RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QCS0_LEIMA

TriTrypDb:

LmjF.20.1260 , LMJLV39_200018900 , LMJSD75_200018900

Length:

844

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCS0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	358	362	PF00656	0.735
CLV_C14_Caspase3-7	71	75	PF00656	0.536
CLV_C14_Caspase3-7	784	788	PF00656	0.654
CLV_C14_Caspase3-7	814	818	PF00656	0.587
CLV_NRD_NRD_1	334	336	PF00675	0.742
CLV_NRD_NRD_1	369	371	PF00675	0.617
CLV_NRD_NRD_1	474	476	PF00675	0.490
CLV_NRD_NRD_1	48	50	PF00675	0.572
CLV_NRD_NRD_1	71	73	PF00675	0.543
CLV_NRD_NRD_1	725	727	PF00675	0.673
CLV_NRD_NRD_1	733	735	PF00675	0.641
CLV_PCSK_FUR_1	367	371	PF00082	0.621
CLV_PCSK_KEX2_1	366	368	PF00082	0.627
CLV_PCSK_KEX2_1	369	371	PF00082	0.627
CLV_PCSK_KEX2_1	474	476	PF00082	0.490
CLV_PCSK_KEX2_1	48	50	PF00082	0.572
CLV_PCSK_KEX2_1	725	727	PF00082	0.673
CLV_PCSK_KEX2_1	83	85	PF00082	0.609
CLV_PCSK_KEX2_1	87	89	PF00082	0.668
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.558
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.609
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.668
CLV_PCSK_SKI1_1	480	484	PF00082	0.531
CLV_PCSK_SKI1_1	558	562	PF00082	0.558
CLV_PCSK_SKI1_1	622	626	PF00082	0.697
CLV_PCSK_SKI1_1	73	77	PF00082	0.494
CLV_PCSK_SKI1_1	789	793	PF00082	0.562
DEG_APCC_DBOX_1	368	376	PF00400	0.671
DEG_APCC_DBOX_1	479	487	PF00400	0.455
DEG_APCC_DBOX_1	580	588	PF00400	0.656
DEG_SCF_FBW7_1	292	299	PF00400	0.579
DEG_SCF_FBW7_2	494	500	PF00400	0.607
DOC_CKS1_1	188	193	PF01111	0.731
DOC_CKS1_1	319	324	PF01111	0.683
DOC_CKS1_1	494	499	PF01111	0.606
DOC_CKS1_1	559	564	PF01111	0.653
DOC_CYCLIN_RxL_1	722	731	PF00134	0.659
DOC_CYCLIN_yCln2_LP_2	228	231	PF00134	0.592
DOC_CYCLIN_yCln2_LP_2	756	762	PF00134	0.570
DOC_MAPK_DCC_7	474	484	PF00069	0.501
DOC_MAPK_DCC_7	797	807	PF00069	0.583
DOC_MAPK_gen_1	366	377	PF00069	0.599
DOC_MAPK_gen_1	460	466	PF00069	0.547
DOC_MAPK_gen_1	577	587	PF00069	0.789
DOC_MAPK_MEF2A_6	539	547	PF00069	0.686
DOC_MIT_MIM_1	534	543	PF04212	0.501
DOC_PP2B_LxvP_1	228	231	PF13499	0.592
DOC_PP2B_LxvP_1	543	546	PF13499	0.554
DOC_PP2B_LxvP_1	690	693	PF13499	0.708
DOC_PP2B_LxvP_1	756	759	PF13499	0.567
DOC_PP4_FxxP_1	656	659	PF00568	0.689
DOC_USP7_MATH_1	159	163	PF00917	0.694
DOC_USP7_MATH_1	170	174	PF00917	0.564
DOC_USP7_MATH_1	254	258	PF00917	0.800
DOC_USP7_MATH_1	294	298	PF00917	0.837
DOC_USP7_MATH_1	320	324	PF00917	0.673
DOC_USP7_MATH_1	344	348	PF00917	0.686
DOC_USP7_MATH_1	397	401	PF00917	0.558
DOC_USP7_MATH_1	43	47	PF00917	0.583
DOC_USP7_MATH_1	60	64	PF00917	0.597
DOC_USP7_MATH_1	623	627	PF00917	0.710
DOC_USP7_MATH_1	637	641	PF00917	0.712
DOC_USP7_MATH_1	65	69	PF00917	0.588
DOC_USP7_MATH_1	650	654	PF00917	0.594
