	PF00069	0.685
MOD_GSK3_1	176	183	PF00069	0.766
MOD_GSK3_1	205	212	PF00069	0.527
MOD_GSK3_1	22	29	PF00069	0.346
MOD_GSK3_1	231	238	PF00069	0.799
MOD_GSK3_1	243	250	PF00069	0.766
MOD_NEK2_1	133	138	PF00069	0.653
MOD_NEK2_1	155	160	PF00069	0.745
MOD_NEK2_1	162	167	PF00069	0.712
MOD_PIKK_1	222	228	PF00454	0.838
MOD_Plk_4	155	161	PF00069	0.728
MOD_Plk_4	255	261	PF00069	0.695
MOD_ProDKin_1	217	223	PF00069	0.602
MOD_ProDKin_1	236	242	PF00069	0.839
TRG_DiLeu_BaEn_4	41	47	PF01217	0.346
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.346
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.411
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.530
TRG_ENDOCYTIC_2	119	122	PF00928	0.546
TRG_ENDOCYTIC_2	20	23	PF00928	0.363
TRG_ENDOCYTIC_2	203	206	PF00928	0.617
TRG_NES_CRM1_1	71	84	PF08389	0.436
TRG_NLS_MonoExtC_3	165	171	PF00514	0.760

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I3	Leptomonas seymouri	54%	100%
A0A3S7WW05	Leishmania donovani	93%	100%
A4HYV7	Leishmania infantum	94%	100%
E9AIG4	Leishmania braziliensis	80%	100%
E9AUQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%