Putative calpain-like cysteine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calpain-like cysteine peptidase, putative

Species:

Leishmania major

UniProt:

Q4QCS5_LEIMA

TriTrypDb:

LmjF.20.1210 , LMJLV39_200018300 , LMJSD75_200018200 , LMJSD75_200018300

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCS5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0019538	protein metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004175	endopeptidase activity	4	9
GO:0004197	cysteine-type endopeptidase activity	5	9
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	9
GO:0008233	peptidase activity	3	9
GO:0008234	cysteine-type peptidase activity	4	9
GO:0016787	hydrolase activity	2	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	341	347	PF00089	0.392
CLV_NRD_NRD_1	297	299	PF00675	0.460
CLV_PCSK_KEX2_1	297	299	PF00082	0.460
CLV_PCSK_SKI1_1	102	106	PF00082	0.265
CLV_PCSK_SKI1_1	331	335	PF00082	0.453
DEG_SPOP_SBC_1	122	126	PF00917	0.434
DOC_ANK_TNKS_1	147	154	PF00023	0.418
DOC_CYCLIN_RxL_1	197	208	PF00134	0.465
DOC_MAPK_gen_1	133	143	PF00069	0.441
DOC_MAPK_gen_1	297	304	PF00069	0.391
DOC_MAPK_gen_1	68	77	PF00069	0.463
DOC_MAPK_MEF2A_6	68	77	PF00069	0.465
DOC_PP1_RVXF_1	198	205	PF00149	0.434
DOC_PP2B_LxvP_1	73	76	PF13499	0.434
DOC_PP4_FxxP_1	15	18	PF00568	0.463
DOC_PP4_FxxP_1	320	323	PF00568	0.368
DOC_USP7_MATH_1	165	169	PF00917	0.467
DOC_USP7_MATH_1	173	177	PF00917	0.451
LIG_14-3-3_CanoR_1	178	187	PF00244	0.424
LIG_14-3-3_CanoR_1	34	38	PF00244	0.447
LIG_14-3-3_CanoR_1	344	348	PF00244	0.413
LIG_14-3-3_CanoR_1	398	404	PF00244	0.395
LIG_14-3-3_CanoR_1	410	414	PF00244	0.434
LIG_APCC_ABBA_1	322	327	PF00400	0.399
LIG_APCC_ABBAyCdc20_2	321	327	PF00400	0.395
LIG_BIR_II_1	1	5	PF00653	0.285
LIG_BRCT_BRCA1_1	123	127	PF00533	0.572
LIG_deltaCOP1_diTrp_1	305	313	PF00928	0.360
LIG_EH1_1	195	203	PF00400	0.465
LIG_eIF4E_1	210	216	PF01652	0.418
LIG_FHA_1	34	40	PF00498	0.447
LIG_FHA_1	376	382	PF00498	0.510
LIG_FHA_1	6	12	PF00498	0.489
LIG_FHA_2	108	114	PF00498	0.423
LIG_FHA_2	360	366	PF00498	0.478
LIG_FHA_2	369	375	PF00498	0.475
LIG_LIR_Gen_1	207	218	PF02991	0.431
LIG_LIR_Gen_1	307	318	PF02991	0.346
LIG_LIR_Gen_1	340	349	PF02991	0.330
LIG_LIR_Gen_1	408	414	PF02991	0.546
LIG_LIR_Gen_1	79	89	PF02991	0.486
LIG_LIR_Nem_3	207	213	PF02991	0.435
LIG_LIR_Nem_3	240	245	PF02991	0.421
LIG_LIR_Nem_3	305	309	PF02991	0.327
LIG_LIR_Nem_3	340	345	PF02991	0.326
LIG_LIR_Nem_3	377	382	PF02991	0.523
LIG_LYPXL_S_1	195	199	PF13949	0.265
LIG_LYPXL_yS_3	196	199	PF13949	0.465
LIG_LYPXL_yS_3	379	382	PF13949	0.442
LIG_MYND_3	75	79	PF01753	0.434
LIG_Pex14_1	306	310	PF04695	0.360
LIG_SH2_CRK	89	93	PF00017	0.462