DOC_USP7_MATH_1	666	670	PF00917	0.593
DOC_USP7_MATH_1	675	679	PF00917	0.685
DOC_USP7_MATH_1	769	773	PF00917	0.642
DOC_USP7_MATH_1	811	815	PF00917	0.683
DOC_USP7_UBL2_3	281	285	PF12436	0.670
DOC_USP7_UBL2_3	423	427	PF12436	0.596
DOC_USP7_UBL2_3	73	77	PF12436	0.509
DOC_USP7_UBL2_3	83	87	PF12436	0.590
DOC_WW_Pin1_4	166	171	PF00397	0.722
DOC_WW_Pin1_4	183	188	PF00397	0.524
DOC_WW_Pin1_4	250	255	PF00397	0.746
DOC_WW_Pin1_4	292	297	PF00397	0.686
DOC_WW_Pin1_4	318	323	PF00397	0.712
DOC_WW_Pin1_4	361	366	PF00397	0.687
DOC_WW_Pin1_4	411	416	PF00397	0.747
DOC_WW_Pin1_4	434	439	PF00397	0.699
DOC_WW_Pin1_4	447	452	PF00397	0.551
DOC_WW_Pin1_4	493	498	PF00397	0.607
DOC_WW_Pin1_4	558	563	PF00397	0.585
DOC_WW_Pin1_4	677	682	PF00397	0.679
DOC_WW_Pin1_4	767	772	PF00397	0.600
DOC_WW_Pin1_4	816	821	PF00397	0.578
LIG_14-3-3_CanoR_1	171	175	PF00244	0.633
LIG_14-3-3_CanoR_1	374	378	PF00244	0.700
LIG_14-3-3_CanoR_1	379	387	PF00244	0.656
LIG_14-3-3_CanoR_1	581	585	PF00244	0.626
LIG_14-3-3_CanoR_1	725	730	PF00244	0.677
LIG_14-3-3_CanoR_1	795	803	PF00244	0.560
LIG_Actin_WH2_2	365	381	PF00022	0.621
LIG_BRCT_BRCA1_1	118	122	PF00533	0.590
LIG_BRCT_BRCA1_1	652	656	PF00533	0.698
LIG_Clathr_ClatBox_1	544	548	PF01394	0.606
LIG_EH1_1	142	150	PF00400	0.569
LIG_eIF4E_1	538	544	PF01652	0.505
LIG_FHA_1	231	237	PF00498	0.701
LIG_FHA_1	287	293	PF00498	0.695
LIG_FHA_1	319	325	PF00498	0.800
LIG_FHA_1	382	388	PF00498	0.725
LIG_FHA_1	486	492	PF00498	0.562
LIG_FHA_1	493	499	PF00498	0.535
LIG_FHA_1	525	531	PF00498	0.481
LIG_FHA_1	540	546	PF00498	0.502
LIG_FHA_1	630	636	PF00498	0.722
LIG_FHA_1	658	664	PF00498	0.607
LIG_FHA_2	307	313	PF00498	0.709
LIG_FHA_2	494	500	PF00498	0.607
LIG_FHA_2	652	658	PF00498	0.698
LIG_FHA_2	91	97	PF00498	0.564
LIG_IBAR_NPY_1	752	754	PF08397	0.632
LIG_Integrin_RGD_1	200	202	PF01839	0.696
LIG_Integrin_RGD_1	822	824	PF01839	0.685
LIG_LIR_Apic_2	653	659	PF02991	0.692
LIG_LIR_Gen_1	384	391	PF02991	0.668
LIG_LIR_Gen_1	473	484	PF02991	0.526
LIG_LIR_Gen_1	517	524	PF02991	0.463
LIG_LIR_Nem_3	161	167	PF02991	0.698
LIG_LIR_Nem_3	384	389	PF02991	0.568
LIG_LIR_Nem_3	473	479	PF02991	0.542
LIG_LIR_Nem_3	517	522	PF02991	0.457
LIG_MYND_1	112	116	PF01753	0.571
LIG_NRBOX	539	545	PF00104	0.520
LIG_PDZ_Class_2	839	844	PF00595	0.693
LIG_SH2_PTP2	476	479	PF00017	0.599
LIG_SH2_SRC	476	479	PF00017	0.599
LIG_SH2_STAT3	405	408	PF00017	0.536
LIG_SH2_STAT5	476	479	PF00017	0.599
LIG_SH2_STAT5	529	532	PF00017	0.556
LIG_SH3_2	280	285	PF14604	0.571
LIG_SH3_3	13	19	PF00018	0.686
LIG_SH3_3	185	191	PF00018	0.719
LIG_SH3_3	236	242	PF00018	0.658
LIG_SH3_3	245	251	PF00018	0.711
LIG_SH3_3	274	280	PF00018	0.593
LIG_SH3_3	412	418	PF00018	0.672
LIG_SH3_3	422	428	PF00018	0.617
LIG_SH3_3	491	497	PF00018	0.594
