Putative RNA-binding regulatory protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumillio protein 9, putative

Species:

Leishmania major

UniProt:

Q4QCQ9_LEIMA

TriTrypDb:

LmjF.20.1365 , LMJLV39_200020200 , LMJSD75_200020200

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QCQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCQ9

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	3
GO:0010608	post-transcriptional regulation of gene expression	6	3
GO:0019222	regulation of metabolic process	3	3
GO:0050789	regulation of biological process	2	3
GO:0060255	regulation of macromolecule metabolic process	4	3
GO:0065007	biological regulation	1	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003723	RNA binding	4	13
GO:0003729	mRNA binding	5	3
GO:0005488	binding	1	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	60	64	PF00656	0.513
CLV_C14_Caspase3-7	96	100	PF00656	0.303
CLV_NRD_NRD_1	121	123	PF00675	0.463
CLV_NRD_NRD_1	130	132	PF00675	0.462
CLV_NRD_NRD_1	15	17	PF00675	0.596
CLV_NRD_NRD_1	246	248	PF00675	0.402
CLV_NRD_NRD_1	454	456	PF00675	0.647
CLV_PCSK_KEX2_1	121	123	PF00082	0.463
CLV_PCSK_KEX2_1	130	132	PF00082	0.462
CLV_PCSK_KEX2_1	15	17	PF00082	0.596
CLV_PCSK_KEX2_1	246	248	PF00082	0.402
CLV_PCSK_KEX2_1	287	289	PF00082	0.540
CLV_PCSK_KEX2_1	313	315	PF00082	0.534
CLV_PCSK_KEX2_1	454	456	PF00082	0.680
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.540
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.613
CLV_PCSK_SKI1_1	176	180	PF00082	0.466
CLV_PCSK_SKI1_1	246	250	PF00082	0.416
CLV_PCSK_SKI1_1	294	298	PF00082	0.482
CLV_PCSK_SKI1_1	47	51	PF00082	0.454
CLV_Separin_Metazoa	173	177	PF03568	0.501
DEG_APCC_DBOX_1	120	128	PF00400	0.442
DEG_APCC_DBOX_1	175	183	PF00400	0.501
DEG_APCC_DBOX_1	246	254	PF00400	0.482
DOC_CYCLIN_RxL_1	243	252	PF00134	0.490
DOC_MAPK_FxFP_2	418	421	PF00069	0.593
DOC_MAPK_gen_1	72	80	PF00069	0.454
DOC_MAPK_MEF2A_6	72	80	PF00069	0.499
DOC_PP2B_LxvP_1	338	341	PF13499	0.607
DOC_PP4_FxxP_1	418	421	PF00568	0.593
DOC_PP4_FxxP_1	465	468	PF00568	0.562
DOC_USP7_MATH_1	365	369	PF00917	0.740
DOC_USP7_UBL2_3	305	309	PF12436	0.448
DOC_WW_Pin1_4	40	45	PF00397	0.516
DOC_WW_Pin1_4	447	452	PF00397	0.605
LIG_14-3-3_CanoR_1	121	125	PF00244	0.453
LIG_14-3-3_CanoR_1	204	212	PF00244	0.501
LIG_14-3-3_CanoR_1	30	37	PF00244	0.498
LIG_14-3-3_CanoR_1	336	341	PF00244	0.598
LIG_14-3-3_CanoR_1	55	65	PF00244	0.589
LIG_Actin_WH2_1	246	263	PF00022	0.546
LIG_Actin_WH2_1	58	76	PF00022	0.562
LIG_Actin_WH2_2	59	76	PF00022	0.560
LIG_BIR_II_1	1	5	PF00653	0.499
LIG_BIR_III_3	1	5	PF00653	0.499
LIG_CaM_IQ_9	297	313	PF13499	0.542
LIG_EH1_1	270	278	PF00400	0.473
LIG_FHA_1	214	220	PF00498	0.518
LIG_FHA_1	356	362	PF00498	0.711
LIG_FHA_1	96	102	PF00498	0.437
LIG_FHA_2	341	347	PF00498	0.619
LIG_FHA_2	436	442	PF00498	0.546
LIG_FHA_2	86	92	PF00498	0.417
