Thioredoxin-like_fold domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCR4_LEIMA

TriTrypDb:

LmjF.20.1320 , LMJLV39_200019600 , LMJSD75_200019600

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.459
CLV_C14_Caspase3-7	9	13	PF00656	0.686
CLV_NRD_NRD_1	333	335	PF00675	0.419
CLV_PCSK_KEX2_1	246	248	PF00082	0.502
CLV_PCSK_KEX2_1	333	335	PF00082	0.427
CLV_PCSK_KEX2_1	74	76	PF00082	0.734
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.418
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.723
CLV_PCSK_SKI1_1	215	219	PF00082	0.400
CLV_PCSK_SKI1_1	233	237	PF00082	0.453
DEG_APCC_DBOX_1	175	183	PF00400	0.494
DEG_APCC_DBOX_1	341	349	PF00400	0.421
DOC_CDC14_PxL_1	296	304	PF14671	0.343
DOC_MAPK_DCC_7	294	304	PF00069	0.368
DOC_MAPK_gen_1	219	228	PF00069	0.373
DOC_MAPK_MEF2A_6	219	227	PF00069	0.396
DOC_MIT_MIM_1	216	225	PF04212	0.387
DOC_PP1_RVXF_1	231	238	PF00149	0.355
DOC_USP7_MATH_1	34	38	PF00917	0.624
DOC_USP7_MATH_1	43	47	PF00917	0.539
DOC_WW_Pin1_4	204	209	PF00397	0.475
DOC_WW_Pin1_4	246	251	PF00397	0.420
LIG_14-3-3_CanoR_1	120	124	PF00244	0.617
LIG_14-3-3_CanoR_1	137	143	PF00244	0.386
LIG_14-3-3_CanoR_1	233	238	PF00244	0.461
LIG_14-3-3_CanoR_1	315	325	PF00244	0.347
LIG_BRCT_BRCA1_1	233	237	PF00533	0.321
LIG_BRCT_BRCA1_1	248	252	PF00533	0.344
LIG_BRCT_BRCA1_1	269	273	PF00533	0.447
LIG_BRCT_BRCA1_1	3	7	PF00533	0.624
LIG_FHA_1	101	107	PF00498	0.600
LIG_FHA_1	141	147	PF00498	0.507
LIG_FHA_1	306	312	PF00498	0.395
LIG_FHA_2	227	233	PF00498	0.365
LIG_FHA_2	275	281	PF00498	0.446
LIG_FHA_2	90	96	PF00498	0.707
LIG_LIR_Gen_1	129	140	PF02991	0.533
LIG_LIR_Gen_1	249	260	PF02991	0.340
LIG_LIR_Nem_3	129	135	PF02991	0.552
LIG_LIR_Nem_3	234	240	PF02991	0.440
LIG_LIR_Nem_3	249	255	PF02991	0.255
LIG_LIR_Nem_3	268	274	PF02991	0.282
LIG_NRBOX	221	227	PF00104	0.358
LIG_PCNA_yPIPBox_3	137	146	PF02747	0.516
LIG_SH2_CRK	53	57	PF00017	0.620
LIG_SH2_STAP1	39	43	PF00017	0.691
LIG_SH2_STAT5	198	201	PF00017	0.386
LIG_SH2_STAT5	240	243	PF00017	0.420
LIG_SH3_3	153	159	PF00018	0.634
LIG_SH3_3	16	22	PF00018	0.648
LIG_SH3_3	294	300	PF00018	0.407
LIG_SUMO_SIM_par_1	253	258	PF11976	0.326
LIG_TRAF2_1	82	85	PF00917	0.631
LIG_TRAF2_2	188	193	PF00917	0.541
LIG_WW_1	50	53	PF00397	0.600
MOD_CK1_1	130	136	PF00069	0.447
MOD_CK1_1	231	237	PF00069	0.334
MOD_CK1_1	283	289	PF00069	0.412
MOD_CK1_1	37	43	PF00069	0.746
MOD_CK2_1	226	232	PF00069	0.358
MOD_CK2_1	306	312	PF00069	0.411
MOD_GlcNHglycan	208	211	PF01048	0.414
MOD_GlcNHglycan	25	28	PF01048	0.721
MOD_GlcNHglycan	308	311	PF01048	0.460
MOD_GlcNHglycan	58	61	PF01048	0.734
MOD_GlcNHglycan	84	88	PF01048	0.705
MOD_GlcNHglycan	92	95	PF01048	0.695
MOD_GSK3_1	126	133	PF00069	0.571
MOD_N-GLC_1	12	17	PF02516	0.645
MOD_N-GLC_1	305	310	PF02516	0.396
MOD_N-GLC_1	89	94	PF02516	0.676
MOD_NEK2_1	1	6	PF00069	0.483
MOD_NEK2_1	140	145	PF00069	0.471
MOD_NEK2_1	150	155	PF00069	0.514
MOD_NEK2_1	265	270	PF00069	0.358
MOD_NEK2_1	274	279	PF00069	0.315
MOD_NEK2_2	2	7	PF00069	0.623
MOD_NEK2_2	344	349	PF00069	0.464
MOD_PIKK_1	12	18	PF00454	0.599
MOD_PKA_2	119	125	PF00069	0.643
MOD_Plk_1	130	136	PF00069	0.561
MOD_Plk_1	150	156	PF00069	0.376
MOD_Plk_1	231	237	PF00069	0.358
MOD_Plk_1	65	71	PF00069	0.593
MOD_Plk_4	2	8	PF00069	0.680
MOD_Plk_4	233	239	PF00069	0.393
MOD_Plk_4	280	286	PF00069	0.333
MOD_Plk_4	34	40	PF00069	0.630
MOD_Plk_4	344	350	PF00069	0.430
MOD_ProDKin_1	204	210	PF00069	0.478
MOD_ProDKin_1	246	252	PF00069	0.411
MOD_SUMO_rev_2	174	182	PF00179	0.498
TRG_DiLeu_BaEn_1	177	182	PF01217	0.496
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.420
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.353
TRG_ER_diArg_1	332	334	PF00400	0.389
TRG_ER_diArg_1	47	50	PF00400	0.630
TRG_Pf-PMV_PEXEL_1	162	167	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7C6	Leptomonas seymouri	70%	83%
A0A0S4J7N8	Bodo saltans	48%	100%
A0A1X0NWG2	Trypanosomatidae	54%	100%
A0A3S7WW26	Leishmania donovani	97%	84%
A4HYX5	Leishmania infantum	97%	84%
E9AII7	Leishmania braziliensis	90%	90%
E9AUS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	82%
V5B5H3	Trypanosoma cruzi	58%	100%