DUF3533 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCT0_LEIMA

TriTrypDb:

LmjF.20.1160 , LMJLV39_200017200 , LMJSD75_200017000

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QCT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	253	255	PF00675	0.398
CLV_NRD_NRD_1	78	80	PF00675	0.323
CLV_PCSK_KEX2_1	253	255	PF00082	0.367
CLV_PCSK_KEX2_1	78	80	PF00082	0.349
CLV_PCSK_PC7_1	74	80	PF00082	0.311
CLV_PCSK_SKI1_1	123	127	PF00082	0.607
CLV_PCSK_SKI1_1	269	273	PF00082	0.543
CLV_Separin_Metazoa	258	262	PF03568	0.562
DEG_Nend_UBRbox_3	1	3	PF02207	0.465
DOC_CKS1_1	170	175	PF01111	0.338
DOC_CYCLIN_RxL_1	266	274	PF00134	0.607
DOC_MAPK_DCC_7	87	96	PF00069	0.412
DOC_MAPK_gen_1	66	75	PF00069	0.588
DOC_MAPK_gen_1	78	84	PF00069	0.539
DOC_MAPK_MEF2A_6	227	234	PF00069	0.273
DOC_MAPK_MEF2A_6	68	77	PF00069	0.579
DOC_MAPK_MEF2A_6	87	96	PF00069	0.412
DOC_PP1_RVXF_1	72	78	PF00149	0.638
DOC_PP4_FxxP_1	247	250	PF00568	0.297
DOC_PP4_FxxP_1	88	91	PF00568	0.262
DOC_USP7_MATH_1	25	29	PF00917	0.408
DOC_USP7_MATH_1	276	280	PF00917	0.675
DOC_USP7_UBL2_3	269	273	PF12436	0.615
DOC_USP7_UBL2_3	295	299	PF12436	0.687
DOC_WW_Pin1_4	145	150	PF00397	0.377
DOC_WW_Pin1_4	169	174	PF00397	0.318
DOC_WW_Pin1_4	87	92	PF00397	0.504
LIG_14-3-3_CanoR_1	68	74	PF00244	0.615
LIG_14-3-3_CanoR_1	79	85	PF00244	0.555
LIG_Actin_WH2_2	100	117	PF00022	0.402
LIG_deltaCOP1_diTrp_1	226	231	PF00928	0.346
LIG_FHA_1	172	178	PF00498	0.304
LIG_FHA_1	52	58	PF00498	0.356
LIG_FHA_1	70	76	PF00498	0.592
LIG_FHA_2	111	117	PF00498	0.330
LIG_FHA_2	211	217	PF00498	0.363
LIG_LIR_Apic_2	246	250	PF02991	0.366
LIG_LIR_Gen_1	213	220	PF02991	0.357
LIG_LIR_Nem_3	160	166	PF02991	0.365
LIG_LIR_Nem_3	209	214	PF02991	0.466
LIG_LIR_Nem_3	255	259	PF02991	0.541
LIG_LIR_Nem_3	45	50	PF02991	0.350
LIG_LYPXL_yS_3	163	166	PF13949	0.382
LIG_PCNA_PIPBox_1	204	213	PF02747	0.369
LIG_Pex14_2	210	214	PF04695	0.297
LIG_SH2_CRK	122	126	PF00017	0.391
LIG_SH2_CRK	215	219	PF00017	0.322
LIG_SH2_NCK_1	37	41	PF00017	0.340
LIG_SH2_STAP1	215	219	PF00017	0.357
LIG_SH3_3	86	92	PF00018	0.412
LIG_SUMO_SIM_anti_2	135	140	PF11976	0.404
LIG_SUMO_SIM_anti_2	80	86	PF11976	0.615
LIG_SUMO_SIM_par_1	2	7	PF11976	0.411
LIG_SxIP_EBH_1	78	91	PF03271	0.581
LIG_WRC_WIRS_1	207	212	PF05994	0.372
LIG_WRC_WIRS_1	244	249	PF05994	0.413
MOD_CDK_SPK_2	145	150	PF00069	0.359
MOD_CK1_1	80	86	PF00069	0.513
MOD_CK2_1	110	116	PF00069	0.394
MOD_CMANNOS	228	231	PF00535	0.434
MOD_GlcNHglycan	130	133	PF01048	0.635
MOD_GlcNHglycan	290	293	PF01048	0.513
MOD_GlcNHglycan	60	63	PF01048	0.438
MOD_GlcNHglycan	79	82	PF01048	0.590
MOD_GSK3_1	106	113	PF00069	0.412
MOD_GSK3_1	153	160	PF00069	0.497
MOD_GSK3_1	206	213	PF00069	0.322
MOD_GSK3_1	58	65	PF00069	0.427
MOD_N-GLC_1	128	133	PF02516	0.527
MOD_NEK2_1	237	242	PF00069	0.330
MOD_NEK2_1	58	63	PF00069	0.316
MOD_NEK2_1	64	69	PF00069	0.438
MOD_NEK2_1	77	82	PF00069	0.492
MOD_NEK2_2	206	211	PF00069	0.322
MOD_PIKK_1	15	21	PF00454	0.565
MOD_PIKK_1	158	164	PF00454	0.619
MOD_PKA_2	77	83	PF00069	0.445
MOD_Plk_1	128	134	PF00069	0.643
MOD_Plk_4	134	140	PF00069	0.506
MOD_Plk_4	206	212	PF00069	0.372
MOD_Plk_4	230	236	PF00069	0.282
MOD_Plk_4	27	33	PF00069	0.429
MOD_Plk_4	80	86	PF00069	0.485
MOD_ProDKin_1	145	151	PF00069	0.452
MOD_ProDKin_1	169	175	PF00069	0.374
MOD_ProDKin_1	87	93	PF00069	0.357
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.229
TRG_ENDOCYTIC_2	122	125	PF00928	0.473
TRG_ENDOCYTIC_2	163	166	PF00928	0.467
TRG_ENDOCYTIC_2	182	185	PF00928	0.310
TRG_ENDOCYTIC_2	191	194	PF00928	0.297
TRG_ENDOCYTIC_2	215	218	PF00928	0.297
TRG_ENDOCYTIC_2	256	259	PF00928	0.453
TRG_ER_diArg_1	10	13	PF00400	0.541
TRG_ER_diArg_1	252	254	PF00400	0.447
TRG_ER_diArg_1	77	79	PF00400	0.518
TRG_ER_diLys_1	295	299	PF00400	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7W3	Leptomonas seymouri	56%	100%
A0A3Q8IAV6	Leishmania donovani	93%	100%
A0A422NLI0	Trypanosoma rangeli	24%	100%
A4HYV8	Leishmania infantum	94%	100%
E9AIG5	Leishmania braziliensis	77%	100%
E9AUQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%