RNasePH-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome-associated protein 1, putative

Species:

Leishmania major

UniProt:

Q4QCR0_LEIMA

TriTrypDb:

LmjF.20.1360 , LMJLV39_200020100 , LMJSD75_200020100

Length:

406

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000176	nuclear exosome (RNase complex)	3	2
GO:0000177	cytoplasmic exosome (RNase complex)	5	2
GO:0000178	exosome (RNase complex)	4	2
GO:0005730	nucleolus	5	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1905354	exoribonuclease complex	3	2

Expansion

Sequence features

Q4QCR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCR0

Function

Biological processes
Term	Name	Level	Count
GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic	8	2
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	2
GO:0000460	maturation of 5.8S rRNA	9	2
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	2
GO:0000469	cleavage involved in rRNA processing	7	2
GO:0000956	nuclear-transcribed mRNA catabolic process	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006401	RNA catabolic process	5	2
GO:0006402	mRNA catabolic process	6	2
GO:0006417	regulation of translation	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009890	negative regulation of biosynthetic process	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0009894	regulation of catabolic process	4	2
GO:0009896	positive regulation of catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010558	negative regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0010629	negative regulation of gene expression	6	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0016072	rRNA metabolic process	7	2
GO:0016073	snRNA metabolic process	7	2
GO:0016075	rRNA catabolic process	7	2
GO:0016078	tRNA catabolic process	7	2
GO:0016180	snRNA processing	8	2
GO:0017148	negative regulation of translation	7	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0019439	aromatic compound catabolic process	4	2
GO:0031123	RNA 3'-end processing	7	2
GO:0031125	rRNA 3'-end processing	9	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031327	negative regulation of cellular biosynthetic process	6	2
GO:0031329	regulation of cellular catabolic process	5	2
GO:0031331	positive regulation of cellular catabolic process	6	2
GO:0034248	regulation of amide metabolic process	5	2
GO:0034249	negative regulation of amide metabolic process	6	2
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	9	2
GO:0034470	ncRNA processing	7	2
GO:0034472	snRNA 3'-end processing	8	2
GO:0034473	U1 snRNA 3'-end processing	9	2
GO:0034475	U4 snRNA 3'-end processing	9	2
GO:0034476	U5 snRNA 3'-end processing	9	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0034660	ncRNA metabolic process	6	2
GO:0034661	ncRNA catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043487	regulation of RNA stability	3	2
GO:0043488	regulation of mRNA stability	4	2
GO:0043628	regulatory ncRNA 3'-end processing	8	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0043633	polyadenylation-dependent RNA catabolic process	6	2
GO:0043634	polyadenylation-dependent ncRNA catabolic process	7	2