LIG_LIR_Apic_2	416	421	PF02991	0.662
LIG_LIR_Nem_3	188	193	PF02991	0.450
LIG_LIR_Nem_3	266	271	PF02991	0.381
LIG_LIR_Nem_3	285	289	PF02991	0.516
LIG_PDZ_Class_2	468	473	PF00595	0.604
LIG_Pex14_2	465	469	PF04695	0.635
LIG_SH2_STAT3	193	196	PF00017	0.343
LIG_SH2_STAT5	119	122	PF00017	0.556
LIG_SH2_STAT5	148	151	PF00017	0.486
LIG_SH2_STAT5	210	213	PF00017	0.427
LIG_SH2_STAT5	379	382	PF00017	0.774
LIG_SH3_3	251	257	PF00018	0.550
LIG_SH3_3	277	283	PF00018	0.579
LIG_SH3_3	312	318	PF00018	0.646
LIG_SH3_3	347	353	PF00018	0.610
LIG_SH3_3	359	365	PF00018	0.523
LIG_SH3_3	4	10	PF00018	0.663
LIG_SH3_3	402	408	PF00018	0.550
LIG_SH3_3	443	449	PF00018	0.699
LIG_UBA3_1	219	226	PF00899	0.450
MOD_CDK_SPxxK_3	40	47	PF00069	0.512
MOD_CDK_SPxxK_3	447	454	PF00069	0.657
MOD_CK1_1	117	123	PF00069	0.460
MOD_CK1_1	64	70	PF00069	0.568
MOD_CK2_1	123	129	PF00069	0.437
MOD_CK2_1	365	371	PF00069	0.789
MOD_CK2_1	435	441	PF00069	0.651
MOD_CK2_1	85	91	PF00069	0.391
MOD_GlcNHglycan	134	138	PF01048	0.560
MOD_GlcNHglycan	17	20	PF01048	0.526
MOD_GlcNHglycan	408	411	PF01048	0.661
MOD_GlcNHglycan	441	445	PF01048	0.740
MOD_GSK3_1	199	206	PF00069	0.430
MOD_GSK3_1	325	332	PF00069	0.750
MOD_GSK3_1	336	343	PF00069	0.678
MOD_GSK3_1	351	358	PF00069	0.698
MOD_GSK3_1	91	98	PF00069	0.450
MOD_N-GLC_2	112	114	PF02516	0.473
MOD_NEK2_1	105	110	PF00069	0.431
MOD_NEK2_1	149	154	PF00069	0.448
MOD_NEK2_1	220	225	PF00069	0.501
MOD_PIKK_1	114	120	PF00454	0.463
MOD_PIKK_1	149	155	PF00454	0.443
MOD_PIKK_1	373	379	PF00454	0.763
MOD_PIKK_1	53	59	PF00454	0.550
MOD_PK_1	336	342	PF00069	0.570
MOD_PKA_1	15	21	PF00069	0.543
MOD_PKA_2	120	126	PF00069	0.482
MOD_PKA_2	15	21	PF00069	0.561
MOD_PKA_2	203	209	PF00069	0.512
MOD_PKA_2	29	35	PF00069	0.482
MOD_PKA_2	355	361	PF00069	0.704
MOD_Plk_1	133	139	PF00069	0.551
MOD_Plk_4	105	111	PF00069	0.418
MOD_Plk_4	123	129	PF00069	0.271
MOD_Plk_4	61	67	PF00069	0.572
MOD_ProDKin_1	40	46	PF00069	0.511
MOD_ProDKin_1	447	453	PF00069	0.603
MOD_SUMO_for_1	304	307	PF00179	0.444
TRG_ENDOCYTIC_2	268	271	PF00928	0.472
TRG_ER_diArg_1	14	16	PF00400	0.669
TRG_ER_diArg_1	245	247	PF00400	0.450
TRG_ER_diArg_1	292	295	PF00400	0.480
TRG_ER_diArg_1	71	74	PF00400	0.571
TRG_NES_CRM1_1	177	188	PF08389	0.501
TRG_NES_CRM1_1	68	79	PF08389	0.458
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	455	459	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILR0	Leptomonas seymouri	56%	72%
A0A1X0P8D8	Trypanosomatidae	21%	82%
A0A3Q8IA47	Leishmania donovani	95%	80%
A0A3R7NHA6	Trypanosoma rangeli	25%	83%
A0A3S7WW64	Leishmania donovani	75%	87%
A4HYX9	Leishmania infantum	95%	80%
A4HYY0	Leishmania infantum	75%	87%
E8NHJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AIJ1	Leishmania braziliensis	82%	100%
E9AUS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QCQ8	Leishmania major	90%	100%