DUF1935 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1935), putative

Species:

Leishmania major

UniProt:

Q4QCS1_LEIMA

TriTrypDb:

LmjF.20.1250 , LMJLV39_200018700 , LMJSD75_200018700

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCS1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.483
CLV_PCSK_KEX2_1	152	154	PF00082	0.337
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.335
DEG_SCF_FBW7_1	20	26	PF00400	0.548
DOC_CKS1_1	20	25	PF01111	0.564
DOC_CKS1_1	76	81	PF01111	0.669
DOC_PIKK_1	82	90	PF02985	0.549
DOC_PP1_RVXF_1	184	191	PF00149	0.262
DOC_SPAK_OSR1_1	111	115	PF12202	0.625
DOC_USP7_MATH_1	175	179	PF00917	0.491
DOC_USP7_MATH_1	18	22	PF00917	0.601
DOC_USP7_MATH_1	181	185	PF00917	0.391
DOC_USP7_MATH_1	2	6	PF00917	0.546
DOC_USP7_MATH_1	23	27	PF00917	0.636
DOC_USP7_MATH_1	53	57	PF00917	0.646
DOC_USP7_MATH_1	61	65	PF00917	0.615
DOC_WW_Pin1_4	10	15	PF00397	0.732
DOC_WW_Pin1_4	115	120	PF00397	0.655
DOC_WW_Pin1_4	19	24	PF00397	0.669
DOC_WW_Pin1_4	223	228	PF00397	0.480
DOC_WW_Pin1_4	75	80	PF00397	0.706
LIG_14-3-3_CanoR_1	168	174	PF00244	0.453
LIG_14-3-3_CanoR_1	186	191	PF00244	0.389
LIG_BIR_III_2	224	228	PF00653	0.476
LIG_BRCT_BRCA1_1	169	173	PF00533	0.453
LIG_FHA_1	37	43	PF00498	0.584
LIG_FHA_1	68	74	PF00498	0.634
LIG_FHA_2	219	225	PF00498	0.389
LIG_FHA_2	230	236	PF00498	0.483
LIG_FHA_2	55	61	PF00498	0.658
LIG_LIR_Apic_2	117	123	PF02991	0.616
LIG_LIR_Nem_3	215	219	PF02991	0.463
LIG_PCNA_yPIPBox_3	136	149	PF02747	0.335
LIG_PDZ_Class_2	231	236	PF00595	0.604
LIG_SH2_PTP2	120	123	PF00017	0.536
LIG_SH2_STAP1	27	31	PF00017	0.548
LIG_SH2_STAT5	120	123	PF00017	0.536
LIG_SH2_STAT5	220	223	PF00017	0.421
LIG_SH2_STAT5	6	9	PF00017	0.521
LIG_SH3_3	124	130	PF00018	0.575
LIG_SH3_3	17	23	PF00018	0.649
LIG_SH3_3	5	11	PF00018	0.699
LIG_SH3_3	73	79	PF00018	0.748
LIG_SUMO_SIM_anti_2	69	78	PF11976	0.595
LIG_SUMO_SIM_par_1	37	44	PF11976	0.550
LIG_SUMO_SIM_par_1	4	13	PF11976	0.548
LIG_TRAF2_1	104	107	PF00917	0.494
LIG_UBA3_1	144	152	PF00899	0.335
MOD_CDK_SPxK_1	75	81	PF00069	0.663
MOD_CK1_1	16	22	PF00069	0.668
MOD_CK1_1	25	31	PF00069	0.625
MOD_CK1_1	41	47	PF00069	0.700
MOD_CK1_1	56	62	PF00069	0.591
MOD_CK1_1	64	70	PF00069	0.630
MOD_CK1_1	9	15	PF00069	0.649
MOD_CK2_1	54	60	PF00069	0.690
MOD_GlcNHglycan	183	186	PF01048	0.291
MOD_GlcNHglycan	27	30	PF01048	0.663
MOD_GlcNHglycan	43	46	PF01048	0.720
MOD_GlcNHglycan	47	50	PF01048	0.617
MOD_GlcNHglycan	62	66	PF01048	0.637
MOD_GSK3_1	10	17	PF00069	0.617
MOD_GSK3_1	18	25	PF00069	0.584
MOD_GSK3_1	2	9	PF00069	0.719
MOD_GSK3_1	41	48	PF00069	0.758
MOD_GSK3_1	56	63	PF00069	0.546
MOD_GSK3_1	67	74	PF00069	0.630
MOD_N-GLC_1	159	164	PF02516	0.354
MOD_N-GLC_1	71	76	PF02516	0.699
MOD_NEK2_1	167	172	PF00069	0.491
MOD_NEK2_2	175	180	PF00069	0.453
MOD_NEK2_2	218	223	PF00069	0.475
MOD_PIKK_1	105	111	PF00454	0.618
MOD_PIKK_1	205	211	PF00454	0.453
MOD_PKA_2	167	173	PF00069	0.453
MOD_PKA_2	54	60	PF00069	0.636
MOD_Plk_1	175	181	PF00069	0.345
MOD_Plk_1	36	42	PF00069	0.546
MOD_Plk_1	71	77	PF00069	0.763
MOD_Plk_4	2	8	PF00069	0.557
MOD_Plk_4	71	77	PF00069	0.614
MOD_ProDKin_1	10	16	PF00069	0.734
MOD_ProDKin_1	115	121	PF00069	0.650
MOD_ProDKin_1	19	25	PF00069	0.670
MOD_ProDKin_1	223	229	PF00069	0.490
MOD_ProDKin_1	75	81	PF00069	0.703
TRG_DiLeu_BaEn_2	206	212	PF01217	0.453
TRG_DiLeu_BaEn_4	88	94	PF01217	0.542
TRG_ENDOCYTIC_2	135	138	PF00928	0.355
TRG_ENDOCYTIC_2	216	219	PF00928	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEW9	Leishmania donovani	78%	100%
A0A3R7K2X3	Trypanosoma rangeli	25%	100%
A4HYW8	Leishmania infantum	78%	100%
E9AII0	Leishmania braziliensis	47%	84%
E9AUR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	89%