GO:0043928	exonucleolytic catabolism of deadenylated mRNA	9	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046700	heterocycle catabolic process	4	2
GO:0048518	positive regulation of biological process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050779	RNA destabilization	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051248	negative regulation of protein metabolic process	6	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051254	positive regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0061013	regulation of mRNA catabolic process	6	2
GO:0061014	positive regulation of mRNA catabolic process	7	2
GO:0061157	mRNA destabilization	5	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071025	RNA surveillance	6	2
GO:0071027	nuclear RNA surveillance	7	2
GO:0071028	nuclear mRNA surveillance	8	2
GO:0071029	nuclear ncRNA surveillance	7	2
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process	8	2
GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process	8	2
GO:0071042	nuclear polyadenylation-dependent mRNA catabolic process	7	2
GO:0071046	nuclear polyadenylation-dependent ncRNA catabolic process	8	2
GO:0071047	polyadenylation-dependent mRNA catabolic process	6	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	2
GO:0090501	RNA phosphodiester bond hydrolysis	6	2
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	2
GO:0106354	tRNA surveillance	7	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1903311	regulation of mRNA metabolic process	6	2
GO:1903313	positive regulation of mRNA metabolic process	7	2
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2
GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	7	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	358	362	PF00656	0.655
CLV_C14_Caspase3-7	81	85	PF00656	0.550
CLV_NRD_NRD_1	137	139	PF00675	0.486
CLV_NRD_NRD_1	34	36	PF00675	0.449
CLV_NRD_NRD_1	344	346	PF00675	0.460
CLV_PCSK_FUR_1	135	139	PF00082	0.537
CLV_PCSK_KEX2_1	137	139	PF00082	0.533
CLV_PCSK_KEX2_1	34	36	PF00082	0.449
CLV_PCSK_KEX2_1	344	346	PF00082	0.460
CLV_PCSK_SKI1_1	149	153	PF00082	0.437
CLV_PCSK_SKI1_1	29	33	PF00082	0.398
DEG_APCC_DBOX_1	137	145	PF00400	0.447
DEG_SPOP_SBC_1	185	189	PF00917	0.710
DOC_CYCLIN_RxL_1	251	263	PF00134	0.418
DOC_MAPK_DCC_7	255	264	PF00069	0.343
DOC_MAPK_gen_1	107	114	PF00069	0.461
DOC_MAPK_gen_1	135	143	PF00069	0.386
DOC_MAPK_gen_1	255	264	PF00069	0.358
DOC_MAPK_MEF2A_6	107	114	PF00069	0.395
DOC_MAPK_MEF2A_6	255	264	PF00069	0.343
DOC_PP2B_LxvP_1	257	260	PF13499	0.426
DOC_USP7_MATH_1	185	189	PF00917	0.725
DOC_USP7_MATH_1	193	197	PF00917	0.714
DOC_USP7_MATH_1	202	206	PF00917	0.684
DOC_USP7_MATH_1	272	276	PF00917	0.547
DOC_USP7_MATH_1	56	60	PF00917	0.665
DOC_USP7_MATH_1	78	82	PF00917	0.402
DOC_USP7_MATH_1	91	95	PF00917	0.652
DOC_USP7_MATH_2	353	359	PF00917	0.454
DOC_WW_Pin1_4	187	192	PF00397	0.583
DOC_WW_Pin1_4	299	304	PF00397	0.341
DOC_WW_Pin1_4	41	46	PF00397	0.589
DOC_WW_Pin1_4	76	81	PF00397	0.393
LIG_14-3-3_CanoR_1	285	291	PF00244	0.566
LIG_APCC_ABBA_1	226	231	PF00400	0.459
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_BIR_III_2	115	119	PF00653	0.384
LIG_FHA_1	3	9	PF00498	0.523
LIG_FHA_1	70	76	PF00498	0.368
LIG_FHA_1	77	83	PF00498	0.417
LIG_FHA_2	310	316	PF00498	0.342
LIG_FHA_2	399	405	PF00498	0.444