LIG_SH3_3	518	524	PF00018	0.499
LIG_SH3_3	644	650	PF00018	0.646
LIG_SH3_3	679	685	PF00018	0.653
LIG_SH3_4	427	434	PF00018	0.604
LIG_SUMO_SIM_anti_2	373	379	PF11976	0.644
LIG_SUMO_SIM_par_1	480	485	PF11976	0.483
LIG_TRAF2_1	497	500	PF00917	0.616
LIG_UBA3_1	584	589	PF00899	0.600
LIG_WRC_WIRS_1	287	292	PF05994	0.684
LIG_WW_3	819	823	PF00397	0.585
MOD_CDC14_SPxK_1	186	189	PF00782	0.667
MOD_CDC14_SPxK_1	364	367	PF00782	0.681
MOD_CDC14_SPxK_1	414	417	PF00782	0.702
MOD_CDC14_SPxK_1	819	822	PF00782	0.581
MOD_CDK_SPK_2	166	171	PF00069	0.729
MOD_CDK_SPK_2	361	366	PF00069	0.590
MOD_CDK_SPK_2	558	563	PF00069	0.588
MOD_CDK_SPxK_1	183	189	PF00069	0.664
MOD_CDK_SPxK_1	361	367	PF00069	0.685
MOD_CDK_SPxK_1	411	417	PF00069	0.702
MOD_CDK_SPxK_1	816	822	PF00069	0.584
MOD_CK1_1	117	123	PF00069	0.666
MOD_CK1_1	169	175	PF00069	0.697
MOD_CK1_1	203	209	PF00069	0.659
MOD_CK1_1	3	9	PF00069	0.650
MOD_CK1_1	318	324	PF00069	0.633
MOD_CK1_1	373	379	PF00069	0.634
MOD_CK1_1	381	387	PF00069	0.596
MOD_CK1_1	429	435	PF00069	0.676
MOD_CK1_1	453	459	PF00069	0.685
MOD_CK1_1	509	515	PF00069	0.533
MOD_CK1_1	639	645	PF00069	0.791
MOD_CK1_1	68	74	PF00069	0.604
MOD_CK1_1	728	734	PF00069	0.626
MOD_CK2_1	203	209	PF00069	0.659
MOD_CK2_1	493	499	PF00069	0.540
MOD_CK2_1	651	657	PF00069	0.698
MOD_CK2_1	90	96	PF00069	0.593
MOD_DYRK1A_RPxSP_1	411	415	PF00069	0.585
MOD_GlcNHglycan	12	16	PF01048	0.630
MOD_GlcNHglycan	2	5	PF01048	0.644
MOD_GlcNHglycan	205	208	PF01048	0.860
MOD_GlcNHglycan	344	347	PF01048	0.685
MOD_GlcNHglycan	357	360	PF01048	0.629
MOD_GlcNHglycan	391	394	PF01048	0.590
MOD_GlcNHglycan	399	402	PF01048	0.477
MOD_GlcNHglycan	410	414	PF01048	0.580
MOD_GlcNHglycan	428	431	PF01048	0.697
MOD_GlcNHglycan	511	514	PF01048	0.590
MOD_GlcNHglycan	604	607	PF01048	0.686
MOD_GlcNHglycan	614	617	PF01048	0.736
MOD_GlcNHglycan	677	680	PF01048	0.720
MOD_GlcNHglycan	783	786	PF01048	0.660
MOD_GlcNHglycan	797	800	PF01048	0.549
MOD_GlcNHglycan	8	11	PF01048	0.644
MOD_GSK3_1	110	117	PF00069	0.578
MOD_GSK3_1	166	173	PF00069	0.645
MOD_GSK3_1	183	190	PF00069	0.528
MOD_GSK3_1	250	257	PF00069	0.758
MOD_GSK3_1	292	299	PF00069	0.658
MOD_GSK3_1	429	436	PF00069	0.718
MOD_GSK3_1	452	459	PF00069	0.716
MOD_GSK3_1	569	576	PF00069	0.669
MOD_GSK3_1	6	13	PF00069	0.650
MOD_GSK3_1	612	619	PF00069	0.684
MOD_GSK3_1	657	664	PF00069	0.651
MOD_GSK3_1	673	680	PF00069	0.659
MOD_GSK3_1	806	813	PF00069	0.686
MOD_GSK3_1	823	830	PF00069	0.612
MOD_GSK3_1	832	839	PF00069	0.585
MOD_N-GLC_1	151	156	PF02516	0.683
MOD_N-GLC_1	389	394	PF02516	0.723
MOD_N-GLC_2	744	746	PF02516	0.690
MOD_NEK2_1	151	156	PF00069	0.678
MOD_NEK2_1	181	186	PF00069	0.695
MOD_NEK2_1	224	229	PF00069	0.656
MOD_NEK2_1	286	291	PF00069	0.709
MOD_NEK2_1	389	394	PF00069	0.564
MOD_NEK2_1	452	457	PF00069	0.684
