DUF1935 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1935), putative

Species:

Leishmania major

UniProt:

Q4QCR9_LEIMA

TriTrypDb:

LmjF.20.1270 , LMJLV39_200019000 , LMJSD75_200019000

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.442
CLV_C14_Caspase3-7	139	143	PF00656	0.502
CLV_PCSK_SKI1_1	48	52	PF00082	0.661
DOC_PP1_RVXF_1	46	52	PF00149	0.679
DOC_PP4_FxxP_1	67	70	PF00568	0.666
DOC_USP7_MATH_1	10	14	PF00917	0.845
DOC_USP7_MATH_1	148	152	PF00917	0.502
DOC_USP7_UBL2_3	42	46	PF12436	0.652
DOC_WW_Pin1_4	131	136	PF00397	0.580
LIG_14-3-3_CanoR_1	20	25	PF00244	0.784
LIG_14-3-3_CanoR_1	97	101	PF00244	0.550
LIG_APCC_ABBA_1	38	43	PF00400	0.712
LIG_APCC_ABBAyCdc20_2	97	103	PF00400	0.478
LIG_deltaCOP1_diTrp_1	94	101	PF00928	0.482
LIG_FHA_1	54	60	PF00498	0.605
LIG_FHA_2	13	19	PF00498	0.645
LIG_LIR_Apic_2	64	70	PF02991	0.636
LIG_LIR_Gen_1	28	38	PF02991	0.653
LIG_LIR_Gen_1	95	103	PF02991	0.478
LIG_LIR_Nem_3	28	33	PF02991	0.682
LIG_LIR_Nem_3	95	101	PF02991	0.478
LIG_REV1ctd_RIR_1	112	120	PF16727	0.502
LIG_SH3_3	147	153	PF00018	0.580
LIG_SH3_3	158	164	PF00018	0.497
LIG_SH3_3	171	177	PF00018	0.469
LIG_SH3_3	34	40	PF00018	0.718
LIG_SH3_4	69	76	PF00018	0.788
LIG_SUMO_SIM_par_1	129	139	PF11976	0.346
LIG_TRAF2_1	15	18	PF00917	0.841
LIG_TRAF2_1	92	95	PF00917	0.730
MOD_CK1_1	106	112	PF00069	0.580
MOD_CK2_1	12	18	PF00069	0.840
MOD_CK2_1	88	94	PF00069	0.760
MOD_GlcNHglycan	11	15	PF01048	0.762
MOD_GlcNHglycan	5	8	PF01048	0.783
MOD_GlcNHglycan	90	93	PF01048	0.726
MOD_GSK3_1	106	113	PF00069	0.580
MOD_GSK3_1	25	32	PF00069	0.604
MOD_N-GLC_1	101	106	PF02516	0.442
MOD_NEK2_1	101	106	PF00069	0.442
MOD_NMyristoyl	1	7	PF02799	0.774
MOD_PK_1	20	26	PF00069	0.842
MOD_PKA_2	96	102	PF00069	0.562
MOD_Plk_1	106	112	PF00069	0.495
MOD_Plk_4	110	116	PF00069	0.447
MOD_ProDKin_1	131	137	PF00069	0.580
MOD_SPalmitoyl_4	1	7	PF01529	0.774
MOD_SUMO_rev_2	23	28	PF00179	0.761
MOD_SUMO_rev_2	80	90	PF00179	0.841
TRG_DiLeu_BaEn_4	17	23	PF01217	0.754
TRG_Pf-PMV_PEXEL_1	20	25	PF00026	0.784

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE64	Leptomonas seymouri	45%	100%
A0A3S7WW30	Leishmania donovani	93%	100%
A4HYX0	Leishmania infantum	93%	100%
E9AII2	Leishmania braziliensis	73%	100%
E9AUR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%