LIG_FHA_2	95	101	PF00498	0.624
LIG_GBD_Chelix_1	246	254	PF00786	0.219
LIG_LIR_Apic_2	196	200	PF02991	0.563
LIG_LIR_Apic_2	315	320	PF02991	0.489
LIG_LIR_Apic_2	365	369	PF02991	0.536
LIG_LIR_Gen_1	139	148	PF02991	0.469
LIG_LIR_Gen_1	289	298	PF02991	0.350
LIG_LIR_Gen_1	377	386	PF02991	0.500
LIG_LIR_Gen_1	61	69	PF02991	0.502
LIG_LIR_Nem_3	139	143	PF02991	0.491
LIG_LIR_Nem_3	377	382	PF02991	0.512
LIG_LIR_Nem_3	61	67	PF02991	0.503
LIG_NRBOX	295	301	PF00104	0.326
LIG_PDZ_Class_3	401	406	PF00595	0.519
LIG_SH2_CRK	338	342	PF00017	0.416
LIG_SH2_PTP2	366	369	PF00017	0.579
LIG_SH2_PTP2	64	67	PF00017	0.488
LIG_SH2_SRC	248	251	PF00017	0.220
LIG_SH2_SRC	64	67	PF00017	0.488
LIG_SH2_STAP1	124	128	PF00017	0.383
LIG_SH2_STAP1	248	252	PF00017	0.414
LIG_SH2_STAT5	140	143	PF00017	0.430
LIG_SH2_STAT5	219	222	PF00017	0.366
LIG_SH2_STAT5	335	338	PF00017	0.446
LIG_SH2_STAT5	366	369	PF00017	0.579
LIG_SH2_STAT5	64	67	PF00017	0.509
LIG_SH3_3	305	311	PF00018	0.345
LIG_SH3_3	364	370	PF00018	0.646
LIG_SH3_4	282	289	PF00018	0.416
LIG_SUMO_SIM_par_1	297	302	PF11976	0.332
LIG_TRFH_1	349	353	PF08558	0.453
MOD_CK1_1	186	192	PF00069	0.716
MOD_CK1_1	2	8	PF00069	0.495
MOD_CK1_1	357	363	PF00069	0.547
MOD_CK1_1	371	377	PF00069	0.582
MOD_CK1_1	44	50	PF00069	0.651
MOD_CK1_1	94	100	PF00069	0.707
MOD_CK2_1	309	315	PF00069	0.337
MOD_CK2_1	398	404	PF00069	0.499
MOD_CK2_1	6	12	PF00069	0.412
MOD_CK2_1	60	66	PF00069	0.411
MOD_CK2_1	94	100	PF00069	0.709
MOD_GlcNHglycan	125	128	PF01048	0.519
MOD_GlcNHglycan	191	194	PF01048	0.714
MOD_GlcNHglycan	204	207	PF01048	0.531
MOD_GlcNHglycan	237	240	PF01048	0.501
MOD_GlcNHglycan	357	360	PF01048	0.575
MOD_GlcNHglycan	370	373	PF01048	0.531
MOD_GlcNHglycan	69	72	PF01048	0.567
MOD_GlcNHglycan	93	96	PF01048	0.677
MOD_GSK3_1	181	188	PF00069	0.696
MOD_GSK3_1	189	196	PF00069	0.667
MOD_GSK3_1	2	9	PF00069	0.535
MOD_GSK3_1	37	44	PF00069	0.517
MOD_GSK3_1	56	63	PF00069	0.502
MOD_GSK3_1	90	97	PF00069	0.638
MOD_N-GLC_1	67	72	PF02516	0.501
MOD_N-GLC_1	91	96	PF02516	0.782
MOD_N-GLC_2	376	378	PF02516	0.416
MOD_NEK2_1	143	148	PF00069	0.332
MOD_NEK2_1	235	240	PF00069	0.478
MOD_NEK2_2	260	265	PF00069	0.390
MOD_PKA_2	100	106	PF00069	0.700
MOD_Plk_1	176	182	PF00069	0.650
MOD_Plk_4	362	368	PF00069	0.614
MOD_Plk_4	60	66	PF00069	0.428
MOD_Plk_4	69	75	PF00069	0.321
MOD_Plk_4	78	84	PF00069	0.432
MOD_ProDKin_1	187	193	PF00069	0.586
MOD_ProDKin_1	299	305	PF00069	0.348
MOD_ProDKin_1	41	47	PF00069	0.590
MOD_ProDKin_1	76	82	PF00069	0.396
TRG_DiLeu_BaEn_2	221	227	PF01217	0.457
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.461
TRG_ENDOCYTIC_2	140	143	PF00928	0.430
TRG_ENDOCYTIC_2	338	341	PF00928	0.402
TRG_ENDOCYTIC_2	64	67	PF00928	0.488
TRG_ER_diArg_1	136	138	PF00400	0.447
TRG_ER_diArg_1	34	36	PF00400	0.454
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD98	Leptomonas seymouri	69%	96%
A0A0S4JA55	Bodo saltans	28%	100%
A0A1X0NWT9	Trypanosomatidae	45%	100%
A0A3R7M9T9	Trypanosoma rangeli	49%	100%
A0A3S7WW44	Leishmania donovani	93%	100%
A4HYX8	Leishmania infantum	94%	100%
C9ZII6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AIJ0	Leishmania braziliensis	83%	100%
E9AUS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5D565	Trypanosoma cruzi	46%	100%