LIG_SH2_GRB2like	60	63	PF00017	0.434
LIG_SH2_GRB2like	89	92	PF00017	0.465
LIG_SH2_PTP2	301	304	PF00017	0.341
LIG_SH2_SRC	112	115	PF00017	0.465
LIG_SH2_STAP1	89	93	PF00017	0.470
LIG_SH2_STAT3	137	140	PF00017	0.434
LIG_SH2_STAT5	301	304	PF00017	0.361
LIG_SH2_STAT5	51	54	PF00017	0.477
LIG_SH3_3	215	221	PF00018	0.496
LIG_SH3_3	274	280	PF00018	0.571
LIG_SH3_3	401	407	PF00018	0.516
LIG_SUMO_SIM_anti_2	119	126	PF11976	0.434
LIG_SUMO_SIM_anti_2	212	217	PF11976	0.445
LIG_SUMO_SIM_par_1	380	385	PF11976	0.489
LIG_TRAF2_1	387	390	PF00917	0.338
MOD_CK1_1	121	127	PF00069	0.444
MOD_CK1_1	168	174	PF00069	0.500
MOD_CK2_1	160	166	PF00069	0.576
MOD_CK2_1	168	174	PF00069	0.437
MOD_CK2_1	368	374	PF00069	0.523
MOD_CMANNOS	239	242	PF00535	0.250
MOD_CMANNOS	303	306	PF00535	0.350
MOD_GlcNHglycan	170	173	PF01048	0.273
MOD_GlcNHglycan	174	178	PF01048	0.304
MOD_GlcNHglycan	258	262	PF01048	0.461
MOD_GlcNHglycan	305	309	PF01048	0.314
MOD_GlcNHglycan	313	316	PF01048	0.320
MOD_GSK3_1	118	125	PF00069	0.552
MOD_GSK3_1	155	162	PF00069	0.453
MOD_GSK3_1	333	340	PF00069	0.401
MOD_GSK3_1	355	362	PF00069	0.435
MOD_GSK3_1	364	371	PF00069	0.504
MOD_GSK3_1	405	412	PF00069	0.452
MOD_GSK3_1	52	59	PF00069	0.457
MOD_GSK3_1	87	94	PF00069	0.535
MOD_NEK2_1	263	268	PF00069	0.433
MOD_NEK2_1	334	339	PF00069	0.462
MOD_NEK2_1	359	364	PF00069	0.468
MOD_PIKK_1	17	23	PF00454	0.496
MOD_PIKK_1	397	403	PF00454	0.445
MOD_PKA_2	33	39	PF00069	0.447
MOD_PKA_2	343	349	PF00069	0.553
MOD_PKA_2	397	403	PF00069	0.392
MOD_Plk_1	118	124	PF00069	0.434
MOD_Plk_1	165	171	PF00069	0.439
MOD_Plk_1	211	217	PF00069	0.465
MOD_Plk_1	364	370	PF00069	0.514
MOD_Plk_1	374	380	PF00069	0.452
MOD_Plk_4	205	211	PF00069	0.504
MOD_Plk_4	337	343	PF00069	0.430
MOD_Plk_4	348	354	PF00069	0.378
MOD_Plk_4	56	62	PF00069	0.554
TRG_DiLeu_BaEn_4	389	395	PF01217	0.363
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.398
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.434
TRG_ENDOCYTIC_2	196	199	PF00928	0.466
TRG_ENDOCYTIC_2	210	213	PF00928	0.463
TRG_ENDOCYTIC_2	301	304	PF00928	0.341
TRG_ENDOCYTIC_2	310	313	PF00928	0.325
TRG_ENDOCYTIC_2	379	382	PF00928	0.486
TRG_ENDOCYTIC_2	51	54	PF00928	0.493
TRG_ENDOCYTIC_2	82	85	PF00928	0.503
TRG_ENDOCYTIC_2	89	92	PF00928	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NJ61	Trypanosomatidae	27%	73%
A4HJ23	Leishmania braziliensis	30%	86%
E8NHF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	81%
E8NHM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	71%
E8NHQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	93%
E9AIH6	Leishmania braziliensis	73%	76%
E9AUR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	75%