MOD_NEK2_1	469	474	PF00069	0.518
MOD_NEK2_1	506	511	PF00069	0.562
MOD_NEK2_1	547	552	PF00069	0.589
MOD_NEK2_1	564	569	PF00069	0.460
MOD_NEK2_1	612	617	PF00069	0.798
MOD_NEK2_2	43	48	PF00069	0.646
MOD_NEK2_2	524	529	PF00069	0.552
MOD_NEK2_2	651	656	PF00069	0.600
MOD_NMyristoyl	1	7	PF02799	0.654
MOD_PIKK_1	209	215	PF00454	0.680
MOD_PIKK_1	381	387	PF00454	0.481
MOD_PKA_1	370	376	PF00069	0.519
MOD_PKA_1	569	575	PF00069	0.580
MOD_PKA_1	725	731	PF00069	0.655
MOD_PKA_2	170	176	PF00069	0.657
MOD_PKA_2	209	215	PF00069	0.673
MOD_PKA_2	334	340	PF00069	0.721
MOD_PKA_2	373	379	PF00069	0.692
MOD_PKA_2	580	586	PF00069	0.627
MOD_PKA_2	6	12	PF00069	0.576
MOD_PKA_2	610	616	PF00069	0.658
MOD_PKA_2	725	731	PF00069	0.659
MOD_Plk_1	315	321	PF00069	0.625
MOD_Plk_1	381	387	PF00069	0.607
MOD_Plk_1	823	829	PF00069	0.711
MOD_Plk_4	110	116	PF00069	0.586
MOD_Plk_4	144	150	PF00069	0.571
MOD_Plk_4	170	176	PF00069	0.657
MOD_Plk_4	224	230	PF00069	0.645
MOD_Plk_4	323	329	PF00069	0.638
MOD_Plk_4	524	530	PF00069	0.547
MOD_Plk_4	539	545	PF00069	0.492
MOD_Plk_4	580	586	PF00069	0.626
MOD_Plk_4	651	657	PF00069	0.650
MOD_ProDKin_1	166	172	PF00069	0.717
MOD_ProDKin_1	183	189	PF00069	0.527
MOD_ProDKin_1	250	256	PF00069	0.749
MOD_ProDKin_1	292	298	PF00069	0.685
MOD_ProDKin_1	318	324	PF00069	0.711
MOD_ProDKin_1	361	367	PF00069	0.685
MOD_ProDKin_1	411	417	PF00069	0.751
MOD_ProDKin_1	434	440	PF00069	0.695
MOD_ProDKin_1	447	453	PF00069	0.553
MOD_ProDKin_1	493	499	PF00069	0.607
MOD_ProDKin_1	558	564	PF00069	0.581
MOD_ProDKin_1	677	683	PF00069	0.682
MOD_ProDKin_1	767	773	PF00069	0.601
MOD_ProDKin_1	816	822	PF00069	0.584
MOD_SUMO_rev_2	499	509	PF00179	0.545
MOD_SUMO_rev_2	68	78	PF00179	0.550
MOD_SUMO_rev_2	784	791	PF00179	0.655
MOD_SUMO_rev_2	826	835	PF00179	0.659
TRG_DiLeu_BaEn_1	130	135	PF01217	0.659
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.629
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.525
TRG_ENDOCYTIC_2	24	27	PF00928	0.683
TRG_ENDOCYTIC_2	476	479	PF00928	0.599
TRG_ER_diArg_1	264	267	PF00400	0.657
TRG_ER_diArg_1	367	370	PF00400	0.625
TRG_ER_diArg_1	47	49	PF00400	0.582
TRG_ER_diArg_1	474	476	PF00400	0.490
TRG_ER_diArg_1	725	727	PF00400	0.688
TRG_NES_CRM1_1	534	548	PF08389	0.520
TRG_NLS_Bipartite_1	72	90	PF00514	0.617
TRG_NLS_MonoExtC_3	365	370	PF00514	0.558
TRG_NLS_MonoExtC_3	82	87	PF00514	0.629
TRG_NLS_MonoExtN_4	365	370	PF00514	0.567
TRG_NLS_MonoExtN_4	458	464	PF00514	0.551
TRG_NLS_MonoExtN_4	83	90	PF00514	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0G6	Leptomonas seymouri	35%	100%
A0A3Q8IAM5	Leishmania donovani	84%	100%
A4HYW9	Leishmania infantum	84%	100%
E9AII1	Leishmania braziliensis	55%	100%
E9AUR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%